Category: 31301-51-6

Electric Literature of 31301-51-6, Adding some certain compound to certain chemical reactions, such as: 31301-51-6, name is 2-Chloro-5-fluoropyridine,molecular formula is C5H3ClFN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31301-51-6.

1st step A tetrahydrofuran (5 ml) solution containing 2-chloro-5-fluoropyridine (500 mg) was added to a tetrahydrofuran (20 ml) solution containing lithium-N,N-diisopropylamide (2M tetrahydrofuran/ethylbenzene/heptane solution) (2.9 ml) at -75C in a nitrogen atmosphere, followed by stirring at -75C for 3 hours. Subsequently, a tetrahydrofuran (5 ml) solution containing iodine (1.16 g) was added, followed by stirring at -75C for 1 hour. Then, water/tetrahydrofuran (2 ml/8 ml), water (10 ml), and 3M aqueous sodium thiosulfate were slowly added at -75C, -50C, and -35C, respectively, to the reaction solution. The reaction solution was adjusted to room temperature, followed by extraction with ethyl acetate. The resultant was washed with saturated saline and dried over anhydrous sodium sulfate. Thereafter, the solvent was distilled away under reduced pressure, the obtained residue was purified by silica gel chromatography (n-hexane : ethyl acetate = 20:1 to 10:1), and a white solid of 2-chloro-5-fluoro-4-iodopyridine (457 mg) was thus obtained. 1H-NMR (CDCl3, 300MHz) delta:8.14 (s, 1H), 7.77 (d, 1H, J = 4.3Hz) 2nd step

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 31301-51-6, 2-Chloro-5-fluoropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FUJIFILM Corporation; FUJIWARA, Hideyasu; SATO, Kimihiko; MIZUMOTO, Shinsuke; SATO, Yuichiro; KURIHARA, Hideki; KUBO, Yohei; NAKATA, Hiyoku; BABA, Yasutaka; TAMURA, Takashi; KUNIYOSHI, Hidenobu; HAGIWARA, Shinji; YAMAMOTO, Mari; (630 pag.)EP2589592; (2018); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 31301-51-6, Adding some certain compound to certain chemical reactions, such as: 31301-51-6, name is 2-Chloro-5-fluoropyridine,molecular formula is C5H3ClFN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31301-51-6.

1st step A tetrahydrofuran (5 ml) solution containing 2-chloro-5-fluoropyridine (500 mg) was added to a tetrahydrofuran (20 ml) solution containing lithium-N,N-diisopropylamide (2M tetrahydrofuran/ethylbenzene/heptane solution) (2.9 ml) at -75C in a nitrogen atmosphere, followed by stirring at -75C for 3 hours. Subsequently, a tetrahydrofuran (5 ml) solution containing iodine (1.16 g) was added, followed by stirring at -75C for 1 hour. Then, water/tetrahydrofuran (2 ml/8 ml), water (10 ml), and 3M aqueous sodium thiosulfate were slowly added at -75C, -50C, and -35C, respectively, to the reaction solution. The reaction solution was adjusted to room temperature, followed by extraction with ethyl acetate. The resultant was washed with saturated saline and dried over anhydrous sodium sulfate. Thereafter, the solvent was distilled away under reduced pressure, the obtained residue was purified by silica gel chromatography (n-hexane : ethyl acetate = 20:1 to 10:1), and a white solid of 2-chloro-5-fluoro-4-iodopyridine (457 mg) was thus obtained. 1H-NMR (CDCl3, 300MHz) delta:8.14 (s, 1H), 7.77 (d, 1H, J = 4.3Hz) 2nd step

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 31301-51-6, 2-Chloro-5-fluoropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FUJIFILM Corporation; FUJIWARA, Hideyasu; SATO, Kimihiko; MIZUMOTO, Shinsuke; SATO, Yuichiro; KURIHARA, Hideki; KUBO, Yohei; NAKATA, Hiyoku; BABA, Yasutaka; TAMURA, Takashi; KUNIYOSHI, Hidenobu; HAGIWARA, Shinji; YAMAMOTO, Mari; (630 pag.)EP2589592; (2018); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31301-51-6, name is 2-Chloro-5-fluoropyridine, the common compound, a new synthetic route is introduced below. Product Details of 31301-51-6

j00200J To a stirred solution of 2-chloro-5-fluoropyridine (10.0 g, 76.0 mmol, 1.0 eq.) in anhydrous THF (100 ml) was added LDA (58 mL, 116 mmol, 2M) dropwise at -78 C under N2. The mixture was kept at this temperature for 3 h, to which was added a solution of ?2 (23.2 g, 91.0 mmol) in THF (100 mL) dropwise at -78 C. The mixture was stirred for 1 h, and quenched with water (200 mL). The aqueous mixture was warmed to rt, ad extracted with EtOAc (100 mL x 2). The combined organic layers were washed with brine (50 mL x 2), dried over Na2 SO4, filtered and concentrated under vacuum. The crude product was purified by chromatography on silica gel (PE to EtOAc/PE = 1/20, v/v) to afford 2-chloro-5-fluoro-4-iodopyridine (11.8 g, 60%) as a white solid. ?H NMR (400 IVIHz, CDC13): 8.13 (s, 1H), 7.76 (d, 1H).

The synthetic route of 31301-51-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; QIAN, Shawn; (109 pag.)WO2017/1936; (2017); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem