Category: 31106-82-8

Kazancioglu, Mustafa Z.; Quirion, Kevin; Wipf, Peter; Skoda, Erin M. published an article in 2022. The article was titled 《Enantioselective synthesis and selective functionalization of 4-aminotetrahydroquinolines as novel GLP-1 secretagogues》, and you may find the article in Chirality.Quality Control of 2-(Bromomethyl)pyridine hydrobromide The information in the text is summarized as follows:

Polysubstituted tetrahydroquinolines were obtained in moderate to high yields (28% to 92%) and enantiomeric ratios (er 89:11 to 99:1) by a three-component Povarov reaction using a chiral phosphoric acid catalyst. Significantly, post-Povarov functional group interconversions allowed a rapid access to a library of 36 enantioenriched 4-aminotetrahydroquinoline derivatives featuring five points of diversity. Selected analogs were assayed for their ability to function as glucagon-like peptide-1 (GLP-1) secretagogues. After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Quality Control of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Quality Control of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Gallant, Sarah K.; Tipker, Ryan M.; Glueck, David S. published an article in Organometallics. The title of the article was 《Copper-Catalyzed Asymmetric Alkylation of Secondary Phosphines via Rapid Pyramidal Inversion in P-Stereogenic Cu-Phosphido Intermediates》.Quality Control of 2-(Bromomethyl)pyridine hydrobromide The author mentioned the following in the article:

Development of metal-catalyzed asym. synthesis of P-stereogenic phosphines was guided by the hypothesis that pyramidal inversion occurs rapidly in metal-phosphido intermediates, but this process was not observed directly for all metals of interest. The authors report an enantioselective Cu(Josiphos)-catalyzed alkylation of secondary phosphines and observation of the reaction intermediates, including variable temperature NMR studies of low-barrier pyramidal inversion at P in the key P-stereogenic terminal phosphido complexes Cu(diphos*)(PRR’), and a study of their reversible formation from secondary phosphine-silanolate complexes Cu(diphos*)[PHR(R’)](OSiMe3). The experimental process involved the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Quality Control of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Lemouzy, Sebastien; Jean, Marion; Giordano, Laurent; Herault, Damien; Buono, Gerard published 《The Hydroxyalkyl Moiety As a Protecting Group for the Stereospecific Alkylation of Masked Secondary Phosphine-Boranes》.Organic Letters published the findings.Product Details of 31106-82-8 The information in the text is summarized as follows:

The synthesis of functionalized tertiary phosphine-boranes has been developed via a chemodivergent approach from readily accessible (hydroxymethyl) phosphine-boranes under mild conditions. O-Alkylation or decarbonylative P-alkylation product could be exclusively obtained. The P-alkylation reaction was found to proceed in moderate to very good yields and very high enantiospecificity (es >95%) using a variety of alkyl halides as electrophiles. The configurational stability of the sodium phosphido-borane intermediate was also investigated and allowed a deeper understanding of the reaction mechanism, furnishing secondary phosphine-boranes in moderate yield and enantiopurity. In the experimental materials used by the author, we found 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,ChemistrySelect included an article by Lemouzy, Sebastien; Jean, Marion; Deplante, Fabien; Albalat, Muriel; Herault, Damien; Buono, Gerard. Formula: C6H7Br2N. The article was titled 《Tunable P-Stereogenic P,N-Phosphine Ligands Design: Synthesis and Coordination Chemistry to Palladium》. The information in the text is summarized as follows:

The synthesis of P,N heterobidentate phosphine / palladium complexes was realized from P-stereogenic enantiopure ligands. Five, six or seven membered ring complexes were fully characterized, notably by x-ray diffraction, allowing the study of the chelation to a palladium (II) dichloride unit. The nature of nitrogen coordination site as well as the size of the ring modify the bite-angle at the solid state. In the part of experimental materials, we found many familiar compounds, such as 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Formula: C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Formula: C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C6H7Br2NIn 2021 ,《Evaluating Metal-Ligand Interactions of Metal-Binding Isosteres Using Model Complexes》 was published in Inorganic Chemistry. The article was written by Seo, Hyeonglim; Prosser, Kathleen E.; Kalaj, Mark; Karges, Johannes; Dick, Benjamin L.; Cohen, Seth M.. The article contains the following contents:

Bioisosteres are a useful approach to address pharmacokinetic liabilities and improve drug-like properties. Specific to developing metalloenzyme inhibitors, metal-binding pharmacophores (MBPs) have been combined with bioisosteres, to produce metal-binding isosteres (MBIs) as alternative scaffolds for use in fragment-based drug discovery (FBDD). Picolinic acid MBIs have been reported and evaluated for their metal-binding ability, pharmacokinetic properties, and enzyme inhibitory activity. However, their structural, electronic, and spectroscopic properties with metal ions other than Zn(II) have not been reported, which might reveal similarities and differences between MBIs and the parent MBPs. To this end, [M(TPA)(MBI)]+ (M = Ni(II) and Co(II), TPA = tris(2-pyridylmethyl)amine) is presented as a bioinorganic model system for investigating picolinic acid, four heterocyclic MBIs, and 2,2′-bipyridine. These complexes were characterized by x-ray crystallog. as well as NMR, IR, and UV-vis spectroscopies, and their magnetic moments were accessed. In addition, [(TpPh,Me)Co(MBI)] (TpPh,Me = hydrotris(3,5-phenylmethylpyrazolyl)borate) was used as a second model compound, and the limitations and attributes of the two model systems are discussed. These results demonstrate that bioinorganic model complexes are versatile tools for metalloenzyme inhibitor design and can provide insights into the broader use of MBIs. After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Electric Literature of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Electric Literature of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Chapman, Michael R.; Kwan, Maria H. T.; King, Georgina E.; Kyffin, Benjamin A.; Blacker, A. John; Willans, Charlotte E.; Nguyen, Bao N. published 《Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions》.Green Chemistry published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

A novel, rapid and efficient route to imidazo[1,2-a]pyridines I [R = H, 7-CH3, 6-NO2, etc.] under ambient, aqueous and metal-free conditions was reported. The NaOH-promoted cycloisomerization of N-propargylpyridiniums gave quant. yield in a few minutes (10 g scale). A comparison of common green metrics to current routes showed clear improvements, with at least a one order of magnitude increase in space-time-yield. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Category: pyridine-derivatives)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Martell, Mark; Ocheje, Michael U.; Gelfand, Benjamin S.; Rondeau-Gagne, Simon; Welch, Gregory C. published their research in New Journal of Chemistry in 2021. The article was titled 《Sidechain engineering of N-annulated perylene diimide molecules》.Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide The article contains the following contents:

The synthesis and characterization of six new N-annulated perylene diimide (N-PDI) mols. consisting of different alkyl-based heteroatom and waxy infused sidechains is reported. Amino, urea, quaternary Me ammonium, iminopyridine, hexadecyl and pyridine moieties were all appended to the pyrrolic N-position of N-annulated PDI. These N-PDI derivatives have been synthesized using facile SN2 chem. resulting in high yields and without the need for purification via column chromatog. To further demonstrate the functional diversification offered by N-PDI we appended a cyano group to the 6,7-bay positions opposite the N-annulation site and tested utility in organic field effect transistor devices. Complete characterization of these N-PDI derivatives was completed using UV-Vis spectroscopy, cyclic voltammetry and solubility determination to observe how the appended sidechains affect structure-properties relationships. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromideIn 2019 ,《Synthesis of Iridium(III) and Rhodium(III) Complexes Bearing C8-Metalated Theophylline Ligands by Directed C-H Activation》 was published in Organometallics. The article was written by Tan, Tristan Tsai Yuan; Hahn, F. Ekkehardt. The article contains the following contents:

The directed C-H activation at the C8 position of N-donor tethered theophylline with iridium(III) and rhodium(III) is presented. The donor strength of the N-tethered donor group has been varied. Proligands bearing a strongly donating imidazolin-2-ylidene or the weaker donating pyridine group were both metalated under similar conditions, suggesting that the electron d. at the metal center does not play a significant role in the C-H activation step, which was concluded to proceed via a carboxylate-assisted route. The synthesis and characterization of iridium(III) and rhodium(III) complexes bearing chelating CNHC^Cazolato ligands (M = Ir: [4], M = Rh: [5]) and Npyridine^Cazolato ligands (M = Ir: [7], M = Rh: [8]) are reported. In addition, the NHC complexes which are the precursors to the CNHC^Cazolato complexes (M = Ir: [2], M = Rh: [3]) were isolated and characterized. In the part of experimental materials, we found many familiar compounds, such as 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Unusual Recognition and Separation of Hydrated Metal Sulfates [M2(μ-SO4)2(H2O)n, M = ZnII, CdII, CoII, MnII] by a Ditopic Receptor》 was written by Ghosh, Tamal Kanti; Dutta, Ranjan; Ghosh, Pradyut. SDS of cas: 31106-82-8This research focused onzinc cadmium cobalt manganese pyridinylmethylaminoethylbutylurea sulfate complex preparation; binding constant transition metal pyridinylmethylaminoethylbutylurea sulfate; crystal structure transition metal pyridinylmethylaminoethylbutylurea sulfate. The article conveys some information:

A ditopic receptor L1, having metal binding bis(2-picolyl) donor and anion binding urea group, is synthesized and explored toward metal sulfate recognition via formation of dinuclear assembly, (L1)2M2(SO4)2. Mass spectrometric anal., 1H-DOSY NMR, and crystal structure anal. reveal the existence of a dinuclear assembly of MSO4 with two units of L1. 1H NMR study reveals significant downfield chem. shift of -NH protons of urea moiety of L1 selectively with metal sulfates (e.g., ZnSO4, CdSO4) due to second-sphere interactions of sulfate with the urea moiety. Variable-temperature 1H NMR studies suggest the presence of intramol. hydrogen bonding interaction toward metal sulfate recognition in solution state, whereas intermol. H-bonding interactions are observed in solid state. In contrast, anions in their tetrabutylammonium salts fail to interact with the urea -NH probably due to poor acidity of the tert-Bu urea group of L1. Metal sulfate binding selectivity in solution is further supported by isothermal titration calorimetric studies of L1 with different Zn salts in DMSO, where a binding affinity is observed for ZnSO4 (Ka = 1.23 × 106), which is 30- to 50-fold higher than other Zn salts having other counteranions in DMSO. Sulfate salts of CdII/CoII also exhibit binding constants in the order of ∼1 × 106 as in the case of ZnSO4. Pos. role of the urea unit in the selectivity is confirmed by studying a model ligand L2, which is devoid of anion recognition urea unit. Structural characterization of four MSO4 [M = ZnII, CdII, CoII, MnII] complexes of L1, i.e., complex 1, [(L1)2(Zn)2(μ-SO4)2]; complex 2, [(L1)2(H2O)2(Cd)2(μ-SO4)2]; complex 3, [(L1)2(H2O)2(Co)2(μ-SO4)2]; and complex 4, [(L1)2(H2O)2(Mn)2(μ-SO4)2], reveal the formation of sulfate-bridged eight-membered crownlike binuclear complexes, similar to one of the concentration-dependent dimeric forms of MSO4 as observed in solid state. Finally, L1 is found to be highly efficient in removing ZnSO4 from both aqueous and semiaq. medium as complex 1 in the presence of other competing ZnII salts via precipitation through crystallization Powder X-ray diffraction anal. has also confirmed bulk purity of complex 1 obtained from the above competitive crystallization experiment In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8SDS of cas: 31106-82-8) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.SDS of cas: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Vernia, Jennifer E.; Warmin, Mary R.; Krause, Jeanette A.; Tierney, David L.; Baldwin, Michael J. published 《Photochemistry and Anion-Controlled Structure of Fe(III) Complexes with an α-Hydroxy Acid-Containing Tripodal Amine Chelate》.Inorganic Chemistry published the findings.Computed Properties of C6H7Br2N The information in the text is summarized as follows:

The tripodal amine chelate with two pyridyl groups and an α-hydroxy acid (AHA) group, Pyr-TPA-AHA, was synthesized. Different Fe(III) complexes form with this chelate depending upon the counterion of the Fe(III) source used in the synthesis. A dinuclear complex, Fe(III)2(Pyr-TPA-AHA)2(μ-O), 1, and mononuclear complexes Fe(III)(Pyr-TPA-AHA)X (X = Cl- or Br-, 2 and 3, resp.) were synthesized. 2 Can be easily converted to 1 by addition of silver nitrate or a large excess of water. The structure of 1 was solved by x-ray crystallog. (C32H34N6O7Fe2·13H2O, a 14.1236(6), b 14.1236(6), c 21.7469(15) Å, α = β = γ 90.°, tetragonal, P42212, Z = 4). 2 And 3 each have simple quasireversible cyclic voltammograms with E1/2 (vs. aqueous Ag/AgCl) = +135 mV for 2 and +470 for 3 in acetonitrile. The cyclic voltammogram for 1 in acetonitrile has a quasireversible feature at E1/2 = -285 mV and an irreversible cathodic feature at -1140 mV. All three complexes are photochem. active upon irradiation with UV light, resulting in cleavage of the AHA group and reduction of the iron to Fe(II). Photolysis of 1 results in reduction of both Fe(III) ions in the dinuclear complex for each AHA group that is cleaved, while photolysis of 2 and 3 results in reduction of a single Fe(III) for each AHA cleavage. The quantum yields for 2 and 3 are significantly higher than that of 1. The experimental process involved the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Computed Properties of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem