Category: 3510-66-5

In 2022,Jia, Kai; Ma, Wenchao; Yan, Yintao; Zhang, Chenming; Jiang, Chao published an article in Synlett. The title of the article was 《A Mild and Efficient Synthesis of Pyrazolo[1,5-a]pyridines Mediated by Triphenylphosphine/Diiodine》.Application In Synthesis of 2-Bromo-5-methylpyridine The author mentioned the following in the article:

A synthesis of 2,3-diaryl-substituted pyrazolo[1,5-a]pyridines in moderate to good yields under metal-free and mild conditions was described. The intramol. cyclization of the oxime substrates was mediated by PPh3/I2, which led directly to pyrazolo[1,5-a]pyridines without the formation of a 2H-azirine intermediate. Various substituents on the aryl rings were compatible with the method.2-Bromo-5-methylpyridine(cas: 3510-66-5Application In Synthesis of 2-Bromo-5-methylpyridine) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lu, Yinfu; Wang, Jinglan; Wu, Yaqian; Xu, Shengxian; Zhao, Feng; He, Haifeng; Wang, Yibo published their research in Polyhedron in 2021. The article was titled 《Yellow-green luminescence of four-coordinate copper(I) complexes bearing N-heterocyclic carbene (NHC) ligands: Synthesis, photophysical and computational studies》.Related Products of 3510-66-5 The article contains the following contents:

The synthesis and photophys. investigation of a series of six copper(I) complexes [(1,2-Ph2PC6H4OC6H4PPh2)(1-PhCH2BimMe2-3-PyR1R2)Cu][PF6] (1-6; BimMe2 = 5,6-dimethylbenzimidazol-2-ylidene; PyR1R2 = 6-R1-5-R2-2-pyridyl) bearing benzimidazolylidene-type N-heterocyclic carbene (NHC) ligands with different groups are reported. Their photophys. properties can be tuned by adjusting the groups at the R1/R2 positions of the pyridine ring. The lowest-lying metal-to-ligand (MLCT) absorption bands at 325-437 nm can be observed for all the complexes. Upon excitation with UV light all the complexes emit bright yellow-green light (λem = 540-573 nm) with higher emission quantum yields of 21.1-55.6% and excited state lifetimes on the microsecond scale (τ = 30.6-62.1μs) in PMMA films. The substituents (R2 = COMe, F, Br, Me, or OMe) on R2-position of the pyridine ring were shown to have effects on the emission wavelengths of these complexes, while the introduction of R1 substituents (R1 = CH3) shows negligible effects on the emission wavelength but allow the enhancement of photoluminescence quantum yield (Φ) of the complexes. Addnl., the electronic properties, absorption and emission profiles of these complexes were further explored using DFT/TDDFT methods. In the experimental materials used by the author, we found 2-Bromo-5-methylpyridine(cas: 3510-66-5Related Products of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Related Products of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Nickel-Catalyzed 1,2-Arylboration of Vinylarenes》 were Wang, Wang; Ding, Chao; Pang, Hailiang; Yin, Guoyin. And the article was published in Organic Letters in 2019. Synthetic Route of C6H6BrN The author mentioned the following in the article:

A novel Ni-catalyzed 1,2-arylboration of vinylarenes is reported. A variety of 2-boryl-1,1-diarylalkanes, which constitute a class of significant pharmacophores, are efficiently prepared from readily available olefins and aryl halides in the presence of bis(pinacolato)diboron under mild reaction conditions. The success of this three-component cascade is mainly attributed to the redox-active N-based ligand. Also, this method exhibits good functional group tolerance and excellent chemo- and stereoselectivity. In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-methylpyridine(cas: 3510-66-5Synthetic Route of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Synthetic Route of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Planar-chiral [2.2]Paracyclophane-based Pyridonates as Ligands for Tantalum-catalyzed Hydroaminoalkylation》 were Braun, Carolin; Nieger, Martin; Braese, Stefan; Schafer, Laurel L.. And the article was published in ChemCatChem in 2019. Application of 3510-66-5 The author mentioned the following in the article:

By using planar chiral [2.2]paracyclophane-containing N,O-chelating ligands for tantalum-catalyzed hydroaminoalkylation, one of the most versatile catalytic systems for this reaction to date was obtained [e.g., 4-methoxy-N-methylaniline + 1-octene I (90%)]. Convenient Csp3-Csp3 bond formation of amines with terminal and internal alkenes was enabled by the same in situ synthesized catalytic system of [2.2]paracyclophane-based pyridonates and Ta(CH2TMS)3Cl2 that shows also very promising results for N-containing heterocycles. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Application of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Campos, Joana F.; Cailler, Manon; Claudel, Remi; Prot, Benjamin; Besson, Thierry; Berteina-Raboin, Sabine published an article in 2021. The article was titled 《Demonstration of green solvent performance on O,S,N-heterocycles synthesis: metal-free click chemistry and Buchwald-Hartwig coupling》, and you may find the article in Molecules.Application In Synthesis of 2-Bromo-5-methylpyridine The information in the text is summarized as follows:

In this work, the efficiency of three solvents: eucalyptol (1,8-cineole), cyclopentyl Me ether (CPME), and 2-methyltetrahydrofuran (2-MeTHF) for the synthesis of O,S,N-heterocyclic compounds e.g., I was demonstrated. In the experimental materials used by the author, we found 2-Bromo-5-methylpyridine(cas: 3510-66-5Application In Synthesis of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Application In Synthesis of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 3510-66-5In 2020 ,《Synthesis of Benzo-Fused 11H-Pyrido[2,1-b]quinazolin-11-ones by a Buchwald-Hartwig Coupling/Pyridine Dearomatization Sequence in Eucalyptol》 appeared in Synthesis. The author of the article were Campos, Joana F.; Pacheco-Benichou, Alexandra; Fruit, Corinne; Besson, Thierry; Berteina-Raboin, Sabine. The article conveys some information:

The synthesis of a new library of polyheterocyclic 11H-pyrido[2,1-b]quinazolin-11-one derivatives was investigated. Satisfactory conditions were obtained via sequential C-N Buchwald-Hartwig coupling and pyridine dearomatization. In this work, traditional solvents were replaced by the bio-sourced eucalyptol, confirming the interest in it as a green solvent in chem. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions》 were Zhang, Xitao; Feng, Xiujuan; Zhang, Haixia; Yamamoto, Yoshinori; Bao, Ming. And the article was published in Green Chemistry in 2019. Related Products of 3510-66-5 The author mentioned the following in the article:

A convenient and efficient method for the synthesis of 2-halogen-substituted pyridines I [R = H, 6-Me, 4-Br, etc.; R1 = Cl, Br] was described. The decarboxylative halogenation of 2-picolinic acids with dihalomethane proceeded smoothly via N-chlorocarbene intermediates to afford 2-halogen-substituted pyridines in satisfactory to excellent yields under transition-metal-free conditions. This new type of decarboxylative halogenation was operationally simple and exhibited high functional-group tolerance. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Related Products of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Related Products of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Transition-Metal-Free Coupling Reactions: PPh3-Promoted Sonogashira-Type Cross-Couplings of Heteroaryl Halides with Terminal Alkynes》 was published in ChemistrySelect in 2020. These research results belong to Tian, Wan-Fa; He, Ke-Han; Li, Na; Fen; Liu; Mai, Xi; Feng, Li-Hua; He, Yong-Qin. Name: 2-Bromo-5-methylpyridine The article mentions the following:

Synthesis phenylethynyl heteroaryl I [Ar1 = 2-pyridyl, 6-Me-3-pyridyl, 3-quinolyl, etc.; Ar2 = Ph 2-FC6H4, 4-MeOC6H4, etc.] via Sonogashira-type cross-coupling reaction of heteroaryl halides with terminal alkynes under mild transition-metal-free conditions using PPh3 and Cs2CO3/NEt3 was reported, a wide range of functional groups was tolerated under optimized conditions. Furthermore, the protocol would be extended to the Suzuki-type cross-coupling of heteroaryl halides with phenylboronic acid, to gave the Ph heteroaryl II [Ar3 = 3-pyridyl, 5-pyrimidinyl, 3-quinolyl, etc.] in good to excellent yields. A test reaction on gram scale delivered the product in reasonably high yield and thus had the potential of promising applications in drug discovery and functional materials. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Name: 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Name: 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yao, Xing-Qi; Tong, Wen-Yan; Wang, Kang; Qu, Shuanglin; Wang, Jianbo published their research in Organometallics in 2021. The article was titled 《Azacycle-Directed Formal Aromatic C(sp2)-H Insertion with Cr(0) Fischer Carbene Complex via Oxidative Hydrogen Migrationã€?HPLC of Formula: 3510-66-5 The article contains the following contents:

An azacycle-directed intermol. aromatic C(sp2)-H functionalization of Cr(0) Fischer carbene complexes under catalyst-free conditions is reported. Arenes with pyridines, pyrimidine, and pyrazole as directing groups reacted with chromium(0) carbene complexes in good yields and excellent regioselectivities. According to the mechanistic studies based on experiments and computations with d. functional theory (DFT), the reaction is proposed to follow an unconventional mechanism via oxidative hydrogen migration and reductive elimination, which is different from the classical electrophilic substitution mechanism.2-Bromo-5-methylpyridine(cas: 3510-66-5HPLC of Formula: 3510-66-5) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.HPLC of Formula: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Yin, Si-Yong; Pan, Chongqing; Zhang, Wen-Wen; Liu, Chen-Xu; Zhao, Fangnuo; Gu, Qing; You, Shu-Li published an article in Organic Letters. The title of the article was 《SCpRh(III)-Catalyzed Enantioselective Synthesis of Atropisomers by C2-Arylation of Indoles with 1-Diazonaphthoquinonesã€?Quality Control of 2-Bromo-5-methylpyridine The author mentioned the following in the article:

The Rh(III)-catalyzed highly enantioselective C2-arylation of indole derivatives with 1-diazonaphthoquinones is reported. In the presence of 2.5 mol % SCpRh complex and 20 mol% AgNO3, the C2-arylation reactions of indoles proceeded smoothly, affording a wide range of C2-arylated indole atropisomers in good yields and enantioselectivity (�6% yield, �7% ee) under mild conditions. The method displays a broad substrate scope and good functional group tolerance. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-methylpyridine(cas: 3510-66-5Quality Control of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem