Category: 3510-66-5

In 2022,Biallas, Phillip; Yamazaki, Ken; Dixon, Darren J. published an article in Organic Letters. The title of the article was 《Difluoroalkylation of Tertiary Amides and Lactams by an Iridium-Catalyzed Reductive Reformatsky Reaction》.Recommanded Product: 3510-66-5 The author mentioned the following in the article:

An iridium catalyzed, reductive alkylation of abundant tertiary lactams and amides using 1-2 mol % of Vaska’s complex (IrCl(CO)(PPh3)2), tetramethyldisiloxane (TMDS) and difluoro-Reformatsky reagents (BrZnCF2R) for the general synthesis of medicinally relevant α-difluoroalkylated tertiary amines, is described. A broad scope (42 examples), including N-aryl and N-heteroaryl substituted lactams, demonstrated an excellent functional group tolerance. Furthermore, late-stage drug functionalizations, a gram scale synthesis and common downstream transformations proved the potential synthetic relevance of this new methodol. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Jiang, Ting; Cao, Ya-Nan; Xu, Jin-Bu; Gao, Feng; Zheng, Ling-Li published an article in Scientific Reports. The title of the article was 《Molecular-docking-guided design, palladium-catalyzed synthesis and anticancer activity of paclitaxel-benzoxazoles hybrids》.Name: 2-Bromo-5-methylpyridine The author mentioned the following in the article:

A series of new paclitaxel-benzoxazoles hybrids I (R = Ph, 2-naphthyl, 3-pyridyl, etc.; R1 = O-tert-Bu, Ph) were designed based on both the mol. docking mode of beta-tubulin with paclitaxel derivatives I (R = Ph, 3-pyridyl; R1 = Ph), and the activity-structure relationship of C-13 side chain in paclitaxel. Palladium-catalyzed direct Csp2-H arylation of benzoxazoles with different aryl-bromides was used as the key synthetic strategy for the aryl-benzoxazoles moieties in the hybrids. Twenty-six newly synthesized hybrids were screened for their antiproliferative activity against human cancer cell lines such as human breast cancer cells (MDA-MB-231) and liver hepatocellular cells (HepG2) by the MTT assay and results were compared with paclitaxel. Interestingly, most hybrids showed significantly active against both cell lines at concentration of 50μM, which indicated that the hybrid strategy is effective to get structural simplified paclitaxel analogs with high anti-tumor activity. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Name: 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Name: 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chi, Benjamin K.; Widness, Jonas K.; Gilbert, Michael M.; Salgueiro, Daniel C.; Garcia, Kevin J.; Weix, Daniel J. published an article in 2022. The article was titled 《In-Situ Bromination Enables Formal Cross-Electrophile Coupling of Alcohols with Aryl and Alkenyl Halides》, and you may find the article in ACS Catalysis.Recommanded Product: 2-Bromo-5-methylpyridine The information in the text is summarized as follows:

The use of 1° and 2° alcs. in cross-electrophile coupling with aryl and vinyl halides to form C(sp3)-C(sp2) bonds R-R1 [R = 2,2-dimethyl-1,3-dioxolan-4-yl, piperidinyl-1-carboxylate, 4,4-difluorocyclohexyl, etc.; R1 = 5-methylpyridinyl, 6-methoxypyridin-3-yl, 4-fluorophenyl, etc.] in a one-pot strategy utilizing a very fast (<1 min) bromination was reported. The reaction's simple benchtop setup and broad scope (42 examples, 56% ± 15% average yield) facilitated use at all scales. The potential in parallel synthesis applications was demonstrated by successfully coupling all combinations of 8 alcs. with 12 aryl cores in a 96-well plate. In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 2-Bromo-5-methylpyridine) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Selective C-C bond formation from rhodium-catalyzed C-H activation reaction of 2-arylpyridines with 3-aryl-2H-azirines》 were Baek, Yonghyeon; Kim, Jinwoo; Hyunseok Kim; Jung, Seung Jin; Ryu, Ho; Kim, Suyeon; Son, Jeong-Yu; Um, Kyusik; Han, Sang Hoon; Seo, Hyung Jin; Heo, Juyoung; Lee, Kooyeon; Baik, Mu-Hyun; Lee, Phil Ho. And the article was published in Chemical Science in 2019. Formula: C6H6BrN The author mentioned the following in the article:

A novel method for the synthesis of acylmethyl-substituted 2-arylpyridine derivatives I [R1 = Ph, 4-MeC6H4, 2-ClC6H4, etc.; R2 = 4-Me, 5-C(O)Me, 5-CF3, etc.; R3 = H, Me, F, C(O)Me, CO2Et] was synthesized via rhodium-catalyzed C-H activation reaction of 3-aryl-2H-azirines with 2-arylpyridines and explored a prototype reaction using DFT-calculations Computational studies quickly revealed and prototype exptl. work confirmed that neither the formation of the expected metal nitrene complexes nor the C-N coupling were viable. Instead, azirine ring-opening followed by C-C coupling was found to be much more favorable to give imines that readily underwent hydrolysis in aqueous conditions to form compounds I. This new method was highly versatile and selective toward a wide range of substrates with high functional group tolerance. The results came from multiple reactions, including the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Formula: C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Griffin, Jeremy D.; Vogt, David B.; Du Bois, J.; Sigman, Matthew S. published an article in 2021. The article was titled 《Mechanistic Guidance Leads to Enhanced Site-Selectivity in C-H Oxidation Reactions Catalyzed by Ruthenium bis(Bipyridine) Complexes》, and you may find the article in ACS Catalysis.Product Details of 3510-66-5 The information in the text is summarized as follows:

The development of an operationally simple C-H oxidation protocol using an acid-stable, bis(bipyridine)Ru catalyst is described. Electronic differences remote to the site of C-H functionalization are found to affect product selectivity. Site-selectivity is further influenced by the choice of reaction solvent, with highest levels of 2° methylene oxidation favored in aqueous dichloroacetic acid. A statistical model is detailed that correlates product selectivity outcomes with computational parameters describing the relative “”electron-richness”” of C-H bonds. The results came from multiple reactions, including the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Product Details of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Product Details of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Biallas, Phillip; Yamazaki, Ken; Dixon, Darren J. published an article in Organic Letters. The title of the article was 《Difluoroalkylation of Tertiary Amides and Lactams by an Iridium-Catalyzed Reductive Reformatsky Reaction》.Recommanded Product: 3510-66-5 The author mentioned the following in the article:

An iridium catalyzed, reductive alkylation of abundant tertiary lactams and amides using 1-2 mol % of Vaska’s complex (IrCl(CO)(PPh3)2), tetramethyldisiloxane (TMDS) and difluoro-Reformatsky reagents (BrZnCF2R) for the general synthesis of medicinally relevant α-difluoroalkylated tertiary amines, is described. A broad scope (42 examples), including N-aryl and N-heteroaryl substituted lactams, demonstrated an excellent functional group tolerance. Furthermore, late-stage drug functionalizations, a gram scale synthesis and common downstream transformations proved the potential synthetic relevance of this new methodol. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,ACS Omega included an article by Oppong-Quaicoe, Anita A.; DeBoef, Brenton. Formula: C6H6BrN. The article was titled 《FeCl2-Mediated Rearrangement of Allylic Alcohols》. The information in the text is summarized as follows:

Aryllithium reagents underwent one-pot regioselective addition and rearrangement reactions with cyclic α,β-unsaturated ketones and an acyclic diaryl-α,β,γ,δ-dienone in the presence of FeCl2 to yield cyclic secondary β-arylallylic alcs. Addition of an arylithium to an α’-methyl-α,β-enone followed by FeCl2-mediated rearrangement of the mixture of diastereomers indicated that the rearrangement is stereoselective.2-Bromo-5-methylpyridine(cas: 3510-66-5Formula: C6H6BrN) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Acylation of 2-benzylpyridine N-oxides and subsequent in situ [3,3]-sigmatropic rearrangement reaction》 was published in Tetrahedron Letters in 2020. These research results belong to Jing, Hua-qing; Li, Hong-liang; Antilla, Jon C.. Application In Synthesis of 2-Bromo-5-methylpyridine The article mentions the following:

An effective method for the acylation of 2-benzylpyridine N-oxides and their fast in situ [3,3]-sigmatropic rearrangement was reported. This transformation has a wide substrate scope under mild conditions, giving moderate to excellent yields. The application for the synthesis of chiral phenyl-2-pyridylmethanol products was briefly explored. Furthermore, an interesting example of tandem substitution and in situ [3,3]-sigmatropic rearrangement of 2-benzylpyridine N-oxide with benzenecarboximidoyl chloride was reported. In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Application In Synthesis of 2-Bromo-5-methylpyridine) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application In Synthesis of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《One-Pot Synthesis of Indoles and Pyrazoles via Pd-Catalyzed Couplings/Cyclizations Enabled by Aqueous Micellar Catalysis》 was written by Landstrom, Evan B.; Akporji, Nnamdi; Lee, Nicholas R.; Gabriel, Christopher M.; Braga, Felipe C.; Lipshutz, Bruce H.. Application In Synthesis of 2-Bromo-5-methylpyridine And the article was included in Organic Letters in 2020. The article conveys some information:

An effective one-pot synthesis of either indoles or pyrazoles can be achieved via Pd-catalyzed aminations followed by subsequent cyclizations facilitated by aqueous micellar catalysis. This new technol. includes efficient couplings with low loadings of palladium, a more stable source of the required hydrazine moiety, greater atom economy for the initial coupling, and reduced reaction temperatures, all leading to environmentally responsible processes. In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-methylpyridine(cas: 3510-66-5Application In Synthesis of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Application In Synthesis of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Roy, Sebastien A.; Zgheib, Jose; Zhou, Cuihan; Arndtsen, Bruce A. published an article in 2021. The article was titled 《Palladium catalyzed synthesis of indolizines via the carbonylative coupling of bromopyridines, imines and alkynes》, and you may find the article in Chemical Science.Formula: C6H6BrN The information in the text is summarized as follows:

Authors report herein the development of a palladium-catalyzed, multicomponent synthesis of indolizines. The reaction proceeds via the carbonylative formation of a high energy, mesoionic pyridine-based 1,3-dipole, which can underwent spontaneous cycloaddition with alkynes. Overall, this provides a route to prepare indolizines in a modular fashion from combinations of com. available or easily generated reagents: 2-bromopyridines, imines and alkynes. After reading the article, we found that the author used 2-Bromo-5-methylpyridine(cas: 3510-66-5Formula: C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem