Category: 29682-15-3

《Tricyclic imidazole antagonists of the Neuropeptide S Receptor》 was written by Trotter, B. Wesley; Nanda, Kausik K.; Manley, Peter J.; Uebele, Victor N.; Condra, Cindra L.; Gotter, Anthony L.; Menzel, Karsten; Henault, Martin; Stocco, Rino; Renger, John J.; Hartman, George D.; Bilodeau, Mark T.. Quality Control of Methyl 5-bromopicolinateThis research focused ontricyclic imidazole antagonist Neuropeptide S Receptor preparation. The article conveys some information:

A new structural class of potent antagonists of the Neuropeptide S Receptor (NPSR) is reported. High-throughput screening identified a tricyclic imidazole antagonist of NPSR, and medicinal chem. optimization of this structure was undertaken to improve potency against the receptor as well as CNS penetration. Detailed herein are synthetic and medicinal chem. studies that led to the identification of antagonists I and II which demonstrate potent in vitro NPSR antagonism and central exposure in vivo. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3Quality Control of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Quality Control of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Sutherland, Hamish S.; Lu, Guo-Liang; Tong, Amy S. T.; Conole, Daniel; Franzblau, Scott G.; Upton, Anna M.; Lotlikar, Manisha U.; Cooper, Christopher B.; Palmer, Brian D.; Choi, Peter J.; Denny, William A. published an article in European Journal of Medicinal Chemistry. The title of the article was 《Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis》.Quality Control of Methyl 5-bromopicolinate The author mentioned the following in the article:

Drug resistant tuberculsosis (TB) is global health crisis that demands novel treatment strategies. Bacterial ATP synthase inhibitors such as bedaquiline and next-generation analogs (such as TBAJ-876) have shown promising efficacy in patient populations and preclin. studies, resp., suggesting that selective targeting of this enzyme presents a validated therapeutic strategy for the treatment of TB. In this work, we report tetrahydronaphthalene amides (THNAs) as a new class of ATP synthase inhibitors that are effective in preventing the growth of Mycobacterium tuberculosis (M.tb) in culture. Design, synthesis and comprehensive structure-activity relationship studies for approx. 80 THNA analogs are described, with a small selection of compounds exhibiting potent (in some cases MIC90 <1 μg/mL) in vitro M.tb growth inhibition taken forward to pharmacokinetic and off-target profiling studies. Ultimately, we show that some of these THNAs possess reduced lipophilic properties, decreased hERG liability, faster mouse/human liver microsomal clearance rates and shorter plasma half-lives compared with bedaquiline, potentially addressing of the main concerns of persistence and phospholipidosis associated with bedaquiline. In the part of experimental materials, we found many familiar compounds, such as Methyl 5-bromopicolinate(cas: 29682-15-3Quality Control of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kariofillis, Stavros K.; Jiang, Shutian; Zuranski, Andrzej M.; Gandhi, Shivaani S.; Martinez Alvarado, Jesus I.; Doyle, Abigail G. published an article in 2022. The article was titled 《Using Data Science To Guide Aryl Bromide Substrate Scope Analysis in a Ni/Photoredox-Catalyzed Cross-Coupling with Acetals as Alcohol-Derived Radical Sources》, and you may find the article in Journal of the American Chemical Society.Product Details of 29682-15-3 The information in the text is summarized as follows:

Ni/photoredox-catalyzed (deutero)methylation and alkylation of aryl halides RX (R = Ph, Ac, t-Bu, etc.; X = Br, Cl) and benzaldehyde di(alkyl) acetals R1CH(OR2)2 (R1 = Ph, 4-(1H-imidazol-4-yl)benzen-1-yl, 5-tert-butyl-2-chlorophenyl, etc.; R2 = Me, Et, Bn, etc.) that serve as alc.-derived radical sources were reported. Reaction development, mechanistic studies, and late-stage derivatization of a biol. relevant aryl chloride, fenofibrate, are presented. Then, the integration of data science techniques, including DFT featurization, dimensionality reduction, and hierarchical clustering, to delineate a diverse and succinct collection of aryl bromides that is representative of the chem. space of the substrate class was described. By superimposing scope examples from published Ni/photoredox methods on this same chem. space, areas of sparse coverage and high vs. low average yields were identified, enabling comparisons between prior art and this new method. Addnl., it was demonstrated that the systematically selected scope of aryl bromides RBr can be used to quantify population-wide reactivity trends and reveal sources of possible functional group incompatibility with supervised machine learning. In the experiment, the researchers used many compounds, for example, Methyl 5-bromopicolinate(cas: 29682-15-3Product Details of 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Product Details of 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Bremer, Paul T.; Xue, Song; Janda, Kim D. published 《Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain》.Chemical Communications (Cambridge, United Kingdom) published the findings.Recommanded Product: 29682-15-3 The information in the text is summarized as follows:

In developing small-mol. inhibitors of botulinum neurotoxin serotype A light chain (BoNT/A LC), substituted picolinic acids were identified. Extensive investigation into the SAR of the picolinic acid scaffold revealed 5-(1-butyl-4-chloro-1H-indol-2-yl)picolinic acid (I), which possessed low micromolar activity against BoNT/A. Kinetic and docking studies demonstrated binding of I to the β-exosite: a largely unexplored site on the LC that holds therapeutic relevance for botulism treatment. After reading the article, we found that the author used Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2012,Delcamp, Jared H.; Yella, Aswani; Nazeeruddin, Mohammad K.; Graetzel, Michael published 《Modulating dye E(S+/S*) with efficient heterocyclic nitrogen containing acceptors for DSCs》.Chemical Communications (Cambridge, United Kingdom) published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

Acceptor motifs based on nitrogen containing heterocycles have been synthesized for use in dye-sensitized solar cells (DSCs). Through the selective addition of nitrogen atoms and increased conjugation of the nitrogen containing heterocycles the excited-state oxidation potential, E(S+/S*), may be conveniently tuned with minimal effect on the ground-state oxidation potential, E(S+/S), of the dye. The experimental process involved the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3Category: pyridine-derivatives)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Liu, Boao; Dang, Feifan; Feng, Zhao; Tian, Zhuanzhuan; Zhao, Jiang; Wu, Yong; Yang, Xiaolong; Zhou, Guijiang; Wu, Zhaoxin; Wong, Wai-Yeung published 《Novel iridium(III) complexes bearing dimesitylboron groups with nearly 100% phosphorescent quantum yields for highly efficient organic light-emitting diodes》.Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published the findings.SDS of cas: 29682-15-3 The information in the text is summarized as follows:

A series of cyclometalated iridium (III) complexes, Ir-B-1, Ir-B-2, Ir-B-3, and Ir-B-4, were synthesized with the 2-phenylpyridine (ppy) type main ligand possessing a dimesitylboron group and the auxiliary ligand containing other main-group element units showing unique charge injection/transporting features. Their thermal stability, photophys. and electrochem. properties, and electroluminescent (EL) performances have been characterized. Time-dependent d. functional theory (TD-DFT) calculations were carried out to study the photophys. properties of these complexes. All these complexes can emit intense orange phosphorescence with extremely high quantum yields of nearly 100% measured in neat films at room temperature Moreover, the solution-processed organic light-emitting devices (OLEDs) using these complexes as orange emitters can show very high EL efficiencies with the maximum luminance efficiency (ηL) of 85.1 cd A-1, corresponding to a power efficiency (ηP) of 69.7 lm W-1 and an external quantum efficiency (ηext) of 28.1%. In the part of experimental materials, we found many familiar compounds, such as Methyl 5-bromopicolinate(cas: 29682-15-3SDS of cas: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.SDS of cas: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem