Category: 329214-79-1

Yang, Lichen; Uemura, Nao; Nakao, Yoshiaki published the artcile< meta-Selective C-H Borylation of Benzamides and Pyridines by an Iridium-Lewis Acid Bifunctional Catalyst>, Category: pyridine-derivatives, the main research area is meta selective borylation benzamide pyridine iridium aluminum bifunctional catalyst; borane pyridyl benzamide derivative preparation.

The authors report herein the Ir-catalyzed meta-selective C-H borylation of benzamides by using a newly designed 2,2′-bipyridine (bpy) ligand bearing an alkylaluminum biphenoxide moiety. The authors also demonstrate the Ir-catalyzed C3-selective C-H borylation of pyridine with a 1,10-phenanthroline (Phen) ligand bearing an alkylborane moiety. Probably the Lewis acid-base interaction between the Lewis acid moiety and the aminocarbonyl group or the sp2-hybridized N atom accelerates the reaction and controls the site-selectivity.

Journal of the American Chemical Society published new progress about Benzamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lamola, Jairus L.; Moshapo, Paseka T.; Holzapfel, Cedric W.; Christopher Maumela, Munaka published the artcile< Palladium-catalyzed borylation of aryl bromides and chlorides using phosphatrioxa-adamantane ligands>, Computed Properties of 329214-79-1, the main research area is palladium catalyst borylation aryl bromide chloride phosphatrioxa adamantane; aryl boronate ester preparation.

Catalysts based on the combination of Pd(OAc)2 and the electron-deficient phosphatrioxa-adamantane ligands are described for borylation of aryl bromides and chlorides. Catalytic evaluation of a small library of phosphatrioxa-adamantane ligands provided some insights on the preferred ligand steric profile for borylation reactions. The corresponding aryl boronate esters were accessed under mild conditions (25-70°) and isolated in high yields (up to 96%).

Tetrahedron Letters published new progress about Adamantanes Role: CAT (Catalyst Use), USES (Uses) (phosphatrioxa-). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Computed Properties of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guo, Xuan; Lv, Fang; Zhao, Zifeng; Gu, Jiannan; Qu, Bo; Xiao, Lixin; Chen, Zhijian published the artcile< Spirobifluorene-based oligopyridine derivatives as electron-transporting materials for green phosphorescent organic light-emitting diodes>, Synthetic Route of 329214-79-1, the main research area is spirobifluorene oligopyridine electron transporting material phosphorescent OLED.

The electron-transporting materials (ETMs), 2,7-bis(3,5-di (pyridin-3-yl)phenyl)-9,9′-spirobi [fluorene] (3-4PySF) and 2,7-bis(3,5-di (pyridin-4-yl)phenyl)-9,9′-spirobi [fluorene] (4-4PySF) were designed and synthesized by combining spirobifluorene moiety with di(pyridine-3-yl)phenyl and di(pyridine-4-yl)phenyl, resp. The spirobifluorene moiety improves materials’ rigid twisted structure to ensure the morphol. stability of amorphous film, and pyridine acts as electron acceptor to enhance electron-transporting ability of materials. The dependence of electron-transporting property on the position of substituted pyridine rings was studied. The m.p. (Tm) of 4-4PySF is estimated to be 41°C higher than that of 3-4PySF. And the higher c.d. in the electron only devices exhibited by 4-4PySF revealed the effect of nitrogen atom position on the charge-transporting properties. Green PhOLEDs based on bis(2-phenylpyridine)iridium (III) (2,2,6,6-tetramethylheptane-3,5-diketonate) (Ir (ppy)2tmd) as the emitter and 3-4PySF, 4-4PySF and 1,3,5-tris(N-phenylbenzimid azol-2-yl-benzene (TPBi) as ETMs were fabricated. Compared to the device based on the conventional ETM TPBi, the devices based on new ETMs exhibited a higher maximum external quantum efficiency (EQE) of 20.5% and a lower turn-on voltage (Von) of 2.6 V.

Organic Electronics published new progress about Crystal structure. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Synthetic Route of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Spock, Matthew; Carter, Trever R.; Bollinger, Katrina A.; Han, Changho; Baker, Logan A.; Rodriguez, Alice L.; Peng, Li; Dickerson, Jonathan W.; Qi, Aidong; Rook, Jerri M.; O’Neill, Jordan C.; Watson, Katherine J.; Chang, Sichen; Bridges, Thomas M.; Engers, Julie L.; Engers, Darren W.; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W.; Bender, Aaron M. published the artcile< Discovery of VU6028418: A Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor Antagonist>, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is preparation oral mAChR4 antagonist dystonia movement disorder.

Herein, we report the SAR leading to the discovery of VU6028418, a potent M4 mAChR antagonist with high subtype-selectivity and attractive DMPK properties in vitro and in vivo across multiple species. VU6028418 was subsequently evaluated as a preclin. candidate for the treatment of dystonia and other movement disorders. During the characterization of VU6028418, a novel use of deuterium incorporation as a means to modulate CYP inhibition was also discovered.

ACS Medicinal Chemistry Letters published new progress about Canis familiaris. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Owada, Tsukasa; Sasabe, Hisahiro; Sukegawa, Yoshihito; Watanabe, Taiki; Maruyama, Tomohiro; Watanabe, Yuichiro; Yokoyama, Daisuke; Kido, Junji published the artcile< A terpyridine-modified chrysene derivative as an electron transporter to improve the lifetime in phosphorescent OLEDs>, SDS of cas: 329214-79-1, the main research area is terpyridine chrysene derivative electron transporter phosphorescent organic LED lifetime.

A terpyridine-modified chrysene derivative, abbreviated as B3TPyC, was designed and developed to be used as electron-transport layers (ETLs) toward the construction of highly stable phosphorescent OLEDs. A green phosphorescent OLED with a B3TPyC ETL exhibited a low turn-on voltage of 2.4 V at 1 cd m-2 and an external quantum efficiency of 17.5% at 1000 cd m-2 with a long operation lifetime at 50% of the initial luminance (LT50) of over 258 h at c.d. 25 mA cm-2 (an initial luminance of ∼12,000 cd m-2), which corresponds to a LT50 of 19,000 h at 1000 cd m-2. This is >1.5 times longer than the time of luminance decay provided by the phenylpyridine counterpart named B3PyPC. These results clearly show the potential and usefulness of terpyridine-based chrysene derivatives to be applied in high-performance OLEDs with high operational stability.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Atomic force microscopy. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, SDS of cas: 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Xiaojie; Popli, Henna; Kwon, Ohyun; Malissa, Hans; Pan, Xin; Park, Bumwoo; Choi, Byoungki; Kim, Sunghan; Ehrenfreund, Eitan; Boehme, Christoph; Vardeny, Z. Valy published the artcile< Isotope Effect in the Magneto-Optoelectronic Response of Organic Light-Emitting Diodes Based on Donor-Acceptor Exciplexes>, Safety of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is OLED magneto optoelectronic response donor acceptor exciplex; Rabi oscillations; electrically detected magnetic resonance; exciplexes; magneto-electroluminescence; organic light-emitting diodes (OLEDs); reverse intersystem crossing.

The isotope effect is studied in the magneto-electroluminescence (MEL) and pulsed elec. detected magnetic resonance of organic light-emitting diodes based on thermally activated delayed fluorescence (TADF) from donor-acceptor exciplexes that are either protonated (H) or deuterated (D). It is found that at ambient temperature, the exchange of H to D has no effect on the spin-dependent current and MEL responses in the devices. However, at cryogenic temperatures, where the reverse intersystem crossing (RISC) from triplet to singlet exciplex diminishes, a pronounced isotope effect is observed These results show that the RISC process is not governed by the hyperfine interaction as thought previously, but proceeds through spin-mixing in the triplet exciplex. The observations are corroborated by elec. detected transient spin nutation experiments that show relatively long dephasing time at ambient temperature, and interpreted in the context of a model that involves exchange and hyperfine interactions in the spin triplet exciplex. These findings deepen the understanding of the RISC process in TADF materials.

Advanced Materials (Weinheim, Germany) published new progress about Activation energy (of conductivity). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Safety of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Demonti, Luca; Saffon-Merceron, Nathalie; Mezailles, Nicolas; Nebra, Noel published the artcile< Cross-Coupling through Ag(I)/Ag(III) Redox Manifold>, Name: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is silver trifluoromethyl tervalent argentate preparation reductive elimination arylboronate; trifluoromethyl arene preparation coupling arylboronate trifluoromethylargentate reductive elimination; crystal mol optimized electronic structure tervalent trifluoromethyl argentate complex; AgIII chemistry; cross-coupling; fluorine; high-valent species; trifluoromethylation.

Trifluoromethyl argentates(III) undergo reductive elimination with arylboronic acids, yielding trifluoromethylarenes. In ample variety of transformations, the presence of silver as an additive or co-catalyst is believed to be innocuous for the efficiency of the operating metal catalyst. Even though Ag additives are required often as coupling partners, oxidants or halide scavengers, its role as a catalytically competent species is widely neglected in cross-coupling reactions. Most likely, this is due to the erroneously assumed incapacity of Ag to undergo 2e- redox steps. Definite proof is herein provided for the required elementary steps to accomplish the oxidative trifluoromethylation of arenes through AgI/AgIII redox catalysis (i. e. CEL coupling), namely: (i) easy AgI/AgIII 2e- oxidation mediated by air; (ii) bpy/phen ligation to AgIII; (iii) boron-to-AgIII aryl transfer; and (iv) ulterior reductive elimination of benzotrifluorides from an [aryl-AgIII-CF3] fragment. More precisely, an ultimate entry and full characterization of organosilver(III) compounds [K]+[AgIII(CF3)4]- (K-1), [(bpy)AgIII(CF3)3] (2) and [(phen)AgIII(CF3)3] (3), is described. The utility of 3 in cross-coupling has been showcased unambiguously, and a large variety of arylboron compounds was trifluoromethylated via [AgIII(aryl)(CF3)3]- intermediates. This work breaks with old stereotypes and misconceptions regarding the inability of Ag to undergo cross-coupling by itself.

Chemistry – A European Journal published new progress about Boronic acids, esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (arylboronates). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Name: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hara, Naofumi; Aso, Koki; Li, Qiao-Zhi; Sakaki, Shigeyoshi; Nakao, Yoshiaki published the artcile< C2-selective alkylation of pyridines by rhodium-aluminum complexes>, Application of C11H16BNO2, the main research area is pyridine alkylation alkene vinylsilane CH activation rhodium aluminum catalyst; alkylpyridine preparation alkylation CH activation vinylsilane alkene bimetallic catalyst.

A C2- and mono-selective alkylation of various pyridines and azines with unactivated alkenes and vinylarenes using a heterobimetallic Rh-Al catalyst is reported. The use of aliphatic alkenes exclusively affords the linear alkylation products, while vinylarenes mainly afford branched alkylation products. The details of the reaction mechanism are revealed by DFT calculations: the reductive elimination of the products is rate-determining, which is consistent with the exptl. results. The origin of the linear/branched selectivity is elucidated based on deformation/interaction anal.

Tetrahedron published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Application of C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Yanjun; Ye, Ziqi; Lin, Yu-Mei; Liu, Yan; Zhang, Yumeng; Gong, Lei published the artcile< Organophotocatalytic selective deuterodehalogenation of aryl or alkyl chlorides>, Quality Control of 329214-79-1, the main research area is deuterated aryl heteroaryl compound green preparation; aryl chloride alkyl organophotocatalyst selective deuterodehalogenation.

A photocatalytic system consisting of an aryl-amine photocatalyst and a disulfide co-catalyst in the presence of sodium formate as an electron and hydrogen donor was developed. Accordingly, many aryl chlorides, alkyl chlorides, and other halides were converted to deuterated products at room temperature in air (>90 examples, up to 99% D-incorporation). The mechanistic studies revealed that the aryl amine served as reducing photoredox catalyst to initiate cleavage of the C-Cl bond, at the same time as energy transfer catalyst to induce homolysis of the disulfide for consequent deuterium transfer process. This economic and environmentally-friendly method could be used for site-selective D-labeling of a number of bioactive mols. and direct H/D exchange of some drug mols.

Nature Communications published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Quality Control of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tessarolo, Jacopo; Lee, Haeri; Sakuda, Eri; Umakoshi, Keisuke; Clever, Guido H. published the artcile< Integrative Assembly of Heteroleptic Tetrahedra Controlled by Backbone Steric Bulk>, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is palladium fluorenonedipyridyl cage complex preparation luminescence; crystal structure palladium fluorenonedipyridyl cage complex.

A bent fluorenone-based dipyridyl ligand LA reacts with PdII cations to a solvent-dependent dynamic library of [PdnL2n] assemblies, constituted by a [Pd3LA6] ring and a [Pd4LA8] tetrahedron as major components, and a [Pd6LA12] octahedron as minor component. Introduction of backbone steric hindrance in ligand LB allows exclusive formation of the [Pd6LB12] octahedron. Combining equimolar amounts of both ligands results in integrative self-sorting to give an unprecedented [Pd4LA4LB4] heteroleptic tetrahedron. Key to the non-statistical assembly outcome is exploiting the structural peculiarity of the [Pd4L8] tetrahedral topol., where the four lean ligands occupy two doubly bridged edges and the bulky ligands span the four remaining, singly bridged edges. Hence, the system finds a compromise between the entropic drive to form an assembly smaller than the octahedron and the enthalpic prohibition of pairing two bulky ligands on the same edge of the triangular ring. The emission of luminescent LA is maintained in both homoleptic [Pd3LA6] and heteroleptic [Pd4LA4LB4].

Journal of the American Chemical Society published new progress about Crystal structure. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem