Category: 3731-52-0

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 3731-52-0, Name is Pyridin-3-ylmethanamine, SMILES is NCC1=CC=CN=C1, belongs to pyridine-derivatives compound. In a document, author is Chaubey, Bhawna, introduce the new discover, Product Details of 3731-52-0.

Aqueous photo-degradation of Flupyradifurone (FPD) in presence of a natural Humic Acid (HA): A quantitative solution state NMR analysis

The present study aims to characterize the molecular interaction and photo-degradation behaviour of halogen (-F and -Cl) containing novel insecticide, flupyradifurone, (FPD) in the presence of humic acid (KHA), isolated from Karwar, western Rajasthan, India. Time-dependent photo-degradation kinetics of UV-exposed FPD is quantified in the absence and presence of KHA employing one dimensional H-1 and 19F solution-state NMR. The pseudo first-order photo-degradation rate constant quantified for FPD showed a significant decrease in the presence of KHA. Interestingly, variable degradation rates are found from H-1 and F-19 NMR spectral changes indicating chemical moiety wise degradation of FPD. Further, NMR saturation transfer difference (STD), relaxation, and diffusion experiments have been employed for the complete evaluation of binding interactions of KHA with FPD and its major degradation product difluoroacetic acid (DFA). STD experiments revealed that FPD binds to KHA through the chlorinated pyridine ring while the -F containing moiety of FPD does not show any detectable interaction. Relevant kinetic parameters, namely association constants and Gibbs free energy of interaction are quantified at neutral pH conditions by diffusion experiments depicting a stronger and more spontaneous association of FPD with KHA (KA = 55.55 M-1) compared to that of DFA-KHA (KA = 10.90 M-1). Both FPD and DFA bind with KHA through weak non-covalent interaction indicating the encapsulation of these molecules within KHA hindering the photo-degradation process of FPD. Concomitantly, it is also envisaged that FPD will be more persistent in soil compared to DFA that may leach out to groundwater.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 3731-52-0 is helpful to your research. Product Details of 3731-52-0.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Related Products of 3731-52-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3731-52-0, name is Pyridin-3-ylmethanamine, molecular formula is C6H8N2, molecular weight is 108.14, as common compound, the synthetic route is as follows.

PREPARATION 19; Preparation of 2-bromo-4-methyl-vV-(pyridin-3-ylmethyl)thiazole-5-carboxamide; To a solution of 2-bromo-4-methylthiazole-5-carboxylic acid ( 10.00 g, 45.00 mmol) and 4-methylmorpholine (6.5 mL, 59.0 mmol) in tetrahydrofuran ( 150 mL) was added isobutyl chloroformate (6.5 mL, 49.6 mmol) at 0 0C. The resulting mixture was stirred at room temperature for 1 hour and 3-(aminomethyl)pyridine (5.2 mL, 51.4 mmol) was added. The reaction mixture was stirred at ambient temperature for 17 hours, and then concentrated in vacuo. The residue was purified by column chromatography to afford 2-bromo-4-methyl-jV-(pyridin-3-ylmethyl)thiazole-5-carboxamide in 52% yield (7.3 g): 1H NMR (300 MHz, CDCl3) delta 8.39-8.80 (m, 2H), 7.80-7.72 (m, IH), 7.40-7.35 (m, I H), 6.47 (br s, I H), 4.60 (d, J= 6.0 Hz, 2H), 2.64 (s, 3H); MS (ES+) we 312.1 (M + 1 ), 314.1 (M + 1 ).

Statistics shows that 3731-52-0 is playing an increasingly important role. we look forward to future research findings about Pyridin-3-ylmethanamine.

Reference:
Patent; NOVARTIS AG; XENON PHARMACEUTICALS INC.; WO2008/127349; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem