Category: 30529-70-5

Adding a certain compound to certain chemical reactions, such as: 30529-70-5, 2-Chloro-6-methylnicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H6ClNO2, blongs to pyridine-derivatives compound. COA of Formula: C7H6ClNO2

Description 47: methyl l-chloro–methyl-S-pyridinecarboxylate (D47); To a solution of 2-chloro-6-methyl-3-pyridinecarboxylic acid (8 g, 46.6 mmol) (available from Sigma-Aldrich No.357847) in DCM (100 ml) and MeOH (50.0 ml) stirred under nitrogen at room temperature was added TMS-diazomethane 2 M in hexane (46.6 ml, 93 mmol). The reaction mixture was stirred at room temperature for 20 minutes. The solvents were removed to give the title compound D47 (7 g).MS: (ES/+) m/z: 186 (M+l) C8H8ClNO2 requires 185.1H NMR (400 MHz, CDCl3) ppm 8.10 (d, 1 H), 7.18 (d, 1 H), 3.96 (s, 3 H), 2.61 (s, 3 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,30529-70-5, 2-Chloro-6-methylnicotinic acid, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; AMANTINI, David; DI FABIO, Romano; WO2010/122151; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 30529-70-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 30529-70-5, name is 2-Chloro-6-methylnicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

Methyl iodide (10.33 ml) was added to a stirred suspension of 2-chloro-6-nicotinic acid (22.8 g) and potassium carbonate (36.8 g) in DMF (190 ml), under an inert atmosphere at ambient temperature. After stirring vigorously for 16 hours the suspension was filtered and the solid residue washed with 10% methanol/dichloromethane (100 ml). The filtrate was then concentrated under reduced pressure and the residue diluted with water (250 ml), extracted with dichloromethane (3¡Á150 ml) and the combined extracts dried and concentrated under reduced pressure. Purification by bulb to bulb distillation (140 C. 0.05 mmHg) gave methyl 2-chloro-6-nicotinoate as a white solid (23.6 g). 1H NMR (CDCl3) delta 2.50 (3H, s), 3.85 (3H, s), 7.10 (1H, d), 8.00 (1H, d). MS(MH+) 186.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 30529-70-5, 2-Chloro-6-methylnicotinic acid.

Reference:
Patent; AstraZeneca UK Limited; Zeneca-Pharma SA; US6342765; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem