As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35779-35-2, name is Di(pyridin-3-yl)methanone, molecular formula is C11H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: Di(pyridin-3-yl)methanone
A round bottom flask was charged with di(pyridin-3-yl)methanone (500 mg, 2.72 mmol), MeOH (30 mL), and CH2C12 (15 mL) and cooled to 0 C. NaBH4 (51 mg, 1.35 mmol) was added in one portion. The solution was stirred for 1 h at 0 C and quenched with IN NaOH and the reaction was extracted with CH2CI2 (3X). The organic layers were combined, dried over Na2S04 and concentrated under reduced pressure. Crude di(pyridin-3-yl)methanol (505 mg, 100%) was used in the next step without further purification. XH NMR 400 MHz (CDC13) delta 8.32 (s, 2H), 8.24 (d, J= 4.8 Hz, 2H), 7.47 (d, J= 7.9 Hz, 2H), 7.09 – 7.01 (m, 2H), 5.67 (s, 1H).
With the rapid development of chemical substances, we look forward to future research findings about 35779-35-2.
Reference:
Patent; ABIDE THERAPEUTICS; THE SCRIPPS RESEARCH INSTITUTE; CISAR, Justin, S.; GRICE, Chery, A.; JONES, Todd, K.; NIPHAKIS, Micah, J.; CHANG, Jae, Won; LUM, Kenneth, M.; CRAVATT, Benjamin, F.; WO2013/103973; (2013); A1;,
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