Synthetic Route of 3510-66-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3510-66-5, name is 2-Bromo-5-methylpyridine, molecular formula is C6H6BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Add 6-bromo-3-methylpyridine to methanol, reduce the temperature to 20-30 C in an ice-water bath, and slowly drop the methanol solution of sodium methoxide into the reaction system, keeping the internal temperature below 40 C. , Heated to reflux, reacted at 70-80 C for 12h, the reaction equation is as follows:The temperature of the reaction solution was reduced to 45-50 C, and concentrated to half the volume under reduced pressure; the temperature was reduced to 25-30 C, and water was added. The amount of water added was 5.5-8.0 times that of 6-bromo-3-methylpyridine, and stirred for 10min. ; The treatment solution was extracted three times with dichloromethane. The amount of dichloromethane was 10.0-12.0 times that of 6-bromo-3-methylpyridine. The organic phases were combined and washed once with water. -Methoxy-3-methylpyridine, yield 94.3%, GC purity 99.1%.Among them, the amount of methanol is 4.5-5.0 times that of 6-bromo-3-methylpyridine.The molar ratio of 6-bromo-3-methylpyridine to sodium methoxide is 1: 1.4.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3510-66-5, 2-Bromo-5-methylpyridine.
Reference:
Patent; Nanjing Habo Pharmaceutical Technology Co., Ltd.; Zhao Xiaolin; Cui Jiayi; Wang Jinzhu; Zhao Bing; Ai Yangbao; (10 pag.)CN110878043; (2020); A;,
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