Category: 29682-15-3

《Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis》 was written by Li, Junyou; Liu, Mengqi; Li, Yazhou; Sun, Dan-dan; Shu, Zhihao; Tan, Qian; Guo, Shimeng; Xie, Rongrong; Gao, Lixin; Ru, Hongbo; Zang, Yi; Liu, Hong; Li, Jia; Zhou, Yu. Product Details of 29682-15-3 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Farnesoid X receptor (FXR) plays a key role in bile acid homeostasis, inflammation, fibrosis, and metabolism of lipid and glucose and becomes a promising therapeutic target for nonalcoholic steatohepatitis (NASH) or other FXR-dependent diseases. The phase III trial results of obeticholic acid demonstrate that the FXR agonists emerge as a promising intervention in patients with NASH and fibrosis, but this bile acid-derived FXR agonist brings severe pruritus and an elevated risk of cardiovascular disease for patients. Herein, we reported our efforts in the discovery of a series of non-bile acid FXR agonists, and 36 compounds were designed and synthesized based on the structure-based drug design and structural optimization strategies. Particularly, compound 42(I) is a highly potent and selective FXR agonist, along with good pharmacokinetic profiles, high liver distribution, and preferable in vivo efficacy, indicating that it is a potential candidate for the treatment of NASH or other FXR-dependent diseases. The results came from multiple reactions, including the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3Product Details of 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Product Details of 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C7H6BrNO2In 2016 ,《Discovery of 2-((R)-4-(2-Fluoro-4-(methylsulfonyl)phenyl)-2-methylpiperazin-1-yl)-N-((1R,2s,3S,5S,7S)-5-hydroxyadamantan-2-yl)pyrimidine-4-carboxamide (SKI2852): A Highly Potent, Selective, and Orally Bioavailable Inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1)》 was published in Journal of Medicinal Chemistry. The article was written by Ryu, Je Ho; Lee, Jung A.; Kim, Shinae; Shin, Young Ah; Yang, Jewon; Han, Hye Young; Son, Hyun Joo; Kim, Yong Hyuk; Sa, Joon Ho; Kim, Jae-Sun; Lee, Jungeun; Lee, Jeeyeon; Park, Hyeung-geun. The article contains the following contents:

A series of picolinamide- and pyrimidine-4-carboxamide-based inhibitors of 11β-hydroxysteroid dehydrogenase type 1 was synthesized and evaluated to optimize the lead compound The combination of the replacement of a pyridine ring of the lead compd with a pyrimidine ring and the introduction of an addnl. fluorine substituent at the 2-position of the Ph ring resulted in the discovery of a potent, selective, and orally bioavailable inhibitor, SKI2852, which demonstrated no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity. Repeated oral administration of SKI2852 significantly reduced blood glucose and HbA1c levels and improved the lipid profiles in ob/ob mice. Moreover, the HbA1c-lowering effect of metformin was synergistically enhanced in combination with SKI2852. In the part of experimental materials, we found many familiar compounds, such as Methyl 5-bromopicolinate(cas: 29682-15-3Formula: C7H6BrNO2)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Formula: C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2015,Jornet-Molla, Veronica; Romero, Francisco M. published 《Synthesis of rigid ethynyl-bridged polytopic picolinate ligands for MOF applications》.Tetrahedron Letters published the findings.Safety of Methyl 5-bromopicolinate The information in the text is summarized as follows:

Segmented homopolytopic ligands that consist of a rigid central arylene platform, ethynylene spacers, and terminal chelating picolinate subunits have been synthesized in good yields in a two-step procedure involving a Sonogashira-type cross coupling reaction between the ester Me 5-bromopyridine-2-carboxylate and several arylacetylenes, followed by hydrolysis of the resulting Me picolinates [e.g., Me 5-bromopyridine-2-carboxylate + 1,4-diethynylbenzene followed by hydrolysis afforded ligand I]. A similar strategy has been employed for the preparation of heteroditopic ligands containing picolinate and a second non-chelating pyridine or benzoate unit. The compounds are potential candidates for organic linkers in metal-organic frameworks (MOFs). The results came from multiple reactions, including the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3Safety of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2013,Aik, WeiShen; Demetriades, Marina; Hamdan, Muhammad K. K.; Bagg, Eleanor. A. L.; Yeoh, Kar Kheng; Lejeune, Clarisse; Zhang, Zhihong; McDonough, Michael A.; Schofield, Christopher J. published 《Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)》.Journal of Medicinal Chemistry published the findings.Reference of Methyl 5-bromopicolinate The information in the text is summarized as follows:

The fat mass and obesity associated protein (FTO) is a potential target for anti-obesity medicines. FTO is a 2-oxoglutarate (2OG)-dependent N-Me nucleic acid demethylase that acts on substrates including 3-methylthymidine, 3-methyluracil, and 6-methyladenine. To identify FTO inhibitors, we screened a set of 2OG analogs and related compounds using differential scanning fluorometry- and liquid chromatog.-based assays. The results revealed sets of both cyclic and acyclic 2OG analogs that are FTO inhibitors. Identified inhibitors include small mols. that have been used in clin. studies for the inhibition of other 2OG oxygenases. Crystallog. analyses reveal inhibition by 2OG cosubstrate or primary substrate competitors as well as compounds that bind across both cosubstrate and primary substrate binding sites. The results will aid the development of more potent and selective FTO inhibitors.Methyl 5-bromopicolinate(cas: 29682-15-3Reference of Methyl 5-bromopicolinate) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2001,Song, Jinhua J.; Yee, Nathan K. published 《A Concise Synthesis of Fusaric Acid and (S)-(+)-Fusarinolic Acid》.Journal of Organic Chemistry published the findings.Synthetic Route of C7H6BrNO2 The information in the text is summarized as follows:

The authors have developed the most efficient synthesis of the naturally occurring alkaloid title compounds to date (four steps with overall yield of 55% and 70%, resp.). This synthesis is based on a unified and flexible strategy using 5-bromo-2-iodopyridine as a template and is readily applicable to analog synthesis. The carbonylative ester formation was found to occur exclusively at the C2 position of the pyridine ring under catalysis of Pd(PHh3)2Cl2 to afford the monoester in excellent yield without the complication of diester formation. A greatly improved synthesis of 5-bromo-2-iodopyridine is also reported. In addition to this study using Methyl 5-bromopicolinate, there are many other studies that have used Methyl 5-bromopicolinate(cas: 29682-15-3Synthetic Route of C7H6BrNO2) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Synthetic Route of C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2015 ,《Discovery of a High Affinity and Selective Pyridine Analog as a Potential Positron Emission Tomography Imaging Agent for Cannabinoid Type 2 Receptor》 appeared in Journal of Medicinal Chemistry. The author of the article were Slavik, Roger; Grether, Uwe; Muller Herde, Adrienne; Gobbi, Luca; Fingerle, Jurgen; Ullmer, Christoph; Kramer, Stefanie D.; Schibli, Roger; Mu, Linjing; Ametamey, Simon M.. The article conveys some information:

As part of our efforts to develop CB2 PET imaging agents, we investigated 2,5,6-substituted pyridines as a novel class of potential CB2 PET ligands. A total of 21 novel compounds were designed, synthesized, and evaluated for their potency and binding properties toward human and rodent CB1 and CB2. The most promising ligand 6a was radiolabeled with carbon-11 to yield 16 ([11C]RSR-056). Specific binding of 16 to CB2-pos. spleen tissue of rats and mice was demonstrated by in vitro autogadiog. and verified in vivo in PET and biodistribution experiments Furthermore, 16 was evaluated in a lipopolysaccharid (LPS) induced murine model of neuroinflammation. Brain radioactivity was strikingly higher in the LPS-treated mice than the control mice. Compound 16 is a promising radiotracer for imaging CB2 in rodents. It might serve as a tool for the investigation of CB2 receptor expression levels in healthy tissues and different neuroinflammatory disorders in humans. After reading the article, we found that the author used Methyl 5-bromopicolinate(cas: 29682-15-3Category: pyridine-derivatives)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《High Triplet Energy Level Achieved by Tuning the Arrangement of Building Blocks in Phosphorescent Polymer Backbones for Furnishing High Electroluminescent Performances in Both Blue and White Organic Light-Emitting Devices》 was written by Liu, Boao; Dang, Feifan; Tian, Zhuanzhuan; Feng, Zhao; Jin, Deyuan; Dang, Wanping; Yang, Xiaolong; Zhou, Guijiang; Wu, Zhaoxin. Formula: C7H6BrNO2This research focused ontriplet energy phosphorescent polymer blue white organic LED; diode blue white emitting organic phosphorescent polymer triplet energy; electroluminescent device organic blue white phosphorescent polymer triplet energy; OLEDs; charge-carrier injection/transporting; functionalization; high triplet energy level; phosphorescent polymers; polymer backbone. The article conveys some information:

A high triplet energy level (ET) of ∼2.83 eV was achieved in a novel polymer backbone through tuning the arrangement of 2 kinds of building blocks, showing enhanced hole injection/transporting capacity. Based on this new polymer backbone with high ET, both blue and white phosphorescent polymers were developed with a trade-off between high ET and enhanced charge-carrier transporting ability. Their photophys. features, electrochem. behaviors, and electroluminescent (EL) properties were characterized. Benefitting from the advantages associated with the novel polymer backbone, the blue phosphorescent polymers show top-ranking EL performances with a maximum luminance efficiency (ηL) of 15.22 cd A-1, corresponding to a power efficiency (ηP) of 12.64 lm W-1, and external quantum efficiency (ηext) of 6.22% and the stable Commission Internationale de L’Eclairage (CIE) coordinates of (0.19, 0.38). Also, blue-orange (B-O) complementary-colored white phosphorescent polymers based on this novel polymer backbone were also obtained showing encouraging EL efficiencies of 12.34 cd A-1, 9.59 lm W-1, and 4.10% in the optimized WOLED together with exceptionally stable CIE coordinates of (Δx = 0.014, Δy = 0.010) in a wide driving voltage range from 4 to 16 V. All of these attractive EL results achieved by these novel phosphorescent polymers show the great potential of this new polymer backbone in developing highly efficient phosphorescent polymers. The experimental process involved the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3Formula: C7H6BrNO2)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Formula: C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Zhang, Mengjia; Weng, Zhiqiang published 《Copper-Mediated Trifluoromethylthiolation of Heteroaryl Bromides》.Advanced Synthesis & Catalysis published the findings.Related Products of 29682-15-3 The information in the text is summarized as follows:

An efficient protocol for the copper-mediated trifluoromethylthiolation of heteroaryl bromides has been achieved using the copper complex (bpy)Cu(SCF3) as trifluoromethylthiolation reagent. This procedure provides a straightforward synthetic method for heteroaryl trifluoromethyl sulfides from readily available, simple starting materials. The reaction demonstrates a broad substrate scope and tolerates a wide array of functional groups, including nitrile, ester, chloro, nitro, or methoxy substituents. The synthesis of the target compounds was achieved by a reaction of (2,2′-bipyridine-κN1,κN1′)(1,1,1-trifluoromethanethiolato-κS)copper with aryl bromides, such as 2-bromopyridine derivatives, 3-bromopyridine derivatives, 4-bromopyridine derivatives, bromoquinoline derivatives, 2-bromoquinoxaline, 2-bromopyrimidine, 2-bromothiazole derivatives, 6-(bromo)imidazo[1,2-a]pyridine. After reading the article, we found that the author used Methyl 5-bromopicolinate(cas: 29682-15-3Related Products of 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Related Products of 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Rabal, Obdulia; Sanchez-Arias, Juan A.; Cuadrado-Tejedor, Mar; de Miguel, Irene; Perez-Gonzalez, Marta; Garcia-Barroso, Carolina; Ugarte, Ana; Estella-Hermoso de Mendoza, Ander; Saez, Elena; Espelosin, Maria; Ursua, Susana; Haizhong, Tan; Wei, Wu; Musheng, Xu; Garcia-Osta, Ana; Oyarzabal, Julen published 《Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer’s Disease》.Journal of Medicinal Chemistry published the findings.Electric Literature of C7H6BrNO2 The information in the text is summarized as follows:

Simultaneous inhibition of phosphodiesterase 5 (PDE5) and histone deacetylases (HDAC) has recently been validated as a potentially novel therapeutic approach for Alzheimer’s Disease (AD). To further extend this concept, the authors designed and synthesized the first chem. series of dual acting PDE5 and HDAC inhibitors, and the authors validated this systems therapeutics approach. Following the implementation of structure- and knowledge-based approaches, initial hits were designed and were shown to validate the hypothesis of dual in vitro inhibition. Then, an optimization strategy was pursued to obtain a proper tool compound for in vivo testing in AD models. Initial hits were translated into mols. with adequate cellular functional responses (histone acetylation and cAMP/cGMP response element-binding (CREB) phosphorylation in the nanomolar range), an acceptable therapeutic window (>1 log unit) and the ability to cross the blood-brain barrier, leading to the identification of 7 as a candidate for in vivo proof-of-concept testing. In the experimental materials used by the author, we found Methyl 5-bromopicolinate(cas: 29682-15-3Electric Literature of C7H6BrNO2)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Electric Literature of C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Wodtke, Robert; Hauser, Christoph; Ruiz-Gomez, Gloria; Jaeckel, Elisabeth; Bauer, David; Lohse, Martin; Wong, Alan; Pufe, Johanna; Ludwig, Friedrich-Alexander; Fischer, Steffen; Hauser, Sandra; Greif, Dieter; Pisabarro, M. Teresa; Pietzsch, Jens; Pietsch, Markus; Loeser, Reik published 《Nε-Acryloyllysine Piperazides as Irreversible Inhibitors of Transglutaminase 2: Synthesis, Structure-Activity Relationships, and Pharmacokinetic Profiling》.Journal of Medicinal Chemistry published the findings.Recommanded Product: Methyl 5-bromopicolinate The information in the text is summarized as follows:

Transglutaminase 2 (TGase 2)-catalyzed transamidation represents an important post-translational mechanism for protein modification with implications in physiol. and pathophysiol. conditions, including fibrotic and neoplastic processes. Consequently, this enzyme is considered a promising target for the diagnosis of and therapy for these diseases. In this study, we report on the synthesis and kinetic characterization of Nε-acryloyllysine piperazides as irreversible inhibitors of TGase 2. Systematic structural modifications on 54 new compounds were performed with a major focus on fluorine-bearing substituents due to the potential of such compounds to serve as radiotracer candidates for positron emission tomog. The determined inhibitory activities ranged from 100 to 10,000 M-1 s-1, which resulted in comprehensive structure-activity relationships. Structure-activity correlations using various substituent parameters accompanied by covalent docking studies provide an advanced understanding of the mol. recognition for this inhibitor class within the active site of TGase 2. Selectivity profiling of selected compounds for other transglutaminases demonstrated an excellent selectivity toward transglutaminase 2. Furthermore, an initial pharmacokinetic profiling of selected inhibitors was performed, including the assessment of potential membrane permeability and liver microsomal stability. The experimental part of the paper was very detailed, including the reaction process of Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Recommanded Product: Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem