Category: 33252-29-8

Related Products of 33252-29-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33252-29-8, name is 6-Chloropicolinonitrile, molecular formula is C6H3ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a 1L four-necked flask equipped with a mechanical stirring and condensation device,Put in 600g of homemade 2-chloro 6-cyanopyridine and 12g of tungsten hexachloride at atmospheric pressure,Heat up to 150 , start stirring, and continuously introduce chlorine gas at a rate of 100mL/min.Control the reaction temperature at 150 ~ 155 , continuous chlorine reaction for 20h,Sampling gas chromatography analysis, calculated conversion rate of raw materials, product selectivity are shown in Table 2.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 33252-29-8, 6-Chloropicolinonitrile.

Reference:
Patent; Nanjing Hong Sun Biochemical Co., Ltd.; Chen Honglong; Mu Dengyou; Wang Fujun; Jiang Jianhua; Xue Yi; Chen Xinchun; (7 pag.)CN111072558; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 33252-29-8 ,Some common heterocyclic compound, 33252-29-8, molecular formula is C6H3ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: In a 1L four-necked flask equipped with a mechanical stirring and condensation device,Put in homemade 2-chloro 6-cyanopyridine (calculated as pure product,The same below) 600g, tungsten hexachloride 12g, phosphorus pentachloride 12g, atmospheric pressure,Heat up to 150 , start stirring, and continuously introduce chlorine gas at a rate of 100mL/min.Control the reaction temperature at 150 ~ 155 , continuous reaction for 20h,Sampling gas chromatography analysis, raw material conversion rate and product yield are shown in Table 2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 33252-29-8, 6-Chloropicolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing Hong Sun Biochemical Co., Ltd.; Chen Honglong; Mu Dengyou; Wang Fujun; Jiang Jianhua; Xue Yi; Chen Xinchun; (7 pag.)CN111072558; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 33252-29-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 33252-29-8 as follows.

Weigh 2.38 g of 2-chloro-6-cyanopyridine and 0.05 g of ETS-10 in a reaction tube.Add 50mL of water, heat up to 110 C reaction, TLC tracking detection,The reaction was completed in 22 hours, and after cooling, it was centrifuged.The resulting solution is distilled off to obtain a product2-chloro-6-pyridinecarboxamide 1.46 g, yield 94%,The purity is 99.75% (gas chromatography detection). Centrifuged solidRepeat the reaction, the reaction conditions, the amount of raw materials are the same as above, when repeated 4 times,The yield is above 90%, and the yield is 84% in the fifth reaction.The purity is 97% or more.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,33252-29-8, its application will become more common.

Reference:
Patent; Wenzhou University; Xiong Jing; Hu Rongrong; Liu Wuqiang; Tao Yangyang; Feng Xiaogang; Zhou Zheng; (6 pag.)CN104072409; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 33252-29-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 33252-29-8 as follows.

Weigh 2.38 g of 2-chloro-6-cyanopyridine and 0.05 g of ETS-10 in a reaction tube.Add 50mL of water, heat up to 110 C reaction, TLC tracking detection,The reaction was completed in 22 hours, and after cooling, it was centrifuged.The resulting solution is distilled off to obtain a product2-chloro-6-pyridinecarboxamide 1.46 g, yield 94%,The purity is 99.75% (gas chromatography detection). Centrifuged solidRepeat the reaction, the reaction conditions, the amount of raw materials are the same as above, when repeated 4 times,The yield is above 90%, and the yield is 84% in the fifth reaction.The purity is 97% or more.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,33252-29-8, its application will become more common.

Reference:
Patent; Wenzhou University; Xiong Jing; Hu Rongrong; Liu Wuqiang; Tao Yangyang; Feng Xiaogang; Zhou Zheng; (6 pag.)CN104072409; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem