Statistics shows that 357927-50-5 is playing an increasingly important role. we look forward to future research findings about 2-Bromo-4-fluoropyridine.
Application of 357927-50-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.357927-50-5, name is 2-Bromo-4-fluoropyridine, molecular formula is C5H3BrFN, molecular weight is 175.99, as common compound, the synthetic route is as follows.
Under the argon atmosphere, 3 g of 2-bromo-4-fluoropyridine was added to 35 ml of tetrahydrofuran, and 9.38 ml of lithium diisopropylamide (2 mol/1 heptane/tetrahydrofuran/ethylbenzene solution) was added at -780C. After stirring for 2 hours, 5.66 g of iodine was added, and the mixture was further stirred for 4 hours. The reaction solution was poured into an aqueous saturated sodium thiosulfate solution, the resultant solution was extracted with tert-butyl=methyl=ether three times, washed with an aqueous saturated sodium chloride solution, dried with anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel column chromatography to obtain 4.1 g of 2-bromo-5-fluoro-4-iodopyridine. 2-Bromo-5-fluoro-4-iodopyridine.1H-NMR: 7.91 (d, IH), 8.13 (s, IH)
Statistics shows that 357927-50-5 is playing an increasingly important role. we look forward to future research findings about 2-Bromo-4-fluoropyridine.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2009/66786; (2009); A1;,
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