Category: 3718-65-8

Kinetics and mechanism of the electrophilic substitution of heteroaromatic compounds. XL. Standardization of aromatic and heteroaromatic nitration rates was written by Katritzky, Alan R.;Terem, Bulent;Scriven, Eric V.;Clementi, Sergio;Tarhan, H. Okan. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1975.COA of Formula: C7H9NO This article mentions the following:

Methods for extrapolating rates for nitrations in aqueous H2SO4 to different temperatures and acidities are discussed. The determination of standard (25鎺? H0 -6.6) nitration rates (k20) from exptl. measured rates required 4 consecutive steps: determination of the observed rate (k2) at the individual acidity and temperature, involving knowledge of the acidity function followed and its variation with temperature, determination of k2(T) at H0 -6.6, involving construction of the rate profile and its extrapolation to the proper acidity, determination of k2 (25鎺? at the standard acidity, involving evaluation or estimation of the thermodn. parameters at that acidity, and determination of k20, involving correction for minority species reaction, which requires knowledge of the pKa of the substrate at the standard temperature The procedure was applied to literature data for 131 nitration rates. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8COA of Formula: C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.COA of Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Syndiotactic- and heterotactic-specific radical polymerizations of N-n-propyl-浼?fluoroacrylamide and phase-transition behaviors of aqueous solutions of poly(N-n-propyl-浼?fluoroacrylamide) was written by Hirano, Tomohiro;Furutani, Takahiro;Oshimura, Miyuki;Ute, Koichi. And the article was included in Journal of Polymer Science, Part A: Polymer Chemistry in 2012.Quality Control of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

Radical polymerization of N-n-propyl-浼?fluoroacrylamide (NNPFAAm) was studied in several solvents at low temperatures in the presence or absence of Lewis bases, Lewis acids, alkyl alcs., silyl alcs., or fluorinated alcs. Different effects of solvents and additives on stereospecificity were observed in the radical polymerizations of NNPFAAm and its hydrocarbon analogs such as N-isopropylacrylamide (NIPAAm) and N-n-propylacrylamide (NNPAAm); for instance, syndiotactic (and heterotactic) specificities were induced in radical polymerization of NNPFAAm in polar solvents (and in toluene in the presence of alkyl and silyl alcs.), whereas isotactic (and syndiotactic) specificities were induced in radical polymerizations of the hydrocarbon analogs under the corresponding conditions. In contrast, heterotactic specificity induced by fluorinated alcs. was further enhanced in radical polymerization of NNPFAAm. The effects of stereoregularity on the phase-transition behaviors of aqueous solutions of poly(NNPFAAm) were also studied. Different tendencies in stereoregularity were observed in aqueous solutions of poly(NNPFAAm)s from those in solutions of the hydrocarbon analogs such as poly(NIPAAm) and poly (NNPAAm). The polymerization behavior of NNPFAAm and the phase-transition behavior of aqueous poly(NNPFAAm) are discussed based on possible fluorine-fluorine repulsion between the monomer and propagating chain-end, and neighboring monomeric units. 婕?2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Quality Control of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Contact term contribution to lanthanide induced shifts in proton and carbon-13 NMR spectra of pyridine N-oxides was written by Tori, Kazuo;Yoshimura, Yohko;Kainosho, Masatsune;Ajisaka, Katsumi. And the article was included in Tetrahedron Letters in 1973.Quality Control of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

Shifts induced by M(FOD)3, Eu(PTA)3, and M(DPM)3 (M = Eu, Pr, HFOD = 1,1,1,2,2,3,3-heptafluoro-7,7-dimethyloctane-4,6-dione, HPTA = pivaloyltrifluoroacetone, HDPM = dipivaloylmethane) in the 1H and 13C NMR of pyridine N-oxide and its alkyl derivatives included a contact term contribution. Upfield shifts were observed for the 灏?H and 绾?Me PMR signals and the directions of 13C shifts were those predicted for contact interaction. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Quality Control of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Regioselective organometallic synthesis of pyridines, 4-picolines, and 3,5-lutidines substituted in the 2-position by an unsaturated and/or functional group was written by Al-Arnaout, A.;Courtois, G.;Miginiac, L.. And the article was included in Journal of Organometallic Chemistry in 1987.Safety of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

[(Alkoxycarbonyl)oxy]pyridinium chlorides I (R¹ = Et, CH₂CHMe₂; R² = H, Me; R³ = H, Me) were treated with 2-alkenylzinc bromides to give pyridines II (R⁴ = 2-alkenyl). Similarly, II [R⁴ = C椤氬挵(CH:CH)_nCH₂OR⁵ (n = 0, 1; R⁵ = H, Me)] were prepared from I and R⁵OCH₂(CH:CH)_nC椤氬挵MgBr. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Safety of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Thermal behaviour of nitrogen oxides relevant to oxidative denitrogenation was written by Mirshamsi, Sepideh;Yan, Yuwei;Kamal, Sidra;Yasemi, Amir-Arsalan;Gupta, Rajender;de Klerk, Arno;Prado, Glaucia H. C.. And the article was included in Journal of Chemical Thermodynamics in 2019.Formula: C7H9NO This article mentions the following:

Oxidative denitrogenation is an alternative method to hydro-treating, where the nitrogen compounds are oxidized to form nitrogen oxides, which can be separated from the oil by extraction with a polar solvent. During this separation process there is a loss of hydrocarbon material which can be between (10-20) wt% for an oil containing 1 wt% of N. The possibility to release nitrogen as NO_x by thermal treatment and consequently recover the hydrocarbon portion from the N-oxide mol. is the topic explored in this work. The thermochem. of the N-oxides of pyridine, 3-picoline, 2-mercaptopyridine, quinoline, 4-nitropyridine, 3,5-dimethylpyridine, picolinic acid, 4-picoline, 3-hydroxypyridine, nicotinic acid, isonicotinic acid, and nicotinamide was studied. The results showed that the N-oxides of pyridine and 3-picoline evaporated at atm. pressure while the other compounds decomposed after or during melting or during evaporation Decomposition temperatures could be determined for all the N-oxides during thermal anal. at 5 MPa gauge. Infra-red spectroscopy of the residues after thermal treatment indicated that the compounds still contained nitrogen. The suggested chem. taking place upon thermal decomposition in the liquid phase was discussed. N-oxides may form an oxaziridine intermediate, which results in formation of polymeric structures that still contain the nitrogen. Therefore, pyrolysis of the N-oxides subsequent to oxidation seems to be inefficient to liberate the nitrogen as NO_x. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Formula: C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Differentiation of substituent effects from hydrogen bonding and protonation effects in carbon-13 NMR spectra of pyridine N-oxides was written by Szafran, Miroslaw;Brycki, Bogumil;Dega-Szafran, Zofia;Nowak-Wydra, Barbara. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1991.Application of 3718-65-8 This article mentions the following:

Aromatic ¹³C chem. shifts are reported by 4- and 3-substituted pyridine N-oxides in deuteriochloroform, deuterium oxide, perchloric acid (60% in D₂O) and dichloroacetic acid (80% in CDCl₃), and also for O-alkylated derivatives in (CD₃)₂SO and D₂O. The substituent chem. shift data show systematic nonadditivity in comparison with monosubstituted benzenes. Data for the position equation. For this position multiple substituent interactions are responsible for the nonadditive shifts; interactions have both an inductive (polar) and a resonance component. Hydrogen bonding and protonation effectes were differentiated from the substituent effect. The relative ¹³C chem.-shift difference [CΔ₃ – Δ₄)/Δ₃] is a measure of the hydrogen bond and protonation effects and is not subject to substituent effects. 3-(Dimethylamino)pyridine N-oxide is protonated at the dimethylamino group, 4-(dimethylamino)pyridine N-oxide at the oxygen. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Application of 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application of 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction of aromatic N-oxides with dipolarophiles. XV. Formation of the 1,5-sigmatropy products and their double ene reaction products was written by Matsuoka, Toshikazu;Ono, Kikuma;Harano, Kazunobu;Hisano, Takuzo. And the article was included in Chemical & Pharmaceutical Bulletin in 1991.Related Products of 3718-65-8 This article mentions the following:

The pericyclic reaction of 3,5-dimethylpyridine N-oxide with maleimides I ( R = Bu, Ph, substituted Ph) gave furopyridine cycloadducts II formed by the 1,5-sigmatropic rearrangement of the primary exo-cycloadducts. The mol. structure of II (R = Bu) was determined the by the x-ray crystallog. method. In the reaction of 2-alkylpyridine N-oxides III ( R¹ = 3-, 5-Me, 5-Et) with N-substituted maleimides, a series of 1:3 ene reaction products of the type IV (R = Ph, substituted Ph, Bu) were obtained. The primary exo-cycloadducts readily transform into the endo-1,5-sigmatropic rearrangement products, which again react with two mols. of N-substituted maleimide to give the 1:3 ene reaction products. The observed reaction behavior and plausible reaction pathways are discussed in terms of frontier MO considerations. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Related Products of 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Related Products of 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction of aromatic N-oxides with dipolarophiles. Part 18. Formation mechanism and x-ray structure of the cycloadduct from sequential pericyclic reaction of pyridine N-oxides with phenylsulfonylallene was written by Matsuoka, Toshikazu;Hasegawa, Tomoaki;Eto, Masashi;Harano, Kazunobu;Hisano, Takuzo. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1993.Application In Synthesis of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

Sequential pericyclic reactions of pyridine N-oxides (1) with phenylsulfonylpropadiene (2) and 1-phenylsulfonylpropyne (3) were investigated. 3,5-Dimethylpyridine N-oxide (1a) and 2 in CHCl₃ at room temperature gave a mixture of the [1,5]-sigmatropic rearrangement product 4a of the 1:1 cycloadduct and the 1:2 azetidine-type cycloadduct 5a. The structure of 5a was determined crystallog. The reaction rate of 1a with 2 was ∼50,000 times that of 1a with N-phenylmaleimide. The reaction of 1a with 3 did not give 5a but 4a as the sole product. The reactivity, regio- and periselectivity, and formation mechanism of 4 and 5 are examined by FMO. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Application In Synthesis of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application In Synthesis of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Thermodynamic and infrared studies of tertiary amine oxide with bis(2,4-pentanedionato)oxovanadium(IV) was written by Popp, Carl J.;Nelson, John H.;Ragsdale, Ronald O.. And the article was included in Journal of the American Chemical Society in 1969.Synthetic Route of C7H9NO This article mentions the following:

The donor properties of a series of substituted pyridine N-oxide bases toward the reference acid bis(2,4-pentanedionato)oxovanadium(IV) [VO(acac)2] have been studied. Heats of reaction have been determined calorimetrically and, in the case of the 4-substituted pyridine N-oxide, correlate well with σPyNO. The change of the vanadium-vanadyl O stretching frequency (Δ v=o) and the vanadium-2,4-pentanedionate stretching frequency (Δ v-o) upon coordination were studied and were also found to correlate well with enthalpies of reaction. Substitution of alkyl groups in other than the 4 position of the pyridine N-oxide ring causes a decrease in the effective basicity toward the reference acid, VO(acac)2. The usefulness of VO-(acac)2 as a reference acid is discussed. The system is extended to the tertiary amine oxide p-bromo-N,N-dimethylaniline N-oxide and Me3NO. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Synthetic Route of C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Synthetic Route of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fluorine-19 nuclear magnetic resonance study of tin tetrafluoride diadducts of various aromatic amine oxides was written by Ragsdale, Ronald O.;Michelson, C. E.. And the article was included in Inorganic Chemistry in 1970.SDS of cas: 3718-65-8 This article mentions the following:

An 19F NMR study of diadducts of SnF4 with 19 aromatic amine oxides is reported. The results indicate that the steric nature of the ligand is probably more important than the base strength in determining the relative chem. shifts. The trans isomer is identified in all of the complexes whereas the cis isomer is present only with the less bulky ligands. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8SDS of cas: 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.SDS of cas: 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem