Category: 350-03-8

Lan, Xiao-Bing; Ye, Zongren; Huang, Ming; Liu, Jiahao; Liu, Yan; Ke, Zhuofeng published the artcile< Nonbifunctional Outer-Sphere Strategy Achieved Highly Active α-Alkylation of Ketones with Alcohols by N-Heterocyclic Carbene Manganese (NHC-Mn)>, Formula: C7H7NO, the main research area is ketone alc NHC manganese alkylation catalyst; alkylated ketone preparation; amino benzyl alc ketone NHC manganese Friedlander annulation catalyst; quinoline preparation.

The unusual nonbifunctional outer-sphere strategy was successfully utilized in developing an easily accessible N-heterocyclic carbene manganese (NHC-Mn) system for highly active α-alkylation of ketones with alcs. This system was efficient for a wide range of ketones and alcs. under mild reaction conditions, and also for the green synthesis of quinoline derivatives The direct outer-sphere mechanism and the high activity of the present system demonstrate the potential of nonbifunctional outer-sphere strategy in catalyst design for acceptorless dehydrogenative transformations.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Formula: C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fuse, Hiromu; Nakao, Hiroyasu; Saga, Yutaka; Fukatsu, Arisa; Kondo, Mio; Masaoka, Shigeyuki; Mitsunuma, Harunobu; Kanai, Motomu published the artcile< Photocatalytic redox-neutral hydroxyalkylation of N-heteroaromatics with aldehydes>, Formula: C7H7NO, the main research area is hydroxy alkylated isoquinoline preparation; isoquinoline aldehyde hydroxyalkylation photocatalyst; alkylated hydroxy pyridine preparation; pyridine aldehyde hydroxyalkylation photocatalyst; quinoline hydroxy alkylated preparation; aldehyde quinoline hydroxyalkylation photocatalyst.

Hydroxyalkylation of N-heteroaromatics with aldehydes was achieved using a binary hybrid catalyst system comprising an acridinium photoredox catalyst and a thiophosphoric acid organocatalyst. This metal-free hybrid catalysis proceeded under mild conditions for a wide range of substrates, including quinolines, isoquinolines and pyridines as N-heteroaromatics and both aromatic and aliphatic aldehydes to afford hydroxy-alkylated quinolines I [R = H, 6-F, 7-Br, etc; R1 = Me, Ph, propan-1-ol; R2 = Cl, propan-1-ol], hydroxy-alkylated isoquinolines II [R4 = Et, Ph, 4-FC6H4, etc.] and hydroxy-alkylated pyridines III [R5 = H, Br, Ph; R6 = C(O)Me, CO2Me]. The reaction was applicable to late-stage derivatization of drugs and their leads.

Chemical Science published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Formula: C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gargaro, Samantha L.; Klake, Raphael K.; Burns, Kevin L.; Elele, Sharon O.; Gentry, Skyler L.; Sieber, Joshua D. published the artcile< Access to a Catalytically Generated Umpolung Reagent through the Use of Cu-Catalyzed Reductive Coupling of Ketones and Allenes for the Synthesis of Chiral Vicinal Aminoalcohol Synthons>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is oxazolidinone homoallylic alc asym synthesis; ketone regioselective stereoselective reductive coupling oxazolidinyl allene copper catalyst.

Herein, a stereoselective method for the allylation of ketones R1C(O)R2 [R1 = Ph, 4-MeOC6H4, 2-naphthyl, 3-pyridyl, N-tosylpyrrol-3-yl, etc., R2 = Me; R1 = Ph, R2 = Et; R1R2 = 2-C6H4(CH2)3] with a chiral allenamide I is reported. By employing N-heterocyclic carbenes as ligands for the Cu catalyst, good branched selectivity can be obtained with high diastereocontrol. This methodol. allows access to a catalytically generated, polarity-reversed (umpolung) allyl nucleophile to enable the preparation of chiral 1,2-aminoalc. synthons II containing a dissonant functional group relationship.

Organic Letters published new progress about Allenes Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Groman, Aleksandra; Stolarczyk, Elobieta; Mucha, Mariola published the artcile< Purity determination of the starting materials used in the synthesis of pharmaceutical substances>, Electric Literature of 350-03-8, the main research area is bosentan imatinib ethylene glycol acetylpyridine GCFID.

High requirements for the API quality mean that the quality control of the starting material is crucial in the manufacturing process of drug substances. Three sensitive methods for the purity determination of the following starting materials: ethylene glycol (method I), 3-acetylpyridine (method II) and 4-chloromethyl-5- methyl-1,3-dioxol-2-one (method III) used in the syntheses of selected drug substances were developed using GC-FID techniques. All the methods were validated according to the International Conference on Harmonization guidelines. The correlation coefficient values were found to be about 0.99. The calculated RSD values from the replicate injections in the range of 20-120% of the nominal concentration ensured the precision of the methods.

Acta Poloniae Pharmaceutica published new progress about Drugs. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xie, Demeng; Wang, Yingwei; Zhang, Xia; Fu, Zhengyan; Niu, Dawen published the artcile< Alkyl/Glycosyl Sulfoxides as Radical Precursors and Their Use in the Synthesis of Pyridine Derivatives>, SDS of cas: 350-03-8, the main research area is pyridine alkyl regioselective preparation; alkyl glycosyl sulfoxide regioselective stereoselective photochem alkylation methoxypyridinium; Alkyl Sulfoxides; C-Glycosides; Electron Donor-Acceptor Complexes; Photochemistry; Radicals.

Here the use of simple and readily available alkyl sulfoxides as precursors to radicals and their application in the preparation of pyridine derivatives are reported. It was shown that alkyl sulfoxides, N-methoxy pyridinium salts and fluoride anions form electron donor-acceptor (EDA) complexes in solution, which, upon visible light irradiation, undergo a radical chain process to afford various pyridine derivatives smoothly. This reaction displays broad scope with respect to both sulfoxides and N-methoxy pyridinium salts. The synthetic versatility of sulfoxides as a handle in chem. adds to their power as radical precursors. Glycosyl sulfoxides are converted to the corresponding pyridyl C-glycosides with high stereoselectivities. Computational and exptl. studies provide insights into the reaction mechanism.

Angewandte Chemie, International Edition published new progress about Alkylation, regioselective. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, SDS of cas: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Subi, S.; Rose, S. Viola; Reji, T. F. Abbs Fen published the artcile< Synthesis, characterization, DFT study, molecular modelling and biological evaluation of novel 5-aryl-3-(pyridine-3-yl)isoxazole hybrids as potent anticancer agents with inhibitory effect on skin cancer>, Synthetic Route of 350-03-8, the main research area is pyridineyl isoxazole preparation antioxidant antitumor DFT human mol docking.

A novel series of pyridinyl isoxazole derivatives I [Ar = Ph, 4-ClC6H4, 4-MeC6H4, 4-MeOC6H4, PhCH=CH] was synthesized obtained from 5-aryl-3-(pyridine-3-yl)-2-propen-1-ones and hydroxylamine hydrochloride. Geometrical and electronic properties of pyridinyl isoxazole derivative were investigated by using B3LYP/6-31G (d.p) basis sets. The HOMO and LUMO anal. was used to determine the charge transfer within the mol. The pyridinyl isoxazole derivatives I exhibited good docking scores against liver cancer 4MMH. The results revealed clearly compound I [Ar = 4-ClC6H4] exhibited better radical scavenging ability. Among the synthesized pyridinyl isoxazole derivatives, compound I [Ar = 4-ClC6H4] was highly active on the SKMEL cell line (human skin cancer).

Asian Journal of Chemistry published new progress about Antioxidants. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Synthetic Route of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ganguli, Kasturi; Shee, Sujan; Panja, Dibyajyoti; Kundu, Sabuj published the artcile< Cooperative Mn(I)-complex catalyzed transfer hydrogenation of ketones and imines>, Application In Synthesis of 350-03-8, the main research area is alc preparation chemoselective; ketone transfer hydrogenation manganese catalyst; aryl aldehyde transfer hydrogenation manganese catalyst; imine transfer hydrogenation manganese catalyst.

The synthesis and reactivity of Mn(I) complexes bearing bifunctional ligands comprising both the amine N-H and benzimidazole fragments I and II (R = H, Me; R1 = H, Me, phenyl; R2 = H, Me) are reported. Among the various ligands, the N-((1H-benzimidazol-2-yl)methyl)aniline ligand containing Mn(I) complex II (R = R2 = H; R1 = Ph) presented higher reactivity in the transfer hydrogenation (TH) of ketones R3C(O)R4 (R3 = Ph, thiophen-2-yl, cyclopropyl, etc.; R4 = Me, propan-2-yl, tert-Bu, etc.; R3R4 = 9H-fluoren-9-yl, 1,2,3,4-tetrahydronaphthalen-1-yl, cyclohexyl) in 2-propanol. Exptl., it was established that both the benzimidazole and amine N-H proton played a vital role in the enhancement of the catalytic activity. Utilizing this system, a wide range of ketones R3C(O)R4 and aldehydes R5CHO (R5 = 4-CH3C6H4, thiophen-2-yl, pentyl, etc.) was reduced efficiently. Notably, the TH of several imines R6R7C=NR8 (R6 = 4-OCH3C6H4, thiophen-2-yl, naphthalen-2-yl, etc.; R7 = H, Me, Et; R8 = C6H5, 4-OCH3C6H4, CH3(CH2)3, etc.), as well as chemoselective reduction of unsaturated ketones, was achieved in the presence of this catalyst. DFT calculations were carried out to understand the plausible reaction mechanism which disclosed that the transfer hydrogenation reaction followed a concerted outer-sphere mechanism.

Dalton Transactions published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Maji, Ankur; Gupta, Shivangi; Maji, Milan; Kundu, Sabuj published the artcile< Well-Defined Phosphine-Free Manganese(II)-Complex-Catalyzed Synthesis of Quinolines, Pyrroles, and Pyridines>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is quinoline pyrrole pyridine preparation density functional theory; amino alc ketone manganese complex catalyst.

Herein, authors report a simple, phosphine-free, and inexpensive catalytic system based on a manganese(II) complex for synthesizing different important N-heterocycles such as quinolines, pyrroles and pyridines from amino alcs. and ketones. Several control experiments, kinetic studies, and DFT calculations were carried out to support the plausible reaction mechanism. Authors also detected two potential intermediates in the catalytic cycle using ESI-MS anal. Based on these studies, a metal-ligand cooperative mechanism was proposed.

Journal of Organic Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rocco, Dalila; Prescimone, Alessandro; Constable, Edwin C.; Housecroft, Catherine E. published the artcile< Switching conformation of 3,2':6',3''-tpy domains in 4'-(4-n-alkyloxyphenyl)-3,2':6',3''-terpyridines>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is terpyridine preparation crystal structure conformation; 3,2′:6′,3″-terpyridine; conformation; crystal structure; intermolecular interactions.

The preparation and characterization of 4′-(4-n-octyloxyphenyl)-3,2′:6′,3”-terpyridine (8) and 4′-(4-n-nonyloxyphenyl)-3,2′:6′,3”-terpyridine (9) are reported. The single crystal structures of 4′-(4-n-hexyloxyphenyl)-3,2′:6′,3”-terpyridine (6), 4′-(4-n-heptyloxyphenyl)-3,2′:6′,3”-terpyridine (7), and compounds 8 and 9 have been determined The conformation of the 3,2′:6′,3”-tpy unit is trans,trans in 6 and 7, but switches to cis,trans in 8 and 9. This is associated with significant changes in the packing interactions with a more dominant role for van der Waals interactions between adjacent n-alkyloxy chains and C-Hmethylene··· π interactions in 8 and 9. The solid-state structures of 6 and 7 with the n-hexyloxy and n-heptyloxy chains feature interwoven sheets of supramol. assemblies of mols., with pairs of n-alkyloxy chains threaded through cavities in an adjacent sheet.

Molecules published new progress about Conformation. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Wenjun; Chernyshov, Ivan Yu.; van Schendel, Robin K. A.; Weber, Manuela; Mueller, Christian; Filonenko, Georgy A.; Pidko, Evgeny A. published the artcile< Robust and efficient hydrogenation of carbonyl compounds catalysed by mixed donor Mn(I) pincer complexes>, Application In Synthesis of 350-03-8, the main research area is alc preparation; carbonyl compound hydrogenation manganese catalyst.

A highly efficient Mn(I)-CNP pre-catalyst I which gives rise to the excellent productivity (TOF° up to 41 000 h-1) and stability (TON up to 200 000) in hydrogenation catalysis was reported. This system enables near-quant. hydrogenation of ketones RC(O)R1 (R = Ph, 2,3-dihydro-1,4-benzodioxin-6-yl, pentyl, etc.; R1 = Et, Bn, cyclopropyl, etc.; RR1 = -(CH2)5-) and 1,2,3,4-tetrahydronaphthalen-1-one, imines 4-R2C6H4N=CHC6H5 (R2 = H, Br, OMe), aldehydes R3CHO [R3 = Ph, 4-(dimethylamino)phenyl, 4-(benzyloxy)phenyl, furan-2-yl] and formate esters R4OC(O)H (R4 = hexyl, pentyl, 3-methylbutyl) at the catalyst loadings as low as 5-200 p.p.m. The anal. points to the crucial role of the catalyst activation step for the catalytic performance and stability of the system. While conventional activation employing alkoxide bases can ultimately provide catalytically competent species under hydrogen atm., activation of Mn(I) pre-catalyst I with hydride donor promoters, e.g., KHBEt3, dramatically improves catalytic performance of the system and eliminates induction times associated with slow catalyst activation.

Nature Communications published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem