Thimma Sambamoorthy, Manikandan’s team published research in Applied Organometallic Chemistry in 2019 | CAS: 3510-66-5

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 3510-66-5

In 2019,Applied Organometallic Chemistry included an article by Thimma Sambamoorthy, Manikandan; Rengan, Ramesh; Jan Grzegorz, Malecki. Product Details of 3510-66-5. The article was titled 《Efficient construction of C-C bonds from aryl halides/aryl esters with arylboronic acids catalyzed by palladium(II) thiourea complexes》. The information in the text is summarized as follows:

A new set of palladium(II) complexes comprising phenyl(thiazolyl)thiourea ligands I (R = H, Me, NO2) have been successfully synthesized and characterized with the aid of anal. as well as spectral (IR, UV-visible and NMR) methods. A distorted square-planar geometry with N^S coordination mode of thiourea ligands in the new palladium complexes I (R = H, Me) was corroborated by single-crystal X-ray diffraction methods. Interestingly, the palladium(II) thiourea complexes I showed the highest catalytic activity with 0.1 mol% catalyst loading in Suzuki-Miyaura cross-coupling reactions utilizing a range of aryl halides RX (R = 4-acetylphenyl, 5-methylpyridin-2-yl, pyridin-2-yl, etc.; X = Br, Cl) with arylboronic acids R1B(OH)2 (R1 = Ph, 4-chlorophenyl, 6-bromopyridin-3-yl, etc.) as coupling partners in aqueous-organic media. Syntheses of diaryl ketones PhCOR1 using Ph benzoate and arylboronic acids as coupling partners were also achieved with low catalyst loading within 20 h. The potential of prepared catalyst was demonstrated by its wide substrate scope, low catalyst loadings and high isolated yield. Moreover, the influences of key parameters like solvent, base, temperature and catalyst loading were also investigated. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Product Details of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Heng-Hui’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2022 | CAS: 3510-66-5

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Quality Control of 2-Bromo-5-methylpyridine

In 2022,Li, Heng-Hui; Li, Shaoyu; Cheng, Jun Kee; Xiang, Shao-Hua; Tan, Bin published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Direct arylation of N-heterocycles enabled by photoredox catalysis》.Quality Control of 2-Bromo-5-methylpyridine The author mentioned the following in the article:

N-Heterobiaryls are common skeletons found in biol. mols., pharmaceuticals and ligands. Herein, authors document an efficient and redox-neutral photocatalytic system to obtain functionalized N-heterobiaryls under mild conditions. Substrates bearing variegated functional groups are compatible with the developed photocatalytic conditions. This method is translatable to gram-scale synthesis, with a photocatalyst loading as low as 0.1 mol% and minimal variation of the yield. The starting materials are com. available, demonstrating the practicality and accessibility of this methodol. Interestingly, phenols can serve both as coupling partners and proton donors. Arenes without a phenolic hydroxyl group also underwent efficient coupling with HFIP as a solvent. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Quality Control of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Quality Control of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kullmer, Cesar N. Prieto’s team published research in Science (Washington, DC, United States) in 2022 | CAS: 3510-66-5

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.SDS of cas: 3510-66-5

In 2022,Kullmer, Cesar N. Prieto; Kautzky, Jacob A.; Krska, Shane W.; Nowak, Timothy; Dreher, Spencer D.; MacMillan, David W. C. published an article in Science (Washington, DC, United States). The title of the article was 《Accelerating reaction generality and mechanistic insight through additive mapping》.SDS of cas: 3510-66-5 The author mentioned the following in the article:

Reaction generality is crucial in determining the overall impact and usefulness of synthetic methods. Typical generalization protocols require a priori mechanistic understanding and suffer when applied to complex, less understood systems. An additive mapping approach that rapidly expands the utility of synthetic methods while generating concurrent mechanistic insight was developed. Validation of this approach on the metallaphotoredox decarboxylative arylation resulted in the discovery of a phthalimide ligand additive that overcomes many lingering limitations of this reaction and has important mechanistic implications for nickel-catalyzed cross-couplings. After reading the article, we found that the author used 2-Bromo-5-methylpyridine(cas: 3510-66-5SDS of cas: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.SDS of cas: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Seo, Sanghyup’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2021 | CAS: 3510-66-5

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Application of 3510-66-5

Application of 3510-66-5In 2021 ,《Ligand-controlled, Pd/CuH-catalyzed reductive cross-coupling of terminal alkenes and N-heteroaryl bromides》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Seo, Sanghyup; Kim, Donghyeon; Kim, Hyunwoo. The article contains the following contents:

The reductive cross-coupling of terminal alkenes and N-heterocyclic bromides had been demonstrated by ligand optimization of Pd and CuH catalysis. The optimized ligands were Briphos, a π-acceptor monodentate phosphorus ligand, for Pd catalysis and DTB-DPPBz, a sterically bulky bidentate phosphorus ligand, for CuH catalysis. These conditions were further applied to the gram-scale production of clathryimine B. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-methylpyridine(cas: 3510-66-5Application of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Application of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Yingmu’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2019 | CAS: 3510-66-5

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Formula: C6H6BrN

《A mesoporous NNN-pincer-based metal-organic framework scaffold for the preparation of noble-metal-free catalysts》 was written by Zhang, Yingmu; Li, Jialuo; Yang, Xinyu; Zhang, Peng; Pang, Jiandong; Li, Bao; Zhou, Hong-Cai. Formula: C6H6BrNThis research focused onzirconium terpyridinephenylcarboxylate MOF preparation gas adsorption isotherm epoxidation catalyst; borylation catalyst zirconium terpyridinephenylcarboxylate MOF; surface area pore size distribution thermal stability zirconium terpyridinephenylcarboxylate. The article conveys some information:

Through topol.-guided synthesis, a Zr-based mesoporous MOF was successfully constructed, adopting a β-cristobalite-type structure. The MOF is embedded with well-arranged terpyridine coordination sites for facile post-synthetic metalation, and can be effectively used as a general scaffold for the preparation of noble-metal-free catalysts. For instance, the scaffolded metal@MOF material exhibits highly efficient catalytic activity for alkene epoxidation and arene borylation. After reading the article, we found that the author used 2-Bromo-5-methylpyridine(cas: 3510-66-5Formula: C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sasmal, Sheuli’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2020 | CAS: 3510-66-5

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Name: 2-Bromo-5-methylpyridine

《A directing group-assisted ruthenium-catalyzed approach to access meta-nitrated phenols》 was written by Sasmal, Sheuli; Sinha, Soumya Kumar; Lahiri, Goutam Kumar; Maiti, Debabrata. Name: 2-Bromo-5-methylpyridine And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Meta-Selective C-H nitration of phenol derivatives RC6H4OR1 (R = H, 4-Me, 2-MeO, 4-Ph, etc.; R1 = pyridin-2-yl, 5-methylpyridin-2-yl, pyrimidin-2-yl) was developed using a Ru-catalyzed σ-activation strategy. Cu(NO3)2.3H2O was employed as the nitrating source, whereas Ru2(CO)12 was found to be the most suitable metal catalyst for the protocol. Mechanistic studies suggested involvement of an ortho-CAr-H metal intermediate, which promoted meta-electrophilic aromatic substitution and silver-assisted free-radical pathway. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Name: 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Name: 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shafikov, Marsel Z.’s team published research in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2021 | CAS: 3510-66-5

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 2-Bromo-5-methylpyridine

Shafikov, Marsel Z.; Suleymanova, Alfiya F.; Kutta, Roger J.; Brandl, Fabian; Gorski, Aleksander; Czerwieniec, Rafal published an article in 2021. The article was titled 《Dual emissive dinuclear Pt(II) complexes and application to singlet oxygen generation》, and you may find the article in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices.Recommanded Product: 2-Bromo-5-methylpyridine The information in the text is summarized as follows:

Room-temperature dual emission consisting of spectrally separated fluorescence and phosphorescence is highly attractive as a design principle for ratiometric sensing materials, for example, for detection of dioxygen. Compounds susceptible to emission quenching by dioxygen, producing dioxygen in electronically excited states, are also used as photosensitizers for singlet O generation. Combination of the dual emission behavior and efficient energy transfer from one of the emitting states (triplet state) of the dual emissive compound to mol. dioxygen can result in potent photosensitizers easily traceable by fluorescence spectroscopy, which may be advantageous for instance in biol. studies. Herein, the authors present two Pt(II) complexes 1 and 2 of dinuclear structure which exhibit green fluorescence with sub-nanosecond lifetimes and near IR (NIR) phosphorescence with microsecond lifetimes. Such properties are achieved via the design of a strongly π-excessive ditopic ligand with a NĈ-CN̂ coordinating mode that bridges the metal centers. The ligand centered character of the lowest excited singlet (S1) and triplet (T1) states leads to strong exchange interaction of the unpaired electrons and hence to large energy separation ΔE(S1-T1) amounting to 0.6 eV for 1 and 0.7 eV for 2, resp. The large energy gap ΔE(S1-T1) and weak metal contribution to the states S1 and T1 results in unusually long intersystem crossing (ISC) times τISC(S1 → T1) of 27.5 ps (1) and 65.2 ps (2), resp., as determined by transient absorption spectroscopy. Owing to the slow ISC, the T1 → S0 phosphorescence of both 1 and 2 is accompanied by S1 → S0 fluorescence of comparable intensity. The large gap ΔE(S1-T1) provides also a good optical separation of the two emissions. The phosphorescence signal is efficiently quenched in the presence of dioxygen, which is manifested in both the lower relative intensity and shorter decay time of phosphorescence. Thus, the compounds show high potential as ratiometric dioxygen sensing materials. The singlet O photogeneration efficiencies of complexes 1 and 2, measured in air saturated CH2Cl2, are as high as φΔ ≈ 0.77 ± 0.1 and 0.57 ± 0.1, resp. Thus, the compounds represent efficient singlet O photosensitizers.2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 2-Bromo-5-methylpyridine) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Brief introduction of 2-Bromo-5-methylpyridine

According to the analysis of related databases, 3510-66-5, the application of this compound in the production field has become more and more popular.

Electric Literature of 3510-66-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3510-66-5, name is 2-Bromo-5-methylpyridine, molecular formula is C6H6BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

36 g (209 mmol) 2-Bromo-5-methylpyridine and 37.5 g(418 mmol) copper cyanide are refluxed for two hours in 500 mldimethylformamide. After cooling down to50 C, 10percent aqueous ammonia solution (500 ml) is added with stirring. The product is extracted with dichloromethane, the organic phase is dried over magnesium sulfate, and the solvent is removed invacuo. The product is purified by column chromatgraphy (silica, eluent cyclohexane/ethyl acetate 9: 1). Yield: 18 g (73percentof th.)IH-NMR (300MHz, CDCIs) :8 = 2.4 (s, 3H); 7.6(m, 2H); 8.6 (s,1H) ppm.

According to the analysis of related databases, 3510-66-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER HEALTHCARE AG; WO2004/20410; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some scientific research about 3510-66-5

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3510-66-5, 2-Bromo-5-methylpyridine.

Electric Literature of 3510-66-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3510-66-5, name is 2-Bromo-5-methylpyridine, molecular formula is C6H6BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

172 g of thus obtained 2-bromo-5-methylpyridine was dissolved in 1.3 l of carbon tetrachloride, and the system was then heated. At the time refluxing begain (at 77 C.), chlorine gas was bubbled into the system with ultraviolet light irradiation. After a lapse of 5 hours, the completion of the reaction was confirmed by gas chromatography, and the system was cooled and air was bubbled into the system to expel the unreacted chlorine. The system was washed with water several times and dried over anhydrous sodium sulfate. Then, the carbon tetrachloride was distilled off, and the system was allowed to cool. The solid crystals thus-obtained were washed with n-hexane to obtain 152 g of 2-chloro-5-trichloromethylpyridine with a melting point of 51 to 54 C.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3510-66-5, 2-Bromo-5-methylpyridine.

Reference:
Patent; Ishihara Sangyo Kaisha Ltd.; US4184041; (1980); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Analyzing the synthesis route of 2-Bromo-5-methylpyridine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3510-66-5, 2-Bromo-5-methylpyridine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 3510-66-5 ,Some common heterocyclic compound, 3510-66-5, molecular formula is C6H6BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of compound C1 (78.0 g, 456 mmol) and CuCN (45.2 g, 502 mmol) in 400 nriL of DMF was refluxed for 3 h. The mixture was concentrated under vacuum and the residue purified by chromatography on silica gel (eluent: PE/EtOAc = 10/1) to give 7.7 g of compound C2 as a white solid (Yield: 14.3percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3510-66-5, 2-Bromo-5-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PHENEX PHARMACEUTICALS AG; KREMOSER, Claus; ABEL, Ulrich; STEENECK, Christoph; KINZEL, Olaf; WO2011/20615; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem