Category: 36052-26-3

Synthetic Route of 36052-26-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 36052-26-3, name is Methyl 6-aminopicolinate. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of methyl 6-aminopicolinate (1 eq.) in CHCI3 (0.5 M) is added bromine (1 eq. ). The reaction is stirred for 12 h at room temperature. Afterwards, the reaction mixture is washed with saturated sodium thiosulfate and water. The organic phase is washed with brine, dried over Na2SO4, filtered, and concentrated to dryness. The crude product was purified on silicagel (Gradient: 0 – 75% EtOAc in hexane) to provide 1 and 2 as a white solids, m/z 232 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 36052-26-3, Methyl 6-aminopicolinate.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2009/140101; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 36052-26-3, name is Methyl 6-aminopicolinate. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 36052-26-3

d) 6-Amino-5-bromo-pyridine-2-carboxylic acid methyl ester; To a solution of 6-amino-pyridine-2-carboxylic acid methyl ester (10 g, 66.0 mmol) in chloroform (450 mL) was added bromine (3.4 mL, 66.0 mmol) in CHCl3 (100 mL) at room temperature and stirred for 40 hours. The reaction mixture was diluted with CHCl3 and washed with saturated sodium thiosulfate solution and water. The organic phase was dried over sodium sulfate, the solvent was evaporated and the residue purified by silica gel column chromatography using ethyl acetate/hexane as eluent. The title compound obtained as yellow solid (3.3 g, 22%).MS ESI (m/e): 231.0 [(M+H)+].1H NMR (CDCl3, 400 MHz): delta(ppm)=7.76 (d, J=7.88 Hz, 1H), 7.34 (d, J=7.92 Hz, 1H), 5.23 (s, 2H), 3.94 (s, 3H).d) 6-Amino-3-bromo-pyridine-2-carboxylic acid methyl esterIn step d) the isomeric 6-amino-3-bromo-pyridine-2-carboxylic acid methyl ester (3.0 g, 19%) was isolated as side product.MS ESI (m/e): 231.2 [(M+H)+].1H NMR (CDCl3, 400 MHz): delta(ppm)=7.60 (d, J=8.72 Hz, 1H), 6.47 (d, J=7.88 Hz, 1H), 4.71 (s, 2H), 3.94 (s, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 36052-26-3.

Reference:
Patent; Baumann, Karlheinz; Goetschi, Erwin; Green, Luke; Jolidon, Synese; Knust, Henner; Limberg, Anja; Luebbers, Thomas; Thomas, Andrew; US2011/190269; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem