Category: 3731-53-1

Ingale, Ajit P.; Garad, Dnyaneshwar N.; Ukale, Dattatraya; Thorat, Nitin M.; Shinde, Sandeep V. published the artcile< Thiamine hydrochloride as a recyclable organocatalyst for the efficient and chemoselective N-tert-butyloxycarbonylation of amines>, Formula: C6H8N2, the main research area is amine tert butyloxycarbonylation chemoselective thiamine hydrochloride recyclable green organocatalyst.

Thiamine hydrochloride promoted highly efficient and ecofriendly approach has been described for the chemoselective N-tert-butyloxycarbonylation of amines under solvent-free conditions at ambient temperature The demonstrated approach has been applicable for the N-Boc protection of variety of aliphatic, aryl, heteroaryl amines. The chemoselective protection of amino group occurs in chiral amines and amino alc. without racemization in high yield. Thiamine hydrochloride is stable, economical, easy to handle and environmentally friendly.

Synthetic Communications published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chitti, Surendar; Pulya, Sravani; Nandikolla, Adinarayana; Patel, Tarun Kumar; Banoth, Karan Kumar; Murugesan, Sankaranarayanan; Ghosh, Balaram; Chandra Sekhar Kondapalli, Venkata Gowri published the artcile< Design, synthesis and structure-activity relationship studies of novel spirochromanone hydrochloride analogs as anticancer agents>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is aminomethylphenyl spirochromanepiperidineone preparation anticancer mol docking SAR cytotoxicity; anticancer; apoptosis; cytotoxicity; molecular docking; spiro-[chromane-2,4′-piperidine]-4-one.

The authors designed and synthesized 18 spirochromanone derivs I [R = isopropylamino, cyclopentylamino, 4-methoxycyclohexylamino etc.]. The compounds I were characterized and evaluated for anticancer activity against human breast cancer (MCF-7) and murine melanoma (B16F10) cell lines. The anticancer activity ranged from 4.34 to 29.31 μm. The most potent compounds, I [R = dimethylamino, benzylamino] were less toxic against the human embryonic kidney (HEK-293) cell line and ∼ two/∼fourfold selective toward MCF-7 than B16F10 in comparison to the reference, BG-45. Compound , I [R = benzylamino] caused 28.6% total apoptosis, leading to significant cytotoxicity, and arrested the G2 phase of the cell cycle in B16F10 cells. A mol. docking study of compound , I [R = benzylamino] exhibited effective binding at the active site of the epidermal growth factor receptor kinase domain. This study highlights the importance of spirochromanones as anticancer agents.

Future Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lengacher, Raphael; Wang, Youchao; Braband, Henrik; Blacque, Olivier; Gasser, Gilles; Alberto, Roger published the artcile< Organometallic small molecule kinase inhibitors - direct incorporation of Re and 99mTc into Opaganib>, Quality Control of 3731-53-1, the main research area is prostate cancer opaganib bioorganometallic complex anticancer mol theranostics.

[(η5-Cp)ReI(CO)3] was incorporated into the kinase inhibitor Opaganib. The resulting bioorganometallic complex showed a similar anti-cancer activity to Opaganib against PC-3 cancer cells. The IC50 value for the kinase SK2 is 30x higher than that of Opaganib. The 99mTc homolog was synthesized, completing a matched-pair for mol. theranostics.

Chemical Communications (Cambridge, United Kingdom) published new progress about Antitumor agents. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ye, Shanghui; Wu, Congjin; Gu, Pengfei; Xiang, Tai; Zhang, Senyu; Jing, Tongtong; Wang, Shi; Yang, Xiaodi; Li, Yonghua; Huang, Wei published the artcile< A benzoindole-cored building block for deep blue fluorescent materials: synthesis, photophysical properties, and applications in organic light-emitting diodes>, Formula: C6H8N2, the main research area is benzoindole cored blue fluorescent material organic light emitting diode; LED organic benzoindole cored blue fluorescent material; electroluminescent device organic benzoindole cored blue fluorescent material.

Deep blue fluorescent materials are crucial in the commercialization of organic light-emitting diodes (OLEDs) for full-color displays or solid-state lighting sources. Aromatic ring compounds based on a newly designed 2-(pyridine-4-yl)-3-phenyl-1H-benzo[g]indole core, were synthesized, on which donor (D) and acceptor (A) groups are bonded in a Y-typed configuration, forming a D-π-A-π-D structure. The electronic structure and photophys. properties were explored, as well as the applications in the blue OLEDs. Multi-state couplings exist between the D-π-A-π-D 3 moieties, resulting in high luminescence quantum yield ≤76.1% peaking at ∼410 nm, and depressed efficiency roll-off at high luminance. The deep blue OLEDs based on CzCNBPyIp emitter exhibits stable emission peaking at 416 nm with negligible efficiency roll-off at high luminance range of 1,000-10,000 cd m-2, and corresponding CIEx,y = (0.162, 0.085) and maximum EQE = 2.6%, making it among the highest performance solution processed deep blue fluorescent devices. This work provides an alternative method for the deep blue fluorescent materials design toward solution processing OLEDs.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Electron acceptors. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rani, Pooja; Gauri; Husain, Ahmad; Bhasin, K. K.; Kumar, Girijesh published the artcile< A Doubly Interpenetrated CuII Metal-Organic Framework for Selective Molecular Recognition of Nitroaromatics>, COA of Formula: C6H8N2, the main research area is copper pyridinylnaphthalenecarboxamide oxybisbenzoate MOF preparation thermal stability fluorescent sensor; crystal structure copper pyridinylnaphthalenecarboxamide oxybisbenzoate MOF.

Herein, we report the design, synthesis, and structural characterization of a novel 2-fold interpenetrated CuII metal-organic framework Cu-MOF-1 [{Cu2(L)(oba)2}·DMF·H2O]α (where, L = N2,N6-di(pyridin-4-yl)naphthalene-2,6-dicarboxamide and oba2- is 4,41-oxybis(benzoic acid) anion). A single-crystal X-ray anal. reveals that Cu-MOF-1 exhibits a doubly (1 + 1) interpenetrated three-dimensional structure with 6-connected mab topol. Moreover, Cu-MOF-1 showed high fluorescence stability in methanol solution and selectively detected nitroaroms. with high quenching constants and low detection limits of 0.31 × 105 M-1 and 22.65μM for 2,4,6-TNP; 1.34 × 105 M-1 and 18.7μM for 4-NPH; and 1.49 × 105 M-1 and 14.07μM for 4-NA. Notably, ligand L itself did not display any type of recognition for any nitroaroms. in methanol solution The sensing of NACs by Cu-MOF-1 followed mostly the resonance energy transfer mechanism; however, in the case of 4-NPH and 2,4,6-TNP an electron transfer mechanism also exists. Importantly, Cu-MOF-1 shows recyclability up to five cycles without any significant loss in quenching efficiency.

Crystal Growth & Design published new progress about Aromatic nitro compounds Role: ANT (Analyte), ANST (Analytical Study). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, COA of Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gardell, Stephen J.; Hopf, Meghan; Khan, Asima; Dispagna, Mauro; Hampton Sessions, E.; Falter, Rebecca; Kapoor, Nidhi; Brooks, Jeanne; Culver, Jeffrey; Petucci, Chris; Ma, Chen-Ting; Cohen, Steven E.; Tanaka, Jun; Burgos, Emmanuel S.; Hirschi, Jennifer S.; Smith, Steven R.; Sergienko, Eduard; Pinkerton, Anthony B. published the artcile< Boosting NAD+ with a small molecule that activates NAMPT>, Formula: C6H8N2, the main research area is lung carcinoma cell NAMPT SBI797812 NAD.

Pharmacol. strategies that boost intracellular NAD+ are highly coveted for their therapeutic potential. One approach is activation of nicotinamide phosphoribosyltransferase (NAMPT) to increase production of NMN (NMN), the predominant NAD+ precursor in mammalian cells. A high-throughput screen for NAMPT activators and hit-to-lead campaign yielded SBI-797812, a compound that is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 shifts the NAMPT reaction equilibrium towards NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT at His247, promotes consumption of the pyrophosphate byproduct, and blunts feedback inhibition by NAD+. These effects of SBI-797812 turn NAMPT into a “”super catalyst”” that more efficiently generates NMN. Treatment of cultured cells with SBI-797812 increases intracellular NMN and NAD+. Dosing of mice with SBI-797812 elevates liver NAD+. Small mol. NAMPT activators such as SBI-797812 are a pioneering approach to raise intracellular NAD+ and realize its associated salutary effects.

Nature Communications published new progress about Biomarkers. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Guo Cheng; Li, Yan; Chi, Jie; Xu, Na; Wang, Xiu Li; Lin, Hong Yan; Chen, Yong Qiang published the artcile< Multi-functional fluorescent responses of cobalt complexes derived from functionalized amide-bridged ligand>, Quality Control of 3731-53-1, the main research area is cobalt methylenepyridinylnaphthalenedicarboxamide dicarboxylate coordination polymer preparation fluorescent indicator; crystal structure cobalt methylenepyridinylnaphthalenedicarboxamide dicarboxylate coordination polymer.

Multi-functional fluorescent detection for inorganic pollutants and biol. protein is important but challenging. Five multi-functional luminescent coordination polymers (LCPs), [Co2(L)2(PDA)2]·H2O (1), [Co(L)(TPD)(H2O)2]·8H2O (2), [Co(L)(1,3-BDC)]·2H2O (3), [Co(L)(MIP)]·H2O (4) and [Co3(L)3(HIPA)3] (5) [H2PDA = 1,3-phenylenediacetic acid, H2TPD = 2,5-thiophenedicarboxylic acid, 1,3-H2BDC = 1,3-benzenedicarboxylic acid, H2MIP = 5-methylisophthalic acid and H2HIPA = 5-hydroxyisophthalic acid] were successfully synthesized from a naphthalene-dicarboxamide [N,N’-bis(4-methylenepyridin-4-yl)-1,4-naphthalene dicarboxamide (L)] with multi-functional spacers. 1 And 2 show 4-c sql networks. 3-5 display mab, pcu and hxg 3-dimensional frameworks, resp. The title complexes exhibit multi-functional fluorescent responses towards metal ion (Fe3+), anions (CrO42-, Cr2O72- and MnO4-) and biol. protein (bovine serum albumin).

Dyes and Pigments published new progress about Bovine serum albumin Role: ANT (Analyte), ANST (Analytical Study). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lamani, Devappa S.; Badiger, Srikant G.; Singh, Mamata published the artcile< Formation of diaryl sulfides and sulfoxides: Synthesis, characterization and structure activity correlation studies>, Related Products of 3731-53-1, the main research area is diarylsulfide preparation glutathione peroxidase mimetic activity; diarylsulfoxide preparation glutathione peroxidase mimetic activity.

The synthesis of a series of diarylsulfides I [R = C(Me)2CH2OH, 3-pyridyl, 4-MeOC6H4CH2, etc.; X= S] was achieved by reaction of 2,2′-thiobis[benzoyl chloride] with amines followed by the presence of H2O2/t-BuOOH to afford corresponding sulfoxides II [X= S=O]. All the newly synthesized compounds were characterized by 1H, 13C NMR and mass spectroscopic techniques. A detailed mechanistic study indicated that the formation of sulfoxides followed oxidation In addition to synthesis, characterization and mechanistic studies, the glutathione peroxidase(GPx) mimetic activity of the newly synthesized compounds was described. It was observed that the diaryl sulfides having a heterocyclic ring attached to the nitrogen atom facilitated the oxidation of the sulfur center to form the corresponding sulfoxides. The substituents attached to the nitrogen atom played an important role in the catalytic activity of substituted diaryl sulfides. The obtained data supported for the higher antioxidant activity of diaryl sulfides than that of the corresponding sulfoxides.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kumar, Ajay; Sahoo, Subash Chandra; Mehta, Surinder Kumar; Soni, Parmod; Sharma, Vishal; Kataria, Ramesh published the artcile< A luminescent Zn-MOF for the detection of explosives and development of fingerprints>, Related Products of 3731-53-1, the main research area is zinc metal organic framework explosive detection fingerprint.

A luminescent 3D metal-organic framework [Zn(NDA)(AMP)] = PUC1 (where, NDA = naphthalene-2,6-dicarboxylic acid and AMP = 4-aminomethyl pyridine) was synthesized under solvothermal conditions. The synthesized 3D framework was fully characterized with the help of different anal. techniques such as SCXRD, FTIR, TGA, PXRD, SEM, BET, etc. PUC1 exhibited a strong emission peak at 371 nm when excited at 290 nm and the resulting emission was efficiently quenched in the presence of various organic explosive substances like pentaerythritol tetranitrate (PETN), 2,4,6-trinitrophenyl-N-methylnitramine (Tetryl), trinitrotoluene (TNT), 1,3,5-trinitroperhydro-1,3,5-triazine (RDX), and 1,3,5,7-tetranitro-1,3,5,7-tetrazoctane (HMX). PUC1 revealed highly sensitive and selective detection of PETN and Tetryl with high quenching constant values of 0.1 x 106 and 0.12 x 105 M-1 and low detection limits of 0.315 and 0.404 μM resp. The strong luminescent properties of PUC1 lead to its successful application in the development of latent fingermarks on different non-porous surfaces using the powder dusting method. The accuracy and applicability of the synthesized material were determined by developing fingerprints by using secretions from eccrine and apocrine glands on a glass slide and various other surfaces, followed by dusting the surfaces. The results so obtained were found to be very accurate and promising.

Analytical Methods published new progress about Crystallinity. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nie, Xufeng; Zheng, Yanling; Ji, Li; Fu, Haiyan; Chen, Hua; Li, Ruixiang published the artcile< Acceptorless dehydrogenation of amines to nitriles catalyzed by N-heterocyclic carbene-nitrogen-phosphine chelated bimetallic ruthenium (II) complex>, Name: Pyridin-4-ylmethanamine, the main research area is heterocyclic carbene nitrogen phosphine chelate bimetallic ruthenium complex preparation; amine ruthenium complex catalyst dehydrogenation green chem; nitrile preparation.

A clean, atom-economical and environmentally friendly route for acceptorless dehydrogenation of amines to nitriles by combining a new dual N-heterocyclic carbene-nitrogen-phosphine ligand R(CNP)2 (R = o-xylyl) with a ruthenium precursor [RuCl2(η6-C6H6)]2 was developed. In this system, the electronic and steric factors of amines had a negligible influence on the reaction and a broad range of functional groups were well tolerated. All of the investigated amines was converted to nitriles in good yield of up to 99% with excellent selectivity. The unprecedented catalytic performance of this system was attributed to the synergistic effect of two ruthenium centers chelated by R(CNP)2 and a plausible reaction mechanism was proposed according to the active species found via in-situ NMR and HRMS.

Journal of Catalysis published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Name: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem