Category: 33674-96-3

Related Products of 33674-96-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 33674-96-3, name is (6-Bromopyridin-2-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of ( 6-bromopyridin-2-yl) methanol (5.22 g) , PPh3 (8.74 g) and benzotrifluoride (210 mL) was added tetrabromomethane (11.1 g) at 0C. The mixture was stirred at 0C for 2 hr, and the insoluble substance was removed by filtration, and washed with ethyl acetate/diethyl ether. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (7.33 g) . XH NMR (300 MHz, CDCI3) delta 4.50 (2H, s) , 7.39-7.45 (2H, m) , 7.52-7.60 (1H, m) .

According to the analysis of related databases, 33674-96-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KAJITA, Yuichi; MIKAMI, Satoshi; MIYANOHANA, Yuhei; KOIKE, Tatsuki; DAINI, Masaki; OYABU, Norio; OGINO, Masaki; TAKEUCHI, Kohei; ITO, Yoshiteru; TOKUNAGA, Norihito; SUGIMOTO, Takahiro; MIYAZAKI,Tohru; ODA, Tsuneo; HOASHI, Yasutaka; HATTORI,Yasushi; IMAMURA, Keisuke; (413 pag.)WO2019/27058; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 33674-96-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.33674-96-3, name is (6-Bromopyridin-2-yl)methanol, molecular formula is C6H6BrNO, molecular weight is 188.02, as common compound, the synthetic route is as follows.

Carbon tetrabromide (12.90 g, 38.88 mmol) was added in four portions to a solution of (6-bromo-pyridin-2-yl)methanol (5.00 g, 29.91 mmol) and PPh3 (8.24 g, 31.40 mmol) in dichloromethane (50 ml) at 0 C. The resulting solution was stirred 2 hours at 0 C. Solvent was removed under reduced pressure. The title compound was obtained by column chromatography. Spectroscopic data: 1H NMR (300 MHz, Acetone-d6) delta 4.66 (s, 2H) 7.57-7.60 (m, 2H) 7.76 (t, J=7.42 Hz, 1H).

The chemical industry reduces the impact on the environment during synthesis 33674-96-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Allerghan, Inc.; US2008/194650; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33674-96-3, name is (6-Bromopyridin-2-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

To a solution of (6-bromo-pyridin-2-yl)-methanol (1.5 g, 8.0 mmol) in chloroform (10 mL) was added dropwise sulfuryl choride (1.29 mL, 16 mmol) and the reaction stirred overnight. The reaction was concentrated under reduced pressure to provide a yellow semi-solid. The material was triturated with diethyl ether/hexanes and the solid collected to provide 2-bromo-6-chloromethyl-pyridine (900 mg, 4.37 mmol) as a sticky white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 33674-96-3, (6-Bromopyridin-2-yl)methanol.

Reference:
Patent; WYETH; WO2008/73934; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33674-96-3, name is (6-Bromopyridin-2-yl)methanol. A new synthetic method of this compound is introduced below., Recommanded Product: 33674-96-3

To a solution of (6-bromo-pyridin-2-yl)-methanol (2.00 g; 10.64 mmol) in 15 mL of dichloromethane is added dropwise phosphorus tribromide (0.61 mL; 6.44 mmol) at 0C. The mixture is warmed to room temperature and stirred overnight. Additional 100 muL of phosphorus tribromide is added and the reaction mixture is stirred for 3 hours at room temperature. The reaction is quenched with cooled NaHCO3 (half saturated aqueous solution) and extracted two times with dichloromethane. The combined organic layers are dried and concentrated under reduced pressure. (0563) Yield: 2.44 g (91 % of theory) (0564) Mass spectrometry (ESI+): m/z = 250/252 [M+H]+ (Br) (0565) HPLC (Method 1): Retention time = 0.878 min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 33674-96-3, (6-Bromopyridin-2-yl)methanol.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; TRIESELMANN, Thomas; GODBOUT, Cedrickx; HOENKE, Christoph; VINTONYAK, Viktor; (130 pag.)WO2019/149660; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem