Category: 31106-82-8

In 2019,Talanta included an article by Liu, Dan; Liu, Sheng; Zhang, Xinyu; Zhang, Qiong; Yu, Jianhua; Yang, Mingdi; Yang, Xingyuan; Tian, Yupeng; Zhu, Xiaojiao; Zhou, Hongping. SDS of cas: 31106-82-8. The article was titled 《A water-soluble benzoxazole-based probe: Real-time monitoring PPi via situ reaction by two-photon cells imaging》. The information in the text is summarized as follows:

Pyrophosphate (PPi) played crucial roles in various fundamental physiol. processes. Herein, a two-photon absorption (TPA) “”On-Off-On”” type benzoxazole-based fluorescence probe BN (I) was designed and synthesized, which detected PPi through Cu2+ displacing method in situ system in aqueous medium. The on-off-on process of BN recognizing PPi was verified by mass spectra and theor. calculations, which was successfully applied in TPA cells imaging. In the part of experimental materials, we found many familiar compounds, such as 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8SDS of cas: 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.SDS of cas: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2021 ,《Synthesis, Characterization, and Structural Transformation of Picolyl-Functionalized Polynuclear Silver(I)- and Gold(I)-N-Heterocyclic Carbene Complexes》 was published in Organometallics. The article was written by Li, Xin; Zhao, Jing; Shi, Wen-jie; Bai, Sha; Han, Ying-feng. The article contains the following contents:

Three coinage-metal (AgI, CuI, and AuI) NHC complexes featuring picolyl-functionalized NHC ligands were synthesized and fully characterized by NMR spectroscopy and single-crystal X-ray diffraction analyses. The obtained complexes exhibit different geometries depending on the diversified coordination modes of the multidentate ligand toward different metal ions. The trinuclear AgI complex [Ag3(L)2](PF6)3 was directly synthesized by the one-step reaction of picolyl-functionalized diimidazolium salts with Ag2O. Further, transmetalation of [Ag3L2](PF6)3 with CuCl and Au(THT)Cl (THT = tetrahydrothiophene) led to the formation of the unexpected copper(I)-NHC complex {[CuL(CH3CN)Cl]PF6}n with one-dimensional chain structure and the tetranuclear gold(I) complex [Au4L2]Cl(PF6)3, resp. Interestingly, the two trinuclear AuI-NHC complexes [Au3L2]2(2,6-nds)3 and [Au3L2]2(1,5-nds)3 (nds = naphthalenedisulfonate) were further obtained through an anion-induced structural transformation of [Au4L2]Cl(PF6)3. Complexes [Au3L2]2(2,6-nds)3 and [Au3L2]2(1,5-nds)3 were also characterized by mass spectrometry and single-crystal X-ray diffraction studies. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Category: pyridine-derivatives)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Design, synthesis, and in-vitro evaluation of hydroxybenzimidazole-donepezil analogues as multitarget-directed ligands for the treatment of Alzheimer’s disease》 was written by Chaves, Silvia; Resta, Simonetta; Rinaldo, Federica; Costa, Marina; Josselin, Romane; Gwizdala, Karolina; Piemontese, Luca; Capriati, Vito; Pereira-Santos, A. Raquel; Cardoso, Sandra M.; Santos, M. Amelia. HPLC of Formula: 31106-82-8 And the article was included in Molecules in 2020. The article conveys some information:

A series of multi-target-directed ligands (MTDLs), obtained by attachment of a hydroxyphenylbenzimidazole (BIM) unit to donepezil (DNP) active mimetic moiety (benzyl-piperidine/-piperazine) was designed, synthesized, and evaluated as potential anti-Alzheimer’s disease (AD) drugs in terms of biol. activity (inhibition of acetylcholinesterase (AChE) and β-amyloid (Aβ) aggregation), metal chelation, and neuroprotection capacity. Among the DNP-BIM hybrids studied herein, the structural isomerization did not significantly improve the biol. properties, while some substitutions, namely a fluorine atom in each moiety or the methoxy group in the benzyl ring, evidenced higher cholinergic AChE activity. All the compounds were able to chelate Cu and Zn metal ions through their bidentate BIM moieties; but compound I, containing a three-dentate chelating unit, is the strongest Cu(II) chelator. Concerning the viability on neuroblastoma cells, compounds II (R1 = 5-MeO, R2 = H; R1 = H, R2 = 2-F) displayed the highest reduction of Aβ-induced cell toxicity. In silico calculations of some pharmacokinetic descriptors indicate that all the compounds but the nitro derivatives have good potential oral-bioavailability. Overall, it can be concluded that most of the studied DNP-BIM conjugates showed quite good anti-AD properties, therefore deserving to be considered in further studies with the aim of understanding and treating AD. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8HPLC of Formula: 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. HPLC of Formula: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Li, Jia-Yi; Wang, Li; Yin, Li-Ping; Jiang, Xin-Meng; Guo, Kai; Zhang, Chun; Yu, Shan-Shan; Yu, Xiao-Qi; Wang, Qin published an article in ChemistryOpen. The title of the article was 《A Racemic Naphthyl-Coumarin-Based Probe for Quantitative Enantiomeric Excess Analysis of Amino Acids and Enantioselective Sensing of Amines and Amino Alcohols》.Product Details of 31106-82-8 The author mentioned the following in the article:

A new racemic naphthyl-coumarin-based probe was found to bind covalently with amino acids in MeOH-KOH system and thereby generates distinct CD responses. The induced strong CD signals allowed quant. enantiomeric excess anal. of amino acids and enantioselective sensing of amines and amino alcs. The mechanism for the reaction of the coumarin-aldehyde probe with an amino acid was investigated by CD, UV-Vis, NMR, ESI-MS analyses and ECD calculation2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Fluorescent probes for detecting glutathione: Bio-imaging and two reaction mechanisms》 were Xia, Ying; Zhang, Huihui; Zhu, Xiaojiao; Fang, Min; Yang, Mingdi; Zhang, Qiong; Li, Xiaowu; Zhou, Hongping; Yang, Xingyuan; Tian, Yupeng. And the article was published in Dyes and Pigments in 2019. Product Details of 31106-82-8 The author mentioned the following in the article:

A series of compounds (W1-W8) based on triphenylamine with -C=N- or -NH- group, were designed and studied by fluorescence emission spectra and DFT/TDDFT calculations Probes W1-W4 were selectively leveraged to sensitively detect glutathione by two distinct reaction mechanisms, thereinto, W1-W2 featured a convenient detection for glutathione using hydrolysis and W3-W4 utilized displacement to probe glutathione possessing sensitivity and practicability. Compound W5-W8 here provided an avenue for understanding structure-property relationship. Taken considerations for toxicity and biocompatibility together, W1-W4 showed great advance for endogenously and exogenously imaging GSH in living cells. After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Sulfide analogues of flupirtine and retigabine with nanomolar KV7.2/KV7.3 channel opening activity》 were Bock, Christian; Surur, Abdrrahman S.; Beirow, Kristin; Kindermann, Markus K.; Schulig, Lukas; Bodtke, Anja; Bednarski, Patrick J.; Link, Andreas. And the article was published in ChemMedChem in 2019. Category: pyridine-derivatives The author mentioned the following in the article:

The potassium channel openers flupirtine and retigabine have proven to be valuable analgesics or antiepileptics. Their recent withdrawal due to occasional hepatotoxicity and tissue discoloration, resp., leaves a therapeutic niche unfilled. Metabolic oxidation of both drugs gives rise to the formation of electrophilic quinones. These elusive, highly reactive metabolites may induce liver injury in the case of flupirtine and blue tissue discoloration after prolonged intake of retigabine. We examined which structural features can be altered to avoid the detrimental oxidation of the aromatic ring and shift oxidation toward the formation of more benign metabolites. Structure-activity relationship studies were performed to evaluate the KV7.2/3 channel opening activity of 45 derivatives Sulfide analogs were identified that are devoid of the risk of quinone formation, but possess potent KV7.2/3 opening activity. For example, flupirtine analog 3-(3,5-difluorophenyl)-N-(6-(isobutylthio)-2-(pyrrolidin-1-yl)pyridin-3-yl)propanamide (48) has 100-fold enhanced activity (EC50=1.4 nM), a vastly improved toxicity/activity ratio, and the same efficacy as retigabine in vitro. In the experiment, the researchers used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Category: pyridine-derivatives)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Filali Baba, Yassir; Kandri Rodi, Youssef; Mague, Joel T.; Ouzidan, Younes; Ouazzani Chahdi, Fouad; Essassi, El Mokhtar published �Pyridin-2-yl)methyl 6-bromo-2-oxo-1-[(pyridin-2-yl)methyl]-1,2-dihydroquinoline-4-carboxylate�IUCrData published the findings.Quality Control of 2-(Bromomethyl)pyridine hydrobromide The information in the text is summarized as follows:

In the central dihydroquinoline unit of the title compound, C22H16BrN3O3, the dihydropyridinone and benzene rings are inclined to one another by 2.0 (1)°, while the outer pyridine rings are almost perpendicular to the plane of the dihydroquinoline ring system. The conformation of the mol. is partially determined by an intramol. C-H···O hydrogen bond. In the crystal, mols. stack along the b-axis direction through a combination of C-H···N and C-H···O hydrogen bonds and π-π stacking interactions involving the dihydroquinoline units, with a centroid-to-centroid distance of 3.7648 (15) Å. In the experimental materials used by the author, we found 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Quality Control of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C6H7Br2NIn 2017 ,�Pyridin-2-yl)methyl 2-oxo-1-[(pyridin-2-yl)methyl]-1,2-dihydroquinoline-4-carboxylate hemihydrate�appeared in IUCrData. The author of the article were Filali Baba, Yassir; Kandri Rodi, Youssef; Ouzidan, Younes; Mague, Joel T.; Ouazzani Chahdi, Fouad; Essassi, El Mokhtar. The article conveys some information:

In the title compound, C22H17N3O3·0.5H2O, the heterocyclic portion of the dihydroquinoline moiety is distinctly nonplanar. Two quinolinecarboxylate mols. are associated through hydrogen bonding to a disordered lattice water mol. These units stack along the a-axis direction assisted by C-H···O and C-H···N hydrogen bonds, as well as C-H···π(ring) interactions. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8COA of Formula: C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.COA of Formula: C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Qun; Li, Tian; Chen, Hekai; Kong, Jun; Zhang, Liwei; Yin, Hang published an article in 2021. The article was titled 《Design and optimisation of a small-molecule TLR2/4 antagonist for anti-tumour therapy》, and you may find the article in RSC Medicinal Chemistry.COA of Formula: C6H7Br2N The information in the text is summarized as follows:

A small-mol. co-inhibitor that targets the TLR2/4 signalling pathway were developed. After high-throughput screening of a compound library containing 14400 small mols., followed by hit-to-lead structural optimization, the compound I was finally obtained, which has effective inhibitory properties against the TLR2/4 signalling pathways. This compound was found to significantly inhibit multiple pro-inflammatory cytokines released by RAW264.7 cells. This was followed by compound I demonstrating promising efficacy in subsequent anti-tumor experiments The current results provided a novel understanding of the role of TLR2/4 in cancer and a novel strategy for anti-tumor therapy. After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8COA of Formula: C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.COA of Formula: C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liang, Qiuming; Song, Datong published an article in 2021. The article was titled 《Syntheses and Reactivity of Piano-Stool Iron Complexes of Picolyl-Functionalized N-Heterocyclic Carbene Ligands》, and you may find the article in Organometallics.Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide The information in the text is summarized as follows:

[FeClCp*(HL)] (1; HL = 3-methyl-1-(2-picolyl)-imidazol-2-ylidene) was synthesized from the reaction of in situ generated HL ligand and [FeClCp*(TMEDA)] (TMEDA is N,N,N’,N’-tetramethylethylenediamine). The deprotonation of 1 with KHMDS led to removal of a pyridylic proton and the dearomatization of the pyridine ring of the HL ligand, forming [Cp*(L)Fe(μ-N2)FeCp*(L)] (2) under N2 or [(FeCp*)2(μ-H)(μ-L)] (3) under Ar. Complex 2 splits H2 across the L- ligands and the Fe centers to give [FeCp*(H)(HL)] (4). Complex 4 readily converts to [Cp*(L”)Fe(μ-N2)FeCp*(L”)] (5) under N2, where the L”- ligand chelates to the metal center through the carbene C and a pyridyl C. The reactions of 2 with PhSiH3 and Ph2SiH2 give silyl complexes 6 and 7, resp. Compounds of 2, 4, and 5 are active (pre)catalysts for the dehydrogenative coupling of dimethylamine borane. The results came from multiple reactions, including the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem