Category: 3731-53-1

Fanfoni, Lidia; Marsich, Eleonora; Turco, Gianluca; Breschi, Lorenzo; Cadenaro, Milena published the artcile< Development of di-methacrylate quaternary ammonium monomers with antibacterial activity>, Application of C6H8N2, the main research area is dimethacrylate quaternary ammonium monomer antibacterial activity; Antibacterial monomer; Cytotoxicity; MIC/MBC; Structure-activity relationship; bis-quaternary ammonium salt; di-methacrylate monomer.

Nine antibacterial di-methacrylate monomers based on bis-quaternary ammonium salts (bis-QAMs) were synthesized and structurally characterized. The biol. activity of the bis-QAMs was tested in terms of min. inhibitory concentration (MIC) and min. bactericidal concentration (MBC) on different bacterial strains achieving promising results and, in most cases, a complete bactericidal effect using a bis-QAM concentration lower than 1 mg/mL. Two of the structures showed comparable and superior activity against S. mutans than the com. monomer 12-methacryloyloxydodecyl pyridinium bromide (MDBP). All the bis-QAMs here described were able to inhibit S. mutans biofilm formation at a concentration equal to the MIC value. From the anal. of the obtained data, some correlation regarding the structure and the antibacterial activity of the bis-QAMs could be drawn: a flexible alkyl C12 spacer between the two quaternary ammonium moieties increased the monomer antibacterial effect in comparison to the aromatic ones; the equilibrium between hydrophobic and hydrophilic moieties was directly correlated to the bactericidal range of action; the increase of the steric hindrance of the ammonium side groups might be both advantageous or disadvantageous to the antibacterial efficacy depending on the whole monomer chem. structure. Even though the possible correlation between the monomer structures and their bacteriostatic or bactericidal effect is under investigation, the monomers exhibited low cytotoxicity on human dental pulp stem cells, confirming their promising potential in the dental materials′ field.

Acta Biomaterialia published new progress about Antibacterial agents. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhu, Huajian; Li, Wenlong; Shuai, Wen; Liu, Yang; Yang, Limei; Tan, Yuchen; Zheng, Tiandong; Yao, Hong; Xu, Jinyi; Zhu, Zheying; Yang, Dong-Hua; Chen, Zhe-Sheng; Xu, Shengtao published the artcile< Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities>, Formula: C6H8N2, the main research area is colchicine binding antitumor safety profile; benzylbenzamide preparation cytotoxicity antitumor mol docking tubulin inhibitor; Anti-vascular; Antitumor; Druggability; N-benzylbenzamide; Tubulin inhibitors.

A series of novel N-benzylbenzamide derivatives I (R = dimethylaminyl, piperidin-1-yl, morpholin-4-yl, etc.; R1 = H, Cl, NO2, (pyridin-4-ylmethyl)aminyl, etc.; R2 = H, NO2; R3 = (3-hydroxy-4-methoxyphenyl)methyl, (3-fluoro-4-methoxyphenyl)methyl, pyridin-4-ylmethyl, etc.; R4 = H, Me), II (X = Y = N, CH) and III were designed and synthesized as tubulin polymerization inhibitors. Among fifty-one target compounds, I, II and III compound I [R = morpholin-4-yl; R1 = F; R2 = H; R3 = (3-hydroxy-4-methoxyphenyl)methyl; R4 = H] (IV) exhibited significant antiproliferative activities with IC50 values ranging from 12 to 27 nM against several cancer cell lines, and possessed good plasma stability and satisfactory physicochem. properties. Mechanism studies demonstrated that IV bound to the colchicine binding site and displayed potent anti-vascular activity. Notably, the corresponding disodium phosphate III exhibited an excellent safety profile with the LD50 value of 599.7 mg/kg (i.v. injection), meanwhile, it significantly inhibited tumor growth and decreased microvessel d. in liver cancer cell H22 allograft mouse model without obvious toxicity. Collectively, IV and III are novel promising anti-tubulin agents with more druggable properties and deserve to be further investigated for cancer therapy.

European Journal of Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chandrashekhar, Vishwas G.; Baumann, Wolfgang; Beller, Matthias; Jagadeesh, Rajenahally V. published the artcile< Nickel-catalyzed hydrogenative coupling of nitriles and amines for general amine synthesis>, Category: pyridine-derivatives, the main research area is amine preparation; nitrile amine hydrogenative coupling nickel catalyzed.

A homogeneous nickel catalyst for hydrogenative cross coupling of a range of aromatic, heteroaromatic, and aliphatic nitriles with primary and secondary amines or ammonia to give amines was reported. This general hydrogenation protocol was showcased by straightforward and highly selective synthesis of >230 functionalized and structurally diverse amines including pharmaceutically relevant and chiral products, as well as 15N-isotope labeling applications.

Science (Washington, DC, United States) published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Akiu, Mayuko; Tsuji, Takashi; Sogawa, Yoshitaka; Terayama, Koji; Yokoyama, Mika; Tanaka, Jun; Asano, Daigo; Sakurai, Ken; Sergienko, Eduard; Sessions, E. Hampton; Gardell, Stephen J.; Pinkerton, Anthony B.; Nakamura, Tsuyoshi published the artcile< Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition>, Category: pyridine-derivatives, the main research area is nicotinamide phosphoribosyltransferase activator pyrazolyltriazolopyridine pyridinylmethyl urea; CYP inhibition; LogD; NAD(+); NAMPT activators; Triazolopyridines.

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step of the NAD+ salvage pathway. Since NAD+ plays a pivotal role in many biol. processes including metabolism and aging, activation of NAMPT is an attractive therapeutic target for treatment of diverse array of diseases. Herein, we report the continued optimization of novel urea-containing derivatives which were identified as potent NAMPT activators. Early optimization of HTS hits afforded compound 12 (I) , with a triazolopyridine core, as a lead compound CYP direct inhibition (DI) was identified as an issue of concern, and was resolved through modulation of lipophilicity to culminate in 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea (21, II), which showed potent NAMPT activity accompanied with attenuated CYP DI towards multiple CYP isoforms.

Bioorganic & Medicinal Chemistry Letters published new progress about Biological permeation. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vydzhak, Roman N.; Panchishin, Svitlana Ya.; Kachaeva, Maryna V.; Pilyo, Stepan G.; Moskvina, Viktoriia S.; Shablykina, Olga V.; Kozytskiy, Andriy V.; Brovarets, Volodymyr S. published the artcile< Rapid synthetic approaches to libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones and 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones>, Application of C6H8N2, the main research area is dihydrochromenopyrrole dione preparation; hydroxyphenyl dihydropyrrolopyrazolone preparation; Chromeno[2,3-c]pyrroles; Combinatorial library; Dihydrochromeno[2,3-c]pyrrole-3,9-diones; Dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones; Multicomponent cyclization.

An efficient and practical synthetic procedure for libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones I [R =H, 6,7-di-Me, 7-F, etc.; R1 = n-Pr, CH2CH2OH, 2-furylmethyl, etc.; Ar = Ph, 4-MeC6H4, 3,4,5-tri-MeOC6H2, etc.] using a multicomponent process was presented. A convenient synthetic procedure for obtaining functionalized 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones II [R2 = H, 3,5-di-Me, 4-Me-5-Cl, etc.; R3 = 4-BrC6H4, 2-OHC6H4, 3-MeO-4-OHC6H3, etc.; R4 = n-Pr, CH2CH2OH, 2-ClC6H4CH2, etc.] via ring-opening strategy was developed. This protocol was found to be compatible with a wide range of substituents and paves the way for the practical synthesis of title compounds with a broad range of substituents under mild condition. The products could be easily isolated by crystallization without the use of chromatog.

Molecular Diversity published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Moi, Rajib; Nath, Karabi; Biradha, Kumar published the artcile< Tailoring Coordination Polymers by Substituent Effect: A Bifunctional CoII-Doped 1D-Coordination Network with Electrochemical Water Oxidation and Nitroaromatics Sensing>, SDS of cas: 3731-53-1, the main research area is cadmium trispyridinylmethylbenzenetricarboxamide isophthalato complex preparation fluorescence catalyst electrochem; crystal structure cadmium trispyridinylmethylbenzenetricarboxamide isophthalato complex; Coordination polymer; fluorescence; nitroaromatic compounds; sensing; water oxidation.

Three CdII coordination polymers (CPs) were synthesized with a tripodal ligand N,N’,N’ ‘-tris(4-pyridinylmethyl)-1,3,5-benzenetricarboxamide in combination with three different substituted isophthalic acids {[Cd2(L)(NIP)2(H2O)2].4H2O}n, (CP-1), {[Cd2(L)(AIP)2(H2O)2].4H2O}n, (CP-2) and {[Cd(L)(BIP) (H2O)].4H2O}n, (CP-3). The substituent groups on the co-ligand had profound effect on the network topologies of the corresponding CPs as well as their properties. Out of the three, CP-1 and CP-2 form 3-dimensional networks whereas CP-3 was a 1-dimensional linear chain with uncoordinated pyridyl sites. Due to its structural features CP-3 was found to show interesting properties. The 1-dimensional CP containing uncoordinated pyridyl site exhibited an excellent ability for doping with CoII which in turn acts as an efficient water oxidation electrocatalyst with required overpotential of 380 mV for an anodic c.d. of 1 mA cm-2. The CP also exhibited luminescence-based detection of nitroaroms. (LOD: 0.003 mM) without any significant interference in presence of other organic compounds

Chemistry – An Asian Journal published new progress about Coordination polymers Role: ARG (Analytical Reagent Use), CAT (Catalyst Use), PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), ANST (Analytical Study), USES (Uses), PROC (Process), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, SDS of cas: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tsai, Meng-Jung; Luo, Jheng-Hua; Wu, Jing-Yun published the artcile< Two-fold 2D + 2D → 2D interweaved rhombus (4,4) grid: synthesis, structure, and dye removal properties in darkness and in daylight>, Category: pyridine-derivatives, the main research area is pyridinylmethylpyridinyl naphthalimide copper coordination polymer preparation structure rhombus grid.

Compound [Cu(NI-mbpy-44)2(NO3)2]·4H2O (1, NI-mbpy-44 = N-(pyridin-4-ylmethyl)-4-(pyridin-4-yl)-1,8-naphthalimide) adopting a two-dimensional (2D) periodical rhombus (4,4) grid has been synthesized. This grid doubly interweaves in a parallel fashion to result in overall 2D + 2D → 2D networks with approx. 14% sufficient free volumes in which lattice H2O mols. reside. Dye removal studies show that 1 selectively adsorbs anionic methyl orange (MO) and acid orange 7 (AO7) over cationic methylene blue (MB) and malachite green (MG) from aqueous solutions containing single or mixed dyes in darkness at room temperature The exptl. isotherm data were analyzed using linear Langmuir and Freundlich isotherm equations; the results indicated that the Langmuir model showed a better fit for the adsorption of MO and AO7 over 1, with high dark adsorption capacities of 810 and 370 mg g-1, resp., although there could also be other associated mechanisms. The dark adsorption kinetics of MO and AO7 over 1 obeyed the pseudo-second-order kinetic model. Electrostatic attraction appears to be the dominating mechanism for adsorptive removal of MO and AO7 by 1, whereas π-π stacking (MO and AO7) and hydrogen-bonding interactions (AO7) could also be responsible. Exploration of the adsorption performance of MO and AO7, including studying the kinetics in daylight, shows similar results to those obtained in darkness, indicating the negligible influence of daylight on the dye removal. Nevertheless, 1 could liberate NI-mbpy-44 and Cu(II) into water throughout the entire adsorption experiment, which could be a potential environmental hazard, this could cause secondary pollution and mean that 1 is impractical for use as an adsorbent candidate.

Dalton Transactions published new progress about Adsorbents. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vezzu, Keti; Nawn, Graeme; Pagot, Gioele; Negro, Enrico; Nale, Angeloclaudio; Bang, Yannick Herve; Conti, Fosca; Cavinato, Gianni; Di Noto, Vito published the artcile< Relaxation phenomena and conductivity mechanisms in anion-exchange membranes derived from polyketone>, Safety of Pyridin-4-ylmethanamine, the main research area is relaxation conductivity anion exchange membrane polyketone.

A polyketone-b-poly[N-(4 Me-methylpyridium)-ethylenepyrrole+][X-], with X- = I- or OH-, was studied as an example of anion-exchange membrane with potential applications in fuel cells. The polyketone starting material PK and the functionalized polyketones Pyr-FPKmI and Pyr-FPKmOH were studied via Broadband Elec. Spectroscopy (BES) to understand the conductivity mechanism. BES signals are collected in the frequency range of 10-2 – 107 Hz and from -100° to 120°. BES measurements reveal up to three interdomain polarizations phenomena, one electrode polarization event and two β dielec. relaxation modes for both wet Pyr-FPKmI and Pyr-FPKmOH. Ion conductivity for Pyr-FPKmI and Pyr-FPKmOH is 0.0086 and 0.0105 S cm-1 at 80°, resp. The overall conductivity mechanism is attributed to the superposition of two conduction pathways, via delocalization bodies and via interdomain percolation pathways, which are associated with two different phys. phenomena.

Electrochimica Acta published new progress about Anion exchange membranes. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Safety of Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zheng, Yan-Long; Newman, Stephen G. published the artcile< Methyl Esters as Cross-Coupling Electrophiles: Direct Synthesis of Amide Bonds>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is methyl ester amine nickel catalyzed cross coupling amide preparation.

Amide bond formation and transition metal-catalyzed cross-coupling are two of the most frequently used chem. reactions in organic synthesis. Recently, an overlap between these two reaction families was identified when Pd and Ni catalysts were demonstrated to cleave the strong C-O bond present in esters via oxidative addition When simple Me and Et esters are used, this transformation provides a powerful alternative to classical amide bond formations, which commonly feature stoichiometric activating agents. Thus far, few redox-active catalysts have been demonstrated to activate the C(acyl)-O bond of alkyl esters, which makes it difficult to perform informed screening when a challenging reaction needs optimization. We demonstrate that Ni catalysts bearing diverse NHC, phosphine, and nitrogen-containing ligands can all be used to activate Me esters and enable their use in direct amide bond formation.

ACS Catalysis published new progress about Aliphatic esters Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rani, Pooja; Husain, Ahmad; Bhasin, K. K.; Kumar, Girijesh published the artcile< Metal-Organic Framework-Based Selective Molecular Recognition of Organic Amines and Fixation of CO2 into Cyclic Carbonates>, Related Products of 3731-53-1, the main research area is zinc cadmium pyridinylnaphthalenecarboxamide oxybisbenzoate nitroisophthalate MOF preparation cycloaddition catalyst; thermal stability zinc cadmium pyridinylnaphthalenecarboxamide oxybisbenzoate nitroisophthalate; crystal structure zinc cadmium pyridinylnaphthalenecarboxamide oxybisbenzoate nitroisophthalate.

Synthesis and structural depiction of two new metal-organic frameworks (MOFs), namely, [{Zn(L)(oba)}·4H2O]α (Zn-MOF-1) and [{Cd1/2(L)1/2(nipa)1/2(H2O)1/2}·(DMF)1/2(H2O)]α (Cd-MOF-2) (where L = N2,N6-di(pyridin-4-yl)naphthalene-2,6-dicarboxamide, 4,4′-H2oba = 4,4′-oxybisbenzoic acid, and 5-H2nipa = 5-nitroisophthalic acid) are reported. Both Zn-MOF-1 and Cd-MOF-2 have been prepared by reacting ligand L and coligand 4,4′-H2oba or 5-H2nipa with the resp. dihydrates of Zn(OAc)2 and Cd(OAc)2 (OAc = acetate). Crystal structure X-ray anal. discloses that Zn-MOF-1 displays an overall 2D → 3D interpenetrated framework structure. The topol. anal. by ToposPro suggests a (4)-connected uninodal sql topol. with a point symbol of {44·62} having 2D + 2D parallel polycatenation. However, crystal packing of Cd-MOF-2 adapted a porous framework architecture and was topol. simplified as (3,4)-connected binodal 2D net. In addition, both Zn-MOF-1 and Cd-MOF-2 were proved to be multifunctional materials for the recognition of organic amines and in the fixation of CO2 to cyclic carbonates. Remarkably, Zn-MOF-1 and Cd-MOF-2 showed very good fluorescence stability in aqueous media and have shown 98 and 97% quenching efficiencies, resp., for 4-aminobenzoic acid (4-ABA), among all of the researched amines. The mechanistic study of organic amines recognition proposed that fluorescence quenching happened mainly through hydrogen-bonding and π-π stacking interactions. Addnl., cycloaddition of CO2 to epoxide in the presence of Zn-MOF-1 and Cd-MOF-2 afforded up to 96% of cyclic carbonate within 24 h. Both Zn-MOF-1 and Cd-MOF-2 exhibited recyclability for up to five cycles without noticing an appreciable loss in their sensing or catalytic efficiency.

Inorganic Chemistry published new progress about Amines Role: ANT (Analyte), PEP (Physical, Engineering or Chemical Process), ANST (Analytical Study), PROC (Process). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem