Category: 31106-82-8

In 2018,Sensors and Actuators, B: Chemical included an article by Yao, Shun; Zhang, Gaojian; Wang, Haiyan; Song, Jinjin; Liu, Tianyan; Yang, Mingdi; Yu, Jianhua; Yang, Xingyuan; Tian, Yupeng; Zhang, Xuanjun; Zhou, Hongping. SDS of cas: 31106-82-8. The article was titled 《Exploration the effect of structural adjustment on identifying medium and bio-targeting based on two similar coumarin compounds》. The information in the text is summarized as follows:

Two novel similar structural coumarin-based fluorescent compounds L1 and L2 employing ether oxygen chain and 2 – pyridine unit had been prepared to explore the effect of structural adjustment on property. The prepared L2 through slightly adjusting structure of L1 exhibited the prominent fluorescence responses to Hg2+ and Cu2+ in H2O, which could monitor the corresponding metals ion in mitochondria of Hela cells, but L1 only recognized Hg2+ through turn-on fluorescence response in CH3OH/H2O, fluorescence co-localization studies illustrated that the L1 mainly located at lysosome. The recognition mechanism had been established by 1H NMR titration, Job′s plot, MAlDI-TOF mass spectrometry and single crystal structure. Bio-imaging experiments revealed that L1 and L2 could qual. monitor Hg2+ or Cu2+ in Hela cells and mouse kidney tissues. In the experiment, the researchers used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8SDS of cas: 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.SDS of cas: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Spinck, Martin; Bischoff, Matthias; Lampe, Philipp; Meyer-Almes, Franz-Josef; Sievers, Sonja; Neumann, Heinz published an article in 2021. The article was titled 《Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1》, and you may find the article in Journal of Medicinal Chemistry.Product Details of 31106-82-8 The information in the text is summarized as follows:

Sirtuins are signaling hubs orchestrating the cellular response to various stressors with roles in all major civilization diseases. Sirtuins remove acyl groups from lysine residues of proteins, thereby controlling their activity, turnover, and localization. The seven human sirtuins, SirT1-7, are closely related in structure, hindering the development of specific inhibitors. Screening 170,000 compounds, we identify and optimize SirT1-specific benzoxazine inhibitors, Sosbo, which rival the efficiency and surpass the selectivity of selisistat (EX527). The compounds inhibit the deacetylation of p53 in cultured cells, demonstrating their ability to permeate biol. membranes. Kinetic anal. of inhibition and docking studies reveal that the inhibitors bind to a complex of SirT1 and NAD, similar to selisistat. These new SirT1 inhibitors are valuable alternatives to selisistat in biochem. and cell biol. studies. Their greater selectivity may allow the development of better targeted drugs to combat SirT1 activity in diseases such as cancer, Huntington’s chorea, or anorexia. In the part of experimental materials, we found many familiar compounds, such as 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Igawa, Hideyuki; Takahashi, Masashi; Kakegawa, Keiko; Kina, Asato; Ikoma, Minoru; Aida, Jumpei; Yasuma, Tsuneo; Kawata, Yayoi; Ashina, Shuntaro; Yamamoto, Syunsuke; Kundu, Mrinalkanti; Khamrai, Uttam; Hirabayashi, Hideki; Nakayama, Masaharu; Nagisa, Yasutaka; Kasai, Shizuo; Maekawa, Tsuyoshi published 《Correction to Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure-Activity Relationships of Novel 1-(Imidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one Derivatives [Erratum to document cited in CA164:213881]》.Journal of Medicinal Chemistry published the findings.SDS of cas: 31106-82-8 The information in the text is summarized as follows:

In the body of Table 1, chem. structures for the R group are missing; the structures are provided here. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8SDS of cas: 31106-82-8) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. SDS of cas: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Chemistry – A European Journal included an article by Park, Hyunchang; Ahn, Hye Mi; Jeong, Ha Young; Kim, Cheal; Lee, Dongwhan. Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide. The article was titled 《Non-Heme Iron Catalysts for Olefin Epoxidation: Conformationally Rigid Aryl-Aryl Junction To Support Amine/Imine Multidentate Ligands》. The information in the text is summarized as follows:

Atom-transfer chem. represented an important class of reactions catalyzed by metalloenzymes. As a functional mimic of non-heme iron enzymes that deliver oxygen atoms to olefins, the monoiron complexes supported by new N-donor chelates were designed. These ligands took advantage of heme-like conformational rigidity of the π-conjugated mol. backbone and synthetic flexibility of tethering non-heme donor groups for addnl. steric and electronic control. Iron complexes generated in-situ were used to carry out catalytic epoxidation of a wide range of olefin substrates by using mCPBA as a terminal oxidant. The fate of initial iron-peracid adduct and the involvement of iron-oxo species in this process were investigated further by mechanistic probes and isotope exchange studies. Thet anilidopyridyl-derived [N,N]-bidentate motif served as a versatile structural platform to build non-heme ligands for catalytic oxidation chem. The results came from multiple reactions, including the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Exfoliating a CdII-Purine Framework: Conversion of Nanosheets-to-Nanofibers and Studies of Elastic and Capacitive Properties》 were Avasthi, Ilesha; Kulkarni, Manish M.; Verma, Sandeep. And the article was published in Chemistry – A European Journal in 2019. Name: 2-(Bromomethyl)pyridine hydrobromide The author mentioned the following in the article:

Layered bulk crystals are amenable to exfoliation to yield 2D nanosheets through isolation and intercalation processes, which could be further converted to 1D nanoscale structures. The latter inherit gross morphol. and phys. properties associated with the precursor structures. Herein, we report three purine-based crystal structures 1, 2, and 3, where 3 is obtained by a single-crystal-to-single-crystal transformation from 2 and is a conformational polymorph of 1. Next, we describe the sonication-assisted liquid exfoliation of 1, a CdII-purine coordination framework, into nanosheets and nanofibers in a solvent-dependent process. The exfoliation was carefully studied at low temperatures to ascertain this unique conversion. This work also features the determination of the Young’s modulus and surface potential of the bioinspired CdII-based nanostructures by using amplitude modulation-frequency modulation at. force microscopy and Kelvin probe force microscopy, resp., revealing their interesting elastic and capacitive properties for their possible use in electronics and energy devices. Electron impedance spectroscopy measurements further established a higher value of capacitance for the exfoliated CdII framework as compared to the ligand alone. In the part of experimental materials, we found many familiar compounds, such as 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Name: 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Name: 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Exfoliating a CdII-Purine Framework: Conversion of Nanosheets-to-Nanofibers and Studies of Elastic and Capacitive Properties》 were Avasthi, Ilesha; Kulkarni, Manish M.; Verma, Sandeep. And the article was published in Chemistry – A European Journal in 2019. Name: 2-(Bromomethyl)pyridine hydrobromide The author mentioned the following in the article:

Layered bulk crystals are amenable to exfoliation to yield 2D nanosheets through isolation and intercalation processes, which could be further converted to 1D nanoscale structures. The latter inherit gross morphol. and phys. properties associated with the precursor structures. Herein, we report three purine-based crystal structures 1, 2, and 3, where 3 is obtained by a single-crystal-to-single-crystal transformation from 2 and is a conformational polymorph of 1. Next, we describe the sonication-assisted liquid exfoliation of 1, a CdII-purine coordination framework, into nanosheets and nanofibers in a solvent-dependent process. The exfoliation was carefully studied at low temperatures to ascertain this unique conversion. This work also features the determination of the Young’s modulus and surface potential of the bioinspired CdII-based nanostructures by using amplitude modulation-frequency modulation at. force microscopy and Kelvin probe force microscopy, resp., revealing their interesting elastic and capacitive properties for their possible use in electronics and energy devices. Electron impedance spectroscopy measurements further established a higher value of capacitance for the exfoliated CdII framework as compared to the ligand alone. In the part of experimental materials, we found many familiar compounds, such as 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Name: 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Name: 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Igawa, Hideyuki; Takahashi, Masashi; Kakegawa, Keiko; Kina, Asato; Ikoma, Minoru; Aida, Jumpei; Yasuma, Tsuneo; Kawata, Yayoi; Ashina, Shuntaro; Yamamoto, Syunsuke; Kundu, Mrinalkanti; Khamrai, Uttam; Hirabayashi, Hideki; Nakayama, Masaharu; Nagisa, Yasutaka; Kasai, Shizuo; Maekawa, Tsuyoshi published 《Correction to Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure-Activity Relationships of Novel 1-(Imidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one Derivatives [Erratum to document cited in CA164:213881]》.Journal of Medicinal Chemistry published the findings.SDS of cas: 31106-82-8 The information in the text is summarized as follows:

In the body of Table 1, chem. structures for the R group are missing; the structures are provided here. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8SDS of cas: 31106-82-8) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. SDS of cas: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Chemistry – A European Journal included an article by Park, Hyunchang; Ahn, Hye Mi; Jeong, Ha Young; Kim, Cheal; Lee, Dongwhan. Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide. The article was titled 《Non-Heme Iron Catalysts for Olefin Epoxidation: Conformationally Rigid Aryl-Aryl Junction To Support Amine/Imine Multidentate Ligands》. The information in the text is summarized as follows:

Atom-transfer chem. represented an important class of reactions catalyzed by metalloenzymes. As a functional mimic of non-heme iron enzymes that deliver oxygen atoms to olefins, the monoiron complexes supported by new N-donor chelates were designed. These ligands took advantage of heme-like conformational rigidity of the π-conjugated mol. backbone and synthetic flexibility of tethering non-heme donor groups for addnl. steric and electronic control. Iron complexes generated in-situ were used to carry out catalytic epoxidation of a wide range of olefin substrates by using mCPBA as a terminal oxidant. The fate of initial iron-peracid adduct and the involvement of iron-oxo species in this process were investigated further by mechanistic probes and isotope exchange studies. Thet anilidopyridyl-derived [N,N]-bidentate motif served as a versatile structural platform to build non-heme ligands for catalytic oxidation chem. The results came from multiple reactions, including the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Mechanistic study of carboxylic acid and phosphate ester cleavage by oximate metal complexes surpassing the limiting reactivity of highly basic free oximate anions》 was written by Lugo-Gonzalez, Jose Carlos; Gomez-Tagle, Paola; Flores-Alamo, Marcos; Yatsimirsky, Anatoly K.. Name: 2-(Bromomethyl)pyridine hydrobromideThis research focused onzinc cadmium oximate complex preparation crystal structure chem stability; cleavage catalyst zinc cadmium oximate complex. The article conveys some information:

Two tridentate and one tetradentate new ligands containing the terminal oxime group separated from secondary amino and pyridine groups as addnl. binding sites by two or three methylene groups were prepared Their acid-base properties, as well as the composition and stability of their complexes with Zn(II) and Cd(II) ions, were determined by potentiometric and spectrophotometric titrations The x-ray structure of a Cd(II) complex of a related tridentate oxime ligand previously studied in solution was determined All oximate complexes show high reactivity in the cleavage of aryl acetates, paraoxon, parathion and 4-nitrophenyl di-Ph phosphate, with rate constants significantly surpassing the limiting rate constants observed for highly basic free oximate anions. The second-order rate constants for individual oximate complexes in solution are assigned to each ligand, metal cation and substrate. The results of the cleavage of 4-substituted Ph acetates were analyzed in terms of Bronsted correlations with the leaving group pKa, which demonstrated a change in the rate determining step from the nucleophilic attack to the leaving group departure upon an increase in the leaving group basicity. The zero slope of the Bronsted correlation for the nucleophilic attack indicates transition state stabilization through electrophilic assistance by the metal ion. This interpretation is supported by metal selectivity in the relative efficiency of the cleavage of paraoxon and parathion. The existence of the alpha-effect in ester cleavage by coordinated oximates is confirmed by an anal. of the Bronsted correlations with the nucleophile basicity for metal bound oximate and alkoxo or hydroxo nucleophiles. The very high reactivity of the oximate complexes of the new ligands is attributed to transition state stabilization and to the removal of the solvational imbalance of oximate anions that impedes the expected increase in the reactivity of highly basic free anions. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Name: 2-(Bromomethyl)pyridine hydrobromide) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Name: 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Gealageas, Ronan; Devineau, Alice; So, Pauline P. L.; Kim, Catrina M. J.; Surendradoss, Jayakumar; Buchwalder, Christian; Heller, Markus; Goebeler, Verena; Dullaghan, Edith M.; Grierson, David S.; Putnins, Edward E. published 《Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases》.Journal of Medicinal Chemistry published the findings.Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide The information in the text is summarized as follows:

Studies indicate that MAO-B is induced in peripheral inflammatory diseases. To target peripheral tissues using MAO-B inhibitors that do not permeate the blood-brain barrier (BBB) the MAO-B-selective inhibitor deprenyl was remodeled by replacing the terminal acetylene with a CO2H function, and incorporating a para-OCH2Ar motif (compounds 10a-s). Further, in compound 32 ((S)-N-[1-cyano-3-[4-[(3,4-dichlorobenzyl)oxy]phenyl]propan-2-yl]-N-methylglycine hydrochloride) the C-2 side chain corresponded to CH2CN. In vitro, 10c (N-[(R)-[1-[4-(3-chlorobenzyloxy)phenyl]propan-2-yl](methyl)]glycine hydrochloride), 10j, 10k, and 32 were identified as potent reversible MAO-B inhibitors, and all four compounds were more stable than deprenyl in plasma, liver microsomal, and hepatocyte stability assays. In vivo, they demonstrated greater plasma bioavailability. Assessment of in vitro BBB permeability showed that compound 10k is a P-glycoprotein (P-gp) substrate and 10j displayed mild interaction. Importantly, compounds 10c, 10j, 10k, and 32 displayed significantly reduced BBB permeability after i.v., s.c., and oral administration. These polar MAO-B inhibitors are pertinent leads for evaluation of efficacy in noncentral nervous system (CNS) inflammatory disease models. The results came from multiple reactions, including the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem