Category: 350-03-8

Chaudhari, Chandan; Sato, Katsutoshi; Ogura, Yuta; Miayahara, Shin-Ichiro; Nagaoka, Katsutoshi published the artcile< Pr2O3 Supported Nano-layered Ruthenium Catalyzed Acceptorless Dehydrogenative Synthesis of 2-Substituted Quinolines and 1,8-Naphthyridines from 2-Aminoaryl Alcohols and Ketones>, Formula: C7H7NO, the main research area is quinoline naphthyridine preparation; aminoaryl alc ketone dehydrogenation ruthenium nanocatalyst.

Pr2O3 supported Ru nanolayers and Ru nanoparticles catalysts were examined for the synthesis of quinolines I (R = Me, Ph, pyridin-3-yl, etc.; R1 = H, Me; RR1 = -(CH2)4-). The Ru nanolayer was most active catalyst and showed a broad substrate scope. Structure-activity relationship demonstrated that the metallic state and morphol. of Ru as well as the basic site of Pr2O3 were indispensable factors of this catalytic system.

ChemCatChem published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Formula: C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Lin; Zhang, Ling; Chen, Qian; Li, Linlin; Jiang, Jian; Sun, Hao; Zhao, Chong; Yang, Yuanyong; Li, Chun published the artcile< Cinchona-Alkaloid-Derived NNP Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones>, Application of C7H7NO, the main research area is cinchona alkaloid based NNP ligand catalyst preparation DFT; chiral secondary alc enantioselective preparation; ketone hydrogenation iridium cinchona alkaloid based NNP ligand.

Herein, a series of novel and easily accessed cinchona-alkaloid-based NNP ligands I [R = cyclohexyl, Ph, 2-MeOC6H4, etc.; R1 = H, MeO] was developed in two steps. By combining [Ir(COD)Cl]2, 39 ketones including aromatic, heteroaryl, and alkyl ketones were hydrogenated, all affording valuable chiral secondary alcs. with 96.0-99.9% ee. A plausible reaction mechanism was discussed by NMR, HRMS, DFT and an activating model involving trihydride was verified.

Organic Letters published new progress about Cinchona alkaloids Role: CAT (Catalyst Use), PRP (Properties), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application of C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Akhlaghpasand, Mohammadhosein; Tizro, Mahdi; Raoofi, Amir; Meymand, Arman Zeinaddini; Farhadieh, Mohammaderfan; Khodagholi, Fariba; Khatmi, Aysan; Soltani, Reza; Hoseini, Yadolah; Jahanian, Ali; Boroujeni, Mahdi Eskandarian; Aliaghaei, Abbas published the artcile< Grafted human chorionic stem cells restore motor function and preclude cerebellar neurodegeneration in rat model of cerebellar ataxia>, Reference of 350-03-8, the main research area is cerebellar ataxia chorionic stem cell neurodegeneration; 3-acetylpyridine; Cerebellar ataxia; Chorionic stem cells; Neurodegeneration; Transplantation.

Abstract: Cerebellar ataxia (CA) is a form of ataxia that adversely affects the cerebellum. Cell replacement therapy (CRT) has been considered as a potential treatment for neurol. disorders. In this report, we investigated the neuro-restorative effects of human chorionic stem cells (HCSCs) transplantation on rat model of CA induced by 3-acetylpyridine (3-AP). In this regard, HCSCs were isolated and phenotypically determined Next, a single injection of 3-AP was administered for ataxia induction, and bilateral HCSCs implantation was conducted 3 days after 3-AP injection, followed by expression anal. of a number of apoptotic, autophagic and inflammatory genes as well as vascular endothelial growth factor (VEGF) level, along with assessment of cerebellar neurodegeneration, motor coordination and muscle activity. The findings revealed that grafting of HCSCs in 3-AP model of ataxia decreased the expression levels of several inflammatory, autophagic and apoptotic genes and provoked the up-regulation of VEGF in the cerebellar region, prevented the degeneration of Purkinje cells caused by 3-AP toxicity and ameliorated motor coordination and muscle function. In conclusion, these data indicate in vivo efficacy of HCSCs in the reestablishment of motor skills and reversal of CA.

Metabolic Brain Disease published new progress about Antigens, Thy-1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Reference of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Chun; Lu, Xunhua; Wang, Mengna; Zhang, Ling; Jiang, Jian; Yan, Shunfa; Yang, Yuanyong; Zhao, Yonglong; Zhang, Lin published the artcile< A simple and efficient asymmetric hydrogenation of heteroaromatic ketones with iridium catalyst composed of chiral diamines and achiral phosphines>, Application In Synthesis of 350-03-8, the main research area is heteroaromatic ketone iridium catalyst stereoselective enantioselective hydrogenation; heteroaryl alc preparation.

An efficient iridium catalyst composed of a simple and com. available o-methoxytriphenylphosphine and 9-Amino (9-deoxy) epi-cinchonine was applied to the asym. hydrogenation of heteroaromatic ketones. A range of simple heteroaromatic ketones were hydrogenated with good to excellent enantioselectivities and high activities. In particular, thiophene ketones and furyl ketones furnished 98.6% ee with up to 2.18 x 104(1/h) TOF. This catalytic system was of practical value.

Tetrahedron Letters published new progress about Enantioselective synthesis. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mangas-Sanchez, Juan; Sharma, Mahima; Cosgrove, Sebastian C.; Ramsden, Jeremy I.; Marshall, James R.; Thorpe, Thomas W.; Palmer, Ryan B.; Grogan, Gideon; Turner, Nicholas J. published the artcile< Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases>, Category: pyridine-derivatives, the main research area is ketone ammonia fungal aminase catalyst enantioselective reductive amination; amine preparation.

The structural and biochem. characterization as well as synthetic applications of two RedAms from Neosartorya spp. was described. (NfRedAm and NfisRedAm) that displayed a distinctive activity amongst fungal RedAms, namely a superior ability to use ammonia as the amine partner. Using these enzymes, The synthesis of a broad range of primary amines, with conversions up to >97% and excellent enantiomeric excess was demonstrated . Temperature dependent studies showed that these homologues also possess greater thermal stability compared to other enzymes within this family. Their synthetic applicability was further demonstrated by the production of several primary and secondary amines with turnover numbers (TN) up to 14 000 as well as continous flow reactions, obtaining chiral amines such as (R)-2-aminohexane in space time yields up to 8.1 g L-1 h-1. The remarkable features of NfRedAm and NfisRedAm highlight their potential for wider synthetic application as well as expanding the biocatalytic toolbox available for chiral amine synthesis.

Chemical Science published new progress about Amines Role: BPN (Biosynthetic Preparation), RCT (Reactant), BIOL (Biological Study), PREP (Preparation), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhong, Rui; Wei, Zeyuan; Zhang, Wei; Liu, Shun; Liu, Qiang published the artcile< A Practical and Stereoselective In Situ NHC-Cobalt Catalytic System for Hydrogenation of Ketones and Aldehydes>, Name: 1-(Pyridin-3-yl)ethanone, the main research area is cobalt complex catalyst preparation; secondary alc primary preparation diastereoselective; ketone hydrogenation cobalt catalyst; aldehyde hydrogenation cobalt catalyst.

Herein, a practical in situ catalytic system generated by easily available pincer NHC precursors, CoCl2 and a base enabled efficient and high-yielding hydrogenation of a broad range of ketones and aldehydes (over 50 examples and a maximum turnover number [TON] of 2,610) to afford alcs. was reported. This was the first example of NHC-Co-catalyzed hydrogenation of C=O bonds using flexible pincer NHC ligands consisting of a N-H substructure. Diastereodivergent hydrogenation of substituted cyclohexanone derivatives was also realized by fine-tuning of the steric bulk of pincer NHC ligands. Addnl., a bis(NHCs)-Co complex was successfully isolated and fully characterized and it exhibited excellent catalytic activity that equals that of the in-situ-formed catalytic system.

Chem published new progress about Alcohols Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Name: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rocco, Dalila; Manfroni, Giacomo; Prescimone, Alessandro; Klein, Y. Maximilian; Gawryluk, Dariusz J.; Constable, Edwin C.; Housecroft, Catherine E. published the artcile< Single and double-stranded 1D-coordination polymers with 4'-(4-Alkyloxyphenyl)-3,2':6',3''-terpyridines and {Cu2(μ-OAc)4} or {Cu4(μ3-OH)2(μ-OAc)2(μ3-OAc)2(AcOκO)2} motifs>, COA of Formula: C7H7NO, the main research area is alkyloxyphenyl terpyridine copper acetate coordination polymer; 1D-coordination polymer; 3,2’:6’,3”-terpyridine; copper(II) acetate; multinuclear cluster.

Five coordination polymers formed from combinations of copper(II) acetate and 4′-(4-alkyloxyphenyl)-3,2′:6′,3”-terpyridines with methoxy (1), n-butoxy (2), n-pentyloxy (3) and n-heptyloxy (4) substituents are reported. Reaction of 1 with Cu(OAc)2·H2O leads to the 1D-polymer [Cu2(μ-OAc)4(1)]n in which {Cu2(μ-OAc)4} paddle-wheel units are connected by ligands 1, or [{Cu4(μ3-OH)2(μ-OAc)2(μ3-OAc)2(AcO-κO)2(1)2}·2MeOH]n in which centrosym. tetranuclear clusters link pairs of ligands 1 to give a double-stranded 1D-polymer. Layering solutions of Cu(OAc)2·H2O (in MeOH) over 2, 3 or 4 (in CHCl3) leads to the assembly of the 1D-polymers [2{Cu2(μ-OAc)4(2)}·1.25MeOH]n, [Cu2(μ-OAc)4(3)]n and [{Cu2(μ-OAc)4(4)}·0.2CHCl3]n. In all compounds, the 3,2′:6′,3”-tpy unit coordinates only through the outer pyridine rings, but the conformation of the 3,2′:6′,3”-tpy responds to changes in the length of the alkyloxy tails leading to changes in the conformation of the polymer backbone and in the packing of the chains in the crystal lattice in the chains featuring {Cu2(μ-OAc)4} paddle-wheel linkers.

Polymers (Basel, Switzerland) published new progress about Coordination polymers Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, COA of Formula: C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mohammad Arshad published the artcile< Design, Drug-Likeness, Synthesis, Characterization, Antimicrobial Activity, Molecular Docking, and MTT Assessment of 1,3-Thiazolidin-4-one Bearing Piperonal and Pyrimidine Moieties>, Category: pyridine-derivatives, the main research area is thiazolidinone piperonal pyrimidine moiety antimicrobial activity mol docking.

The recent study reported the designing of substituted 3-[4-(1,3-benzodioxol-5-yl)-6-(pyridin-2-yl)pyrimidin-2-yl]-2-(pyridin-2-yl)-1,3-thiazolidin-4-one derivatives and assessed computationally to calculate the bioactivity and physicochem. properties. The substituted 3-[4-(1,3-benzodioxol-5-yl)-6-(pyridin-2-yl)pyrimidin-2-yl]-2-(pyridin-2-yl)-1,3-thiazolidin-4-one derivatives represented the bioactivity score in the zone for an active drug mol. and were in compliance with the Lipinski Rule of five. Then the synthesis, characterization, and biol. screening as antimicrobial potential and percent viability of cells were carried out for the substituted 3-[4-(1,3-benzodioxol-5-yl)-6-(pyridin-2-yl)pyrimidin-2-yl]-2-(pyridin-2-yl)-1,3-thiazolidin-4-one derivatives The zone of inhibition and min. inhibitory concentration (MIC) findings portrayed that the compounds-(IV) and compound-(V) possessed better antimicrobial activity than the reference drug ciprofloxacin, while the significant antimicrobial potential was observed by other members of the series. The mol. docking studies were performed to assist the in vitro antimicrobial results and the findings exhibited that significant H-bonding in between the substituted 3-[4-(1,3-benzodioxol-5-yl)-6-(pyridin-2-yl)pyrimidin-2-yl]-2-(pyridin-2-yl)-1,3-thiazolidin-4-one derivatives and the residues of GlcN-6-P-synthase, like ASP 474 (I-IX), SER 316 (I-VI), ASN 522 (I-IX), TRP 313 (V) with good binding affinity ranging -7.7 to -6.8 kcal/mol. The compounds represented the less toxic effects to the HepG2 cells and the percent viability of the cells ranging from 93-98%, 73-78% and 70-76% up to 3.125, 50, 100 mmol/L resp.

Russian Journal of Bioorganic Chemistry published new progress about Antimicrobial agents. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Patel, P. N.; Desai, D. H.; Patel, N. C. published the artcile< Novel Terpyridine Derivatives of Benzothiazole and Copper(II) Complex: Synthesis and Spectral Studies>, Application In Synthesis of 350-03-8, the main research area is crystal structure copper benzothiazolylterpyridine complex; benzothiazolylterpyridine preparation copper complex.

Novel terpyridine derivatives of benzothiazole were synthesized by simple multicomponent 1-pot reaction of benzothiazole-2-carbaldehyde, ammonium hydroxide, and isomeric acetyl pyridines with isolated yields of 92-98%. All the prepared derivatives were characterized by NMR, IR, and high-resolution mass spectra. A Cu(II) complex was prepared selectively from the terpyridine derivative obtained from 2-acetylpyridine and was characterized by single-crystal x-ray anal. UV-visible spectra were recorded for all the synthesized compounds

Russian Journal of Organic Chemistry published new progress about Crystal structure. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rocco, Dalila; Novak, Samantha; Prescimone, Alessandro; Constable, Edwin C.; Housecroft, Catherine E. published the artcile< Coordination networks assembled from Co(NCS)2 and 4'-[4-(naphthalen-1-yl)phenyl]-3,2':6',3''-terpyridine: Role of lattice solvents>, Electric Literature of 350-03-8, the main research area is cobalt naphthalenylphenylterpyridine complex preparation thermal stability; crystal structure cobalt naphthalenylphenylterpyridine complex.

The preparation and characterization of 4′-[4-(naphthalen-1-yl)phenyl]-3,2′:6′,3”-terpyridine (1) are described. Reactions of 1 with Co(NCS)2 under conditions of crystal growth by layering using different solvent combinations produced crystals of [Co(1)2(NCS)2]n·2nCHCl3 and [Co(1)2(NCS)2]n·2nC6H5Me, each of which comprised a (4,4) net. The orientations of 1 with respect to the planar network defined by the Co atoms are significantly different in [Co(1)2(NCS)2]n·2nC6H5Me compared to [Co(1)2(NCS)2]n·2nCHCl3, and the toluene mols. in [Co(1)2(NCS)2]n·2nC6H5Me are involved in π-stacking interactions. The solvent-accessible void-space in the latter consists of a series of interlinked cavities in contrast to the open channels in [Co(1)2(NCS)2]n·2nCHCl3. Thermogravimetric anal. was used to investigate solvent loss and uptake in the two coordination networks. After solvent loss from [Co(1)2(NCS)2]n·2nCHCl3, CHCl3, CDCl3 or CH2Cl2 could be taken up by the lattice. In contrast, removal of toluene from [Co(1)2(NCS)2]n·2nC6H5Me was found to be irreversible.

Polyhedron published new progress about Crystal structure. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem