Category: 3430-22-6

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3430-22-6, name is 3-Bromo-4-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 3430-22-6

EXAMPLE 5 STR14 3-Bromoisonicotinic acid: 12.9 g (75 mmole) of 3-bromo-4-picoline was added to a purple solution of 23.7 g (0.15 mole) of potassium permanganate in 600 mL of water. This mixture was vigorously stirred 36 hrs. at 45 C. The resulting black solid was filtered and washed with 4*50 mL of hot water. The filtrate was concentrated to ~50 mL. A viscous liquid with black solid resulted. This was filtered through celite, which was washed with 3*20 mL of water. 150 mL of ice cold 2N hydrochloric acid was added. The resulting voluminous white precipitate was filtered and the solid was dried in vacuo to give 3-bromoisonicotinic acid as white powder. 1 H NMR (D6 -DMSO, 400 MHz): delta8.84 (s; H2); 8.63 (d; J=5 Hz; H6); 7.66 (d; J=5 Hz; H5)

With the rapid development of chemical substances, we look forward to future research findings about 3430-22-6.

Reference:
Patent; Merck & Co. Inc.; US5294610; (1994); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3430-22-6, name is 3-Bromo-4-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 3430-22-6

EXAMPLE 5 STR14 3-Bromoisonicotinic acid: 12.9 g (75 mmole) of 3-bromo-4-picoline was added to a purple solution of 23.7 g (0.15 mole) of potassium permanganate in 600 mL of water. This mixture was vigorously stirred 36 hrs. at 45 C. The resulting black solid was filtered and washed with 4*50 mL of hot water. The filtrate was concentrated to ~50 mL. A viscous liquid with black solid resulted. This was filtered through celite, which was washed with 3*20 mL of water. 150 mL of ice cold 2N hydrochloric acid was added. The resulting voluminous white precipitate was filtered and the solid was dried in vacuo to give 3-bromoisonicotinic acid as white powder. 1 H NMR (D6 -DMSO, 400 MHz): delta8.84 (s; H2); 8.63 (d; J=5 Hz; H6); 7.66 (d; J=5 Hz; H5)

With the rapid development of chemical substances, we look forward to future research findings about 3430-22-6.

Reference:
Patent; Merck & Co. Inc.; US5294610; (1994); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 3430-22-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3430-22-6, name is 3-Bromo-4-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 3.98 g of the acid obtained in the previous step (20 mmol, 1 eq.) in 50 ml of methanol is reflux heated in the presence of 4 ml of concentrated sulfuric acid. The mixture is allowed to return to ambient temperature and extracted 3 times with ethyl acetate. The organic phase is dried on Na2SO4 and the solvent is evaporated. 2.65 g (62%) of esterified product is obtained. NMR (1H, CDCl3): 4.02 (s; 3H), 7.64 (d, J=4.9 Hz; 1H), 8.63 (d, J=4.9 Hz; 1H), 8.88 (s; 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3430-22-6, 3-Bromo-4-methylpyridine.

Reference:
Patent; Imbert, Thierry; Monse, Barbara; Koek, Wouter; US2005/80085; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 3430-22-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3430-22-6, name is 3-Bromo-4-methylpyridine, molecular formula is C6H6BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The apparatus was installed, and 3-bromo-4-methylpyridine (13 g, 0.78 mol), Co0.27CuO3 (0.5 g), water was added to the three-necked flask in turn, and the mixture was stirred, and the oil bath was slowly heated to 90 C.Oxygen is initially introduced to maintain the reaction temperature until no oxygen is absorbed under the secondary reaction conditions.The catalyst was filtered off, then slowly added with a NaOH solution to adjust pH = 4, followed by stirring for 10 minutes.There is solid precipitation,The crude product 3-bromoisonicotinic acid was obtained, which was recrystallized from acetone to give a white powdery solid, which was filtered and dried in vacuo.A final yield of 14 g of 3-bromoisonicotinic acid was obtained.The yield was 90%.

According to the analysis of related databases, 3430-22-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dalian Jindian Biological Technology Co., Ltd.; Jin Feng; (5 pag.)CN109851551; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem