Category: 32710-65-9

Reference of 32710-65-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32710-65-9, name is 2,6-Dichloroisonicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

Example 7. Synthesis of (Z)-2-(2-(3-(2-chloro-6-methoxypyridin-4-yl)-lH- l,2 -triazol-l-yl)vinyl)-l,3,4-oxadiazole (-10).[00316] Synthesis of 2-chloro-6-methoxyisonicotinonitrile: [00317] In a 25-mL, 3N round-bottomed flask equipped with thermometer pocket fitted with an nitrogen inlet and a rubber septum, NaH (0.112 g, 1.0 eq.), methanol (0.11 mL, 1.0 eq.), suspended in N-methyl pyrolidine (5 mL). The reaction mixture was stir at 25-30 C for 30 minutes. To this reaction mixture 2,6-dichloroisonicotinonitrile was added at 0-5 C. The progress of the reaction was followed by TLC analysis on silica gel with 10% EtOAc- hexane as mobile phase which shows that starting material was consumed after 2 hours staring at 0-5 C. Reaction was quenched by water, precipitate was observed that was filter by filter paper and wash with hexane to give required compound (0.51 g, crude). Reaction was stirred for 20 min with water solid was separated and compound was collected by filtration on a Buchner funnel and washed with of hexane (30 mL); Yield: 0.51 g crude 2- chloro-6-methoxyisonicotinonitrile.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 32710-65-9, 2,6-Dichloroisonicotinonitrile.

Reference:
Patent; KARYOPHARM THERAPEUTICS, INC.; SANDANAYAKA, Vincent, P.; SHACHAM, Sharon; SHECHTER, Sharon; MCCAULEY, Dilara; WO2012/99807; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 32710-65-9, name is 2,6-Dichloroisonicotinonitrile, molecular formula is C6H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2,6-Dichloroisonicotinonitrile

Synthesis of 2-chloro-6-methoxy-pyridine-4-carbonitrile 25F A solution of compound 24 (2.0 g, 1 1.6 mmol) in methanol (20 mL) was added with sodium methoxyde (628 mg, 1 mol eq) and the mixture was heated at 60C for 6h. The reaction was cooled, evaporated to dryness and then water was added (300 mL). The aqueous phase was extracted with EtOAc (3×25 mL) and the recombined organic phases were dried over sodium sulfate and evaporated under reduced pressure to afford 25F as transparent viscous oil (1.95g, quantitative yield). FontWeight=”Bold” FontSize=”10″ HNMR (DMSO, 200 MHz) delta 3.80 (s, 3H), 7.17 (s, 1H), 7.90 (s, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 32710-65-9.

Reference:
Patent; PHARMESTE S.R.L. IN LIQUIDATION; FRUTTAROLO, Francesca; PAVANI, Maria Giovanna; BENCIVENNI, Serena; GATTI, Raffaele; NAPOLETANO, Mauro; WO2014/135617; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 32710-65-9, name is 2,6-Dichloroisonicotinonitrile, molecular formula is C6H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2,6-Dichloroisonicotinonitrile

Synthesis of 2-chloro-6-methoxy-pyridine-4-carbonitrile 25F A solution of compound 24 (2.0 g, 1 1.6 mmol) in methanol (20 mL) was added with sodium methoxyde (628 mg, 1 mol eq) and the mixture was heated at 60C for 6h. The reaction was cooled, evaporated to dryness and then water was added (300 mL). The aqueous phase was extracted with EtOAc (3×25 mL) and the recombined organic phases were dried over sodium sulfate and evaporated under reduced pressure to afford 25F as transparent viscous oil (1.95g, quantitative yield). FontWeight=”Bold” FontSize=”10″ HNMR (DMSO, 200 MHz) delta 3.80 (s, 3H), 7.17 (s, 1H), 7.90 (s, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 32710-65-9.

Reference:
Patent; PHARMESTE S.R.L. IN LIQUIDATION; FRUTTAROLO, Francesca; PAVANI, Maria Giovanna; BENCIVENNI, Serena; GATTI, Raffaele; NAPOLETANO, Mauro; WO2014/135617; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 32710-65-9, name is 2,6-Dichloroisonicotinonitrile, molecular formula is C6H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2,6-Dichloroisonicotinonitrile

Synthesis of 2-chloro-6-methoxy-pyridine-4-carbonitrile 25F A solution of compound 24 (2.0 g, 1 1.6 mmol) in methanol (20 mL) was added with sodium methoxyde (628 mg, 1 mol eq) and the mixture was heated at 60C for 6h. The reaction was cooled, evaporated to dryness and then water was added (300 mL). The aqueous phase was extracted with EtOAc (3×25 mL) and the recombined organic phases were dried over sodium sulfate and evaporated under reduced pressure to afford 25F as transparent viscous oil (1.95g, quantitative yield). FontWeight=”Bold” FontSize=”10″ HNMR (DMSO, 200 MHz) delta 3.80 (s, 3H), 7.17 (s, 1H), 7.90 (s, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 32710-65-9.

Reference:
Patent; PHARMESTE S.R.L. IN LIQUIDATION; FRUTTAROLO, Francesca; PAVANI, Maria Giovanna; BENCIVENNI, Serena; GATTI, Raffaele; NAPOLETANO, Mauro; WO2014/135617; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 32710-65-9 ,Some common heterocyclic compound, 32710-65-9, molecular formula is C6H2Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 61Mol Weight: 218.70[00616] Synthesis of Intermediate (1)Molecular Weig ht: 173.00 Molecular Weight: 168.58[00617] In a 25-mL,3Nround-bottomed flask equipped with thermometer pocket fitted with a nitrogen inlet and a rubber septum, NaH (0.1 12 g, 1.0 eq.), methanol (0.1 1 mL, 1.0 eq.), suspended in N-Methyl pyrolidine (5 niL). The reaction mixture was stirred at 25-30C for 30 min. To this reaction mixture 2, 6-Dichloro,4-cyano-pyridine was added at 0-5 C. The progress of the reaction was followed by TLC analysis on silica gel with 10%EtOAc- hexane as mobile phase which shows completion after 2 h staring at 0-5 C. Reaction was quenched by water and precipitate was observed which was filtered and wash with hexane to give required compound (0.51 g, Crude). Reaction was stirred for 20 min with water and solid was separated and compound was collected by filtration and washed with hexane (30mL).Yield:0.51 g Crude.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,32710-65-9, its application will become more common.

Reference:
Patent; KARYOPHARM THERAPEUTICS, INC.; SHECHTER, Sharon; KAUFFMAN, Michael; SANDANYAKA, Vincent, P.; SHACHAM, Sharon; WO2011/109799; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem