Category: 3222-50-2

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3222-50-2, name is 4-Methylnicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 3222-50-2

4-Methylnicotinic acid (2.50 g, 14.4 mmol), EDCI (4.14 mg, 21.6 mmol) and HOBt (2.92 mg, 21.6 mmol) were combined in DMF (1 ml) and CH2Cl2 (75 ml) to give a pale yellow solution. To this solution was added ammonium chloride (2.31 g, 43.2 mmol) followed by DIPEA (12.5 ml, 72.0 mmol) and the resulting mixture was stirred at room temperature for 16 hours. The solvent was removed in vacuo and diluted with saturated aqueous NaHCO3 (50 ml) and CH2Cl2 (50 ml). The solution was then basicified to pH -14 with ION NaOH. The phases were separated and the aqueous layer was extracted with CH2Cl2 (5 x 50 ml). The combined organic extracts were dried (Na2SO4), filtered and concentrated under reduced pressure. The crude material was purified by flash column chromatography on silica gel (94:5:1, CH2Cl2/MeOH/NH4OH) to generate 4-methyl-nicotinamide as an off-white solid (0.95 g, 48%). 1H-NMR (CDCl3) delta 2.53 (s, 3H), 7.20 (d, IH, J= 4 Hz), 8.53 (d, IH, J= 4 Hz), 8.69 (s, IH).

With the rapid development of chemical substances, we look forward to future research findings about 3222-50-2.

Reference:
Patent; ANORMED INC.; WO2006/138350; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3222-50-2, name is 4-Methylnicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 3222-50-2

4-Methylnicotinic acid (2.50 g, 14.4 mmol), EDCI (4.14 mg, 21.6 mmol) and HOBt (2.92 mg, 21.6 mmol) were combined in DMF (1 ml) and CH2Cl2 (75 ml) to give a pale yellow solution. To this solution was added ammonium chloride (2.31 g, 43.2 mmol) followed by DIPEA (12.5 ml, 72.0 mmol) and the resulting mixture was stirred at room temperature for 16 hours. The solvent was removed in vacuo and diluted with saturated aqueous NaHCO3 (50 ml) and CH2Cl2 (50 ml). The solution was then basicified to pH -14 with ION NaOH. The phases were separated and the aqueous layer was extracted with CH2Cl2 (5 x 50 ml). The combined organic extracts were dried (Na2SO4), filtered and concentrated under reduced pressure. The crude material was purified by flash column chromatography on silica gel (94:5:1, CH2Cl2/MeOH/NH4OH) to generate 4-methyl-nicotinamide as an off-white solid (0.95 g, 48%). 1H-NMR (CDCl3) delta 2.53 (s, 3H), 7.20 (d, IH, J= 4 Hz), 8.53 (d, IH, J= 4 Hz), 8.69 (s, IH).

With the rapid development of chemical substances, we look forward to future research findings about 3222-50-2.

Reference:
Patent; ANORMED INC.; WO2006/138350; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 3222-50-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3222-50-2, name is 4-Methylnicotinic acid. A new synthetic method of this compound is introduced below.

General procedure: Into a 1L open reactor was added 500g of carboxylic acid raw material (chemically pure) and stirring was turned on (600 r/min) from the reactorThe bottom is continuously fed with ammonia gas (chemical purity, water content of 5.1% by weight, flow rate of 100 g/min) to the carboxylic acid feed. After the reaction was allowed to proceed for TC hours at the reaction temperature TA, ammonia gas flow was stopped. The contents of the reactor were sampled and subjected to nuclear magnetic proton and elemental analysis to characterize the amide intermediate. Specific reaction conditions and characterization results are shown in Table A-1, Table A-2, Table A-3, Table A-4, Table A-5 and Table A-6. These characterization results show that the amide intermediates obtained have an extremely high purity (above 99%).In this embodiment, the ammonia gas can be directly replaced with waste ammonia gas (from Yangzi Petrochemical Plant, containing approximately50wt% of ammonia gas, the rest were toluene, oxygen, nitrogen, steam, carbon monoxide, and carbon dioxide, and the flow rate of this waste ammonia was 130g/min).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3222-50-2, 4-Methylnicotinic acid, and friends who are interested can also refer to it.

Reference:
Patent; Sinopec Yangzi Petrochemical Co., Ltd.; Sinopec Corporation; Sun Hailong; Wei Yanyu; Gao Yilong; Chen Xinhua; Miao Jun; Li Na; Kan Lin; Bai Jiye; Chen Shaohui; Yang Aiwu; Xu Yuexing; (76 pag.)CN104557357; (2018); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 3222-50-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3222-50-2, name is 4-Methylnicotinic acid. A new synthetic method of this compound is introduced below.

General procedure: Into a 1L open reactor was added 500g of carboxylic acid raw material (chemically pure) and stirring was turned on (600 r/min) from the reactorThe bottom is continuously fed with ammonia gas (chemical purity, water content of 5.1% by weight, flow rate of 100 g/min) to the carboxylic acid feed. After the reaction was allowed to proceed for TC hours at the reaction temperature TA, ammonia gas flow was stopped. The contents of the reactor were sampled and subjected to nuclear magnetic proton and elemental analysis to characterize the amide intermediate. Specific reaction conditions and characterization results are shown in Table A-1, Table A-2, Table A-3, Table A-4, Table A-5 and Table A-6. These characterization results show that the amide intermediates obtained have an extremely high purity (above 99%).In this embodiment, the ammonia gas can be directly replaced with waste ammonia gas (from Yangzi Petrochemical Plant, containing approximately50wt% of ammonia gas, the rest were toluene, oxygen, nitrogen, steam, carbon monoxide, and carbon dioxide, and the flow rate of this waste ammonia was 130g/min).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3222-50-2, 4-Methylnicotinic acid, and friends who are interested can also refer to it.

Reference:
Patent; Sinopec Yangzi Petrochemical Co., Ltd.; Sinopec Corporation; Sun Hailong; Wei Yanyu; Gao Yilong; Chen Xinhua; Miao Jun; Li Na; Kan Lin; Bai Jiye; Chen Shaohui; Yang Aiwu; Xu Yuexing; (76 pag.)CN104557357; (2018); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem