Category: 366-18-7

Karges, Johannes; Jakubaszek, Marta; Mari, Cristina; Zarschler, Kristof; Goud, Bruno; Stephan, Holger; Gasser, Gilles published the artcile< Synthesis and Characterization of an Epidermal Growth Factor Receptor-Selective RuII Polypyridyl-Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy>, Synthetic Route of 366-18-7, the main research area is EGFR RuII polypyridyl nanobody conjugate photosensitizer photodynamic therapy; bioinorganic chemistry; medicinal inorganic chemistry; metal-based drugs; metals in medicine; photodynamic therapy.

There is a current surge of interest in the development of novel photosensitizers (PSs) for photodynamic therapy (PDT), as those currently approved are not completely ideal. Among the tested compounds, we have previously investigated the use of RuII polypyridyl complexes with a [Ru(bipy)2(dppz)]2+ and [Ru(phen)2(dppz)]2+ scaffold (bipy=2,2′-bipyridine; dppz=dipyrido[3,2-a:2′,3′-c]phenazine; phen=1,10-phenanthroline). These complexes selectively target DNA. However, because DNA is ubiquitous, it would be of great interest to increase the selectivity of our PDT PSs by linking them to a targeting vector in view of targeted PDT. Herein, we present the synthesis, characterization, and in-depth photophys. evaluation of a nanobody-containing RuII polypyridyl conjugate selective for the epidermal growth factor receptor (EGFR) in view of targeted PDT. Using ICP-MS and confocal microscopy, we could demonstrate that our conjugate has high selectivity for the EGFR receptor, which is a crucial oncol. target because it is overexpressed and/or deregulated in a variety of solid tumors. However, in contrast to expectations, this conjugate was found to not produce reactive oxygen species (ROS) in cancer cells and is therefore not phototoxic.

ChemBioChem published new progress about Cytotoxicity. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Synthetic Route of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liang, Zhijie; Qiao, Yuanyuan; Li, Miaomiao; Ma, Pengtao; Niu, Jingyang; Wang, Jingping published the artcile< Two synthetic routes generate two isopolyoxoniobates based on {Nb16} and {Nb20}>, Safety of 2,2′-Bipyridine, the main research area is copper bipyridine isopolyoxoniobate preparation thermal stability; crystal structure copper bipyridine isopolyoxoniobate.

Self-assembly reactions of the Lindqvist-ion salt K7HNb6O19·13H2O, SeO2, and [Cu(2,2′-bipy)]2+ give, depending on different routes, two isopolyoxoniobates based on {Nb16} and {Nb20}, resp., which, as new members of the very limited isopolyoxoniobate family, are observed for the 1st time. Also, the solution behavior was studied to determine the stability of the {Nb16} cluster in water.

Dalton Transactions published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oelschlegel, Manuel; Hua, Shao-An; Schmid, Lucius; Marquetand, Philipp; Baeck, Anna; Borter, Jan-Hendrik; Luecken, Jana; Dechert, Sebastian; Wenger, Oliver S.; Siewert, Inke; Schwarzer, Dirk; Gonzalez, Leticia; Meyer, Franc published the artcile< Luminescent Iridium Complexes with a Sulfurated Bipyridine Ligand: PCET Thermochemistry of the Disulfide Unit and Photophysical Properties>, SDS of cas: 366-18-7, the main research area is crystallog luminescent iridium complex sulfurated bipyridine ligand; PCET thermochem disulfide unit photophys property.

Mol. systems combining light harvesting and charge storage are receiving great attention in the context of, for example, artificial photosynthesis and solar fuel generation. As part of ongoing efforts to develop new concepts for photoinduced proton-coupled electron transfer (PCET) reactivities, we report a cyclometallated iridium(III) complex [1]+ equipped with our previously developed sulfurated bipyridine ligand S-Sbpy. A new one-step synthetic protocol for S-Sbpy is developed, starting from com. available 2,2′-bipyridine, which significantly facilitates the use of this ligand. The iridium complex [Ir(ppy)2(S-Sbpy)](PF6) ([1]PF6) features a two-electron reduction with potential inversion (|E1| > |E2|) at moderate potentials (E1 = -1.17, E2 = -1.08 V vs. Fc+/0 at 253 K), leading to a dithiolate species [1]-. Protonation with weak acids allows for determination of pKa = 23.5 in MeCN for the S-H···S- unit of [1]H. The driving forces for both the H atom and the hydride transfer are calculated to be ∼ 60 kcal mol-1 and verified exptl. by reaction with a suitable H atom and a hydride acceptor, demonstrating the ability of [1]+ to serve as a versatile PCET reagent, albeit with limited thermal stability. In the MeCN solution, an orange emission for [1]PF6 from a triplet-excited state was found. D. functional calculations and ultrafast absorption spectroscopy are used to give insight into the excited-state dynamics of the complex and suggest a significantly stretched S-S bond for the lowest triplet-state T1. The structural responsiveness of the disulfide unit is proposed to open an effective relaxation channel toward the ground state, explaining the unexpectedly short lifetime of [1]+. These insights as well as the quant. ground-state thermochem. data provide valuable information for the use of S-Sbpy-functionalized complexes and their disulfide-/dithiol-directed PCET reactivity.

Inorganic Chemistry published new progress about Attenuated-total-reflectance IR spectroscopy. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, SDS of cas: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bedowr, Noha S.; Yahya, Rosiyah B. published the artcile< Synthesis, characterization and thermal stability of binuclear Cu(II) complexes>, Application In Synthesis of 366-18-7, the main research area is copper dodecanoate bipyridine coordination polymer preparation thermal stability.

This research aimed to prepare, characterize and to study thermal properties of the coordination polymers of Cu(II) dodecanoate using ditopic ligands of 2,2′-bipyridine and 4,4′-bipyridine. The freshly prepared Cu(II) complexes were synthesized and characterized by elements composition, functional groups FTIR, UV-visible spectroscopy, magnetic properties, TGA (TGA and DSC) or optical microscopic examination (OPM). Thermally stable Cu(II) dodecanoate complexes were prepared with ditopic ligands of 2,2′-bipyridine and 4,4′-bipyridine for spintronic applications. The exptl. results of the prepared mol. magnets displayed ferromagnetic type of magnetic interactions in the square pyramidal Cu(II) dodecanoate, along with mesomorphic or stable mech. properties.

Journal of Molecular Structure published new progress about Ferromagnetic exchange. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application In Synthesis of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

De Vos, Arthur; Lejaeghere, Kurt; Muniz Miranda, Francesco; Stevens, Christian V.; Van Der Voort, Pascal; Van Speybroeck, Veronique published the artcile< Electronic properties of heterogenized Ru(II) polypyridyl photoredox complexes on covalent triazine frameworks>, Reference of 366-18-7, the main research area is electronic property heterogenized ruthenium polypyridyl photoredox complex covalent triazine.

Ru(II) polypyridyl complexes have been successful for a wide range of photoredox applications thanks to their efficient light-induced metal-to-ligand charge transfer. Using the computational framework of d.-functional theory, we report how these complexes can be anchored onto covalent triazine frameworks while maintaining their favorable electronic properties. We moreover show that variation of the nitrogen content of the framework linkers or complex ligands endows the heterogenized catalyst with a unique versatility, spanning a wide range of absorption characteristics and redox potentials. By judiciously choosing the catalyst building blocks, it is even possible to selectively guide the charge transfer toward either the scaffold or the accessible pore sites. Rational design of sustainable and efficient photocatalysts thus comes within reach.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Coordination compounds Role: CAT (Catalyst Use), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), USES (Uses), PREP (Preparation). 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Reference of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fu, Zhiwei; Wang, Xiaoyan; Gardner, Adrian M.; Wang, Xue; Chong, Samantha Y.; Neri, Gaia; Cowan, Alexander J.; Liu, Lunjie; Li, Xiaobo; Vogel, Anastasia; Clowes, Rob; Bilton, Matthew; Chen, Linjiang; Sprick, Reiner Sebastian; Cooper, Andrew I. published the artcile< A stable covalent organic framework for photocatalytic carbon dioxide reduction>, Computed Properties of 366-18-7, the main research area is carbon dioxide photocatalytic reduction stable covalent organic framework.

Photocatalytic conversion of CO2 into fuels is an important challenge for clean energy research and has attracted considerable interest. Here we show that tethering mol. catalysts-a rhenium complex, [Re(bpy)(CO)3Cl]-together in the form of a crystalline covalent organic framework (COF) affords a heterogeneous photocatalyst with a strong visible light absorption, a high CO2 binding affinity, and ultimately an improved catalytic performance over its homogeneous Re counterpart. The COF incorporates bipyridine sites, allowing for ligation of the Re complex, into a fully p-conjugated backbone that is chem. robust and promotes light-harvesting. A maximum rate of 1040μmol g-1 h-1 for CO production with 81% selectivity was measured. CO production rates were further increased up to 1400μmol g-1 h-1, with an improved selectivity of 86%, when a photosensitizer was added. Addition of platinum resulted in production of syngas, hence, the co-formation of H2 and CO, the chem. composition of which could be adjusted by varying the ratio of COF to platinum. An amorphous analog of the COF showed significantly lower CO production rates, suggesting that crystallinity of the COF is beneficial to its photocatalytic performance in CO2 reduction

Chemical Science published new progress about Condensation (physical). 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Computed Properties of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyrch, Mikaela M.; Williams, Jay M.; Kasperski, Maguire W.; Applegate, Lindsey C.; Forbes, Tori Z. published the artcile< Synthesis and spectroscopic characterization of actinyl(VI) tetrahalide coordination compounds containing 2, 2'-bipyridine>, Computed Properties of 366-18-7, the main research area is uranium neptunium oxo chloro bromo complex preparation crystal structure.

Three new actinide tetrahalide coordination compounds containing 2,2′-bipyridinium (H2bpy) were synthesized by room temperature evaporation and characterized via single crystal x-ray diffraction, Raman spectroscopy, and IR spectroscopy. The solid-state compounds (Np1, U1, and U2) contain the AnO2+2 cation coordinated to four halide (chloride or bromide) atoms to form the anionic tetrahalide mol. unit [AnO2X4]2- (X = Cl, Br) and are charge balanced by the 2,2′-bipyridinium cations that engage in electrostatic interactions with the actinyl complex. Np1 (N2C10H10)[NpO2Cl4] contains 2,2′-bipyridine in the cis conformation where both the nitrogen atoms are directed towards the [NpO2Cl4]2- monomer. Within U1 (N2C10H9)[UO2Cl4], the 2,2′-bipyridine is in a trans conformation, and found in the same orientation in the isomorphous structure U2 (N2C10H9)[UO2Br4]. The compounds were further characterized by vibrational spectroscopy with specific interest in the actinyl cation. Raman spectroscopy provided information on the actinyl sym. stretch (ν1) whereas IR spectroscopy was used to determine the location of the asym. stretch (ν3). Spectral similarities are observed between the two isomorphous structures, but slight variations across structures are associated with bipyridine bands in the various conformations. Addnl. anal. of these vibrational features in U1 and U2 provided information on the actinyl force constants, allowing insight into the relative uranyl bond strength that was compared to similar tetrahalide compounds

Inorganica Chimica Acta published new progress about Actinide complexes Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Computed Properties of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gurgul, Ilona; Mazuryk, Olga; Stachyra, Kamila; Olszanecki, Rafal; Lekka, Malgorzata; Lomzik, Michal; Suzenet, Franck; Gros, Philippe C.; Brindell, Malgorzata published the artcile< Impact of Polypyridyl Ru Complexes on Angiogenesis-Contribution to Their Antimetastatic Activity>, HPLC of Formula: 366-18-7, the main research area is angiogenesis; cell adhesion properties; cell elasticity; cytotoxicity; endothelial cells; focal adhesions; migration; polypyridyl ruthenium (II) complexes; pseudovessel formation.

The use of polypyridyl Ru complexes to inhibit metastasis is a novel approach, and recent studies have shown promising results. We have reported recently that Ru (II) complexes gathering two 4,7-diphenyl-1,10-phenanthroline (dip) ligands and the one being 2,2′-bipyridine (bpy) or its derivative with a 4-[3-(2-nitro-1H-imidazol-1-yl)propyl (bpy-NitroIm) or 5-(4-{4′-methyl-[2,2′-bipyridine]-4-yl}but-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone (bpy-SC) moieties can alter the metastatic cascade, among others, by modulating cell adhesion properties. In this work, we show further studies of this group of complexes by evaluating their effect on HMEC-1 endothelial cells. While all the tested complexes significantly inhibited the endothelial cell migration, Ru-bpy addnl. interrupted the pseudovessels formation. Functional changes in endothelial cells might arise from the impact of the studied compounds on cell elasticity and expression of proteins (vinculin and paxillin) involved in focal adhesions. Furthermore, mol. studies showed that complexes modulate the expression of cell adhesion mols., which has been suggested to be one of the factors that mediate the activation of angiogenesis. Based on the performed studies, we can conclude that the investigated polypyridyl Ru (II) complexes can deregulate the functionality of endothelial cells which may lead to the inhibition of angiogenesis.

International Journal of Molecular Sciences published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, HPLC of Formula: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Heinz-Kunert, Sherrie L.; Pandya, Ashma; Dang, Viet Thuc; Tran, Phuong Nguyen; Ghosh, Sabari; McElheny, Dan; Santarsiero, Bernard D.; Ren, Zhong; Nguyen, Andy I. published the artcile< Assembly of π-Stacking Helical Peptides into a Porous and Multivariable Proteomimetic Framework>, HPLC of Formula: 366-18-7, the main research area is .

The evolution of proteins from simpler, self-assembled peptides provides a powerful blueprint for the design of complex synthetic materials. Previously, peptide-metal frameworks using short sequences (≤3 residues) have shown great promise as proteomimetic materials that exhibit sophisticated capabilities. However, their development has been hindered due to few variable residues and restricted choice of side-chains that are compatible with metal ions. Herein, we developed a noncovalent strategy featuring π-stacking bipyridyl residues to assemble much longer peptides into crystalline frameworks that tolerate even previously incompatible acidic and basic functionalities and allow an unprecedented level of pore variations. Single-crystal X-ray structures are provided for all variants to guide and validate rational design. These materials exhibit hallmark proteomimetic behaviors such as guest-selective induced fit and assembly of multimetallic units. Significantly, we demonstrate facile optimization of the framework design to substantially increase affinity toward a complex organic mol.

Journal of the American Chemical Society published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, HPLC of Formula: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Bo; Li, Jun; Pang, Ming; Wang, Ying-Shuo; Liu, Meng-Zhen; Zhao, Hui-Meng published the artcile< Four Discrete Silver Iodobismuthates/Bromobismuthates with Metal Complexes: Syntheses, Structures, Photocurrent Responses, and Theoretical Studies>, COA of Formula: C10H8N2, the main research area is silver iodobismuthate bromobismuthate iron nickel complex preparation crystal structure; photocurrent crystal mol structure silver iodobismuthate bromobismuthate iron nickel.

Using in situ formed metal complexes of [Fe(bipy)3]2+ or [Ni(bipy)3]2+ (bipy = 2,2′-bipyridine) as templates, four new Ag-Bi-X (X = I and Br) compounds are first isolated in the metal-complex-decorated heterometallic halobismuthate family, namely [M(bipy)3]AgBiI6 (M = Fe (1), Ni (2)), [Fe(bipy)3]AgBiBr6 (3), and [Ni(bipy)3]AgBiBr6 (4). Compounds 1-4 feature discrete [AgBiX6]n2n- anions, exhibiting three polymorphisms that may be ascribed to the different stackings and the flexible condensations of [BiX6] octahedrons and [AgX4] tetrahedra/[AgX3] triangles. UV-vis diffuse reflectance analyses reveal that they are narrow band gap semiconductor materials (ca. 1.82-2.13 eV). Intriguingly, the title compounds display excellent photoelec. switching properties, with photocurrent d. following the order 3 > 4 > 2 > 1. In addition, the comparative studies of intermol. interactions, theor. band structures, d. of states, and effective masses of three polymorphisms have also been investigated.

Inorganic Chemistry published new progress about Band structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem