Category: 366-18-7

Gurgul, Ilona; Mazuryk, Olga; Lomzik, Michal; Gros, Philippe C.; Rutkowska-Zbik, Dorota; Brindell, Malgorzata published the artcile< Unexplored features of Ru(II) polypyridyl complexes - towards combined cytotoxic and antimetastatic activity>, Synthetic Route of 366-18-7, the main research area is cytotoxicity antimetastatic polypyridyl Ru II.

Therefore, scientists have to concentrate their efforts on designing compounds affecting not only the primary tumor, but also efficiently inhibiting metastasis. Herein, we report two families of Ru(II) polypyridyl complexes bearing 2,2′-bipyridine substituted by a semicarbazone 2-formylopyridine moiety as one of the ligands and 4,4′-di-tert-butyl-2,2′-dipyridyl or 4,7-diphenyl-1,10-phenanthroline as auxiliary ligands. These complexes strengthen cells’ adherent properties and inhibit the activity of metalloproteinases (MMPs) in vitro, which is relevant in anti-metastatic treatment. The in vitro studies were performed on human lung adenocarcinoma (A549) and human pancreatic cancer (PANC-1) cells, which have a well-documented invasive potential. The induced alteration of the tumor cells’ adhesion properties correlated with the high cytotoxic effect exerted by the complexes and their excellent cellular uptake. It was also proved that both complexes directly inhibit M-MP2 and M-MP9 enzyme activities, which are essential for the development of tumor metastasis. The results of this study indicate that the biol. properties of polypyridyl Ru(II) complexes extend beyond the standard cytotoxic activity and represent an important step towards designing new anti-metastatic agents.

Metallomics published new progress about Cytotoxicity. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Synthetic Route of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Diz, Maria; Duran-Carril, Maria L.; Castro, Jesus; Alvo, Samuel; Bada, Lucia; Vina, Dolores; Garcia-Vazquez, Jose A. published the artcile< Antitumor activity of copper(II) complexes with Schiff bases derived from N′-tosylbenzene-1,2-diamine>, Related Products of 366-18-7, the main research area is Antitumoral activity; Copper; Electrochemical synthesis; Hydrogen bonds; Schiff bases ligands; Stacking interactions; Structure elucidation.

The electrochem. oxidation of anodic metal copper in a solution of the ligands N-[(5-tert-butyl-2-hydroxyphenyl)methylidine]-N′-tosylbenzene-1,2-diamine [H2L1] and N-[(3,5-di-tert-butyl-2-hydroxyphenyl)methylidine]-N′-tosylbenzene-1,2-diamine, [H2L2] afforded homoleptic [CuL] compounds or solvate [CuLS] complexes. The addition to the electrochem. cell of coligands (L′) such as 2,2′-bipyridine (2-bpy), 4,4′-bipyridine(4-bpy) or 1,10-phenanthroline (phen) allowed the synthesis, in one step, of heteroleptic [CuLL′] compounds, namely [CuL1(H2O)] (1), [CuL1(2,2′-bpy)]·CH3CN (2), [CuL1(phen)]·H2O (3), [Cu2L12(4,4′-bpy)] (4), [CuL2(CH3OH)] (5), [CuL2(2,2′-bpy)] (6), [CuL2(phen)] (7) and [Cu2L22(4,4′-bpy)] (8). The crystal structures of both ligands, H2L1, H2L2, and those of the complexes (2), (4), (5), (6) and (7) have been determined by X-ray diffraction techniques. Coordination polyhedron around metal atom is square planar for [CuL2(CH3OH)] (5) and [Cu2L12(4,4′-bpy)] (4) and square pyramid for the other complexes with addnl. chelating ligands. The cytotoxic activity of this new series of copper(II) complexes against the SH-SY5Y neuroblastoma cell line and U87-MG and U373-MG glioblastoma cell lines has been investigated. Most of the test compounds showed higher activity than cisplatin in the three cell lines. Among this series, compound [CuL1(phen)] (3) displayed the highest activity with IC50 equal to 1.77 μM on SH-SY5Y whereas compound [Cu2L12(4.4′-bpy)] (4) resulted the most potent compounds on U87 MG and U373 MG glioblastoma cell lines. Studies on the cytotoxic activity of these derivatives suggest that these compounds induce cell death by a mechanism other than apoptosis.

Journal of Inorganic Biochemistry published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Related Products of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Xiaoxia; Cai, Wenjuan; Liu, Gang; Tu, Yayi; Fan, Congbin; Pu, Shouzhi published the artcile< A highly selective colorimetric and fluorescent probe Eu(tdl)2abp for H2S sensing: Application in live cell imaging and natural water>, Category: pyridine-derivatives, the main research area is Eu(tdl)(2)abp; H(2)S; Large stokes shift; Living cells; Natural water.

Using 4-([2,2′: 6′, 2′- terpyridin] -4′-yl) -N, N-dimethylaniline (tdl) as auxiliary ligand and 6-azido-2,2′-bipyridine (abp) as recognition ligand, a europium complex fluorescent probe Eu(4-([2,2′: 6′, 2′-terpyridin] -4′ -yl) -N, N-dimethylaniline)2-6-azido-2,2′-bipyridine Eu(tdl)2abp for efficient and specific recognition of hydrogen sulfide (H2S) was successfully synthesized and characterized by NMR and MS. Eu(tdl)2abp represented “”on-off”” fluorescence signals for H2S and its color changes could be identified with naked eyes. Eu(tdl)2abp had short response time (2 min) to H2S, high selectivity and good anti-interference, large stokes shift (207 nm). In various samples, when H2S existed, the azide group was reduced to amine group, resulting in closed fluorescence signal, and the fluorescence intensity reached the degree of quenching without being affected by other interference. At the same time, there was a good linear relationship between relative fluorescence intensity and H2S concentration with the detection limit (LOD) of 0.64 μM. The sensing mechanism of Eu(tdl)2abp to detect H2S was characterized by 1H NMR and HR-MS. Eu(tdl)2abp was used with success for the sensitive detection of H2S in natural water and living cells.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gao, Xu-Sheng; Dai, Hai-Jie; Tang, Yuerou; Ding, Mei-Juan; Pei, Wen-Bo; Ren, Xiao-Ming published the artcile< Crystal Structures, Photoluminescence, and Magnetism of Two Novel Transition-Metal Complex Cocrystals with Three-Dimensional H-Bonding Organic Framework or Alternating Noncovalent Anionic and Cationic Layers>, Category: pyridine-derivatives, the main research area is copper zinc bipyridine benzenedicarboxylate cocrystal photoluminescence magnetism crystal structure; transition metal complex cocrystal hydrogen bonding organic framework.

Cocrystn. may alter material physicochem. properties; thus, the strategy of forming a cocrystal is generally used to improve the material performance for practical applications. In this study, two transition-metal complex cocrystals [Zn(bpy)3]H0.5BDC·H1.5BDC·0.5bpy·3H2O (1) and [Cu2(BDC)(bpy)4]BDC·bpy·2H2O (2) have been achieved using a hydrothermal reaction, where bpy and H2BDC represent 2,2′-bipyridine and benzene-1,3-dicarboxylic acid, resp. Cocrystals were characterized by microanal., IR spectroscopy, and UV-visible spectroscopy. Cocrystal 1 contains five components and crystallizes in a monoclinic space group P21/n. The H0.5BDC1.5-, H1.5BDC0.5-, and H2O mols. construct three-dimensional H-bonding organic framework; the [Zn(bpy)3]2+ coordination cations and uncoordinated bpy mols. reside in channels, where two coordinated bpy ligands in [Zn(bpy)3]2+ and one uncoordinated bpy adopt sandwich-type alignment via π···π stacking interactions. Cocrystal 2 with four components crystallizes in a triclinic space group P-1 to form alternating layers; the binuclear [Cu2(bpy)4(BDC)]2+ cations and uncoordinated bpy mols. build the cationic layers, and the BDC2- species with disordered lattice water mols. form the anionic layers. Cocrystal 1 shows intense photoluminescence at an ambient condition with a quantum yield of 14.96% and decay time of 0.48 ns, attributed to the π* → π electron transition within phenyl/pyridyl rings, and 2 exhibits magnetic behavior of an almost isolated spin system with rather weak antiferromagnetic coupling in the [Cu2(bpy)4(BDC)]2+ cation.

ACS Omega published new progress about Antiferromagnetic exchange. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hooda, Anjli; Nehra, Kapeesha; Dalal, Anuj; Singh, Sitender; Kumar Saini, Raman; Kumar, Sanjay; Singh, Devender published the artcile< Terbium complexes of an asymmetric β-diketone: Preparation, photophysical and thermal investigation>, Formula: C10H8N2, the main research area is preparation terbium asym beta diketonate substituted bipyridin complex; thermal decomposition terbium asym beta diketonate substituted bipyridin complex; luminescence terbium asym beta diketonate substituted bipyridin complex; emission spectra terbium asym beta diketonate substituted bipyridin complex; band gap terbium asym beta diketonate substituted bipyridin complex; cyclic voltammetry terbium asym beta diketonate substituted bipyridin complex; chromaticity terbium asym beta diketonate substituted bipyridin complex.

Chromophoric 1,3-diketone ligand was used to prepare novel ternary complexes of terbium with differently substituted 2,2′-bipyridines as auxiliary ligands. These prepared complexes were thoroughly studied with the help of numerous spectroscopic techniques. IR spectral anal. suggested the coordination of diketone and ancillary ligand to the Tb(III) ion through oxygen and nitrogen atom, resp. Photoluminescence emission spectra of complexes have displayed only characteristic peaks of Tb3+ ion suggesting the efficient sensitization of metal ion by chromophoric ligands. Emission spectra of all complexes have displayed the ligand sensitized green emission due to the 5D4→7F5 transition situated at ∼548 nm. Colorimetric study and color purity of complexes reveal the green luminous character of synthesized complexes. Thermogravimetric measurements revealed the thermal stability of the complexes. Optical and electronic band gaps are in good agreement with each other that shows their importance as semiconductor material. These trivalent complexes of terbium could be used as the green component in displays and light emissive materials.

Inorganica Chimica Acta published new progress about Absorption spectra. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sung, Hui-Ling; Hu, Zhi-Jia; Chen, Chong-You; Wu, Jing-Yun published the artcile< Thermally stable dinuclear Co(II) and Zn(II) complexes of tetra-phosphonate and 2,2'-bipyridine>, Quality Control of 366-18-7, the main research area is tetrakis phosphorylmethyl benzene dinuclear cobalt zinc bipyridine preparation structure; crystal mol structure dinuclear cobalt zinc bipyridine tetra phosphonate.

Two dinuclear phosphonate-based transition metal complexes, [Co2(H6tpmb)2(2,2′-bipy)2(H2O)2] (1) and [Zn2(H6tpmb)2(2,2′-bipy)2] (2), have been synthesized at 60° by the reactions of 1,2,4,5-tetrakis(phosphorylmethyl)benzene (H8tpmb) and 2,2′-bipyridine (2,2′-bipy) ligands, with CoCl2·6H2O and Zn(NO3)2·6H2O, resp. These two complexes are characterized by single-crystal x-ray diffraction, XRD, IR and elemental anal. Complexes 1 and 2 both adopt dinuclear macrocycle structures in which the Co(II) center in the former has an octahedral coordination geometry of {CoN2O4} while the Zn(II) center in the latter shows a square pyramidal coordination geometry of {ZnN2O3} with a τ value of 0.01. The H8tpmb ligand adopting the cis,trans,cis,trans conformation was partially deprotonated to be the H6tpmb2- dianion in both complexes 1 and 2. TG anal. shows that complexes 1 and 2 both are thermally stable upon heating to 250°.

Inorganica Chimica Acta published new progress about Coordination sphere. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Quality Control of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wan, Yupeng; Lyu, Heng; Du, Hengyi; Wang, Dunjia; Yin, Guodong published the artcile< Synthesis and photophysical properties of europium pentafluorinated β-diketonate complexes>, Product Details of C10H8N2, the main research area is preparation europium pentafluorinated beta diketonate dipyridine phenanthroline complex; photoluminescence europium pentafluorinated beta diketonate dipyridine phenanthroline complex; thermal decomposition europium pentafluorinated beta diketonate dipyridine phenanthroline complex.

Two pentafluorinated β-diketone ligands, 4,4,5,5,5-pentafluoro-1-(4-methoxyphenyl)pentane-1,3-dione (PFMP) and 4,4,5,5,5-pentafluoro-1-(4-dimethyl amino-phenyl)pentane-1,3-dione (PFAP), had been employed to synthesize six novel europium(III) complexes with ancillary ligands 2,2-dipyridine, 1,10-phenanthroline and 4,7-diphenyl-1,10-phenanthroline. The synthesized europium(III) complexes were characterized by FTIR, 1H NMR, UV-visible, luminescence spectroscopy, elemental anal. and TGA. The photoluminescence spectra of these complexes showed the typical europium(III) red emissions in solid state and chloroform solution, assigned to 5D0 → 7Fj (j = 0-4) transitions. The higher values of intensity parameter Ω2 indicated that the europium ion was in a highly polarizable ligand field in these complexes. Europium(III) complexes with the β-diketone PFMP exhibited much better photoluminescence properties than complexes with the β-diketone PFAP. Especially, the europium(III) complex of the β-diketone PFMP with the auxiliary ligand 2,2-dipyridine displayed the longest lifetime value, the highest quantum yield and good CIE color coordinates matching the pure red color (x = 0.67, y = 0.33) in these complexes. In addition, the proposed energy transfer mechanisms and the thermal stability of these complexes were also studied and analyzed.

Research on Chemical Intermediates published new progress about Emission spectra. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Product Details of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Amthor, Sebastian; Braun, Hanna; Groene, Julius; Nauroozi, Djawed; Jacob, Timo; Rau, Sven published the artcile< Tailored protective groups for surface immobilization of ruthenium dyes>, Application of C10H8N2, the main research area is phosphonatomethyl silylphosphonatomethyl bipyridine ruthenium complex preparation surface immobilization dye.

McKenna reaction conditions are applied to the [Ru(4,4′-(CH2PO3Et2)2)(bpy)](PF6)2 model chromophore in order to obtain [Ru(4,4′-(CH2PO3TMS2)2)(bpy)](Br2-x)(PF6)x (x = 0-2) (2) by replacing the alkyl moieties of the phosphonates with TMS groups (TMS = trimethylsilyl). The model complex is immobilized onto both NiO powder and NiO electrodes on FTO (fluorine doped tin oxide) using organic solvents. The stability of surface binding in aqueous media and the DSC performance of 2 are tested and compared to those of a conventional dye of structure [Ru(4,4′-(CH2PO3TBA2)2)(bpy)](PF6)2 (1) (TBA = tetra-Bu ammonium). This is the first example of a ruthenium based chromophore with a phosphonic acid silyl-ester being directly immobilized onto a NiO surface. In addition, complex 2 exhibits superior stability towards desorption in aqueous media and at the same time showing improved DSC performance and stability in acetonitrile and a slightly higher dye loading on the electrode surface compared to 1.

Dalton Transactions published new progress about Chromophores. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oftadeh, Mohsen; Barfarakh, Zahra; Ravari, Fatemeh published the artcile< Luminescent excited-state intramolecular proton-transfer dyes based on 4-functionalized 6,6′-dimethyl-3,3′-dihydroxy-2,2′-bipyridine (BP(OH)2-Rs); DFT simulation study>, Application of C10H8N2, the main research area is ESIPT process; Excited state; Functionalized bipyridine dyes; Luminescence; Simulation.

The 4-functionalized 6,6′-dimethyl-3,3′-dihydroxy-2,2′-bipyridine dyes (BP(OH)2-Rs) have exhibited dienol and diketo emissions. The optimum geometrical structures for ground, singlet and triplet excited states are computed by DFT/B3LYP/6-31++G that showed the planarity of BP(OH)2-Rs structure. The emission spectra of the mols. are determined in the gas-phase at singlet and triplet excited states using CIS/6-31++G. The theor. calculations are carried out for BP(OH)2-Rs to understand the impact of different substituents (R = -H (I), -Br (II), -TMS (III), -C2H (IV), -terpyridine (V) and -bodipy (diazaboraindacene) (VI)) on excited-state intramol. proton transfer (ESIPT) in singlet and triplet excited states. Based on the calculations, the concerted diproton transfer proceeds in the triplet excited state, in which nπ* state has a significant participation in ESIPT. The spectral variation at ESIPT emission of BP(OH)2-Rs is influenced by the electron-acceptor ability of the substituents. The compound V revealed a higher spectral intensity compared to the others. From the comparison with the exptl. data, the mol. V is almost planar agreed with the X-ray structure and trend variation of wavelengths. The mol. VI contains bodipy chromophore that excitation energy transfers completely from BP(OH)2 core to a bodipy substituent, leading to emission from the lowest-lying bodipy substituent, and consequently, ESIPT does not occur for this dye.

Journal of Molecular Graphics & Modelling published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Anisimov, Anton A.; Vysochinskaya, Yulia S.; Kononevich, Yuriy N.; Dolgushin, Fedor M.; Muzafarov, Aziz M.; Shchegolikhina, Olga I. published the artcile< Polyhedral phenylnickelsodiumsiloxanolate transformation in the presence of aromatic nitrogen-containing ligands>, Recommanded Product: 2,2′-Bipyridine, the main research area is nickel sodium polyhedral phenyl siloxanolate complex preparation crystal structure.

Two new polyhedral phenylmetallasiloxane complexes, {[PhSi(O)O-]6(Ni2+)6(Na+)2(μ3-OH)2[PhSi(O)O-]6}•2(BIPY)•4(DMF) (1) and {[PhSi(O)O-]6(Ni2+)3(Na+)6(μ5-OH)2[PhSi(O)O-]5}•7(PY)•2(BuOH)•2(H2O) (2) formed in the process of recrystallization of polyhedral phenylnickelsodiumsiloxane (Na+)2{[PhSi(O)O-]6(Ni2+)4(Na+)4(μ3-OH)2[PhSi(O)O-]6}•16(BuOH) (A) from DMF in the presence of 2,2-bipyridine (complex 1) or from pyridine (complex 2) are described. σ-Donor ligands of the pyridine series (pyridine and 2,2-bipyridine) play a crucial role in the process of dissociation of the initial metallasiloxane framework and its reassembly on a new matrix of metal ions. Not only the metal-containing cationic layer is reconstructed with a change in the number, ratio, and spatial arrangement of nickel and sodium cations, but also changes the size of cyclic siloxane ligands.

Inorganica Chimica Acta published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Recommanded Product: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem