Category: 329214-79-1

Kashiwagi, Yukiyasu; Kubono, Koji; Tamai, Toshiyuki published the artcile< Crystal structure of catena-poly[[[bis(3-oxo-1,3-diphenylprop-1-enolato-κ2O,O')zinc(II)]- μ2-tris[4-(pyridin-3-yl)phenyl]amine-k2N:N'] tetrahydrofuran monosolvate]>, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is crystal coordination polymer structure hydrogen bond geometry; C—H⋯π inter­actions; coordination polymer; crystal structure; tri­aryl­amine; β-diketonato zinc(II).

The reaction of bis(3-oxo-1,3-diphenylprop-1-enolato-k2O,O’)zinc(II), [Zn(dbm)2], with tris[4-(pyridin-3-yl)phenyl]amine (T3PyA) in THF (THF) afforded the title crystalline coordination polymer, {[Zn(C15H11O2)2(C33H24N4)].C4H8O}n. The asym. unit contains two independent halves of Zn(dbm)2, one T3PyA and one THF. Each ZnII atom is located on an inversion center and adopts an elongated octahedral coordination geometry, ligated by four O atoms of two dbm ligands in equatorial positions and by two N atoms of pyridine moieties from two different bridging T3PyA ligands in axial positions. The crystal packing shows a one-dimensional polymer chain in which the two pyridyl groups of the T3PyA ligand bridge two independent Zn atoms of Zn(dbm)2. In the crystal, the coordination polymer chains are linked via C-H…π interactions into a sheet structure parallel to (010). The sheets are crosslinked via further C-H…π interactions into a three-dimensional network. The solvate THF mol. shows disorder over two sets of at. sites having occupancies of 0.631 (7) and 0.369 (7).

Acta Crystallographica, Section E: Crystallographic Communications published new progress about Crystal structure. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Watanabe, Taiki; Sasabe, Hisahiro; Owada, Tsukasa; Maruyama, Tomohiro; Watanabe, Yuichiro; Katagiri, Hiroshi; Kido, Junji published the artcile< Chrysene-based Electron-transporters Realizing Highly Efficient and Stable Phosphorescent OLEDs>, Category: pyridine-derivatives, the main research area is chrysene electron transporter phosphorescence organic light emitting diode.

A series of chrysene-based electron-transporters named BnPyPCs (n = 2, 3, 4) end-capped with two 3,5-di(pyridin-n-yl)phenyl moieties with high thermal and elec. stability were successfully developed. BnPyPCs showed Tm values greater than 390°C and were used for highly efficient green phosphorescent OLEDs with maximum external quantum efficiency values greater than 20% and long operation lifetime at high brightness of approx. 11000 cd m-2 at a c.d. of 25 mA cm-2.

Chemistry Letters published new progress about Density functional theory. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Prakash, Muthuraj; Itoh, Yukihiro; Fujiwara, Yoshie; Takahashi, Yukari; Takada, Yuri; Mellini, Paolo; Elboray, Elghareeb E.; Terao, Mitsuhiro; Yamashita, Yasunobu; Yamamoto, Chika; Yamaguchi, Takao; Kotoku, Masayuki; Kitao, Yuki; Singh, Ritesh; Roy, Rohini; Obika, Satoshi; Oba, Makoto; Wang, Dan Ohtan; Suzuki, Takayoshi published the artcile< Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach>, Reference of 329214-79-1, the main research area is fat mass obesity associated protein inhibitor preparation cancer.

Fat mass obesity-associated protein (FTO) is a DNA/RNA demethylase involved in the epigenetic regulation of various genes and is considered a therapeutic target for obesity, cancer, and neurol. disorders. Here, we aimed to design novel FTO-selective inhibitors by merging fragments of previously reported FTO inhibitors. Among the synthesized analogs, compound 11b, which merges key fragments of Hz (3) and MA (4), inhibited FTO selectively over alkylation repair homolog 5 (ALKBH5), another DNA/RNA demethylase. Treatment of acute monocytic leukemia NOMO-1 cells with a prodrug of 11b decreased the viability of acute monocytic leukemia cells, increased the level of the FTO substrate N6-methyladenosine in mRNA, and induced upregulation of MYC and downregulation of RARA, which are FTO target genes. Thus, Hz (3)/MA (4) hybrid analogs represent an entry into a new class of FTO-selective inhibitors.

Journal of Medicinal Chemistry published new progress about Acute monocytic leukemia. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Reference of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shen, Ni; Li, Runhan; Liu, Can; Shen, Xuzhong; Guan, Wei; Shang, Rui published the artcile< Photocatalytic Cross-Couplings of Aryl Halides Enabled by o-Phosphinophenolate and o-Phosphinothiophenolate>, Application of C11H16BNO2, the main research area is phosphinophenolate catalyzed cross coupling aryl halide boronate phosphite pyrrole; thiophenolate catalyzed cross coupling aryl halide boronate phosphite pyrrole; arylboronic acid ester preparation; aryl phosphonate preparation; arylpyrrole derivative preparation.

O-Phosphinophenolate and o-phosphinothiophenolate are potent photocatalysts with strong reducing ability to activate aryl chlorides and bromides under visible light for borylation, arylation, and phosphorylation. Exptl. and theor. studies revealed that the o-diphenylphosphino substituent results in a narrow optical gap and facilitates intersystem crossing to access triplet states, which promote phenolate and thiophenolate to function as effective visible-light-photoredox catalysts. The results presented herein suggest promising utility of synthetically modified phenolates and thiophenolates as photoredox catalysts.

ACS Catalysis published new progress about Amination. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Application of C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Trobe, Melanie; Vareka, Martin; Schreiner, Till; Dobrounig, Patrick; Doler, Carina; Holzinger, Ella B.; Steinegger, Andreas; Breinbauer, Rolf published the artcile< A Modular synthesis of teraryl-based α-helix mimetics, part 3: Iodophenyltriflate core fragments featuring side chains of proteinogenic amino acids>, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is peptidomimetic helix teraryl amino acid synthesis protein interaction inhibitor; Suzuki Miyaura coupling Wittig reaction iodo salicylic aldehyde amination; Inhibitors; Peptide mimetics; Protein–protein interactions; Suzuki coupling; Triflate.

Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein-protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics using a benzene core unit featuring two leaving groups of differentiated reactivity in the Pd-catalyzed cross-coupling used for teraryl assembly. In previous publications we have introduced the methodol. of 4-iodophenyltriflates decorated with the side chains of some of the proteinogenic amino acids. We herein report the core fragments corresponding to the previously missing amino acids Arg, Asn, Asp, Met, Trp and Tyr. Therefore, our set now encompasses all relevant amino acid analogs with the exception of His. In order to be compatible with the triflate moiety, some of the nucleophilic side chains had to be provided in a protected form to serve as stable building blocks. Addnl., cross-coupling procedures for the assembly of teraryls were investigated.

European Journal of Organic Chemistry published new progress about Amination. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hou, Shaohua; Yang, Xiping; Tong, Yu; Yang, Yuejing; Chen, Quanwei; Wan, Boheng; Wei, Ran; Wang, Yuchen; Zhang, Yanmin; Kong, Bo; Huang, Jianhang; Chen, Yadong; Lu, Tao; Hu, Qinghua; Du, Ding published the artcile< Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis>, Safety of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is triazolylpyridinyl indolecarboxamide preparation ASK1 inhibitor ulcerative colitis; structure triazolylpyridinyl indolecarboxamide inhibition ASK1; mol docking pharmacokinetics permeability triazolylpyridinyl indolecarboxamide ASK1 inhibitor; 1H-indole-2-carboxamide derivatives; ASK1 inhibitor; Ulcerative colitis.

Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase (MAPK) family, is implicated in many human diseases. Here, we describe the structural optimization of a hit compound and conduct further structure-activity relationship (SAR) studies that result in the development of the indole-2-carboxamide I. I displays potent anti-ASK1 kinase activity and stronger inhibitory effect on ASK1 in AP1-HEK293 cells than previously described ASK1 inhibitor GS-4997. Besides improved in vitro activity, I also exhibits an appropriate in vivo PK profile. In a dextran sulfate sodium (DSS)-induced mouse model of ulcerative colitis (UC), I shows significant anti-UC efficacy and markedly attenuates DSS-induced body weight loss, colonic shortening, elevation in disease activity index (DAI) and inflammatory cell infiltration in colon tissues. Mechanistically, I represses the phosphorylation of ASK1-p38/JNK signaling pathways and suppresses the overexpression of inflammatory cytokines. Together, these findings suggest that ASK1 inhibitors can potentially be used as a therapeutic strategy for UC.

European Journal of Medicinal Chemistry published new progress about Biological permeation. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Safety of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hoque, Emdadul Md; Bisht, Ranjana; Unnikrishnan, Anju; Dey, Sayan; Mahamudul Hassan, Mirja Md; Guria, Saikat; Rai, Rama Nand; Sunoj, Raghavan B.; Chattopadhyay, Buddhadeb published the artcile< Iridium-Catalyzed Ligand-Controlled Remote para-Selective C-H Activation and Borylation of Twisted Aromatic Amides>, Synthetic Route of 329214-79-1, the main research area is regioselective remote para borylation CH activation twisted aromatic amide; aryl boronate preparation regioselective remote para borylation aromatic amide; potential energy surface para CH borylation twisted aromatic amide; Borylation; C−H Activation; Density Functional Calculations; Iridium Catalyst; Para Selectivity.

A method of para-selective borylation of fully twisted aromatic amides ArCONBoc2 is described, yielding boronamides 4-pinBC6HnX4-nCONBoc2 (X = alkyl, alkoxy, aryl, halo, CN). The borylation proceeded via an unprecedented substrate-ligand distortion between the twisted aromatic amides and a newly designed ligand framework, 4,5-diaza-9H-fluorene (defa) that is different from the traditionally used ligand (dtbpy) for the C-H borylation reactions. The designed ligand defa has led to the development of a new type of catalytic system that shows excellent para selectivity for a range of aromatic amides. Moreover, the designed ligand has shown excellent reactivity and selectivity for a range of heterocyclic aromatic amides. The identification of key transition states and intermediates using the DFT computations associated with the three regio-isomeric pathways revealed that the most efficient catalytic pathway with the defa ligand leads to the para borylation while in the case of bpy the borylation at the para and meta sites compete.

Angewandte Chemie, International Edition published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Synthetic Route of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Guo-Xi; Chen, Yuwen; Zhu, Jie-Ji; Song, Jia-Yu; Tang, Shan-Shun; Ma, Dongge; Tong, Qing-Xiao published the artcile< Rational design of pyridine-containing emissive materials for high performance deep-blue organic light-emitting diodes with CIEy ∼ 0.06>, Reference of 329214-79-1, the main research area is rational design pyridine containing emissive material high performance deep.

Charge balance does matter for emission materials to obtain high-performance organic light-emitting diodes (OLEDs), and it is well-known that the electron-transporting ability is inferior to the hole-transporting for the majority of organic emitting materials, especially for blue-emitting compounds Hence, systematically investigating the effect of the electron-withdrawing group on fluorophore is of vital importance. In this study, we designed and synthesized two deep-blue phenanthro[9,10-d]imidazole (PI) based materials named DPy-PPI and DmPy-PPI by using pyridine-containing groups as electron acceptor as well as adjusting the conjugation length. The photophys., theor., thermal and electrochem. properties of the compounds were investigated systematically, and the relationship between the conjugation length of substituent groups on phenanthroimidazole and the EL performance was clarified. Both of them exhibited good thermal stability and high photoluminescence quantum yields. Non-doped devices based on DPy-PPI and DmPy-PPI as emitter achieved deep-blue emissions with the Commission Internationale de L’Eclairage (CIE) index of (0.14, 0.06) and (0.15, 0.08) and high external quantum efficiencies (EQEmax) of 4.24% and 3.74%, resp. Meanwhile, using DPy-PPI and DmPy-PPI as the host materials, yellow-orange phosphorescent organic light-emitting diodes (PHOLEDs) were fabricated with EQEmax, CEmax and PEmax of 20.55%, 63.86 cd/A, 37.08 lm/W and 18.14%, 55.84 cd/A, 32.47 lm/W, resp. Furthermore, the red PHOLEDs were also constructed using DPy-PPI and DmPy-PPI as the host with EQEmax, CEmax and PEmax of 14.53%, 17.04 cd/A, 18.51 lm/W and 16.62%, 23.58 cd/A, 21.16 lm/W, resp. And we believe this work can provide some insight suggestions for scientific researchers to design deep-blue emitting materials.

Dyes and Pigments published new progress about Blue-emitting electroluminescent devices. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Reference of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Huai-Wei; Qiao, Yu-Han; Wu, Jia-Xue; Wang, Qiu-Ping; Tian, Meng-Xin; Li, Yong-Fei; Yao, Qing-Xia; Li, Da-Cheng; Dou, Jian-Min; Lu, Yi published the artcile< RhIII-Catalyzed C-H (Het)arylation/Vinylation of N-2,6-Difluoroaryl Acrylamides>, Product Details of C11H16BNO2, the main research area is arylboronate difluorophenyl acrylamide rhodium catalyst regioselective diastereoselective arylation; aryl difluorophenyl acrylamide preparation; vinylboronate difluorophenyl acrylamide rhodium catalyst regioselective diastereoselective vinylation; vinyl difluorophenyl acrylamide preparation.

RhIII-catalyzed sp2 C-H cross-coupling of acrylamides with organoboron reactants was accomplished using a com.available N-2,6-difluoroaryl acrylamide auxiliary. A broad range of aryl and vinyl boronates as well as a variety of heterocyclic boronates with strong coordinating ability served as the coupling partners. This transformation proceeded under moderate reaction conditions with excellent functional group tolerance and high regioselectivity.

Organic Letters published new progress about Acrylamides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Product Details of C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nitelet, Antoine; Thevenet, Damien; Schiavi, Bruno; Hardouin, Christophe; Fournier, Jean; Tamion, Rodolphe; Pannecoucke, Xavier; Jubault, Philippe; Poisson, Thomas published the artcile< Copper-Photocatalyzed Borylation of Organic Halides under Batch and Continuous-Flow Conditions>, Formula: C11H16BNO2, the main research area is copper photocatalyzed borylation aryl heteroaryl vinyl alkyl halide; aryl vinyl alkyl boronic acid ester preparation electrochem; borylation; continuous flow; copper; photocatalysis; visible light.

The Cu-photocatalyzed borylation of aryl, heteroaryl, vinyl and alkyl halides (I and Br) is reported. The reaction proceeded using a new heteroleptic Cu complex under irradiation with blue LEDs, giving the corresponding boronic-acid esters in good to excellent yields. The reaction was extended to continuous-flow conditions to allow an easy scale-up. The mechanism of the reaction was studied and a mechanism based on a reductive quenching (Cu(I)/Cu(I)*/Cu(0)) was suggested.

Chemistry – A European Journal published new progress about Boronic acids, esters Role: SPN (Synthetic Preparation), PREP (Preparation). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Formula: C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem