Category: 31106-82-8

In 2016,Wang, Hongyue; Wang, Ze; Li, Shaoheng; Qiu, Yuntao; Liu, Bowen; Song, Zhiguang; Liu, Zhihui published 《Synthesis of novel thiazoline catalysts and their application in Michael addition reaction》.Chemical Research in Chinese Universities published the findings.Recommanded Product: 31106-82-8 The information in the text is summarized as follows:

Several novel chiral thiazoline catalysts containing thiazoline, thiourea and proline were efficiently synthesized from com. available L-cysteine. These ligands were subsequently applied to the asym. Michael reaction between cyclohexanone and various β-nitrostyrene. The result showed that the optimal catalyst for this reaction was 2-methylpyridine containing chiral thiazoline ligand , the organocatalyst with thiazoline, thiourea and chiral proline motif, which efficiently promoted the enantioselective conjugate addition of cyclohexanone to various nitroalkenes to yield the corresponding addition products in high to excellent yields with enantiomeric excess(e.e.) up to 95% and diastereoselectivity ratio(dr.) up to 99:1. The results came from multiple reactions, including the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Recommanded Product: 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Recommanded Product: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Nicolaou, K. C.; Rhoades, Derek; Wang, Yanping; Bai, Ruoli; Hamel, Ernest; Aujay, Monette; Sandoval, Joseph; Gavrilyuk, Julia published 《12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents》.Journal of the American Chemical Society published the findings.Product Details of 31106-82-8 The information in the text is summarized as follows:

The synthesis and biol. evaluation of a series of 12,13-aziridinyl epothilone B analogs is described. These compounds were accessed by a practical, general process that involved a 12,13-olefinic Me ketone as a starting material obtained by ozonolytic cleavage of epothilone B followed by tungsten-induced deoxygenation of the epoxide moiety. The attachment of the aziridine structural motif was achieved by application of the Ess-Kurti-Falck aziridination, while the heterocyclic side chains were introduced via stereoselective phosphonate-based olefinations. In order to ensure high (E) selectivities for the latter reaction for electron-rich heterocycles, it became necessary to develop and apply an unprecedented modification of the venerable Horner-Wadsworth-Emmons reaction, employing 2-fluoroethoxyphosphonates that may prove to be of general value in organic synthesis. These studies resulted in the discovery of some of the most potent epothilones reported to date. Equipped with functional groups to accommodate modern drug delivery technologies, some of these compounds exhibited picomolar potencies that qualify them as payloads for antibody drug conjugates (ADCs), while a number of them revealed impressive activities against drug resistant human cancer cells, making them desirable for potential medical applications. In the experiment, the researchers used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Progressive structural modification to a zinc-actuated photoinduced electron transfer (PeT) switch in the context of intracellular zinc imaging》 was written by Macias-Contreras, Miguel; Daykin, Kirsten L.; Simmons, J. Tyler; Allen, John R.; Hooper, Zachary S.; Davidson, Michael W.; Zhu, Lei. Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromideThis research focused onzinc actuated photoinduced electron transfer switch intracellular imaging. The article conveys some information:

Photoinduced electron transfer (PeT)-type fluorescent mol. switches are often applied in ion-selective sensors. Zinc-targeting sensors that contain an anilino-based electron donor (aka, the PeT ‘switch’) have multiple advantages over those with an aliphatic amino switch. In addition to the lower pKa value of an aniline than that of a comparably substituted aliphatic amine, which reduces the interference of pH on the spectral properties of the attached fluorophore, the oxidation potentials of anilino groups are lower than those of aliphatic amino counterparts, which make them better electron donors in PeT. The effectiveness of anilino as a PeT switch is evaluated in a series of zinc-sensitive sensors that contain different fluorophores, zinc-binding ligands, and alkyl linkers between ligand and fluorophore. The abilities of these compounds to distinguish high and low intracellular zinc concentrations in living cells are demonstrated. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zinc(II) Complexes of N,N-Di(2-picolyl)hydrazones》 was written by Barsoum, David N.; Kyeremeh-Mensah, Lawrence; Meisner, Quinton J.; Clark, Ronald J.; Masson, Eric; Zhu, Lei. Quality Control of 2-(Bromomethyl)pyridine hydrobromideThis research focused onzinc dipicolylhydrazone complex preparation NMR spectra crystal structure. The article conveys some information:

The authors report on N,N-di(2-picolyl)hydrazone (DPH) ligands that are capable of binding metal ions in two isomeric forms depending on the nature of the hydrazone substituent. When the hydrazone substituent is not coordinating, the metal ion prefers the N,N-di(2-picolyl)amino (DPA) site, which is a known tridentate ligand that anchors on the sp3-hybridized amino nitrogen atom. When the hydrazone substituent is coordinating, the metal ion instead anchors on the sp2-hybridized imino nitrogen atom to afford a different structural isomer. Zinc(II) was used as a representative transition-metal ion for characterizing the coordination chem. of DPH in both solution and solid states, to form [Zn(L)Cl2], [Zn(L)2](ClO4)2 and [Zn(L)](ClO4)2. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Quality Control of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Quality Control of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Substituted 4-phenylthiazoles: Development of potent and selective A1, A3 and dual A1/A3 adenosine receptor antagonists》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Abdelrahman, Aliaa; Yerande, Swapnil G.; Namasivayam, Vigneshwaran; Klapschinski, Tim A.; Alnouri, Mohamad Wessam; El-Tayeb, Ali; Mueller, Christa E.. Category: pyridine-derivatives The article mentions the following:

Adenosine acts as a powerful signaling mol. via four distinct G protein-coupled receptors, designated A1, A2A, A2B and A3 adenosine receptors (ARs). A2A and A2B ARs are Gs-coupled, while A1 and A3 ARs inhibit cAMP production via Gi proteins. Antagonists for A1 and A3 ARs may be useful for the treatment of (neuro)inflammatory diseases including acute kidney injury and kidney failure, pulmonary diseases, and Alzheimer’s disease. In the present study, we optimized the versatile 2-amino-4-phenylthiazole scaffold by introducing substituents at N2 and C5 to obtain A1 and A3 AR antagonists including dual-target compounds Selective A1 antagonists with (sub)nanomolar potency were produced, e.g. 11 and 13. These compounds showed species differences being significantly more potent at the rat as compared to the human A1 AR, and were characterized as inverse agonists. Several potent and selective A3 AR antagonists, e.g. 7, 8, 17 and 22 (Ki values of 5-9 nM at the human A3 AR) were prepared, which were much less potent at the rat orthologue. Moreover, dual A1/A3 antagonists (10, 18) were developed showing Ki values between 8 and 42 nM. Docking and mol. dynamic simulation studies using the crystal structure of the A1 AR and a homol. model of the A3 AR were performed to rationalize the observed structure-activity relationships. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Category: pyridine-derivatives)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Otero-Fraga, Jorge; Suarez-Pantiga, Samuel; Montesinos-Magraner, Marc; Rhein, Dennis; Mendoza, Abraham published 《Direct and Stereospecific [3+2] Synthesis of Pyrrolidines from Simple Unactivated Alkenes》.Angewandte Chemie, International Edition published the findings.Product Details of 31106-82-8 The information in the text is summarized as follows:

Pyrrolidines are important heterocyclic compounds with endless applications in organic synthesis, metal catalysis, and organocatalysis. Their potential as ligands for first-row transition-metal catalysts inspired a new method to access complex poly-heterocyclic pyrrolidines in one step from available materials. This fundamental step forward is based on the discovery of an essential organoaluminum promoter that engages unactivated and electron-rich olefins in intermol. [3+2] cycloadditions In the experimental materials used by the author, we found 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,International Journal of Molecular Sciences included an article by Marx, Sebastien; Bodart, Laurie; Tumanov, Nikolay; Wouters, Johan. Electric Literature of C6H7Br2N. The article was titled 《Design and synthesis of a new soluble natural β-carboline derivative for preclinical study by intravenous injection》. The information in the text is summarized as follows:

Harmine is a natural β-carboline compound showing several biol. activities, including antiproliferative properties, but this soluble natural mol. lacks selectivity. Harmine derivatives were reported to overcome this problem, but they are usually poorly soluble Here, we designed and synthesized a new 2, 7, 9-trisubstituted mol. (1-methyl-7-(3-methylbutoxy)-9- propyl-2-[(pyridin-2-yl)methyl]-9H-pyrido[3,4-b]indol-2-ium bromide) with a solubility of 1.87 ± 0.07 mg/mL in a simulated injection vehicle. This compound is stable for at least 72 h in acidic and physiol. conditions (pH 1.1 and 7.4) as well as in a simulated injection vehicle (physiol. liquid + 0.1% Tween 80). Solubility in those media is 1.06 ± 0.08 mg/mL and 1.62 ± 0.13 mg/mL at pH 7.4 and 1. The synthesized mol. displays a significant activity on five different cancer cell lines (IC50 range from 0.2 to 2 μM on A549, MDA-MB-231, PANC-1, T98G and Hs683 cell lines). This compound is also more active on cancer cells (MDA-MB-231) than on normal cells (MCF-10a) at IC50 concentrations Due to its high activity at low concentration, such solubility values should be sufficient for further in vivo antitumoral activity evaluation via i.v. injection. The experimental process involved the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Electric Literature of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Electric Literature of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Minimum structural requirements for inhibitors of the zinc finger protein TRAF6》 was written by Radwan, Mohamed O.; Koga, Ryoko; Hida, Tomohiro; Ejima, Tomohiko; Kanemaru, Yosuke; Tateishi, Hiroshi; Okamoto, Yoshinari; Inoue, Jun-ichiro; Fujita, Mikako; Otsuka, Masami. Recommanded Product: 31106-82-8This research focused onzing finger TRAF6 inhibitor NF kappa B; Molecular docking; NF-κB; TRAF6; Zinc finger. The article conveys some information:

Zinc fingers have rarely been regarded as drug targets. On the contrary, the zinc-binding site of enzymes has often been considered a target of inhibitors. We previously developed a dithiol compound called SN-1(I) that binds to the zinc finger protein tumor necrosis factor receptor-associated factor 6 (TRAF6) and suppresses downstream nuclear factor-κB (NF-κB) signaling. To determine the minimal structure requirements of TRAF6 inhibitors based on I, NF-κB inhibitory activity and cytotoxicity of its derivatives including new compounds were examined SN-2(II), an oxidative type of prodrug of I with 2-nitrophenylthio groups via disulfide, has the min. structure for an inhibitor of TRAF6, as seen with cellular experiments The importance of two side chains with a thiol group was shown with mol. modeling. This study may lead to development of selective TRAF6 inhibitors in the near future. The results came from multiple reactions, including the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Recommanded Product: 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromideIn 2017 ,《(Aminomethylene)phosphonate Analogues as ZnII Chelators: Synthesis and Characterization》 appeared in European Journal of Inorganic Chemistry. The author of the article were Hevroni, Bosmat Levi; Jantz, Thomas; Gottlieb, Hugo E.; Fischer, Bilha. The article conveys some information:

A series of (aminomethylene)phosphonate (AMP) analogs, 8-14, bearing one or two heterocyclic moieties (imidazolyl, pyridyl, and thiazolyl) on the aminomethylene group, were synthesized as potential ZnII chelators. The complexes of analogs 8-14 with ZnII ions were characterized by their stoichiometry, geometry, coordination sites, acid/base equilibrium, and stability constants Analogs 8-14 form stable water-soluble 2:1 L/ZnII complexes, as established by ZnII titration, monitored by UV/visible spectrophotometry and by 1H and 31P NMR spectroscopy. Acidity and stability constants were established for each derivative by potentiometric pH titrations ML2 type ZnII complexes of AMP, bearing either an imidazolyl or pyridyl moiety, 8, 10, and 12, exhibit high log β values (17.68, 16.92, and 16.65, resp.), while for the AMP-thiazolyl (14) complex with ZnII, log β is 12.53. Generally, ligands 9, 11, and 13, bearing two heterocyclic moieties, present higher log β values (22.25, 21.00, and 18.28, resp.) vs. analogs bearing one heterocyclic moiety. Addnl., based on 1H, 13C, and 31P NMR spectroscopic data, the authors propose a structure of the AMP-(Im)2-ZnII complex in solution, where the ZnII coordination sites involve the phosphonate moiety and both imidazolyl rings of the two binding mols., forming an octahedral geometry around the ZnII ion. In summary, the authors propose a new family of water-soluble high-affinity ZnII chelators, in particular AMP-(Im)2, which forms the most stable complex (log β 22).2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Facile Synthesis of Amphiphilic Bottlebrush Block Copolymers Bearing Pyridine Pendants via Click Reaction from Protected Alkyne Side Groups》 was published in Macromolecules (Washington, DC, United States) in 2020. These research results belong to Kim, Myung-Jin; Yu, Yong-Guen; Chae, Chang-Geun; Seo, Ho-Bin; Lee, Jae-Suk. Reference of 2-(Bromomethyl)pyridine hydrobromide The article mentions the following:

We present the facile synthetic platform for the production of amphiphilic bottlebrush block copolymers bearing pyridine pendants through combination of living anionic polymerization (LAP), ring-opening metathesis polymerization (ROMP), and copper-catalyzed azide-alkyne cycloaddition (CuAAC). ω-Norbornenyl poly(4-((trimethylsilyl)ethynyl)styrene) (NBPTMSESt) with controlled mol. weights (Mn = 3-4 kDa) and low dispersity (D = 1.03-1.08) was synthesized by LAP and the subsequent end-capping reaction with exo-N-(n-decyl-10-phenylacrylate)-5-norbornene-2,3-dicarboximide. Well-defined bottlebrush block copolymers (Mn = 134-548 kDa, D = 1.04-1.14) were achieved through sequential ROMP of ω-norbornenyl polystyrene with NBPTMSESt and subsequently deprotected with the clickable alkyne group. Amphiphilic bottlebrush block copolymers were obtained by the click reaction of alkyne and azide functional pyridines in the presence of the organic-soluble catalyst/ligand system of CuBr(PPh3)3 and N,N,N’,N”,N”-pentamethyldiethylenetriamine. These polymers exhibited the three-dimensional ordered porous films through breath-figure self-assembly. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Reference of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Reference of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem