Category: 33631-04-8

Barraclough, Paul published the artcileInotropic ‘A’ ring substituted sulmazole and isomazole analogs, Synthetic Route of 33631-04-8, the main research area is inotropic sulmazole isomazole analog; imidazopyridine preparation inotropic.

A series of “”A”” ring substituted sulmazole I [R = 4-, 5-, 6-MeO, 5-NO2, 5-Cl, 5-Me, 5-Ac; X = S, S(O), O] and isomazole analogs II [R = 2-, 5-, 6-MeO, 5-NH2, 5-NO2; X = S, S(O), O] were prepared and evaluated as inotropic agents. Thus, 5-methoxy-2,3-pyridinediamine was cyclized with 2-methoxy-4-(methylthio)benzoic acid to give I (R = 5-MeO, X = S), which was oxidized to give I [R = 5-MeO, X = S(O)]. PKA’s, protonation sites, and log P values were measured for selected compounds and their electronic properties were calculated No simple correlation between inotropic activity and pKA, protonation site, or log P value was observed However, in vitro inotropism did correlate with the calculated charge d. of the “”B”” ring imidazo nitrogen atom. The 6-position of sulmazole appeared to be the most tolerant toward substituents, the 6-amino derivative I [R = 6-NH, X = S(O)] being a more potent inotrope than sulmazole itself. 4-Methoxyisomazole had comparable in vivo inotropic properties to those of isomazole.

Journal of Medicinal Chemistry published new progress about Inotropics. 33631-04-8 belongs to class pyridine-derivatives, name is 2-Methoxypyridine-3,4-diamine, and the molecular formula is C6H9N3O, Synthetic Route of 33631-04-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Barlin, G. B. published the artcileIonization constants of heterocyclic substances. IX. Protonation of aminopyridines and aminopyrimidinones, Product Details of C6H9N3O, the main research area is pyridines aminohydroxy ionization UV; basicity pyridines aminohydroxy; aminohydroxypyridine ionization UV; pyrimidines aminohydroxy ionization UV; protonation aminohydroxypyridine.

Ionization constants and uv spectra are reported for amino-2-hydroxypyridines (amino-2-pyridones), amino-4-hydroxypyridines(amino-4-pyridones), and amino-2,4-di-hydroxypryimidines (amino-2,4-pyrimidinediones) and their O-and ring N-Me derivatives Protonation of 3- and 5-amino-2-hydroxypyridines and 3,4-diamino-2-hydroxypyridine (I) occurs first at the amino group (the 3-NH2 of I), but 4- and 6-amino-2-hydroxypyridines and 2- and 3-amino-4-hydroxypyridines are protonated first at O. The most basic center of 4,5-diamino-2,6-dihydroxypyrimidine is the 5-NH2 group.

Journal of the Chemical Society [Section] B: Physical Organic published new progress about Ionization. 33631-04-8 belongs to class pyridine-derivatives, name is 2-Methoxypyridine-3,4-diamine, and the molecular formula is C6H9N3O, Product Details of C6H9N3O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Barlin, G. B. published the artcileIonization constants of heterocyclic substances. IX. Protonation of aminopyridines and aminopyrimidinones, HPLC of Formula: 33631-04-8, the publication is Journal of the Chemical Society [Section] B: Physical Organic (1971), 1425-32, database is CAplus.

Ionization constants and uv spectra are reported for amino-2-hydroxypyridines (amino-2-pyridones), amino-4-hydroxypyridines(amino-4-pyridones), and amino-2,4-di-hydroxypryimidines (amino-2,4-pyrimidinediones) and their O-and ring N-Me derivatives Protonation of 3- and 5-amino-2-hydroxypyridines and 3,4-diamino-2-hydroxypyridine (I) occurs first at the amino group (the 3-NH2 of I), but 4- and 6-amino-2-hydroxypyridines and 2- and 3-amino-4-hydroxypyridines are protonated first at O. The most basic center of 4,5-diamino-2,6-dihydroxypyrimidine is the 5-NH2 group.

Journal of the Chemical Society [Section] B: Physical Organic published new progress about 33631-04-8. 33631-04-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine,Ether, name is 2-Methoxypyridine-3,4-diamine, and the molecular formula is C6H9N3O, HPLC of Formula: 33631-04-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Barraclough, Paul published the artcileInotropic ‘A’ ring substituted sulmazole and isomazole analogs, Synthetic Route of 33631-04-8, the main research area is inotropic sulmazole isomazole analog; imidazopyridine preparation inotropic.

A series of “”A”” ring substituted sulmazole I [R = 4-, 5-, 6-MeO, 5-NO2, 5-Cl, 5-Me, 5-Ac; X = S, S(O), O] and isomazole analogs II [R = 2-, 5-, 6-MeO, 5-NH2, 5-NO2; X = S, S(O), O] were prepared and evaluated as inotropic agents. Thus, 5-methoxy-2,3-pyridinediamine was cyclized with 2-methoxy-4-(methylthio)benzoic acid to give I (R = 5-MeO, X = S), which was oxidized to give I [R = 5-MeO, X = S(O)]. PKA’s, protonation sites, and log P values were measured for selected compounds and their electronic properties were calculated No simple correlation between inotropic activity and pKA, protonation site, or log P value was observed However, in vitro inotropism did correlate with the calculated charge d. of the “”B”” ring imidazo nitrogen atom. The 6-position of sulmazole appeared to be the most tolerant toward substituents, the 6-amino derivative I [R = 6-NH, X = S(O)] being a more potent inotrope than sulmazole itself. 4-Methoxyisomazole had comparable in vivo inotropic properties to those of isomazole.

Journal of Medicinal Chemistry published new progress about Inotropics. 33631-04-8 belongs to class pyridine-derivatives, name is 2-Methoxypyridine-3,4-diamine, and the molecular formula is C6H9N3O, Synthetic Route of 33631-04-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Barlin, G. B. published the artcileIonization constants of heterocyclic substances. IX. Protonation of aminopyridines and aminopyrimidinones, Product Details of C6H9N3O, the main research area is pyridines aminohydroxy ionization UV; basicity pyridines aminohydroxy; aminohydroxypyridine ionization UV; pyrimidines aminohydroxy ionization UV; protonation aminohydroxypyridine.

Ionization constants and uv spectra are reported for amino-2-hydroxypyridines (amino-2-pyridones), amino-4-hydroxypyridines(amino-4-pyridones), and amino-2,4-di-hydroxypryimidines (amino-2,4-pyrimidinediones) and their O-and ring N-Me derivatives Protonation of 3- and 5-amino-2-hydroxypyridines and 3,4-diamino-2-hydroxypyridine (I) occurs first at the amino group (the 3-NH2 of I), but 4- and 6-amino-2-hydroxypyridines and 2- and 3-amino-4-hydroxypyridines are protonated first at O. The most basic center of 4,5-diamino-2,6-dihydroxypyrimidine is the 5-NH2 group.

Journal of the Chemical Society [Section] B: Physical Organic published new progress about Ionization. 33631-04-8 belongs to class pyridine-derivatives, name is 2-Methoxypyridine-3,4-diamine, and the molecular formula is C6H9N3O, Product Details of C6H9N3O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Barraclough, Paul published the artcileInotropic ‘A’ ring substituted sulmazole and isomazole analogs, Category: pyridine-derivatives, the publication is Journal of Medicinal Chemistry (1990), 33(8), 2231-9, database is CAplus and MEDLINE.

A series of “A” ring substituted sulmazole I [R = 4-, 5-, 6-MeO, 5-NO₂, 5-Cl, 5-Me, 5-Ac; X = S, S(O), O] and isomazole analogs II [R = 2-, 5-, 6-MeO, 5-NH₂, 5-NO₂; X = S, S(O), O] were prepared and evaluated as inotropic agents. Thus, 5-methoxy-2,3-pyridinediamine was cyclized with 2-methoxy-4-(methylthio)benzoic acid to give I (R = 5-MeO, X = S), which was oxidized to give I [R = 5-MeO, X = S(O)]. PK_A‘s, protonation sites, and log P values were measured for selected compounds and their electronic properties were calculated No simple correlation between inotropic activity and pK_A, protonation site, or log P value was observed However, in vitro inotropism did correlate with the calculated charge d. of the “B” ring imidazo nitrogen atom. The 6-position of sulmazole appeared to be the most tolerant toward substituents, the 6-amino derivative I [R = 6-NH, X = S(O)] being a more potent inotrope than sulmazole itself. 4-Methoxyisomazole had comparable in vivo inotropic properties to those of isomazole.

Journal of Medicinal Chemistry published new progress about 33631-04-8. 33631-04-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine,Ether, name is 2-Methoxypyridine-3,4-diamine, and the molecular formula is C6H9N3O, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem