Category: 350-03-8

Saeidikhoo, Sara; Ezi, Samira; Khatmi, Aysan; Aghajanpour, Fakhroddin; Soltani, Reza; Abdollahifar, Mohammad Amin; Jahanian, Ali; Aliaghaei, Abbas published the artcile< Effect of Sertoli Cell Transplantation on Reducing Neuroinflammation-Induced Necroptosis and Improving Motor Coordination in the Rat Model of Cerebellar Ataxia Induced by 3-Acetylpyridine>, Quality Control of 350-03-8, the main research area is acetylpyridine antiinflammatory agent neuroinflammation cerebellar ataxia; Cell transplantation; Cerebellar ataxia; Neurodegeneration; Sertoli cells.

To date, no certain cure has been found for patients with degenerative cerebellar disease. In this trial, we examined the in vivo and in vitro neuroprotective effects of Sertoli cells (SCs) on alleviating the symptoms of cerebellar ataxia. Testicular cells from an immature male rat were isolated and characterized by immunocytochem. anal. for somatic cell markers (anti-Mullerian hormone, vimentin). The protein assessment had already confirmed the expression of neurotrophic factors of glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial factor (VEGF). In vitro neuroprotective impact of SCs was determined after exposing PC12 cells to Sertoli cell-conditioned media (SC-CM) and H2O2, simultaneously. Afterwards, ataxia rat models were induced by a single dose of 3-AP (3-acetylpyridin), and 3 days later, SCs were bilaterally implanted. Motor and neuromuscular activity test were conducted following SC transplantation. Finally, immunohistochem. against RIPK3 and Iba-1 was done in our generation. The in vivo results revealed substantial improvement in neuromuscular response, while ataxia group exhibited aggravated condition over a 28-day period. Our results suggested enhanced motor function and behavioral characteristics due to the ability of SCs to suppress necroptosis and consequently extend cell survival. Nevertheless, more studies are required to affirm the therapeutic impacts of SC transplantation in human cerebellar ataxia. In vitro data indicated cell viability was increased as a result of SC-CM with a significant reduction in ROS.

Journal of Molecular Neuroscience published new progress about Cell morphology. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Quality Control of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ye, Lina; Fang, Yuanyuan; Ou, Zhongping; Wang, Liping; Xue, Songlin; Lu, Yang; Kadish, Karl M. published the artcile< Axial coordination reactions with nitrogenous bases and determination of equilibrium constants for zinc tetraarylporphyrins containing four β,β′-fused butano and benzo groups in nonaqueous media>, Product Details of C7H7NO, the main research area is zinc tetraarylporphyrin nitrogenous base equilibrium constant.

The axial coordination properties of six zinc tetraarylporphyrins with seven different nitrogenous bases were examined in CH2Cl2 for derivatives containing four β,β′-fused butano or benzo groups and the equilibrium constants (logK) determined using spectral titration methods. The examined compounds are represented as butano(YPh)4PorZn and benzo(YPh)4PorZn, where Por is the porphyrin dianion and Y is a CH3, H or Cl substituent on the para-position of each meso-Ph ring of the macrocycle. The initial four-coordinate butano- and benzoporphyrins will axially bind one nitrogenous base to form five-coordinate derivatives in CH2Cl2 and this leads to a 4-22 nm red-shift of the Soret and Q bands. The logK values range from 1.98 to 4.69 for butano(YPh)4PorZn and from 3.42 to 5.36 for benzo(YPh)4PorZn, with the exact value depending upon the meso and β-substituents of the porphyrin and the conjugate acid dissociation constants (pKa) of the nitrogenous base.

Journal of Porphyrins and Phthalocyanines published new progress about Concentration (process). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Product Details of C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Tong; Zhu, Jian; Strickland, Amy; Ko, Kwang Woo; Sasaki, Yo; Dingwall, Caitlin B.; Yamada, Yurie; Figley, Matthew D.; Mao, Xianrong; Neiner, Alicia; Bloom, A. Joseph; DiAntonio, Aaron; Milbrandt, Jeffrey published the artcile< Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss>, Application In Synthesis of 350-03-8, the main research area is neurotoxin allosteric activation mechanism SARM neuronal loss; NAMPT; NMNAT; Vacor; base exchange reaction; mass spectrometry; metabolism; myelin; neurolytic block; sciatic nerve; tibial nerve.

SARM1 is an inducible TIR-domain NAD+ hydrolase that mediates pathol. axon degeneration. SARM1 is activated by an increased ratio of NMN to NAD+, which competes for binding to an allosteric activating site. When NMN binds, the TIR domain is released from autoinhibition, activating its NAD+ hydrolase activity. The discovery of this allosteric activating site led us to hypothesize that other NAD+-related metabolites might activate SARM1. Here, we show the nicotinamide analog 3-acetylpyridine (3-AP), first identified as a neurotoxin in the 1940s, is converted to 3-APMN, which activates SARM1 and induces SARM1-dependent NAD+ depletion, axon degeneration, and neuronal death. In mice, systemic treatment with 3-AP causes rapid SARM1-dependent death, while local application to the peripheral nerve induces SARM1-dependent axon degeneration. We identify 2-aminopyridine as another SARM1-dependent neurotoxin. These findings identify SARM1 as a candidate mediator of environmental neurotoxicity and suggest that SARM1 agonists could be developed into selective agents for neurolytic therapy.

Cell Reports published new progress about Allosterism. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Bin; Xu, Zhi-Qiang; Xu, Ying-Bo; Yong, Guo-Ping published the artcile< Effects of substituent groups on the crystal structures and luminescence properties of zero-/two-dimensional Zn(II) complexes>, Electric Literature of 350-03-8, the main research area is crystal structure zinc imidazopyridine polymeric monomeric preparation luminescence.

The 3-position substituted imidazo[1,2-a]pyridine ligands C7H4N2Cl-2-(CH:CHC(:O)R)-3 (L1, R = 3-pyridinyl) and (HL2, R = COOH) were facilely synthesized, and used for construction of two novel luminescent Zn(II) complexes, [ZnCl2(L1)2] (1) and [Zn(L2)2]n (2). Single-crystal x-ray diffraction anal. shows that 1 has a zero-dimensional structure, whereas, 2 possesses a two-dimensional polymeric network with rhombic grid motifs. The structural differences between 1 and 2 should be determined by the different substituent groups adjacent to the carbonyl groups of the 3-position substituted imidazo[1,2-a]pyridine ligands. Complex 1 reveals a red shifted emission band, compared to free L1 ligand, whereas, 2 displays a similar emission spectrum as the free HL2 ligand. Such results are also ascribed to substituent group effects and corresponding structural differences.

Inorganic Chemistry Communications published new progress about Crystal structure. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zeng, Liyao; Yang, Huaxin; Zhao, Menglong; Wen, Jialin; Tucker, James H. R.; Zhang, Xumu published the artcile< C1-Symmetric PNP Ligands for Manganese-Catalyzed Enantioselective Hydrogenation of Ketones: Reaction Scope and Enantioinduction Model>, Application In Synthesis of 350-03-8, the main research area is ferrocene chiral PNP ligand manganese preparation ketone enantioselective hydrogenation.

A family of ferrocene-based chiral PNP ligands I (R = t-Bu, cyclohexyl, Ph, R’ = Ph; R = Ph, R’ = H, i-Pr, PhCH2) has been reported. These tridentate ligands were successfully applied in Mn-catalyzed asym. hydrogenation of ketones with high enantioselectivities (92-99% ee for aryl alkyl ketones) as well as high efficiencies (TON up to 2000). In addition, dialkyl ketones could also be hydrogenated smoothly. Manganese intermediates that might be involved in the catalytic cycle were analyzed. DFT calculation was carried out to help understand the chiral induction model. The Mn/PNP catalyst could discriminate two groups with different steric properties by deformation of the phosphine moiety in the flexible 5-membered ring.

ACS Catalysis published new progress about Density functional theory. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mahmoudi, Maedeh; Bayat, Amir-Hossein; Boroujeni, Mahdi Eskandarian; Abdollahifar, Mohammad Amin; Ebrahimi, Vahid; Danyali, Samira; Heidari, Mohammad Hassan; Aliaghaei, Abbas published the artcile< Curcumin protects purkinje neurons, ameliorates motor function and reduces cerebellar atrophy in rat model of cerebellar ataxia induced by 3-AP>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is cerebellar ataxia purkinje neuron curcumin motor function; 3-Acethylpyridine; Cerebellar ataxia; Curcumin; Neuroprotection; Purkinje cells.

Cerebellar ataxias comprise a group of terminal illnesses with ataxia as the main symptom. Curcumin as a yellow polyphenol was extracted from the rhizome of Curcuma longa. Owing to its antioxidant, anti-inflammatory, anti-fibrotic and anti-tumor features, curcumin is considered as a potential therapeutic agent. In this study, we aim to investigate the neuroprotective effects of oral administration of curcumin on a rat model of cerebellar ataxia induced by neurotoxin 3-acetylpyridine. The animals were randomly separated into three groups (control, 3-acetylpyridine, and curcumin + 3-acetylpyridine). Next, motor performance and muscle electromyog. activity were assessed. Then, in the mol. part of the study, the anti-apoptotic role of curcumin in cerebellar ataxia and its relationship to protection of Purkinje cells were investigated. Curcumin treatment improved motor coordination and muscular activity, reduced cleaved caspase-3, and increased glutathione level in 3-AP-lesioned rats as well as total volumes of cerebellar granular and mol. layers.the present study implies that curcumin might have neuroprotective effects to counteract neurotoxicity of 3-AP-induced ataxia.

Journal of Chemical Neuroanatomy published new progress about Electromyography. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gujjarappa, Raghuram; Vodnala, Nagaraju; Musib, Dulal; Malakar, Chandi C. published the artcile< Organocatalytic Decarboxylation and Dual C(sp3)-H Bond Functionalization Toward Facile Access to Divergent 2,6-Diarylpyridines>, Electric Literature of 350-03-8, the main research area is diarylpyridine preparation; ketone amino acid decarboxylation proline catalyst.

An effective organocatalytic protocol toward the assembly of sym. and unsym. 2,6-diarylpyridines I (R1 = H, Me, CN; R2 = Ph, 4-methylphenyl, 2H-1,3-benzodioxol-5-yl, etc.; R3 = Ph, 4-nitrophenyl, pyridin-3-yl, etc.) is demonstrated. The reaction proceeds through organocatalytic decarboxylation of amino acids R4CH(NH2)C(O)OH and dual C(sp3)-H bond oxidation of carbonyl compounds R1CH2C(O)R2 and R1CH2C(O)R3. Catalyst screening revealed that explicit choice of L-proline could lead to the formation of product with maximum yield and selectivity. The developed process appears with operational simplicity and is consistent with broad range of functional groups.

Asian Journal of Organic Chemistry published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fu, Ming-Chen; Shang, Rui; Zhao, Bin; Wang, Bing; Fu, Yao published the artcile< Photocatalytic decarboxylative alkylations mediated by triphenylphosphine and sodium iodide>, Related Products of 350-03-8, the main research area is photocatalytic decarboxylative alkylation triphenylphosphine sodium iodide.

Most photoredox catalysts in current use are precious metal complexes or synthetically elaborate organic dyes, the cost of which can impede their application for large-scale industrial processes. We found that a combination of triphenylphosphine and sodium iodide under 456-nm irradiation by blue light-emitting diodes can catalyze the alkylation of silyl enol ethers by decarboxylative coupling with redox-active esters in the absence of transition metals. Deaminative alkylation using Katritzky’s N-alkylpyridinium salts and trifluoromethylation using Togni’s reagent are also demonstrated. Moreover, the phosphine/iodide-based photoredox system catalyzes Minisci-type alkylation of N-heterocycles and can operate in tandem with chiral phosphoric acids to achieve high enantioselectivity in this reaction.

Science (Washington, DC, United States) published new progress about Acid catalysis (chiral Bronsted acid). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Related Products of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gupta, Shivangi; Maji, Ankur; Panja, Dibyajyoti; Halder, Mita; Kundu, Sabuj published the artcile< CuO NPs catalyzed synthesis of quinolines, pyridines, and pyrroles via dehydrogenative coupling strategy>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is hydroxymethyl aniline ketone copper nanocatalyst oxidative coupling reaction; quinoline preparation; hydroxypropanamine ketone copper nanocatalyst oxidative coupling reaction; pyridine preparation; hydroxyethanamine ketone copper nanocatalyst oxidative coupling reaction; pyrrole preparation.

Copper oxide nanoparticles catalyzed efficient synthesis of quinolines, pyridines, and pyrroles via alc. dehydrogenative coupling strategy are reported. Employing this catalytic system, various functionalized quinolines, pyridines, and pyrroles were synthesized efficiently from different amino alcs. with a diverse range of ketones. A number of control experiments were performed to shed light on the mechanism. This catalyst was recycled up to 6th run and notably, no significant loss was observed in its catalytic activity.

Journal of Catalysis published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aboonajmi, Jasem; Panahi, Farhad; Hosseini, Mina Aali; Aberi, Mahdi; Sharghi, Hashem published the artcile< Iodine-catalyzed synthesis of benzoxazoles using catechols, ammonium acetate, and alkenes/alkynes/ketones via C-C and C-O bond cleavage>, Reference of 350-03-8, the main research area is phenylbenzooxazole preparation; alkene catechol ammonium acetate coupling iodine catalyst; alkyne catechol ammonium acetate coupling iodine catalyst; ketone catechol ammonium acetate coupling iodine catalyst.

An efficient metal-free synthesis strategy of phenylbenzo[d]oxazoles of formula I [R1 = 4-OMe, 5,7-di-tert-bu, 5,7-di-tert-butyl-4-Me, etc.; R2 = Ph, 4-BrC6H4, 4-FC6H4, etc.] was developed via coupling of catechols, ammonium acetate, and alkenes/alkynes/ketones using mol. iodine as the catalyst. The developed methodol. represents an operationally simple, one-pot and large-scale procedure for the preparation of benzoxazole derivatives using mol. iodine as the catalyst.

RSC Advances published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Reference of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem