Category: 3731-53-1

Zhang, Yangmin; Yang, Hanmin; Chi, Quan; Zhang, Zehui published the artcile< Nitrogen-Doped Carbon-Supported Nickel Nanoparticles: A Robust Catalyst to Bridge the Hydrogenation of Nitriles and the Reductive Amination of Carbonyl Compounds for the Synthesis of Primary Amines>, Related Products of 3731-53-1, the main research area is primary amine preparation; nitrogen doped carbon supported nickel nanoparticle catalyst preparation; nitrile aldehyde hydrogenation reductive amination; amines; hydrogenation; nickel; nitrogen-doped carbon; reductive amination.

An efficient method was developed for the synthesis of primary amines either from the hydrogenation of nitriles or reductive amination of carbonyl compounds The reactions were catalyzed by nitrogen-doped mesoporous carbon (MC)-supported nickel nanoparticles (abbreviated as MC/Ni). The MC/Ni catalyst demonstrated high catalytic activity for the hydrogenation of nitriles into primary amines in high yields (81.9-99 %) under mild reaction conditions (80° and 2.5 bar H2). The MC/Ni catalyst also promoted the reductive amination of carbonyl compounds for the synthesis of primary amines at 80° and 1 bar H2. The hydrogenation of nitriles and the reductive amination proceeded through the same intermediates for the generation of the primary amines. To the best of knowledge, no other heterogeneous non-noble metal catalysts have been reported for the synthesis of primary amines under mild conditions, both from the hydrogenation of nitriles and reductive amination.

ChemSusChem published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mizukawa, Yuki; Ikegami-Kawai, Mayumi; Horiuchi, Masako; Kaiser, Marcel; Kojima, Masayoshi; Sakanoue, Seiki; Miyagi, Seiya; Nanga Chick, Christian; Togashi, Hiroyuki; Tsubuki, Masayoshi; Ihara, Masataka; Usuki, Toyonobu; Itoh, Isamu published the artcile< Quest for a potent antimalarial drug lead: Synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines>, Reference of 3731-53-1, the main research area is dimethoxyquinazolinediamine preparation antimalarial; Antimalarial drug; Derivatization; Quinazoline-2,4-diamines; SAR.

Quinazolines have long been known to exert varied pharmacol. activities that make them suitable for use in treating hypertension, viral infections, tumors, and malaria. Since 2014, author’s have synthesized approx. 150 different 6,7-dimethoxyquinazoline-2,4-diamines and evaluated their antimalarial activity via structure-activity relationship studies. Here, author’s summarize the results and report the discovery of 6,7-dimethoxy-N4-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine, which exhibits high antimalarial activity as a promising antimalarial drug lead.

Bioorganic & Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Reference of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gao, Li; Wu, Datong; Tan, Wensheng; Pan, Fei; Xu, Jiale; Tao, Yongxin; Kong, Yong published the artcile< A facile synthesis of two ionized fluorescent carbon dots and selective detection toward Fe2+ and Cu2+>, Name: Pyridin-4-ylmethanamine, the main research area is iron copper carbon dot selective detection.

In this study, a facile synthesis of two ionized carbon dots (CDs-2 and CDs-3) is reported, in which different ionic pairs are formed at the surface of the carbon core. In contrast to CDs-3, the accumulation of carbon core can be clearly observed in the TEM image of CDs-2. This is due to the linkage of the dibromine alkyl group. Compared with naked CDs in the absence of the ionic pair, the maximum emission wavelength undergoes a red-shift of nearly 60 nm. Moreover, protic solvents (water, ethanol and N,N′-dimethyl formamide) have an apparent effect on the emission intensities of CDs-2 and CDs-3. The time-resolved average lifetimes of CDs-2 and CDs-3 are calculated as 56.34 ns and 54.50 ns, resp. Furthermore, they both have much better fluorescence stability in the solution with pH ranging from 2 to 11 due to the presence of the imidazolium cation. It is interesting to see that CDs-2 and CDs-3 have much different responses towards Cu2+ and Fe2+. The CDs-3 solution generates clear fluorescence quenching when treated with Fe2+. In brief, we believe that these findings can inspire more research developments in the synthesis and further application of functional CDs.

Nanoscale Advances published new progress about Carbon quantum dots. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Name: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duong, Thi-Mai Huong; Nobusue, Shunpei; Tada, Hirokazu published the artcile< Preparation of perovskite-derived one dimensional single crystals based on edge-shared octahedrons with pyridine derivatives>, HPLC of Formula: 3731-53-1, the main research area is lead pyridine derivative iodo complex perovskite preparation crystal structure; optical band gap lead pyridine derivative iodo complex perovskite.

Single crystals of hybrid materials based on 1D lead iodide perovskite networks with 2 pyridine (Py) derivatives, 4-Et (4Et)Py and 4-aminomethyl (4AM)Py, were prepared The compounds assembled into edge-shared lead iodide chains that formed needle-shaped crystals with lengths >1 cm. The crystal containing (4Et)Py formed in the triclinic system with P1 symmetry. The mols. were stacked along with the novel triple chain of 1D perovskite-derived networks. The crystal containing 4AMPy formed in the monoclinic system with P21/a symmetry. The amino group formed H bonds to I-. The optical band gaps for the 4EtPy-based and 4AMPy-based crystals are 2.73 eV and 2.64 eV, resp. The slight difference between the functional groups of the 2 mols. governed their crystal structures and hence optical properties.

Journal of Crystal Growth published new progress about Crystal structure. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mizukawa, Yuki; Ikegami-Kawai, Mayumi; Horiuchi, Masako; Kaiser, Marcel; Kojima, Masayoshi; Sakanoue, Seiki; Miyagi, Seiya; Nanga Chick, Christian; Togashi, Hiroyuki; Tsubuki, Masayoshi; Ihara, Masataka; Usuki, Toyonobu; Itoh, Isamu published the artcile< Quest for a potent antimalarial drug lead: Synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines>, Reference of 3731-53-1, the main research area is dimethoxyquinazolinediamine preparation antimalarial; Antimalarial drug; Derivatization; Quinazoline-2,4-diamines; SAR.

Quinazolines have long been known to exert varied pharmacol. activities that make them suitable for use in treating hypertension, viral infections, tumors, and malaria. Since 2014, author’s have synthesized approx. 150 different 6,7-dimethoxyquinazoline-2,4-diamines and evaluated their antimalarial activity via structure-activity relationship studies. Here, author’s summarize the results and report the discovery of 6,7-dimethoxy-N4-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine, which exhibits high antimalarial activity as a promising antimalarial drug lead.

Bioorganic & Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Reference of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gao, Li; Wu, Datong; Tan, Wensheng; Pan, Fei; Xu, Jiale; Tao, Yongxin; Kong, Yong published the artcile< A facile synthesis of two ionized fluorescent carbon dots and selective detection toward Fe2+ and Cu2+>, Name: Pyridin-4-ylmethanamine, the main research area is iron copper carbon dot selective detection.

In this study, a facile synthesis of two ionized carbon dots (CDs-2 and CDs-3) is reported, in which different ionic pairs are formed at the surface of the carbon core. In contrast to CDs-3, the accumulation of carbon core can be clearly observed in the TEM image of CDs-2. This is due to the linkage of the dibromine alkyl group. Compared with naked CDs in the absence of the ionic pair, the maximum emission wavelength undergoes a red-shift of nearly 60 nm. Moreover, protic solvents (water, ethanol and N,N′-dimethyl formamide) have an apparent effect on the emission intensities of CDs-2 and CDs-3. The time-resolved average lifetimes of CDs-2 and CDs-3 are calculated as 56.34 ns and 54.50 ns, resp. Furthermore, they both have much better fluorescence stability in the solution with pH ranging from 2 to 11 due to the presence of the imidazolium cation. It is interesting to see that CDs-2 and CDs-3 have much different responses towards Cu2+ and Fe2+. The CDs-3 solution generates clear fluorescence quenching when treated with Fe2+. In brief, we believe that these findings can inspire more research developments in the synthesis and further application of functional CDs.

Nanoscale Advances published new progress about Carbon quantum dots. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Name: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duong, Thi-Mai Huong; Nobusue, Shunpei; Tada, Hirokazu published the artcile< Preparation of perovskite-derived one dimensional single crystals based on edge-shared octahedrons with pyridine derivatives>, HPLC of Formula: 3731-53-1, the main research area is lead pyridine derivative iodo complex perovskite preparation crystal structure; optical band gap lead pyridine derivative iodo complex perovskite.

Single crystals of hybrid materials based on 1D lead iodide perovskite networks with 2 pyridine (Py) derivatives, 4-Et (4Et)Py and 4-aminomethyl (4AM)Py, were prepared The compounds assembled into edge-shared lead iodide chains that formed needle-shaped crystals with lengths >1 cm. The crystal containing (4Et)Py formed in the triclinic system with P1 symmetry. The mols. were stacked along with the novel triple chain of 1D perovskite-derived networks. The crystal containing 4AMPy formed in the monoclinic system with P21/a symmetry. The amino group formed H bonds to I-. The optical band gaps for the 4EtPy-based and 4AMPy-based crystals are 2.73 eV and 2.64 eV, resp. The slight difference between the functional groups of the 2 mols. governed their crystal structures and hence optical properties.

Journal of Crystal Growth published new progress about Crystal structure. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Van Lommel, Ruben; Rutgeerts, Laurens A. J.; De Borggraeve, Wim M.; De Proft, Frank; Alonso, Mercedes published the artcile< Rationalising Supramolecular Hydrogelation of Bis-Urea-Based Gelators through a Multiscale Approach>, Application of C6H8N2, the main research area is urea gelator supramol hydrogelation density functional theory mol dynamics; aggregation; gels; molecular dynamics; noncovalent interactions; self-assembly.

The current approach to designing low-mol.-weight gelators relies on a laborious trial-and-error process, mainly because of the lack of an accurate description of the noncovalent interactions crucial for supramol. gelation. In this work, we report a multiscale bottom-up approach composed of several computational techniques to unravel the key interactions in a library of synthesized bis-urea-based gelators and rationalize their exptl. observed hydrogelation performance. In addition to d. functional theory calculations and mol. dynamics, the noncovalent interaction index is applied as a tool to visualise and identify the different types of noncovalent interactions. Interestingly, as well as hydrogen bonds between urea moieties, hydrogen bonds between a urea moiety and a pyridine ring were shown to play a detrimental role in the early aggregation phase. These findings enabled us to explain the hydrogelation performance observed in a library of twelve bis-urea derivatives, which were synthesized with 58-95 % yields. From this library, three compounds were discovered to effectively gel water, with the most efficient hydrogelator only requiring a concentration of 0.2 w/v%.

ChemPlusChem published new progress about Aggregation. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Awasthi, Amardeep; Mukherjee, Anagh; Singh, Mandeep; Rathee, Garima; Vanka, Kumar; Chandra, Ramesh published the artcile< Highly efficient chemoselective N-tert butoxycarbonylation of aliphatic/aromatic/heterocyclic amines using diphenylglycoluril as organocatalyst>, Electric Literature of 3731-53-1, the main research area is tertiary butyl carbamate chemoselective preparation DFT; amine tertiary butyldicarbonate carbonylation diphenylglycoluril organocatalyst.

An efficient approach for the chemoselective synthesis of tertiary-butyl-carbamates I [R1 = Ph, 4-BrC6H4, PhCH2CH2, etc.; R2 = H; R1R2 = CH2CH2N(Ph)CH2CH2] via N-tert-butoxycarbonylation of a variety of amines using diphenylglycoluril as organocatalyst was described. For the first time, a plausible mechanism for the N-tert-butoxycarbonylation was proposed using d. functional theory (DFT) calculations supported by NMR studies. The reusability of the organocatalyst and observation of the desired N-Boc protected amines I being formed without the formation of side products like urea, oxazolidinone, isocyanate, and N, N-di-Boc derivatives made the present protocol desirable.

Tetrahedron published new progress about Alkoxycarbonylation. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Electric Literature of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dolui, Dependu; Mir, Ab Qayoom; Dutta, Arnab published the artcile< Probing the peripheral role of amines in photo- and electrocatalytic H2 production by molecular cobalt complexes>, Formula: C6H8N2, the main research area is peripheral amine photo electrocatalysis hydrogen evolution cobalt complex catalyst.

The incorporation of amine functionality in the periphery of a synthetic cobaloxime core induces excellent photo-(TON 180) and electrocatalytic H2 production (TOF 4330 s-1) in aqueous solution The primary amine group displays a superior influence on the catalysis compared to a secondary amine group with an analogous cobaloxime template.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amino group. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem