Category: 31106-82-8

The author of 《Mitochondrion-targeted two-photon probes: Real-time monitoring endogenous GSH via situ reaction in Hela cells》 were Zhang, Huihui; Zhang, Gaojian; Liu, Gang; Xia, Ying; Fang, Min; Zhu, Xiaojiao; Wu, Zhichao; Li, Xiaowu; Yang, Xingyuan; Zhou, Hongping. And the article was published in Dyes and Pigments in 2019. Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide The author mentioned the following in the article:

Mitochondria and glutathione (GSH) play crucial roles in human pathologies. To better understand the disease mechanisms, two-photon fluorescence probes responding to mitochondria and glutathione were urgently pursued. Here, a series of two-photon fluorescence probes (5a, 5b and 5c) were prepared, which could detect GSH as well as target mitochondria. The probes delivered high and rapid selectivity towards GSH among the various biothiols and qual. monitored the endogenous cellular GSH in real-time via a two-photon laser confocal fluorescence microscopy. Furthermore, the theor. understanding of high selectivity in two-photon fluorescence probes were also performed. The combined results demonstrated that the probes would function as efficient tools in bio-imaging and biol. diagnosis. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Biochemistry included an article by Hinchliffe, Philip; Tanner, Carol A.; Krismanich, Anthony P.; Labbe, Genevieve; Goodfellow, Valerie J.; Marrone, Laura; Desoky, Ahmed Y.; Calvopina, Karina; Whittle, Emily E.; Zeng, Fanxing; Avison, Matthew B.; Bols, Niels C.; Siemann, Stefan; Spencer, James; Dmitrienko, Gary I.. Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide. The article was titled 《Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates》. The information in the text is summarized as follows:

There are currently no clin. available inhibitors of metallo-β-lactamases (MBLs), enzymes which hydrolyze β-lactam antibiotics and confer resistance on Gram-neg. bacteria. Here we present 6-phosphonomethylpyridine-2-carboxylates (PMPCs) as potent inhibitors of subclass B1 (IMP-1, VIM-2, NDM-1) and B3 (L1) MBLs. Inhibition followed a competitive, slow-binding model without an isomerization step (IC50 values 0.3 – 7.2 μM; Ki 0.03 – 1.5 μM). Min. inhibitory concentration assays demonstrated potentiation of β-lactam (meropenem) activity against MBL-producing bacteria, including clin. isolates, at concentrations where eukaryotic cells remain viable. Crystal structures revealed unprecedented modes of inhibitor binding to B1 (IMP-1) and B3 (L1) MBLs. In IMP-1, binding does not replace the nucleophilic hydroxide and the PMPC carboxylate and pyridine nitrogen interact closely (2.3 and 2.7 Å, resp.) with the Zn2 ion of the binuclear metal site. The phosphonate group makes limited interactions, but is 2.6 Å from the nucleophilic hydroxide. Furthermore, the presence of a water mol. interacting with the PMPC phosphonate and pyridine N-C2 π-bond, as well as the nucleophilic hydroxide, suggests that the PMPC binds to the MBL active site as its hydrate. Binding is markedly different in L1, with the phosphonate displacing both Zn2, forming a monozinc enzyme, and the nucleophilic hydroxide, while also making multiple interactions with the protein main chain and Zn1. The carboxylate and pyridine nitrogen interact with Ser221/223, resp. (3 Å distance). The potency, low toxicity, cellular activity and amenability to further modification of PMPCs indicate these and similar phosphonate compounds can be further considered for future MBL inhibitor development. The experimental process involved the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Qun; Li, Tian; Chen, Hekai; Kong, Jun; Zhang, Liwei; Yin, Hang published an article in 2021. The article was titled 《Design and optimisation of a small-molecule TLR2/4 antagonist for anti-tumour therapy》, and you may find the article in RSC Medicinal Chemistry.COA of Formula: C6H7Br2N The information in the text is summarized as follows:

A small-mol. co-inhibitor that targets the TLR2/4 signalling pathway were developed. After high-throughput screening of a compound library containing 14400 small mols., followed by hit-to-lead structural optimization, the compound I was finally obtained, which has effective inhibitory properties against the TLR2/4 signalling pathways. This compound was found to significantly inhibit multiple pro-inflammatory cytokines released by RAW264.7 cells. This was followed by compound I demonstrating promising efficacy in subsequent anti-tumor experiments The current results provided a novel understanding of the role of TLR2/4 in cancer and a novel strategy for anti-tumor therapy. After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8COA of Formula: C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.COA of Formula: C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2-(Bromomethyl)pyridine hydrobromideIn 2016 ,《Synthesis and structural analyses of phenylethynyl-substituted tris(2-pyridylmethyl)amines and their copper(II) complexes》 appeared in Dalton Transactions. The author of the article were Lim, Jaebum; Lynch, Vincent M.; Edupuganti, Ramakrishna; Ellington, Andrew; Anslyn, Eric V.. The article conveys some information:

Three new tris(2-pyridylmethyl)amine-based ligands possessing phenylethynyl units were prepared using Sonogashira couplings and substitution reactions. Copper(II) complexes (I) of those tetradentate ligands also were synthesized. Solid-state structures of the six new compounds were determined by single-crystal x-ray diffraction analyses. Examination of the mol. structures of the ligands revealed the expected triangular geometries with virtually undeformed carbon-carbon triple bonds. While the tertiary nitrogen of the free ligands seem to be prevented from participation in supramol. noncovalent interactions by the pyridyl hydrogen at the 3-position, the pyridyl nitrogens play a crucial role in the packing mode of the crystal structure. The nitrogens form weak hydrogen bonds, varied at 2.32-2.66 Å, with the pyridyl hydrogen of its neighboring mol. The [N···H-C] contacts enforce one-dimensional columnar assemblies on ligands that organize into wall-like structures, which in turn assemble into three-dimensional structures through CH-π interactions. Structural analyses of Cu(II) complexes of the ligands revealed propeller-like structures caused by steric crowding of three pyridine ligands. The copper complexes of the ligands having three phenylethynyl substituents showed a remarkably deformed carbon-carbon triple bond enforced by a steric effect of the three Ph groups. Most significantly, a total of seventy noncovalent interactions, classified into twelve types of hydrogen-involving short contacts, were identified. The phenylethynyl substituent participated in forty-two interactions as a hydrogen bond acceptor, and its role was more distinctive in the crystal structures of the Cu(II) complexes. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Reference of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2-(Bromomethyl)pyridine hydrobromideIn 2019 ,《Iron(II) tetrafluoroborate complexes of new tetradentate C-scorpionates as catalysts for the oxidative cleavage of trans-stilbene with H2O2》 appeared in Dalton Transactions. The author of the article were Wang, Denan; Gardinier, James R.; Lindeman, Sergey V.. The article conveys some information:

Attachment of a 2-methylpyridyl group onto the unique 1-nitrogen atom on nitrogen-confused C-scorpionates with either pyrazol-1-yl or 3,5 dimethylpyrazol-1-yl donors gives two new cis-directing tetradentate-N4 ligands (L and L*). The complexes [(L or L*)Fe(CH3CN)2](BF4)2 (1 or 2) were prepared, fully characterized, and investigated for their ability to catalyze the oxidative cleavage of trans-stilbene in CH3CN. Complexes 1 and 2 are capable of catalyzing stilbene cleavage when H2O2 is used as an oxidant but up to six different products are formed, with C:C cleavage products (benzaldehyde and benzoic acid) dominating over four products of oxygen transfer. Catalytic amounts of 1 or 2 enhance the ability for the organic photocatalyst riboflavin tetraacetate to use atm. oxygen and blue light irradiation (450-460 nm) to selectively cleave stilbene to benzaldehyde. However, when benzaldehyde oxidizes further to benzoic acid, the iron species begin giving increasing amounts of stilbene oxygenation products.2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Reference of 2-(Bromomethyl)pyridine hydrobromide) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Reference of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromideIn 2022 ,《Group 12 metal complexes of mixed thia/aza and thia/oxa/aza macrocyclic ligands》 was published in Polyhedron. The article was written by Hodorogea, Ana Maria; Silvestru, Anca; Lippolis, Vito; Pop, Alexandra. The article contains the following contents:

The coordination behavior of the macrocyclic ligands N-(2-pyridylmethyl)-[12]aneNS2O (L1) and N-(2-pyridylmethyl)-[12]aneNS3 (L2) ([12]aneNS2O = 1-aza-4,10-dithia-7-oxacyclododecane, [12]aneNS3 = 1-aza-4,7,10-trithia-cyclododecane) was studied in complexation reactions with ZnCl2, CdI2 and HgCl2. The NMR and mass spectra suggest the formation of the ionic species [LMX]2[MX4] [M = Zn, X = Cl, L = L1 (1), L2 (2); M = Cd, X = I, L = L1 (3), L2 (4); M = Hg, X = Cl, L = L1 (5), L2 (6)]. The x-ray diffraction studies confirmed the formation of the new species 3-6, with [LMX]+ cations and [MX4]2- anions, while for the zinc(II) complex 1 the determined structure corresponds to the hydrolysis product of formula [L1Zn]2[ZnCl3]2[Zn2Cl6]·2H2O (1h), with [L1Zn(H2O)]2+ cations and [ZnCl3(H2O)]- and [Zn2Cl6]2- anions. In all complexes the metal ion is hexacoordinated in cations, while in anions the metal is tetrahedrally surrounded by halido ligands. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Dyes and Pigments included an article by Yan, Zhengquan; Wei, Gang; Guang, Shanyi; Xu, Manman; Ren, Xia; Wu, Rongliang; Zhao, Gang; Ke, Fuyou; Xu, Hongyao. Formula: C6H7Br2N. The article was titled 《A multidentate ligand chromophore with rhodamine-triazole-pyridine units and its acting mechanism for dual-mode visual sensing trace Sn2+》. The information in the text is summarized as follows:

A multidentate ligand chromophore, combining rhodamine, triazole, and pyridine units, was identified and developed for the 1st time. Using triazole and pyridine rings as coordinating functional recognition groups, it was expected to selectively recognize Sn2+ to form some stable 5-member or 6-member rings with nitrogen and oxygen atoms. Under the optimized conditions, the ligand chromophore could selectively react with trace Sn2+ in CH3CN/H2O (99/1, volume/volume), accompanying with obvious changes in fluorescent spectrum, UV-visible spectrum and visual color. For fluorescent anal., a turn-on fluorescence at 587 nm was found and increased linearly at 1.2-6.2 × 10-7 mol L-1 Sn2+ from colorless to orange. For UV-visible one, a new absorption peak at 560 nm emerged with a linear range of 2.0-11.0 × 10-7 mol L-1 Sn2+ from colorless to pink. The action mechanism between the ligand chromophore and Sn2+ was confirmed basing on UV-visible titration, 1H NMR titration, Job’s plot, binding constants and theor. calculation In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Formula: C6H7Br2N) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Formula: C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,ChemSusChem included an article by Gholinejad, Mohammad; Oftadeh, Erfan; Shojafar, Mohammad; Sansano, Jose M.; Lipshutz, Bruce H.. Synthetic Route of C6H7Br2N. The article was titled 《Synergistic Effects of ppm Levels of Palladium on Natural Clinochlore for Reduction of Nitroarenes》. The information in the text is summarized as follows:

The modified naturally occurring clay clinochlore with ppm amounts of palladium that leads to a new and very effective reagent for the reduction of numerous aromatic nitro species RNO2 (R = H3CC(O)NHC6H4, naphthalen-1-yl, pyridin-2-yl, etc.) has been augmented. When palladium nanoparticles are supported on pyridyltriazole-modified clinochlore, iron within clinochlore acts synergistically with palladium to catalyze the reduction of a wide variety of nitroarenes at room temperature in aqueous media. Based on E-factor calculations, the catalyst system is found to be in line with green chem. standards and can be recycled up to five times. In the experiment, the researchers used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Synthetic Route of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Synthetic Route of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Hayashi, Minoru; Nishimura, Yasunobu; Watanabe, Yutaka published 《Syntheses of 3-oxo-λ5-benzophospholes by an intramolecular cyclization of phosphorus-ylide》.Chemistry Letters published the findings.Product Details of 31106-82-8 The information in the text is summarized as follows:

Three synthetic procedures were developed for a new class of P ylide containing conjugate heterocycles, 3-oxo-λ5-benzophospholes. The key to the formation of the heterocycle is unusual intramol. acylation of a P ylide forming an endocyclic ylide. Several types of 2-substituted benzophospholes were synthesized, some of which show fluorescence. After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Mechanosynthesis of Noels-type NHC-Ruthenium Complexes and Applications in Ring-Opening Metathesis Polymerization》 was published in Organometallics in 2020. These research results belong to Quintin, Francois; Pinaud, Julien; Lamaty, Frederic; Bantreil, Xavier. Synthetic Route of C6H7Br2N The article mentions the following:

The use of ball-mills enabled the efficient mechanosynthesis of a variety of N-aryl,N-alkyl imidazolium salts and of corresponding NHC Ag(I) complexes. Transmetalation with Ru via mechanochem. allowed the rapid access (1.5 min to 1 h) to complexes having a similar structure to Noels-type precatalysts. Evaluation of the complexes in the ring-opening metathesis polymerization of norbornene in different solvent, including nontoxic ones, showed a high catalytic activity for one of them, comparable to the one of Noels catalyst.2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Synthetic Route of C6H7Br2N) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Synthetic Route of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem