Category: 29682-15-3

In 2017,Yuan, Yan-Qiu; Yuan, Feng-Ling; Li, Fei-Long; Hao, Zhi-Min; Guo, Jun; Young, David J.; Zhang, Wen-Hua; Lang, Jian-Ping published 《A cuboidal [Ni4O4] cluster as a precursor for recyclable, carbon-supported nickel nanoparticle reduction catalysts》.Dalton Transactions published the findings.SDS of cas: 29682-15-3 The information in the text is summarized as follows:

Cuboidal [Ni4O4] clusters supported by a pyridine alkoxide ligand have been developed. One of these clusters was selected as a precursor for carbon-hosted Ni nanoparticles (NiNPs/C) which were efficient catalysts for the conversion of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) at room temperature In the experiment, the researchers used many compounds, for example, Methyl 5-bromopicolinate(cas: 29682-15-3SDS of cas: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lin, Shengjie; Zhou, Ping; Xu, Tingting; Fan, Lihui; Wang, Xinxin; Yue, Lianglan; Jiang, Zhenzhen; Zhang, Yuanbin; Zhang, Zhengyi; He, Yabing published their research in Inorganic Chemistry in 2021. The article was titled 《Modulation of Topological Structures and Adsorption Properties of Copper-Tricarboxylate Frameworks Enabled by the Effect of the Functional Group and Its Position》.Safety of Methyl 5-bromopicolinate The article contains the following contents:

To push forward the structural development and fully explore the potential utility, it is highly desired but challenging to regulate in a controllable manner the structures and properties of MOFs. The authors reported the structural and functional modulation of Cu(II)-tricarboxylate frameworks by employing a strategy of engineering the functionalities and their positions. Two pairs of unsym. biaryl tricarboxylate ligands modified with a Me group and a pyridinic-N atom at distinct positions were logically designed and synthesized, and their corresponding Cu(II)-based MOFs were solvothermally constructed. Diffraction analyses revealed that the variation of functionalities and their positions furnished three different types of topol. structures, which the authors ascribed to the steric effect exerted by the Me group and the chelating effect involving the pyridinic-N atom. Also, gas adsorption studies showed that three of them are potential candidates as solid separation media for acetylene (C2H2) purification, with the separation potential tailorable by altering functionalities and their locations. At 106.7 kPa and 298 K, the C2H2 uptake capacity varies from 64.1 to 132.4 cm3 (STP) g-1, while the adsorption selectivities of C2H2 over its coexisting components of CO2 and CH4 fall at 3.28-4.60 and 14.1-21.9, resp. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3Safety of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Safety of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of Diethynyltriptycene-Linked Dipyridyl Ligands》 was written by Kodanko, Jeremy J.; Morys, Anna J.; Lippard, Stephen J.. Recommanded Product: 29682-15-3This research focused ontriptycene pyridylethynyl preparation dinucleating ligand; pyridine bromo dual Sonogashira coupling diethynyltriptycene. The article conveys some information:

An efficient route to a new family of dinucleating ligands has been developed. A convergent strategy to these ligands involved dual Sonogashira cross-coupling of 2,3-diethynyltriptycene with a variety of functionally diverse 5-bromopyridines. The resultant ligands were accessed in four steps and 40-50% overall yields from 1,2,4,5-tetrabromobenzene. Synthesis of an imidazole and a quinoline derivative by this method is also described. The results came from multiple reactions, including the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2014,Sharma, Sanjeev; Kim, Hyungjun; Lee, Young Hoon; Kim, Taewon; Lee, Yoon Sup; Lee, Min Hyung published 《Heteroleptic Cyclometalated Iridium(III) Complexes Supported by Triarylborylpicolinate Ligand: Ratiometric Turn-On Phosphorescence Response upon Fluoride Binding》.Inorganic Chemistry published the findings.Synthetic Route of C7H6BrNO2 The information in the text is summarized as follows:

Heteroleptic cyclometalated iridium(III) complexes (CN̂)2Ir(Bpic) (4-6) (CN̂ = dfppy (4), ppy (5), btp (6)) supported by triarylborylpicolinate (Bpic) ancillary ligand were synthesized and characterized. X-ray diffraction (XRD) study of 5 confirmed NÔ chelation of the Bpic ligand to the iridium center forming an (CN̂)2Ir-borane conjugate. While the UV/vis absorption bands of 4-6 remained almost unchanged in the low-energy region upon fluoride addition, a ratiometric turn-on phosphorescence response was observed for 4 and 5. In contrast, the phosphorescence of 6 was little affected by fluoride binding. Exptl. and theor. studies suggest that the LUMO in neutral 4 and 5 is dominated by the Bpic ligand, which makes the weakly emissive 3ML’CT/3LL’CT (L = CN̂; L’ = Bpic) states as the lowest-energy triplet excited state, while the fluoride binding to 4 and 5 induces the highly emissive 3MLCT/3ππ* states centered on the (CN̂)2Ir moiety. Thermally induced conversion from the 3MLCT/3ππ* to the 3ML’CT/3LL’CT states is suggested to be responsible for the low-energy weak phosphorescence in 4 and 5. In addition to this study using Methyl 5-bromopicolinate, there are many other studies that have used Methyl 5-bromopicolinate(cas: 29682-15-3Synthetic Route of C7H6BrNO2) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Synthetic Route of C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Pang, Lijuan; Bezencon, Jacqueline; Kleeb, Simon; Rabbani, Said; Sigl, Anja; Smiesko, Martin; Sager, Christoph P.; Eris, Deniz; Schwardt, Oliver; Ernst, Beat published 《FimH antagonists – solubility vs. permeability》.Carbohydrate Chemistry published the findings.HPLC of Formula: 29682-15-3 The information in the text is summarized as follows:

Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most prevalent infections worldwide. Since frequent antibiotic treatment favors the emergence of antibiotic resistance, efficient non-antibiotic strategies are urgently needed. The first step of the pathogenesis of UTI is the bacterial adherence to urothelial host cells, a process mediated by the mannose-binding adhesin FimH located at the tip of bacterial pili. In a preliminary study, biphenyl α-D-mannopyranosides with an electron-withdrawing carboxylate on the aglycon were identified as potent FimH antagonists. Although passive permeability could be established by masking the carboxylate as an ester, insufficient solubility and fast hydrolysis did not allow to maintain the therapeutic concentration in the bladder for the requested period of time. By modifying the substitution pattern, mol. planarity and symmetry of the biphenyl aglycon could be disrupted leading to improved solubility In addition, when heteroatoms were introduced to the aglycon, antagonists with further improved solubility, metabolic stability as well as passive permeability were obtained. The best representative, the pyrrolylphenyl mannoside 42f exhibited therapeutic urine concentration for up to 6 h and is therefore a promising oral candidate for UTI prevention and/or treatment. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3HPLC of Formula: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: Methyl 5-bromopicolinateIn 2014 ,《An environmentally-friendly one-pot synthesis of 4-sulfonyl benzoic acids》 was published in Tetrahedron Letters. The article was written by Frieman, Bryan A.. The article contains the following contents:

This Letter reported an environmentally-friendly one-pot SNAr reaction of thiols to 4-halobenzoic acid Me esters to provide 4-substituted sulfone benzoic acids and picolinic acids after bleach-mediated oxidative workup. These acid intermediates were synthesized on gram scale, are perfect partners for library synthesis, and have good phys. chem. properties useful for drug discovery. In the experimental materials used by the author, we found Methyl 5-bromopicolinate(cas: 29682-15-3Name: Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Comparative dielectric parameters and conductivity mechanisms of pyridine-based rod-like liquid crystals》 was written by Yilmaz Canli, Nimet; Ocak, Hale; Okutan, Mustafa; Karanlik, Gurkan; Bilgin Eran, Belkiz. Application of 29682-15-3 And the article was included in Phase Transitions in 2020. The article conveys some information:

In this study, the dielec. properties and ac conductivity mechanism of pyridine-based rod-like liquid crystals (LC1 and LC2), which show enantiotropic smectic A mesophase, have been investigated by impedance spectroscopy within the frequency interval of 1 kHz-2 MHz. The variation of real and imaginary component of dielec. constant with angular frequency has been investigated. The temperature-dependent absorption coefficient α, relaxation time τo, dielec. strength value Δε, temperature-dependent changes on crystal, SmA and Iso phases have been given. These values were obtained by fitting the exptl. results in ε’-ω graph with the Cole-Cole equation real equation and Origin Pro Graph program. The frequency dependence of ac conductivities has also been analyzed. Different conductivity mechanisms, i.e. dc conductivity, correlated barrier hoping and quantum mech. tunneling behaviors have been determined for different frequency regions. In the experimental materials used by the author, we found Methyl 5-bromopicolinate(cas: 29682-15-3Application of 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application of 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 29682-15-3In 1997 ,《Regiospecific carboalkoxylation of 2,5-dibromopyridine》 appeared in Synthetic Communications. The author of the article were Chambers, R.J.; Marfat, A.. The article conveys some information:

Carboalkoxylation of 2,5-dibromopyridine with carbon monoxide and an alc. in the presence of palladium acetate and 1,1′-bis(diphenylphosphino)ferrocene (dppf) occurs regiospecifically to afford esters of 5-bromopyridine-2-carboxylic acid in good yield. In the part of experimental materials, we found many familiar compounds, such as Methyl 5-bromopicolinate(cas: 29682-15-3Related Products of 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Related Products of 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of Methyl 5-bromopicolinateIn 2016 ,《A Convenient Process for the Preparation of Heteroaryl Trifluoromethyl Selenoethers》 was published in Chinese Journal of Chemistry. The article was written by Tian, Qinli; Weng, Zhiqiang. The article contains the following contents:

The preparation of heteroaryl trifluoromethyl selenoethers RSeCF3 (R = 3-methoxypyridin-5-yl, imidazo[1,2-a]pyrazin-6-yl, 6-methoxybenzo[d]thiazol-2-yl, etc.) by the trifluoromethylselenolation of heteroaryl bromides RBr with [(bpy)CuSeCF3]2 was investigated. A large number of trifluoromethylselenolated heterocyclic compounds were synthesized in good to excellent yields using this approach. It was demonstrated that this procedure tolerates a wide variety of functional groups. In the experiment, the researchers used many compounds, for example, Methyl 5-bromopicolinate(cas: 29682-15-3Safety of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Carpenter, Joseph; Wu, Gang; Wang, Ying; Cook, Erica M.; Wang, Tao; Sitkoff, Doree; Rossi, Karen A.; Mosure, Kathy; Zhuo, Xiaoliang; Cao, Gary G.; Ziegler, Milinda; Azzara, Anthony V.; Krupinski, Jack; Soars, Matthew G.; Ellsworth, Bruce Alan; Wacker, Dean A. published 《Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis》.ACS Medicinal Chemistry Letters published the findings.Related Products of 29682-15-3 The information in the text is summarized as follows:

Herein we report the discovery and preclin. biol. evaluation of 6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)-7-azaspiro[3.5]non-1-en-7-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid, compound 1 (BMS-986318), a nonbile acid farnesoid X receptor (FXR) agonist. Compound 1 exhibits potent in vitro and in vivo activation of FXR, has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis. The overall profile of compound 1 supports its continued evaluation. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3Related Products of 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem