Category: 3510-66-5

The author of 《Push-pull isomers of indolizino[6,5,4,3-def]phenanthridine decorated with a triarylboron moiety》 were Dong, Lei; Saraci, Felix; Yuan, Kang; Wang, Xiang; Wang, Suning. And the article was published in Organic & Biomolecular Chemistry in 2019. Computed Properties of C6H6BrN The author mentioned the following in the article:

1,3-Dipolar cycloaddition reactions between a new azomethine ylide and three BPhMes2-functionalized internal alkynes produced three pairs of fluorescent push-pull regioisomers I and II (R = 2,4,6-Me3C6H2; 1a-3a, 1b-3b, resp., Ar = C6F5, 5-trifluoromethyl-2-pyridyl, 5-methyl-2-pyridyl), which show distinct electronic and photophys. properties. All the six compounds are found to exhibit charge-transfer (CT) fluorescence, and some of which show rare and interesting temperature “”turn-on”” fluorescence. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Computed Properties of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Computed Properties of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Iridium(III)-Catalyzed Tandem Annulation of Pyridine-Substituted Anilines and α-Cl Ketones for Obtaining 2-Arylindoles》 was published in Journal of Organic Chemistry in 2020. These research results belong to Cui, Xin-Feng; Qiao, Xin; Wang, He-Song; Huang, Guo-Sheng. Recommanded Product: 3510-66-5 The article mentions the following:

A facile and expeditious protocol for the synthesis of 2-arylindole compounds from readily available N-(2-pyridyl)anilines and com. available α-Cl ketones through iridium-catalyzed C-H activation and cyclization is reported here. As a complementary approach to the conventional strategies for indole synthesis, the transformation exhibits powerful reactivity, tolerates a large number of functional groups, and proceeds with good to excellent yields under mild conditions, providing a straightforward method to obtain structurally diverse and valuable indole scaffolds. Furthermore, the reaction could be easily scaled up to gram scale. In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Recommanded Product: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lauzon, Samuel; Caron, Laurent; Ollevier, Thierry published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Efficient stereoselective synthesis of chiral 3,3′-dimethyl-(2,2′-bipyridine)-diol ligand and applications in FeII-catalysis》.COA of Formula: C6H6BrN The article contains the following contents:

A seven step synthesis of a chiral 2,2′-bipyridinediol ligand with 3,3′-dimethyl substituents was achieved starting from com. available materials. The O2-mediated oxidative homocoupling reaction of a chiral pyridine N-oxide was demonstrated to be the key step to prepare the S,S enantiomer of the title ligand with excellent stereoselectivities, i.e., 99% de and >99.5% ee. An unusual heptacoordination of FeII when complexed with the chiral 2,2′-bipyridinediol ligand was highlighted from single crystal diffraction anal. Steric strain due to the 3,3′-dimethyl groups was revealed from the structural anal. of the obtained FeII complex. Asym. induction using this chiral 3,3′-dimethyl-(2,2′-bipyridine)-diol ligand was studied in the Mukaiyama aldol and thia-Michael reactions. An increase of chiral induction in the latter one was achieved using the FeII catalyst made from newly synthesized ligand vs. Bolm’s ligand. After reading the article, we found that the author used 2-Bromo-5-methylpyridine(cas: 3510-66-5COA of Formula: C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. COA of Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Transition-metal-free direct nucleophilic substitution of carboranyllithium and 2-halopyridines》 was written by Lu, Ju-You; Zhao, Bo; Du, Yongmei; Yang, Jianxin; Lu, Jian. Electric Literature of C6H6BrNThis research focused ontransition metal free nucleophilic substitution carboranyl lithium halopyridine; pyridinyl carborane preparation. The article conveys some information:

A practical and efficient C(cage)-heteroarylation of carborane is presented, via direct nucleophilic substitution of carboranyllithium with 2-halopyridines. This reaction does not need the aid of any transition metal and utilizes readily available carboranyllithium nucleophiles, thereby avoiding transmetalation of carboranyllithium. The process exhibits a broad scope, and a vast array of 2-halopyridines have proven to be suitable substrates. The method serves as a complement to C(cage)-arylation reactions and may find wide applications in materials science and medicinal and coordination chem. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Electric Literature of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Electric Literature of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 2-Bromo-5-methylpyridineIn 2020 ,《Synthesis of Decahydrocyclobuta[cd]indene Skeletons: Rhodium(III)-Catalyzed Hydroarylation and Relay Thiophene-Promoted Intramolecular [2+2] Cycloaddition》 appeared in Advanced Synthesis & Catalysis. The author of the article were Gao, Dingding; Wang, Feng; Liu, Xing-Yu; Feng, Kai-Rui; Zhao, Jia-Ying; Wang, Yu-Hui; Yang, Xiao-Di; Tian, Ping; Lin, Guo-Qiang. The article conveys some information:

The preparation of decahydrocyclobuta[cd]indene skeleton was accomplished through rhodium(III)-catalyzed hydroarylation and relay thiophene-promoted intramol. [2+2] cycloaddition This tandem reaction exhibited broad substrate scope (24 examples) and good functional group compatibility. Control experiments revealed the important role of sulfur (S) heteroatom, thus a tentative mechanism with thiophene-promoted double Michael additions was proposed to explain this formal [2+2] cycloaddition Moreover, the resulting polycyclic products displayed potent anti-cancer activities against breast cancer cell lines MDA-MB-468. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Quality Control of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Quality Control of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Norman, Jacob P.; Larson, Nathaniel G.; Entz, Emily D.; Neufeldt, Sharon R. published an article in Journal of Organic Chemistry. The title of the article was 《Unconventional Site Selectivity in Palladium-Catalyzed Cross-Couplings of Dichloroheteroarenes under Ligand-Controlled and Ligand-Free Systems》.Safety of 2-Bromo-5-methylpyridine The author mentioned the following in the article:

This work represents the first highly selective method with a broad scope for C4-coupling of dihalogenated N-heteroarenes such as 2,4-dichloropyridine, 2,4-dichloroquinoline, 3,5-dichloro-4-phenylpyridazine, etc. where selectivity is clearly under ligand control. Under the optimized conditions, diverse substituted 2,4-dichloropyridines and related compounds undergo cross-coupling to form C4-C(sp2) and C4-C(sp3) bonds using organoboron, -zinc, and -magnesium reagents such as p-methoxyphenylboronic acid, cyclopentylmagnesium bromide, benzothiophenylzinc chloride, etc. The synthetic utility of this method is highlighted in multistep syntheses that combine C4-selective cross-coupling with subsequent nucleophilic aromatic substitution reactions. The majority of the products herein (71%) have not been previously reported, emphasizing the ability of this methodol. to open up underexplored chem. space. Remarkably, this work finds that ligand-free “”Jeffery”” conditions enhance the C4 selectivity of Suzuki coupling by an order of magnitude (>99:1). These ligand-free conditions enable the first C5-selective cross-couplings of 2,5-dichloropyridine and 2,5-dichloropyrimidine. In the experimental materials used by the author, we found 2-Bromo-5-methylpyridine(cas: 3510-66-5Safety of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Safety of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 2-Bromo-5-methylpyridineIn 2019 ,《Transition-Metal-Free Synthesis of Fused Quinazolinones by Oxidative Cyclization of N-Pyridylindoles》 appeared in Journal of Organic Chemistry. The author of the article were Garia, Alankrita; Jain, Nidhi. The article conveys some information:

An unprecedented synthesis of fused quinazolinones from N-pyridylindoles under oxidative conditions using a combination of (diacetoxyiodo)benzene and K2S2O8 is reported. The reaction is metal-free, has a broad substrate scope, is operationally simple with short reaction time, and provides 11H-pyrido[2,1-b]quinazolin-11-one derivatives in moderate to high yields. It is believed to proceed via an in situ generated 2-hydroxy-1-(pyridin-2-yl)indolin-3-one as the key reaction intermediate, which undergoes a C-C bond cleavage to produce an electrophilic C-3 site in N-pyridyl indole. Subsequent nucleophilic attack by pyridyl nitrogen results in its cyclization. The results came from multiple reactions, including the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Ruthenium-catalyzed synthesis of indole derivatives from N-aryl-2-aminopyridines and alpha-carbonyl sulfoxonium ylides》 were Cui, Xin-Feng; Ban, Zi-Hui; Tian, Wa-Fa; Hu, Fang-Peng; Zhou, Xiao-Qiang; Ma, Hao-Jie; Zhan, Zhen-Zhen; Huang, Guo-Sheng. And the article was published in Organic & Biomolecular Chemistry in 2019. Category: pyridine-derivatives The author mentioned the following in the article:

Indole is a ubiquitous structural motif with important applications in many areas of chem. Given this, a simple and efficient Ru(II)-catalyzed synthesis of indoles I (R = Ph, 4-FC6H4, 3-ClC6H4, 2-thienyl, cyclohexyl, etc., R1 = H, 5-Me, 5-MeO, 6-F, 5-Me-6-Cl, etc., R2 = H, 5-Me, 4-Me, 5-Cl, 5-Br) via intermol. annulation of N-aryl-2-aminopyridines and sulfoxonium ylides was proposed and accomplished. Excellent selectivity and good functional group tolerance of this transformation were observed This protocol provides easy access to a wide variety of useful indoles in the presence of a com. available [Ru(p-cymene)Cl2]2 catalyst. A possible mechanism for the reaction pathway was also proposed. More importantly, this reaction will offer a useful method for the construction of enantioenriched indole frameworks. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Category: pyridine-derivatives)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C6H6BrNIn 2021 ,《Copper-catalyzed, N-auxiliary group-controlled switchable transannulation/nitration initiated by nitro radicals: selective synthesis of pyridoquinazolones and 3-nitroindoles》 appeared in Organic Chemistry Frontiers. The author of the article were Shoberu, Adedamola; Li, Cheng-Kun; Qian, Hai-Feng; Zou, Jian-Ping. The article conveys some information:

Herein, a strategy based on the judicious choice of N-auxiliaries, which stabilize the substrates as well as allow precise and predictable control over their reactivity with tert-Bu nitrite was described. Thus, the stage was set for the copper-assisted, controllable synthesis of pyridoquinazolones or 3-nitroindoles. Mechanistic studies implicate a switch in the mechanism, in which N-2-pyridylindoles reacted via a nitrosation/transannulation process and N-2-pyridoylindoles underwent an amide bond dissociation/nitration sequence. Notably, the subsequent removal of the auxiliary groups was not required in these reactions. In the experimental materials used by the author, we found 2-Bromo-5-methylpyridine(cas: 3510-66-5Computed Properties of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Computed Properties of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C6H6BrNIn 2021 ,《Palladium-catalyzed dearomative cyclocarbonylation of allyl alcohol for the synthesis of quinolizinones》 appeared in Organic & Biomolecular Chemistry. The author of the article were Xu, Pengcheng; Qian, Bo; Qi, Zaojuan; Gao, Bao; Hu, Bin; Huang, Hanmin. The article conveys some information:

An approach for the synthesis of quinolizinone I (R = H, 6-Me, 7-F, etc.; R1 = H, Me, Ph; R2 = H, Me, pentyl; R3 = H, Me; X = N, CH) with potential bioactivity has been developed via palladium-catalytic dearomative cyclocarbonylation of allyl alc. R4C(R1)=C(R2)CH(R3)OH (R4 = pyridin-2-yl, 5-fluoropyridin-2-yl, pyrazin-2-yl, etc.). Diverse quinolizinone compounds I could be attained with good efficiencies. A feasible reaction pathway could be a successive procedure of allylation, dearomatization, CO insertion and the Heck reaction. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-methylpyridine(cas: 3510-66-5Formula: C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem