Category: 3731-53-1

Lan, Chunling Blue; Auclair, Karine published the artcile< Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation>, COA of Formula: C6H8N2, the main research area is amine potassium cyanate ammonium chloride microwave irradiation green chem; urea preparation.

Ammonium chloride promoted the reaction between amines and potassium cyanate to generate monosubstituted ureas in water. This method proceeded rapidly under microwave irradiation and tolerates a broad range of functional groups. Unlike previous strategies, it was compatible with other nucleophiles, acid-labile moieties and most of the common protecting groups. The products precipitate out of solution, allowing facile isolation without column chromatog.

European Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, COA of Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Youcan; Yin, Zhiping; Wang, Hai; Wu, Xiao-Feng published the artcile< Pd/C-Catalyzed Carbonylative Synthesis of 2-Aminobenzoxazinones from 2-Iodoaryl Azides and Amines>, COA of Formula: C6H8N2, the main research area is amine iodoaryl azide carbon monoxide palladium catalyst carbonylation; aminobenzoxazinone preparation.

A palladium-catalyzed carbonylative procedure for the synthesis of 2-aminobenzoxazinones from 1-azido-2-iodobenzenes and amines has been developed. A broad range of 2-aminobenzoxazinone derivatives, e.g., I were prepared in moderate to excellent yields by using Pd/C as the catalyst under CO atm. Notably, by using organic azides as the substrates, external oxidant usage can be successfully avoided and only forms N2 as the byproduct.

Organic Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, COA of Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bokosi, Fostino R. B.; Beteck, Richard M.; Mbaba, Mziyanda; Mtshare, Thanduxolo E.; Laming, Dustin; Hoppe, Heinrich C.; Khanye, Setshaba D. published the artcile< Design, synthesis and biological evaluation of mono- and bisquinoline methanamine derivatives as potential antiplasmodial agents>, Product Details of C6H8N2, the main research area is quinoline methanamine preparation antimalarial; Antiplasmodial; Chloroquine-sensitive; Plasmodium falciparum; Quinoline.

Several classes of antimalarial drugs are currently available, although issues of toxicity and the emergence of drug resistant malaria parasites have reduced their overall therapeutic efficiency. Quinoline based antiplasmodial drugs have unequivocally been long-established and continue to inspire the design of new antimalarial agents. Herein, a series of mono- and bisquinoline methanamine derivatives were synthesized through sequential steps; Vilsmeier-Haack, reductive amination, and nucleophilic substitution, and obtained in low to excellent yields. The resulting compounds were investigated for in vitro antiplasmodial activity against the 3D7 chloroquine-sensitive strain of Plasmodium falciparum, and compounds I and II emerged as the most promising with IC50 values of 0.23 and 0.93μM, resp. The most promising compounds were also evaluated in silico by mol. docking protocols for binding affinity to the {0 0 1} fast-growing face of a hemozoin crystal model.

Bioorganic & Medicinal Chemistry Letters published new progress about Amines Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Product Details of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ceglowski, Michal; Marien, Yoshi W.; Smeets, Sander; De Smet, Lieselot; D′hooge, Dagmar R.; Schroeder, Grzegorz; Hoogenboom, Richard published the artcile< Molecularly Imprinted Polymers with Enhanced Selectivity Based on 4-(Aminomethyl)pyridine-Functionalized Poly(2-oxazoline)s for Detecting Hazardous Herbicide Contaminants>, HPLC of Formula: 3731-53-1, the main research area is molecularly imprinted polymer aminomethylpyridine functionalized polyoxazoline detecting herbicide contaminant; trichlorophenoxyacetate adsorption molecularly imprinted polymer adsorbent.

The detection of hazardous compounds is of importance to control (drinking) water quality. Here, we report the development of poly(2-oxazoline)-based molecularly imprinted polymers (MIPs) for the detection of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). In view of enhanced selectivity of the MIPs, it was hypothesized that incorporation of pyridine groups would lead to stronger interactions with 2,4,5-T. The synthesis of 4-(aminomethyl)pyridine (4-AMP)-functionalized poly(2-methoxycarbonylpropyl-2-oxazoline)s with various degrees of modification was, therefore, investigated via stoichiometric and kinetic control over the functionalization degree. The mol. imprinting of 2,4,5-T is performed by direct amidation of the Me ester side chains with diethylenetriamine. The exptl. data of 2,4,5-T adsorption were interpreted with various models to quantify the adsorption thermodn. and kinetics. The best fit was obtained for a single-site Langmuir model, indicating uniform binding site energies. A further investigation shows that the maximum adsorption capacity is reached at low 4-AMP modification degrees, whereas greater adsorption energies and higher selectivities are observed for higher 4-AMP modification degrees. Finally, the developed 4-AMP-modified MIP adsorbents were successfully used for quantification of 2,4,5-T by direct anal. with ambient mass spectrometry. In comparison with the pure analyte solution, the detection limits decreased by three orders of magnitude.

Chemistry of Materials published new progress about Adsorbents. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hayashi, Mikihiro; Kimura, Takahiro; Oba, Yuta; Takasu, Akinori published the artcile< One-Pot Synthesis of Dual Supramolecular Associative PMMA-Based Copolymers and the Precise Thermal Property Tuning>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is onepot dual supramol associative PMMA copolymer.

Dual supramol. associative polymers have attracted attention for efficient phys. property modification. Herein, a one-pot synthesis of dual supramol. associative poly(Me methacrylate)-based copolymers via reversible addition fragmentation chain transfer (RAFT) copolymerization using a novel methacrylate-type monomer (coded as UP-MA) bearing a urea bond and a pendant pyridine group is demonstrated. UP-MA is synthesized by reacting 4-picolylamine and 2-isocyanatoethyl methacrylate. The subsequent RAFT copolymerization of UP-MA and Me methacrylate (MMA) can be performed by directly adding MMA, a chain transfer agent, and a radical initiator into the reaction solution of UP-MA. The estimated values of radical reactivity ratio (r) for UP-MA and MMA are close to unity, attaining a nearly ideal random sequence of the dual supramol. associative units in the copolymer chain. By blending a metal salt into the random copolymer, coordination bonds between the salt and the pyridine groups are formed, and the urea groups simultaneously form hydrogen bonds, generating a dual supramol. associative network. Precise tuning of the thermal property is realized by changing the fraction of the metal salt and associative groups in the copolymers.

Macromolecular Chemistry and Physics published new progress about Glass transition temperature. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chniti, Sami; Kollar, Laszlo; Benyei, Attila; Takacs, Attila published the artcile< Highly Selective Synthesis of 6-Glyoxylamidoquinoline Derivatives via Palladium-Catalyzed Aminocarbonylation>, Application of C6H8N2, the main research area is quinoline amide preparation chemoselective; iodoquinoline amine carbon monoxide aminocarbonylation palladium catalyst; 6-iodoquinoline; aminocarbonylation; carbon monoxide; double carbonylation; palladium.

The aminocarbonylation of 6-iodoquinoline has been investigated in the presence of large series of amine nucleophiles such as tert-butylamine, cyclohexylamine, furfyrlamine, etc. providing an efficient synthetic route for producing various quinoline-6-carboxamide I (R = cyclohexylaminyl, decan-1-aminyl, 4-methylpiperazin-1-yl, etc.) and quinoline-6-glyoxylamide derivatives II. It was shown, after detailed optimization study, that the formation of amides and ketoamides is strongly influenced by the reaction conditions. Performing the reactions at 40 bar of carbon monoxide pressure in the presence of Pd(OAc)2/2 PPh3, the corresponding 2-ketocarboxamides II were formed as major products (up to 63%). When the monodentate triphenylphosphine was replaced by the bidentate XantPhos, the quinoline-6-carboxamide derivatives I were synthesized almost exclusively under atm. conditions (up to 98%). The isolation and characterization of the new carbonylated products I, II of various structures were also accomplished. Furthermore, the structure of three new mono- and double-carbonylated compounds I, I were unambiguously established by using a single-crystal XRD study.

Molecules published new progress about Amides, oxo Role: SPN (Synthetic Preparation), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Junaid, Ahmad; Lim, Felicia Phei Lin; Zhou, Yvonne Peijun; Chui, Wai Keung; Dolzhenko, Anton V. published the artcile< Fused heterocyclic systems with an s-triazine ring. 34. Development of a practical approach for the synthesis of 5-aza-isoguanines>, Product Details of C6H8N2, the main research area is azaisoguanine fused triazine preparation; azapurine; purine isostere.; triazine; triazole.

In this article, an attempt to develop a practical method for the preparation of 5-aza-isoguanines is reported. Several synthetic approaches were explored to establish a robust general protocol for the preparation of these compounds The significant difference in the reactivity of the C-5 and C-7 electrophilic centers of 1,2,4-triazolo[1,5-a][1,3,5]triazines (5-azapurines) towards nucleophiles was demonstrated. The most practical and general method for the preparation of 5-aza-isoguanines involved a regioselective reaction of ethoxycarbonyl isothiocyanate with a 5-aminotriazole. The intramol. ring closure of the resulted product followed by the S-methylation afforded 7-methylthio-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-one, which could be effectively aminated with various amines. The resulted 5-aza-isoguanines resemble a known purine nucleoside phosphorylase inhibitor and could be interesting for further investigations as potential anticancer agents.

Molecules published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Product Details of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sepehri, Nima; Iraji, Aida; Yavari, Ali; Asgari, Mohammad Sadegh; Zamani, Saeed; Hosseini, Samanesadat; Bahadorikhalili, Saeed; Pirhadi, Somayeh; Larijani, Bagher; Khoshneviszadeh, Mahsima; Hamedifar, Halleh; Mahdavi, Mohammad; Khoshneviszadeh, Mehdi published the artcile< The natural-based optimization of kojic acid conjugated to different thio-quinazolinones as potential anti-melanogenesis agents with tyrosinase inhibitory activity>, Category: pyridine-derivatives, the main research area is kojic acid thio quinazolinone mol docking antimelanogenesis tyrosinase inhibition; Cytotoxicity; Hyperpigmentation; Kojic acid; Quinazolinone; Tyrosinase inhibitor.

Melanin pigment and melanogenesis are a two-edged sword. Melanin has a radioprotection role while melanogenesis has undesirable effects. Targeting the melanogenesis pathway, a series of kojyl thioether conjugated to different quinazolinone derivatives I (R = c-Pr, Ph, 2-pyridyl, etc.) were designed, synthesized, and evaluated for their inhibitory activity against mushroom tyrosinase. All the synthesized compounds were screened for their anti-tyrosinase activity and all derivatives displayed better potency than kojic acid as the pos. control. In this regard, compounds I (R = pyridin-2-ylmethyl) and I (R = 2-pyridyl) the most active compounds showed an IC50 value of 0.46 and 0.50μM, resp. In kinetic evaluation against tyrosinase, I (R = pyridin-2-ylmethyl) depicted an uncompetitive inhibition pattern. Designed compounds also exhibited mild antioxidant capacity. Moreover, compounds I (R = pyridin-2-ylmethyl) and I (R = 2-pyridyl) achieved good potency against the B16F10 cell line to reduce the melanin content, while showing limited toxicity against malignant cells. The proposed binding mode of new inhibitors evaluated through mol. docking was consistent with the results of structure-activity relationship anal.

Bioorganic & Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Rongrong; Peng, Qiyao; Wan, Dan; Yu, Chao; Zhang, Yuan; Hou, Yi; Luo, Quan; Li, Xiong; Zhang, Shuihan; Xie, Lin; Ou, Pinghua; Peng, Yongbo published the artcile< Construction of a lysosome-targetable ratiometric fluorescent probe for H2O2 tracing and imaging in living cells and an inflamed model>, HPLC of Formula: 3731-53-1, the main research area is hydrogen peroxide cell lysosome ratiometric fluorescent imaging.

Hydrogen peroxide (H2O2), an important reactive oxygen species (ROS) with unique destructive oxidation properties, can be produced in lysosomes to fight off pathogens. Although many fluorescent probes have been developed for the detection and imaging of H2O2, the development of a ratiometric fluorescent probe for H2O2 detection and imaging in lysosomes and an inflammation model remains rather scarce. Therefore, it is important to develop an efficient tool for monitoring H2O2 in inflamed tissues to evaluate the physiol. and pathol. relationship between inflammation and lysosomal H2O2. In this work, a new naphthalimide-based lysosome-targeting fluorescent probe (NPT-H2O2) for ratiometric detection and imaging was developed in vitro and in vivo. The probe exhibited two wellresolved emission peaks separated by 125 nm, rapid response (<40 s), and high selectivity and sensitivity toward H2O2, as well as low cytotoxicity in vitro. Inspired by prominent features of these results, we further successfully applied NPT-H2O2 for H2O2 imaging with a dual-channel in living cells, demonstrating that our probe NPT-H2O2 was targeted in the lysosomes. Finally, NPT-H2O2 was used for H2O2 detection in inflamed tissues and achieved satisfactory results. We predict that our probe can be used as a powerful tool to reveal the relationship between physiol. and pathol. of inflammation and lysosomal H2O2. RSC Advances published new progress about Absorption spectra. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gu, Tingting; Kwaku Attatsi, Isaac; Zhu, Weihua; Li, Minzhi; Ndur, Samuel A.; Liang, Xu published the artcile< Enhanced electrocatalytic hydrogen evolutions of Co(II)phthalocyanine through axially coordinated pyridine-pyrene>, HPLC of Formula: 3731-53-1, the main research area is cobalt phthalocyanine immobilized multiwalled carbon nanotube electrocatalytic hydrogen evolution.

Non-precious metal catalysts can effectively evolve hydrogen in aqueous media, but a highly efficient metal-based catalyst is still a significant assignment. Herein, Co(II)phthalocyanine was noncovalently immobilized on multiwalled carbon nanotubes through axial coordination via pyridine-pyrene linker and applied towards hydrogen evolution reactions. This material provided a superiorly enhanced electrocatalyzed performance signifying high efficiency. With this behavior, our target material we believe paves the way towards designing efficient energy production and storage devices.

Inorganica Chimica Acta published new progress about Carbon nanotubes (multiwalled). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem