Category: 366-18-7

Schwarze, Benedikt; Sobottka, Sebastian; Schiewe, Robert; Sarkar, Biprajit; Hey-Hawkins, Evamarie published the artcile< Spectroscopic and Electronic Properties of Molybdacarborane Complexes with Non-innocently Acting Ligands>, Formula: C10H8N2, the main research area is molybdacarborane containing bipyridine phenanthroline noninnocent ligand preparation electrochem; crystal structure molybdacarborane containing bipyridine phenanthroline noninnocent ligand; mol structure molybdacarborane containing bipyridine phenanthroline noninnocent ligand; Raman spectroscopy; carborane; density functional theory calculations; molybdacarborane; spectroelectrochemistry.

The molybdacarboranes [3-{L-κ2N,N}-3-(CO)2-closo-3,1,2-MoC2B9H11] (L = 2,2′-bipyridine (2,2′-bpy, 1a) or 1,10-phenanthroline (1,10-phen, 1b)) incorporating known potentially noninnocent ligands (CO, 2,2′-bpy, 1,10-phen) and the nonspectator nido-carborane ([η5-C2B9H11]2-) ligand were prepared and fully characterized. High-resolution mass spectrometry, single-crystal x-ray diffraction methods, spectroscopy (IR, (resonance) Raman, NMR), cyclic voltammetry and spectroelectrochem. (electrochem. properties) were supported by theor. studies of the electronic structure (DFT, CAS-SCF, TD-DFT).

Chemistry – A European Journal published new progress about Carboranes Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation) (molybdacarboranes containing N,N-donor ligands). 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sharma, Pranay; Gogoi, Anshuman; Verma, Akalesh K.; Frontera, Antonio; Bhattacharyya, Manjit K. published the artcile< Charge-assisted hydrogen bond and nitrile···nitrile interaction directed supramolecular associations in Cu(II) and Mn(II) coordination complexes: anticancer, hematotoxicity and theoretical studies>, COA of Formula: C10H8N2, the main research area is crystal structure copper bipyridine manganese cyanopyridine aqua compound; copper bipyridine manganese cyanopyridine preparation anticancer hematotoxicity activity.

Two new coordination complexes of Cu(II) and Mn(II), viz., [Cu(bpy)(H2O)4]SO4·2H2O (1) and [Mn(4-CNpy)2(H2O)3SO4]·H2O (2) (bpy = 2,2′-bipyridine, 4-CNpy = 4-cyanopyridine), were synthesized and characterized by using single crystal x-ray diffraction, elemental anal., FTIR spectroscopy, electronic spectroscopic techniques and TGA. The crystal structure of 1 uncovers the formation of sulfate-H2O assemblies involving lattice and coordinated H2O mols., while 2 reveals unconventional weak T-shaped CN···CN contacts in the layered architecture. The authors analyzed the unconventional interesting interactions using DFT calculations, mol. electrostatic potential (MEP), the NCI plot and QTAIM computational tools. The interaction energies of the two H-bonded dimers in 1 are very large because of the coulombic attraction between the dicationic H-bonded donor and the dianionic acceptor. It is interesting to observe that despite the energy of the H-bonds being very small compared to the total dimerization energy, the final geometry of the assembly in 1 is due to the charge assisted directional H-bonds instead of the nondirectional ion-pair interactions. The DFT study reveals that the T-shaped CN···CN interaction in 2 is very weak, in good agreement with the small MEP energy at the nitrile C atom. Anticancer studies of the compounds were carried out using Dalton’s lymphoma cell line using MTT and apoptosis assay. The results of compound 1 and 2 mediated cell cytotoxicity on the DL cancer cell line showed a significant concentration-dependent reduction in cell viability, while negligible cytotoxicity was observed in normal (PBMC) cells. The docking simulation results also confirm the interaction of the complexes with the active sites of amino acids of the target proteins. Also, pharmacophore models (2-dimensional and 3-D) for the compounds were mapped to the H-bond donor, pos. ionizable area and hydrophobic features that are important for establishing biol. activities. No hematotoxicity was recorded for the compounds after treatment in normal mice.

New Journal of Chemistry published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Carnizello, Andrea P.; Alves, Jacqueline M.; Pereira, Daiane E.; Campos, Jacqueline C. L.; Barbosa, Marilia I. F.; Batista, Alzir A.; Tavares, Denise C. published the artcile< Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct-[RuCl(CO)(dppb)(bipy)]PF6 [dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2′-bipyridine], by in vitro and in vivo assays>, SDS of cas: 366-18-7, the main research area is cytotoxicity genotoxicity carbonyl ruthenium assay; carbonyl ruthenium complexes; comet assay; genotoxic potential; micronucleus test.

Considering the promising previous results of ct-[RuCl(CO)(dppb)(bipy)]PF6 (where dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2′-bipyridine) as an antitumor agent, novel biol. assays evaluating its toxicogenic potential were performed. The genotoxicity of the compound was evaluated by the in vitro micronucleus test (V79, Chinese hamster lung fibroblasts; HepG2, hepatocellular carcinoma cells), in vivo bone marrow micronucleus test and comet assay in hepatocytes (Swiss mice). The animals were treated with 0.63, 1.25, 2.5 and 5.0 mg/kg body weight (bw) of the compound Neg. (water) and pos. (cisplatin, 1.5 mg/kg bw; Me methanesulfonate, 40 mg/kg bw) controls were included. The parameters considered in the comet assay were the percentage of tail DNA, tail moment and tail length. The results of the in vitro micronucleus tests showed the absence of genotoxicity in V79 cells, while the compound was genotoxic in HepG2 cells at a concentration of 1.25 microM. In the in vivo micronucleus test, the compound was not genotoxic at the different doses evaluated. In the comet assay, only the dose of 5.0 mg/kg bw resulted in a significant increase in the frequency of DNA damage in hepatocytes when compared to the neg. control. The genotoxic effect observed in HepG2 cells and in the liver comet assay indicates that the compound was metabolized by hepatic cells.

Journal of Applied Toxicology published new progress about Analysis. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, SDS of cas: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lin, Qiao; Fu, Yue; Liu, Peng; Diao, Tianning published the artcile< Monovalent Nickel-Mediated Radical Formation: A Concerted Halogen-Atom Dissociation Pathway Determined by Electroanalytical Studies>, HPLC of Formula: 366-18-7, the main research area is monovalent Nickel Mediated radical; concerted Halogen Atom dissociation pathway electroanal.

The recent success of nickel catalysts in stereoconvergent cross-coupling and cross-electrophile coupling reactions partly stems from the ability of monovalent nickel species to activate C(sp3) electrophiles and generate radical intermediates. This electroanal. study of the commonly applied (bpy)Ni catalyst elucidates the mechanism of this critical step. Data rule out outer-sphere electron transfer and two-electron oxidative addition pathways. The linear free energy relationship between rates and the bond-dissociation free energies, the electronic and steric effects of the nickel complexes and the electrophiles, and DFT calculations support a variant of the halogen-atom abstraction pathway, the inner-sphere electron transfer concerted with halogen-atom dissociation This mechanism accounts for the observed reactivity of different electrophiles in cross-coupling reactions and provides a mechanistic rationale for the chemoselectivity obtained in cross-electrophile coupling over homocoupling.

Journal of the American Chemical Society published new progress about Computational chemistry. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, HPLC of Formula: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Jun; Xu, Guan-Cheng; Zhang, Yan-Ping; Luo, Hua-Ying; Li, Jin-Yao; Zhang, Li; Jia, Dian-Zeng published the artcile< Copper(II) complexes with 4-acyl pyrazolone derivatives and diimine coligands: synthesis, structural characterization, DNA binding and antitumor activity>, Product Details of C10H8N2, the main research area is antitumor agent copper dipyridyl pyrazolone salicylidene derived complex; crystal structure copper dipyridyl pyrazolone salicylidene derived complex preparation; electrochem redox potential copper dipyridyl pyrazolone salicylidene derived complex.

Three mixed-ligand Cu(II) complexes [Cu(L)(bpy)] (1), [Cu(L)(phen)] (2) and [Cu(L)(dpq)]·CHCl3 (3) have been synthesized and fully characterized, where H2L = N-(1-phenyl-3-methyl-4-(4-fluorobenzoyl)-5-pyrazolone)-2-salicylidene hydrazide, bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline and dpq = dipyrido[3,2-d:2′,3′-f]quinoxaline. Single crystal x-ray diffraction anal. revealed that complexes 1-3 have mononuclear structure and the Cu(II) ions are located in a five-coordinated distorted square pyramidal geometry. The interaction of the compounds with herring sperm DNA has been studied by absorption titration, ethidium bromide displacement experiments and electrochem. studies. All the compounds could interact intercalatively with DNA, and complex 3 shows the highest DNA binding ability, followed by 2, 1 and H2L. Complexes 1-3 exhibit excellent cytotoxicity against cervical cancer HeLa cells and human esophageal cancer Eca-109 cells. Complex 3 displays the best activity for both cancer cell lines, and the IC50 values are 4.37 ± 0.08 μM and 3.68 ± 0.14 μM for HeLa and Eca-109 cells, resp., which are ∼13 times lower than that of the com. antitumor drug cisplatin. Moreover, complex 3 dose-dependently induces Eca-109 cell apoptosis characterized by nuclear morphol. changes and increased Annexin V+ cells, suggesting that complex 3 inhibited the proliferation of Eca-109 cells by induction of apoptosis. In conclusion, the mixed-ligand complex 3 might be a potential antitumor drug.

New Journal of Chemistry published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Product Details of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Grabner, Sabina; Modec, Barbara published the artcile< Zn(II) curcuminate complexes with 2,2′-bipyridine and carboxylates>, Recommanded Product: 2,2′-Bipyridine, the main research area is Zn(II) complexes; crystal structures; curcumin; stability.

Two novel zinc(II) compounds with curcuminate (abbreviated as cur-), [Zn(CH3COO)(cur)(bpy)] (1)·CH3OH·2H2O (bpy = 2,2′-bipyridine) and [Zn(PhCOO)(cur)(bpy)] (2)·CH3OH, have been synthesized and characterized. Their composition has been determined by single-crystal X-ray structure anal. Complexes 1 and 2 are similar: in both a five-fold coordination environment of zinc(II) consists of a monodentate carboxylate, a chelating bidentate 2,2′-bipyridine, and curcuminate, which is bound via a deprotonated 1,3-dione moiety. In 1, 2,2′-bipyridine nitrogen atoms and curcuminate oxygen atoms form the base of a square pyramid, whereas the acetate oxygen occupies its apex. The O3N2 donor set in 2 defines a polyhedron which more closely resembles a trigonal bipyramid. The packing in the crystal lattices of both compounds is governed by hydrogen-bonds. Complexes 1 and 2 display higher stability than curcumin in buffered media at pH = 7.0, however, the degradation of coordinated cur- is comparable to that of yellow pigment curcumin (curH) when the pH is raised to 7.2. Both complexes 1 and 2 in DMSO exhibit fluorescence with Stokes shifts of 5367 and 4634 cm-1, resp.

Molecules published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Recommanded Product: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Jun-Xia; Du, Zhong-Xiang; Pan, Qiu-Yue; Zhang, Lu-Lu; Liu, Duo-Li published the artcile< The first 3,5,6-trichloropyridine-2-oxyacetate bridged manganese coordination polymer with features of π···π stacking and halogen···halogen interactions: Synthesis, crystal analysis and magnetic properties>, Electric Literature of 366-18-7, the main research area is trichloropyridineoxyacetate bridged manganese bipyridine coordination polymer preparation crystal structure; pi stacking halogen interaction crystal structure magnetic property manganese.

A new coordination polymer [Mn(3,5,6-tcpa)2(2,2′-bipy)]n (1) has been synthesized by the hydrothermal reaction of manganese sulfate hydrate with 3,5,6-trichloropyridine-2-oxyacetic acid (3,5,6-Htcpa) and 2,2′-bipyridine (2,2′-bipy) coligands. The x-ray single-crystal diffraction anal. shows that the MnII center is in deformed octahedral geometry bonded by two pyridyl nitrogen atoms of 2,2′-bipy mol. and four carboxy oxygen atoms of four different 3,5,6-tcpa- ligands. The 3,5,6-tcpa- anions play as bidentate bridging-μ2 linkers and connect neighboring MnII ions together to form the 1D double-stranded chain structure of 1, which displays interesting chair form [Mn2(COO)2] eight-membered rings. 1 Is further assembled into 3D network by the co-effects of π···π stacking and Cl···Cl halogen bonds interactions. In addition, the magnetic characterizations indicated weak antiferromagnetic coupling between MnII centers for 1.

Inorganica Chimica Acta published new progress about Antiferromagnetic exchange. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Santana, Francielli Sousa; Briganti, Matteo; Cassaro, Rafael A. Allao; Totti, Federico; Ribeiro, Ronny Rocha; Hughes, David L.; Nunes, Giovana Gioppo; Reis, Dayane Mey published the artcile< An oxalate-bridged copper(II) complex combining monodentate benzoate, 2,2' -bipyridine and aqua ligands: synthesis, crystal structure and investigation of magnetic properties>, Safety of 2,2′-Bipyridine, the main research area is dinuclear copper(II); ferromagnetic interaction; magnetic properties; noncovalent interaction.

A dinuclear copper(II) complex of formula [{Cu(bipy)(bzt)(OH2)}2(μ-ox)] (1) (where bipy = 2,2′ -bipyridine, bzt = benzoate and ox = oxalate) was synthesized and characterised by diffractometric (powder and single-crystal XRD) and thermogravimetric (TG/DTG) analyses, spectroscopic techniques (IR, Raman, ESR spectroscopy (EPR) and electronic spectroscopy), magnetic measurements and d. functional theory (DFT) calculations The anal. of the crystal structure revealed that the oxalate ligand is in bis(bidentate) coordination mode between two copper(II) centers. The other four positions of the coordination environment of the copper(II) ion are occupied by one water mol., a bidentate bipy and a monodentate bzt ligand. An inversion center located on the ox ligand generates the other half of the dinuclear complex. Intermol. hydrogen bonds and π-π interactions are responsible for the organization of the mols. in the solid state. Molar magnetic susceptibility and field dependence magnetization studies evidenced a weak intramol.-ferromagnetic interaction (J = +2.9 cm-1) between the metal ions. The sign and magnitude of the calculated J value by d. functional theory (DFT) are in agreement with the exptl. data.

Molecules published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dhankhar, Priyanka; Bedi, Manisha; Khanagwal, Jyoti; Taxak, Vinod B.; Khatkar, Satyender P.; Doon, Priti Boora published the artcile< Photoluminescent report on red light emitting europium(III) complexes with heterocyclic acid>, Recommanded Product: 2,2′-Bipyridine, the main research area is red light emitting europium complex heterocyclic acid photoluminescence.

Five luminescent europium (III) carboxylate complexes have been synthesized by using ligand 3-isopropylpyrazole-5-carboxylic acid as primary ligand and 4,4′-dimethyl-2,2′-bipyridyl, 2,2′-bipyridyl, 5,6-dimethyl-1,10-phenanthroline and 1,10-phenanthroline as secondary ligands and characterized through various techniques. These complexes exhibit excellent thermal stability and characteristic europium centered photoemission spectra under the excitation of UV light. Luminescence decay curves, Judd-Ofelt anal., internal quantum efficiency and energy transfer mechanism have also been discussed. The color coordinates and color purity are calculated to investigate red emission of the complexes. The study results reveal that these complexes can be potentially used as red light emitting materials in various optoelectronic devices.

Spectroscopy Letters published new progress about Energy transfer. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Recommanded Product: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dalal, Anuj; Nehra, Kapeesha; Hooda, Anjli; Singh, Devender; Jakhar, Komal; Kumar, Sumit published the artcile< Preparation and photoluminescent characteristics of green Tb(III) complexes with β-diketones and N donor auxiliary ligands>, Product Details of C10H8N2, the main research area is terbium benzoylacetophenone bipyridine complex preparation band gap electrochem; Thermal stability color terbium benzoylacetophenone bipyridine.

This paper presents four octa coordinated ternary terbium complexes based on 2-benzoylacetophenone (BAP) and other auxiliary ligands. For characterization purpose, elemental anal., electrochem. study, thermal anal. and spectroscopic investigations were carried out in detail. Optical band gap (3-4 eV) of complexes was determined from Tauc’s relation. Upon excitation in UV region, emission spectra of complexes demonstrate peaks of Tb3+ ion at ∼616 nm, 589 nm, 548 nm, and 492 nm, attributed to 5D4 → 7FJ (J = 3 to 6) resp. due to energy transfer from ligand to Tb(III) ion via antenna effect. Peak at 548 nm corresponding to 5D4 → 7F5 is responsible for bright green emission of synthesized terbium complexes. CIE color coordinates and color purity further corroborate the green emission of Tb3+ complexes. The complexes were found to be quite stable as studied by thermal anal. The outcomes of characterizations have demonstrated that these complexes could behave as good contenders in lighting systems and displays owing to their photometric characteristics.

Inorganic Chemistry Communications published new progress about Color. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Product Details of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem