Category: 3510-66-5

In 2022,Cauley, Anthony N.; Ramirez, Antonio; Barhate, Chandan L.; Donnell, Andrew F.; Khandelwal, Purnima; Sezen-Edmonds, Melda; Sherwood, Trevor C.; Sloane, Jack L.; Cavallaro, Cullen L.; Simmons, Eric M. published an article in Organic Letters. The title of the article was 《Ni/Photoredox-Catalyzed C(sp2)-C(sp3) Cross-Coupling of Alkyl Pinacolboronates and (Hetero)Aryl Bromides》.HPLC of Formula: 3510-66-5 The author mentioned the following in the article:

Utilizing quinoline as a mild, catalytic additive, broadly applicable conditions for the Ni/photoredox-catalyzed C(sp2)-C(sp3) cross-coupling of (hetero)aryl bromides RBr (R = N-bocpiperidin-4-yl, N-bocindol-5-yl) and alkyl pinacolboronate esters R1R2CH(Bpin) [R1 = H, Me; R2 = Me, Ph, 2-methylphenyl, pyridin-3-yl, pyrimidin-5-yl, etc.; R1R2 = -(CH2)3-, -(CH2)5-, -(CH2)3O(CH2)2-, etc.] were developed, which can be applied to both batch and flow reactions. In addition to primary benzylic nucleophiles, both stabilized and non-stabilized secondary alkyl boronic esters are effective coupling partners. D. functional theory calculations suggest that alkyl radical generation occurs from an alkyl-B(pin)-quinoline complex, which may proceed via an energy transfer process. In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-methylpyridine(cas: 3510-66-5HPLC of Formula: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.HPLC of Formula: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Yamaguchi, Koji; Miyaguchi, Hajime; Ohno, Youkichi; Kanawaku, Yoshimasa published an article in Forensic Toxicology. The title of the article was 《Qualitative analysis of 7- and 8-hydroxyzolpidem and discovery of novel zolpidem metabolites in postmortem urine using liquid chromatography-tandem mass spectrometry》.Related Products of 3510-66-5 The author mentioned the following in the article:

Forensic anal. of Zolpidem (ZOL) is a hypnotic sometimes used in drug-facilitated crimes. Understanding ZOL metabolism is important for proving ZOL intake. In this study, we synthesized standards of hydroxyzolpidems with a hydroxy group attached to the pyridine ring and analyzed them to prove their presence in postmortem urine. We also searched for novel ZOL metabolites in the urine sample using liquid chromatog.-triple quadrupole mass spectrometry (LC-QqQMS) and liquid chromatog.-quadrupole time-of-flight mass spectrometry (LC-QqTOFMS). 7- and 8-Hydroxyzolpidem (7OHZ and 8OHZ, resp.) were synthesized and analyzed using LC-QqQMS. Retention times were compared between the synthetic standards and extracts of postmortem urine. To search for novel ZOL metabolites, first, the urine extract was analyzed with data-dependent acquisition, and the peaks showing the characteristic fragmentation pattern of ZOL were selected. Second, product ion spectra of these peaks at various collision energies were acquired and fragments that could be used for multiple reaction monitoring (MRM) were chosen. Finally, MRM parameters were optimized using the urine extract These peaks were also analyzed using LC-QqTOFMS. The presence of 7OHZ and 8OHZ in urine was confirmed. The highest peak among hydroxyzolpidems was assigned to 7OHZ. The novel metabolites found were zolpidem dihydrodiol and its glucuronides, cysteine adducts of ZOL and dihydro(hydroxy)zolpidem, and glucuronides of hydroxyzolpidems. The presence of novel metabolites revealed new metabolic pathways, which involve formation of an epoxide on the pyridine ring as an intermediate. After reading the article, we found that the author used 2-Bromo-5-methylpyridine(cas: 3510-66-5Related Products of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hassan, Mirja Mahamudul Md; Hoque, Emdadul Md; Dey, Sayan; Guria, Saikat; Roy, Brindaban; Chattopadhyay, Buddhadeb published an article in 2021. The article was titled 《Iridium-Catalyzed Site-Selective Borylation of 8-Arylquinolines》, and you may find the article in Synthesis.Recommanded Product: 3510-66-5 The information in the text is summarized as follows:

The authors report a convenient method for the highly site-selective borylation of 8-arylquinoline. The reaction proceeds smoothly in the presence of a catalytic amount of [Ir(OMe)(cod)]2 and 2-phenylpyridine derived ligand using bis(pinacolato)diborane as the borylating agent. The reactions occur with high selectivity with many functional groups, providing borylated 8-aryl quinolines with good to excellent yield and excellent selectivity. The borylated compounds formed in this method can be transformed into various important synthons by using known transformations. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Wu, Gaorong; Xu, Xiaobo; Wang, Shuai; Chen, Lu; Pang, Binghan; Ma, Tao; Ji, Yafei published an article in Chinese Chemical Letters. The title of the article was 《Metal-free directed C-H borylation of 2-(N-methylanilino)-5-fluoropyridines and 2-benzyl-5-fluoropyridines》.Recommanded Product: 2-Bromo-5-methylpyridine The author mentioned the following in the article:

A novel method for metal-free C-H pyridine-directed borylation of 2-(N-methylanilino)-5-fluoropyridines and 2-benzyl-5-fluoropyridines with BBr3 has been reported, affording complexes R1C6H3(Bpin)-2-XR2-5-FC5H4N-2 (X = N, CH; R1 = H, alkyl, halo; R2 = H, Me). The 5-fluoropyridine directed borylation reaction exhibited high efficiency and site exclusivity. The useful protocol could be executed on a gram-scale easily and the borylated products showed good derivatization applications. Moreover, the practicality of the strategy was expanded by the fact that the directing group could be removed in an acceptable yield. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Recommanded Product: 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Liu, Hao; Chi, Wei; Lin, Meng-Ling; Dong, Lin published an article in Organic Chemistry Frontiers. The title of the article was 《Iridium(III)-catalyzed two-fold C-H alkylation of BINOLs with allyl alcohols》.Synthetic Route of C6H6BrN The author mentioned the following in the article:

Ir(III)-Catalyzed C-H alkylation of BINOL units I (R1 = H, Me, MeO, Br; R2 = H, Me, Ph, etc.; R3 = pyridin-2-yl, 3-methoxypyridin-2-yl, thiazol-2-yl, etc.; R4 = Me, pyridin-2-yl, 3-methoxypyridin-2-yl, etc.) has been well examined by using allyl alcs. CH2=CHCH(R5)OH (R5 = Et, benzyl, thiophen-2-yl, etc.) as coupling partners. Under the advantage of the pyridine guiding group, the efficient protocol allows the rapid synthesis of diverse BINOL carbonyl compounds II and III with the retention of optical purity. In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Synthetic Route of C6H6BrN) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Synthetic Route of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Chen, Yan; Gao, Zhanming; Wang, Lei; Li, Jiansheng; Tang, Yutian; Liu, Chun published an article in ACS Applied Polymer Materials. The title of the article was 《Living Supramolecular Polymerization of Ultrastable Kinetic Species of Ir(III) Complexes in Aqueous Media》.COA of Formula: C6H6BrN The author mentioned the following in the article:

Living supramol. polymerization (LSP) has become a key technol. for the progress of materials science. However, under the influence of hydrophobic interaction, the precise kinetic control of LSP in aqueous media is still challenging. The authors report a strategy to realize the LSP of ultrastable kinetic species that is nearly impossible to assemble spontaneously. Due to the strong hydrophobic interaction, the kinetic species of Ir(III) complex 2 (nanoparticles, 2NP) at 90 and 95% H2O contents can exist stably for >50 days at room temperature By mixing the seeds at an 85% H2O content and the suspension of kinetic species at a 95% H2O content in equal volume, LSP can be carried out at a 90% H2O content, and multicycle LSP at a 90% H2O content can be performed successfully. This LSP strategy broadens the practicality of LSP and is implemented by structurally simple Ir(III) complexes, which provides ideas for broadening the monomer scope of LSP. Time-, temperature-, and concentration-dependent spectroscopic results show that the formation of kinetic species 2NP and thermodn. species 2NS (nanosheets) follows the isodesmic model and the cooperative (nucleation-elongation) model, resp., and 2NP are the off-pathway intermediates of 2NS. This study illustrates an ingenious and precise kinetic control on the LSP in aqueous media. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5COA of Formula: C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《AIBN for Ru-catalyzed meta-CAr-H alkylation》 was published in Organic Chemistry Frontiers in 2020. These research results belong to Yang, Suling; Yan, Bingxu; Zhong, Lei; Jia, Chunqi; Yao, Dan; Yang, Chunli; Sun, Kai; Li, Gang. Reference of 2-Bromo-5-methylpyridine The article mentions the following:

The meta-CAr-H alkylation of arenes with radicals produced from AIBN in the presence of a RuCl3 catalyst was presented. This development not only confirmed that ruthenium-catalyzed meta-CAr-H bond functionalization was a radical process, but also provided an efficient and practical strategy for the preparation of aromatic compounds containing a nitrile group, which were prevalent in a diverse range of biol. active mols. and other functional materials. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Reference of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Reference of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 3510-66-5In 2019 ,《A greener approach toward N-1 heteroarylation of indoles: Synthesis and in vitro evaluation of potential anti-proliferative agents》 appeared in Arabian Journal of Chemistry. The author of the article were Sailaja, E.; Bhavani, S.; Rambabu, D.; Basaveswara Rao, M. V.; Pal, Manojit. The article conveys some information:

A greener approach was developed to synthesize N-pyridyl indoles e.g., I [R1 = R2 = H, R3 = 2-pyridyl] and N-pyrimidinyl indoles e.g., I [R1 = R2 = H, R3 = 2-pyrimidinyl] via an ultrasound assisted selective N-1 heteroarylation of indoles. This methodol. involved reaction of indoles with heteroaryl halides in PEG-400 under ultrasound irradiation Compound I [R1 = R2 = H, R3 = 2-pyrimidinyl] was benzoylated at C-2 position via palladium-mediated C-H bond activation. All the synthesized N-1 heteroarylindoles were tested for their in vitro anti-proliferative properties against cancer (leukemia) and non-cancerous cell lines. Among the tested compounds, compounds I [R1 = H; R2 = 5-OMe; R3 = 2-pyridyl, 5-Me-2-pyridyl, 2-pyrimidinyl] showed promising activity against K562 leukemia cells whereas compound I [R1 = H, R2 = 5-OMe, R3 = 2-pyrimidinyl] showed significant activity against Colo-205 cells. Addnl., none of these N-heteroaryl indoles showed any effect against noncancerous HEK293 cell lines, indicating their selectivity toward cancer cells specifically leukemia. In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Heteroleptic copper(II) complexes with 2-bromo-5-methylpyridine: Structures, features of non-covalent interactions and magnetic behavior》 was written by Adonin, Sergey A.; Novikov, Alexander S.; Chernova, Katerina V.; Vinnik, Denis A.; Taskaev, Sergey V.; Korolkov, Ilya V.; Ilyina, Ekaterina V.; Pavlov, Alexander A.; Novikov, Valentin V.; Sokolov, Maxim N.; Fedin, Vladimir P.. Reference of 2-Bromo-5-methylpyridine And the article was included in Inorganica Chimica Acta in 2020. The article conveys some information:

Isostructural [Cu(2-Br-5-MePy)2X2] (2-Br-5-MePy = 2-bromo-5-methylpyridine, X = Cl 1, Br 2) were prepared and structurally characterized. Magnetic measurements reveal that both complexes demonstrate paramagnetic behavior. The results came from multiple reactions, including the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Reference of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Tris(2-pyridyl) Bismuthines: Coordination Chemistry, Reactivity, and Anion-Triggered Pyridyl Coupling》 was written by Garcia-Romero, Alvaro; Plajer, Alex J.; Miguel, Daniel; Wright, Dominic S.; Bond, Andrew D.; Alvarez, Celedonio M.; Garcia-Rodriguez, Raul. Application In Synthesis of 2-Bromo-5-methylpyridineThis research focused ontris pyridyl bismuthine complex lithium silver mol structure iron; reductive elimination gold. The article conveys some information:

A series of new tris(2-pyridyl) bismuthine ligands of the type [Bi(2-py’)3] have been prepared, containing a range of substituents at various positions within their pyridyl rings (py’). They can act as intact ligands or, as a result of the low C-Bi bond energy, exhibit noninnocent reactivity in the presence of metal ions. Structural studies of Li+ and Ag+ complexes show that the coordination to metal ions using their pyridyl-N atoms and to anions using the Lewis acidity of their Bi(III) centers can be modified by the presence of substituents within the 2-pyridyl rings, especially at the 6- or 3-positions, which can block the donor-N or Lewis acid Bi sites. Electron withdrawing groups (like CF3 or Br) can also severely reduce their ability to act as ligands to metal ions by reducing the electron donating ability of the pyridyl-N atoms. Noninnocent character is found in the reactions with Cu+ and Cu2+, resulting in the coupling of pyridyl groups to form bipyridines, with the rate of this reaction being dependent on the anion present in the metal salts. This leads to the formation of Bi(III)/Cu(I) complexes containing hypervalent [X2Bi(2-R-py)]- (X = Cl, Br) anions. Alternatively, the tris(2-pyridyl) bismuthine ligands can act as 2-pyridyl transfer reagents, transferring 2-py groups to Au(I) and Fe(II). A series of tris(2-pyridyl) bismuthine ligands have been prepared whose cation and anion coordination properties can be controlled by substitution in the Py ring. They can act as intact ligands and display noninnocent reactivity, such as acting as 2-pyridyl transfer reagents and, as a result of the Lewis acidity of their Bi(III) centers, exhibiting anion dependent reactivity. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Application In Synthesis of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Application In Synthesis of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem