Application of 34107-46-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,34107-46-5, its application will become more common.

Reference of 34107-46-5 ,Some common heterocyclic compound, 34107-46-5, molecular formula is C7H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Chromium trioxide (11.5 g) is slowly added to 170 ml of pyridine at 20C, and 10 g of the crude 5-hydroxy-methyl-2-methylpyridine in 70 ml of pyridine is added in one portion to the complex. The temperature is raised to reflux temperature for 2 hours, and the mixture is refluxed for 1.5 hours. After cooling, 250 ml of water is added, and the mixture is extracted with five 150-ml portions of diethyl ether. The combined extracts are dried over magnesium sulfate and concentrated to give 4.2 g of crude 6-methyl-3-pyridinecarbaldehyde.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,34107-46-5, its application will become more common.

Reference:
Patent; Dainippon Pharmaceutical Co., Ltd.; EP210782; (1991); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of (6-Methylpyridin-3-yl)methanol

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 34107-46-5, (6-Methylpyridin-3-yl)methanol, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 34107-46-5 ,Some common heterocyclic compound, 34107-46-5, molecular formula is C7H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

B. Preparation of 6-methylnicotinaldehyde To a solution of oxalyl chloride (2 M in dichloromethane, 9.34 mL, 18.68 mmol) in 30 mL dichloromethane at -60 C. under argon, dimethyl sulfoxide (3.1 g, 2.81 mL, 39.63 mmol) was added over 20 min. The mixture was stirred at -60 C. for 20 min before a solution of (6-methylpyridin-3-yl)methanol in 8 mL dichloromethane was added over 20 min. The reaction mixture was stirred for 20 min, and then triethylamine (8.02 g, 11.05 mL, 79.25 mmol) was added over 10 min. The reaction mixture was allowed to warm up to room temperature and 48 mL water was added. The mixture was extracted with dichloromethane and the combined extracts were dried (Na2SO4), filtered and concentrated. The crude product was purified by automated silica gel chromatography (eluted with ethyl acetate-hexanes) to isolate 1.67 g (85%) of the title compound as a light brown oil. HPLC: retention time=0.19 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 34107-46-5, (6-Methylpyridin-3-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Wu, Gang; Mikkilineni, Amarendra B.; Sher, Philip M.; Murugesan, Natesan; Gu, Zhengxiang; US2006/287341; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem