Category: 366-18-7

Oyamada, Nobuaki; Minamimoto, Hiro; Murakoshi, Kei published the artcile< Room-Temperature Molecular Manipulation via Plasmonic Trapping at Electrified Interfaces>, Safety of 2,2′-Bipyridine, the main research area is plasmonic trapping electrified interface Raman spectra optical tweezers.

For the motion control of individual mols. at room temperature, optical tweezers could be one of the best approaches to realize desirable selectivity with high resolution in time and space. Because of phys. limitations due to the thermal fluctuation, optical manipulation of small mols. at room temperature is still a challenging subject. The difficulty of the manipulation also emerged from the variation of mol. polarizability depending on the choice of mols. as well as the mol. orientation to the optical field. In this article, we have demonstrated plasmonic optical trapping of small size mols. with less than 1 nm at the gap of a single metal nanodimer immersed in an electrolyte solution In situ electrochem. surface-enhanced Raman scattering measurements prove that a plasmonic structure under electrochem. potential control realizes not only the selective mol. condensation but also the formation of unique mixed mol. phases which is distinct from those under a thermodn. equilibrium Through detailed analyses of optical trapping behavior, we established the methodol. of plasmonic optical trapping to create the novel adsorption isotherm under applying an optical force at electrified interfaces.

Journal of the American Chemical Society published new progress about Chemical potential. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qin, Yin; Li, Yilin; Guo, Kaimeng; Tang, Huabiao; Hou, Lifen; Li, Gang published the artcile< Water-assisted proton conductivity of two highly stable imidazole multi-carboxylate-based MOFs>, Safety of 2,2′-Bipyridine, the main research area is crystal structure manganese zinc carboxylimidazoledicarboxylate bipyridine metal organic framework; manganese zinc carboxylimidazoledicarboxylate bipyridine MOF preparation proton conductivity.

Two new chain-like metal-organic frameworks (MOFs), {[Mn(o-CPhH2IDC)(4.4′-bipy)0.5(H2O)2]·3H2O}n (1) (o-CPhH4IDC = 2-phenyl(2-carboxyl)-1-H-imidazole-4,5-dicarboxylic acid; 4,4′-bipy = 4,4′-bipyridine) and {[Zn5(o-CPhH2IDC)2(o-CPhHIDC)2(2,2′-bipy)5]·5H2O}n (2) (2,2′-bipy = 2,2′-bipyridine) were designed and solvothermally or hydrothermally synthesized and structurally characterized. By SEM determinations and PXRD analyses, the high H2O stability and acid and alkali resistance of both MOFs were determined The affluent H-bond networks inside the frameworks formed by imidazole multi-carboxylate ligands and H2O mols. would favor the transfer of protons. Also, the temperature- and humidity-dependent proton conduction properties of the two MOFs were demonstrated. Also, the proton conducting mechanisms will be highlighted herein.

New Journal of Chemistry published new progress about Activation energy (proton conductivity). 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Halevas, Eleftherios; Pekou, Anna; Papi, Rigini; Mavroidi, Barbara; Hatzidimitriou, Antonios G.; Zahariou, Georgia; Litsardakis, George; Sagnou, Marina; Pelecanou, Maria; Pantazaki, Anastasia A. published the artcile< Synthesis, physicochemical characterization and biological properties of two novel Cu(II) complexes based on natural products curcumin and quercetin>, Formula: C10H8N2, the main research area is copper curcumin quercetin bipyridine complex preparation crystal mol structure; antioxidant antiinflammatory DNA binding cleavage copper curcumin quercetin complex; Antioxidant activity; Copper complexes; Curcumin; DNA plasmid binding; Quercetin.

Curcumin and quercetin are two of the most prominent natural polyphenols with a diverse spectrum of beneficial properties, including antioxidant, anti-inflammatory, chemopreventive and chemotherapeutic activity. The complexation of these natural products with bioactive transition metal ions can lead to the generation of novel metallodrugs with enhanced biochem. and pharmacol. activities. Within this framework, the synthesis and detailed structural and physicochem. characterization of two novel complex assemblies of Cu(II) with curcumin and quercetin and the ancillary aromatic chelator 2,2′-bipyridine is presented. The two complexes represent the only crystallog. characterized structures with Cu(II) as the central metal ion and curcumin or quercetin as the ligands. The new complexes were biol. evaluated in vitro for their antioxidant potential, both exhibiting strong scavenging activity in the 2,2-diphenyl-1-picrylhydrazyl assay, and their plasmid DNA binding/cleavage properties. Both complexes appear to be non-toxic in the eukaryotic exptl. model Saccharomyces cerevisiae and merit further investigation of their pharmacol. profile.

Journal of Inorganic Biochemistry published new progress about Anti-inflammatory agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aramesh-Boroujeni, Zahra; Bordbar, Abdol-Khalegh; Khorasani-Motlagh, Mozhgan; Sattarinezhad, Elham; Fani, Najme; Noroozifar, Meissam published the artcile< Synthesis, characterization, and binding assessment with human serum albumin of three bipyridine lanthanide(III) complexes>, HPLC of Formula: 366-18-7, the main research area is bipyridine lanthanide complex HAS mol docking binding affinity; Bpy, 2,2′-bipyridine; BpyDy, bipyridine dysprosium(III); BpyLn, bipyridine lanthanide; BpyTb, bipyridine terbium(III); binding interaction; fluorescence spectroscopy; human serum albumin; lanthanide complex; molecular docking.

In this work, the terbium(III), dysprosium(III), and ytterbium(III) complexes containing 2, 2′-bipyridine (bpy) ligand have been synthesized and characterized using CHN elemental anal., FT-IR, UV-Vis and 1H-NMR techniques and their binding behavior with human serum albumin (HSA) was studied by UV-Vis, fluorescence and mol. docking examinations The exptl. data indicated that all three lanthanide complexes have high binding affinity to HSA with effective quenching of HSA fluorescence via static mechanism. The binding parameters, the type of interaction, the value of resonance energy transfer, and the binding distance between complexes and HSA were estimated from the anal. of fluorescence measurements and Forster theory. The thermodn. parameters suggested that van der Waals interactions and hydrogen bonds play an important role in the binding mechanism. While, the energy transfer from HSA mols. to all these complexes occurs with high probability, the order of binding constants (BpyTb > BpyDy > BpyYb) represents the importance of radius of Ln3+ ion in the complex-HSA interaction. The results of mol. docking calculation and competitive experiments assessed site 3 of HSA, located in subdomain IB, as the most probable binding site for these ligands and also indicated the microenvironment residues around the bound mentioned complexes. The computational results kept in good agreement with exptl. data.

Journal of Biomolecular Structure and Dynamics published new progress about Binding energy. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, HPLC of Formula: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cotton, Simon A.; Raithby, Paul R.; Schiffers, Stephanie; Teat, Simon J.; Warren, John E. published the artcile< The Synthesis and Structure of a Scandium Nitrate Hydroxy-Bridged Dimeric Complex Supported by Bipyridyl Ligands †>, Application of C10H8N2, the main research area is crystal structure; eight coordinate complex; hydroxy group; nitrate complex; scandium complex.

The current discussion on whether scandium, yttrium and lanthanum should represent Group 3 in the Periodic Table or whether lutetium should replace lanthanum in the group has prompted us to further explore the structural chem. of the Group 3 elements and compare the coordination numbers and coordination geometries adopted. The steric and electronic properties of the coordinated ligands have a major influence on the structures adopted. We report the synthesis and crystal structure determination of an unusual dinuclear scandium complex [(bipy)(NO3)2Sc(μ-OH)2Sc(NO3)2(bipy)] obtained by the reaction of hydrated scandium nitrate with 2,2′-bipyridyl (bipy) in either ethanol or nitromethane. The crystal structure of the complex shows that the scandium centers are eight coordinate, and the structure obtained contrasts with related complexes found in the lanthanide series [Ln(bipy)2(NO3)3] and [Ln(phen)2(NO3)3] (phen = phenanthroline) and in [M(terpy)(NO3)3] (M = Sc, Er-Lu), where these complexes are all mononuclear.

Molecules published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nisbet, Matthew L.; Hiralal, Emily; Poeppelmeier, Kenneth R. published the artcile< Crystal structures of three copper(II)-2,2′-bipyridine (bpy) compounds, [Cu(bpy)2(H2O)]-[SiF6]·4H2O, [Cu(bpy)2(TaF6)2] and [Cu(bpy)3][TaF6]2 and a related coordination polymer,[Cu(bpy)(H2O)2SnF6]n>, COA of Formula: C10H8N2, the main research area is copper bipyridine compound coordination polymer crystal structure; copper; crystal structure; d0 early transition metal; hydro­thermal synthesis; main group; racemic compounds.

We report the hydrothermal syntheses and crystal structures of aquabis(2,2′-bipyridine-κ2N,N′)copper(II) hexafluoridosilicate tetrahydrate, [Cu(bpy)2(H2O)]-[SiF6]·4H2O (bpy is 2,2′-bipyridine, C10H8N2), (I), bis(2,2′-bipyridine-3κ2N,N′)-di-μ-fluorido-1:3κ2F:F;2:3κ2F:F-decafluorido-1κ5F,2κ5F-ditantalum(V)copper(II),[Cu(bpy)2(TaF6)2], (II), tris(2,2′-bipyridine-κ2N,N′)copper(II) bis[hexafluoridotantalate(V)], [Cu(bpy)3][TaF6]2, (III), and catena-poly[[diaqua(2,2′-bipyridine-κ2N,N′)copper(II)]-μ-fluorido-tetrafluoridotin-μ-fluorido], [Cu(bpy)(H2O)2SnF6]n, (IV). Compounds (I), (II) and (III) contain locally chiral copper coordination complexes with C2, D2, and D3 symmetry, resp. The extended structures of (I) and (IV) are consolidated by O-H····F and O-H····O hydrogen bonds. The structure of (III) was found to be a merohedral (racemic) twin.

Acta Crystallographica, Section E: Crystallographic Communications published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gomes, Emmanuel M.; Franco, Douglas F.; Scarpari, Sergio L.; Colaco, Marcos V.; Ferreira, Monica S.; Freire, Ricardo O.; Marques, Lippy F. published the artcile< Study of energy transfer mechanism in the EuIII and GdIII homobimetallic complexes containing the anti-inflammatory drug naproxen and N,N-donors ligands>, Safety of 2,2′-Bipyridine, the main research area is naproxen homobimetallic complex donors ligand antiinflammatory agent energy transfer.

In this work, we present the synthesis, solid state characterization and complete photoluminescence study of new important homobimetallic lanthanide complexes containing the non-steroidal anti-inflammatory drug (NSAID) naproxen. The anal. and spectroscopic techniques reveals the formation of eight compounds of general formula [Ln2(nap)6(H2O)4] (Eu 1 and Gd 2), [Ln2(nap)6(bpy)2] (Eu 3 and Gd 4), [Ln2(nap)6(4,4′-dmbpy)2] (Eu 5 and Gd 6) and [Ln2(nap)6(phen)2] (Eu 7 and Gd 8), where: nap = naproxen ligand, bpy =2,2′-bipyridine, 4,4′-dmbpy = 4,4′-dimethyl-2,2′-bipyridine and phen = 1,10-phenanthroline. Using the RM1 model, the mol. structures of the EuIII complexes were calculated, with your optimized ground state geometries used to obtain all details involved in the energy transfer process. From the resp. GdIII complexes were obtained the lowest ligand triplet states, proving that the photoluminescence in the EuIII naproxen complexes is proposed to be a ligand sensitized luminescence process. On the other hand, the position of the triplet states also explains the non-effective energy transfer in the TbIII naproxen complexes. The presence of N,N-donors ligands (bpy, 4,4′-dmbpy and phen) results in an 3-4-fold increase in the quantum efficiency when compared with the EuIII complex without nitrogen ligands. The high values of emission quantum efficiency (η ∼ 70 – 98%) show the EuIII complexes can be potential candidates as emitters in biol. assays.

Journal of Luminescence published new progress about Anti-inflammatory agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qin, Qi-Pin; Wang, Zhen-Feng; Tan, Ming-Xiong; Huang, Xiao-Ling; Zou, Hua-Hong; Zou, Bi-Qun; Shi, Bei-Bei; Zhang, Shu-Hua published the artcile< Complexes of lanthanides(III) with mixed 2,2'-bipyridyl and 5,7-dibromo-8-quinolinoline chelating ligands as a new class of promising anti-cancer agents>, Application of C10H8N2, the main research area is cervical ovarian cancer lanthanide III metal chelation.

Five novel lanthanides(III) complexes, [Lu(Me)(MBrQ)2NO3] (MeMBrQ-Lu), [Ho(MeO)(MBrQ)2NO3] (MeOMBrQ-Ho), [Ho(Me)(MBrQ)2NO3] (MeMBrQ-Ho), [La(Me)2(BrQ)2NO3] (MeBrQ-La) and [Sm(Me)(BrQ)2(CH3OH)NO3] (MeBrQ-Sm) were synthesized in which 2,2′-bipyridyl (4,4′-dimethyl-2,2′-bipyridyl (Me) and 4,4′-dimethoxy-2,2′-bipyridine (MeO)) and 5,7-dibromo-8-quinolinoline derivatives (5,7-dibromo-2-methyl-8-quinolinol (MBrQ-H) and 5,7-dibromo-8-quinolinol (BrQ-H)) act as chelating ligands. The in vitro cytotoxic activities of five Ln(III) complexes have been studied with SK-OV-3/DDP, NCI-H460 and HeLa cancer cells. MeMBrQ-Lu, MeOMBrQ-Ho, MeMBrQ-Ho, MeBrQ-La and MeBrQ-Sm show higher cytotoxicity against the HeLa cells than cisplatin (13.11 ± 0.53 μM). In particular, the MeOMBrQ-Ho and MeMBrQ-Ho complexes exhibit superior cytotoxic activity, with IC50 values at 1.00 ± 0.34 nM and 125.00 ± 1.08 nM. We further demonstrate that MeOMBrQ-Ho and MeMBrQ-Ho inhibit the proliferation of HeLa cells by inhibiting telomerase and targeting mitochondria to induce DNA damage-mediated apoptosis. In addition, MeOMBrQ-Ho significantly inhibits tumor growth with a tumor growth inhibition rate (IR) of 50.8% in a HeLa mouse xenograft model. Taken together, MeOMBrQ-Ho is a novel lanthanide(III) complex with promising antitumor activity.

Metallomics published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Meng; Mu, Yan-Fei; Yao, Shuang; Guo, Song; Guo, Xiang-Wei; Zhang, Zhi-Ming; Lu, Tong-Bu published the artcile< Photosensitizing single-site metal-organic framework enabling visible-light-driven CO2 reduction for syngas production>, Recommanded Product: 2,2′-Bipyridine, the main research area is photosensitizing MOF carbon reduction syngas.

Photocatalytic CO2 reduction into syngas (CO and H2) is one of sustainable strategies for recycling CO2 into value-added products. Herein, a simple and effective two-step self-assembly process was developed to functionalize phosphorescent metal-organic framework (MOF) with single site catalyst. The resulting (Co/Ru)n-UiO-67(bpydc) supplied mol. platform to enable fast multielectron injection from photosensitizers (PSs) to Co-catalyst, leading to the first MOF-based composite photocatalyst for efficient syngas production with a yield of 13,600μmol·g-1 (H2 : CO = 2 : 1) in 16 h, 29.2-fold higher than that of its homogeneous counterpart. The H2/CO ratios can be well controlled by carefully adjusting the molar ratio of PS/catalyst in the MOF platform and the water content in the photocatalytic system. This work provides a prospective strategy for recycling CO2 into H2-rich syngas by merging PSs and single-site catalysts into a MOF platform.

Applied Catalysis, B: Environmental published new progress about Photocatalysts. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Recommanded Product: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gurgul, Ilona; Janczy-Cempa, Ewelina; Mazuryk, Olga; Lekka, Malgorzata; Lomzik, Michal; Suzenet, Franck; Gros, Philippe C.; Brindell, Malgorzata published the artcile< Inhibition of Metastasis by Polypyridyl Ru(II) Complexes through Modification of Cancer Cell Adhesion - In Vitro Functional and Molecular Studies>, COA of Formula: C10H8N2, the main research area is polypyridyl ruthenium complex cancer metastasis cell adhesion.

The effect of polypyridyl Ru(II) complexes on the ability of cancer cells to migrate and invade, two features important in the formation of metastases, is evaluated. In vitro studies are carried out on breast cancer cell lines, MDA-MB-231 and MCF-7, as well as melanoma cell lines A2058 and A375. Three Ru(II) complexes comprising two 4,7-diphenyl-1,10-phenanthroline (dip) ligands and as a third ligand 2,2′-bipyridine (bpy), or its derivative with either 4-[3-(2-nitro-1H-imidazol-1-yl)propyl] (bpy-NitroIm), or 5-(4-{4′-methyl-[2,2′-bipyridine]-4-yl}but-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone (bpy-SC) moiety attached are examined The low sub-toxic doses of the studied compounds greatly affected the cancer cells by inhibiting cell detachment, migration, invasion, transmigration, and re-adhesion, as well as increasing cell elasticity. The mol. studies revealed that the Ru(II) polypyridyl complexes impact the activity of the selected integrins and upregulate the expression of focal adhesion components such as vinculin and paxillin, leading to an increased number of focal adhesion contacts.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem