Category: 3731-53-1

Kiss, Levente; Pop, Alexandra; Shova, Sergiu; Rat, Ciprian I.; Silvestru, Cristian published the artcile< Synthesis and characterization of [4-{(CH2O)2CH}C6H4]2Hg, [4-(O:CH)C6H4]2Hg and [(E)-4-(RN:CH)C6H4]2Hg (R = 2'-py, 4'-py, 2'-pyCH2, 4'-pyCH2)>, Synthetic Route of 3731-53-1, the main research area is crystal structure mol mercury diaryl compound supramol preparation homocoupling.

The reaction of 4-[(CH2O)2CH]C6H4Br (1) with n-BuLi, followed by addition of HgCl2 to the in situ formed organolithium derivative, affords [4-{(CH2O)2CH}C6H4]2Hg (2). Deprotection of the formyl groups of 2 in presence of p-TsOH (p-Ts = 4-MeC6H4SO3) leads to [4-(O:CH)C6H4]2Hg (3). Condensation reactions of 3 with 2-aminopyridine (2-pyNH2), 4-aminopyridine (4-pyNH2), 2-aminomethylpyridine (2-pyCH2NH2), and 4-aminomethylpyridine (4-pyCH2NH2), in CH2Cl2, affords the novel diorganomercury(II) compounds of type [(E)-4-(RN:C)C6H4]2Hg [R = 2′-py (4), 4′-py (5), 2′-pyCH2- (6), 4′-pyCH2 (7)]. Compounds 2 and 3 were useful precursors for the preparation of the corresponding homocoupling products [4-{(CH2O)2CH}C6H4]2 (8) and [4-(O:CH)C6H4]2 (9) in presence of catalytic amounts of palladium(II) acetate. Compounds 2-9 were characterized by multinuclear magnetic resonance (NMR) (1H, 13C{1H}, and 199Hg{1H}, when appropriate) and IR (IR) spectroscopy and by mass spectrometry. The mol. structures of 3, 5, 6, 8, and 9 were determined by single-crystal X-ray diffraction.

Applied Organometallic Chemistry published new progress about Condensation reaction. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Synthetic Route of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Kaizhi; Jiang, Pengbo; Yang, Ming; Ma, Ping; Qin, Jiaheng; Huang, Xiaokang; Ma, Lei; Li, Rong published the artcile< Metal-free nitrogen -doped carbon nanosheets: a catalyst for the direct synthesis of imines under mild conditions>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is transfer hydrogenation nitrile nitrogen doped carbon nanocatalyst; imine preparation amine oxidation nitrile nitrogen doped carbon nanocatalyst.

Herein, a highly stable, porous, multifunctional and metal-free catalyst was developed, which exhibited significant catalytic performance in the oxidation of amines and transfer hydrogenation of nitriles under mild conditions; this could be attributed to the presence of numerous active sites and their outstanding BET surface area. The obtained results showed that most of the yields of imines exceeded 90%, and the cycling performance of the catalyst could be at least seven runs without any decay in the reaction activity, which could be comparable to those of metal catalysts. Subsequently, a kinetic study has demonstrated that the apparent activation energy for the direct synthesis of imines from amines is 67.39 kJ mol-1, which has been performed to testify that the catalytic performances are rational. Via catalyst characterizations and exptl. data, graphitic-N has been proven to be the active site of the catalyst. Hence, this study is beneficial to comprehend the mechanism of action of a metal-free N-doped carbon catalyst in the formation of imines.

Green Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aretz, Christopher D.; Morwitzer, M. Jane; Sanford, Austin G.; Hogan, Alicia M.; Portillo, Madelene V.; Kharade, Sujay V.; Kramer, Meghan; McCarthey, James B.; Trigueros, Renata Rusconi; Piermarini, Peter M.; Denton, Jerod S.; Hopkins, Corey R. published the artcile< Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)-N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 (AeKir1) Channel>, Safety of Pyridin-4-ylmethanamine, the main research area is nitrophenylsulfonylpiperazinylpyridinylmethylaniline preparation Kir1 potassium channel inhibitor Aedes; Kir channels; Zika; larvae; vector-borne diseases.

Mosquito-borne arboviral diseases such as Zika, dengue fever, and chikungunya are transmitted to humans by infected adult female Aedes aegypti mosquitoes and affect a large portion of the world’s population. The Kir1 channel in Ae. aegypti (AeKir1) is an important ion channel in the functioning of mosquito Malpighian (renal) tubules and one that can be manipulated in order to disrupt excretory functions in mosquitoes. We have previously reported the discovery of various scaffolds that are active against the AeKir1 channel. Herein we report the synthesis and biol. characterization of a new 2-nitro-5-(4-(phenylsulfonyl) piperazin-1-yl)-N-(pyridin-4-ylmethyl)anilines scaffold as inhibitors of AeKir1. This new scaffold is more potent in vitro compared to the previously reported scaffolds, and the mols. kill mosquito larvae.

ACS Infectious Diseases published new progress about Aedes aegypti. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Safety of Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Guanglong; Xiao, Keya; Shi, Man; Shuai, Jing; Xu, Zhiping; Li, Zhong; Cheng, Jiagao published the artcile< Study on 4-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-d]pyrimidine Derivatives: Design, Synthesis, Insecticidal Assay and Binding Mode Studies>, HPLC of Formula: 3731-53-1, the main research area is oxotetrahydro pyrazolopyrimidine preparation insecticide docking SAR; GABA receptor; fipronil; insecticidal activity; phenylpyrazole; scaffold hopping.

A series of 4-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesized based on the fipronil low energy conformation by scaffold hopping strategy. Physicochem. properties calculation, insecticidal assay and binding mode studies were also performed. It was found that the target compounds displayed lower insecticidal activities than fipronil. The differences in binding modes between these compounds and fipronil may be the major reason for reduced insecticidal activities.

Chemistry & Biodiversity published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pinkerton, Anthony B.; Sessions, E. Hampton; Hershberger, Paul; Maloney, Patrick R.; Peddibhotla, Satyamaheshwar; Hopf, Meghan; Sergienko, Eduard; Ma, Chen-Ting; Smith, Layton H.; Jackson, Michael R.; Tanaka, Jun; Tsuji, Takashi; Akiu, Mayuko; Cohen, Steven E.; Nakamura, Tsuyoshi; Gardell, Stephen J. published the artcile< Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators>, Reference of 3731-53-1, the main research area is urea nicotinamide phosphoribosyltransferase activator; NAD(+) booster; NAMPT; NAMPT activators; Ureas.

NAD+ is a crucial cellular factor that plays multifaceted roles in wide ranging biol. processes. Low levels of NAD+ have been linked to numerous diseases including metabolic disorders, cardiovascular disease, neurodegeneration, and muscle wasting disorders. A novel strategy to boost NAD+ is to activate nicotinamide phosphoribosyltransferase (NAMPT), the putative rate-limiting step in the NAD+ salvage pathway. We previously showed that NAMPT activators increase NAD+ levels in vitro and in vivo. Herein we describe the optimization of our NAMPT activator prototype (SBI-0797812) leading to the identification of 1-(4-((4-chlorophenyl)sulfonyl)phenyl)-3-(oxazol-5-ylmethyl)urea (34) that showed far more potent NAMPT activation and improved oral bioavailability.

Bioorganic & Medicinal Chemistry Letters published new progress about Cardiovascular disease. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Reference of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yu, Xudong; Guo, Jiangbo; Peng, Pan; Shen, Fengjuan; Li, Yajuan; Geng, Lijun; Wang, Tao published the artcile< Self-assembly induced hydrogelation approach as novel means of selective and visual sensing picric acid>, Formula: C6H8N2, the main research area is hydrogel picric acid sugar derivative isomer hydrogen bonding.

Picric acid is a kind of dangerous and toxic nitroarom. explosive chems. and causes great concern in safety, health and environment issues. However, the visual and selective sensing of picric acid in pure water is still a challenge in recent years. In this work, two novel isomeric sugar-based derivatives denoted as NGs (NG1 and NG2) with different terminal groups (pyridyl segments) have been designed and synthesized. We demonstrate the preparation of picric acid assisted supramol. hydrogels driven by hydrogen bonding interaction, which endows the visual and direct recognition for picric acid via fast and selective gelation approach without expensive equipment. The binding mechanism of NGs with PA both in solutions and gels and the isomeric effect on the gelation properties are studied in detail by several techniques. At last, NG2 based test strips are also developed to detect tiny amount of PA in water in a contact mode.

Applied Surface Science published new progress about Carbohydrates Role: TEM (Technical or Engineered Material Use), USES (Uses) (deriv). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aryal, Gyan H.; Rana, Ganesh R.; Guo, Fei; Hunter, Kenneth W.; Huang, Liming published the artcile< Heparin sensing based on multisite-binding induced highly ordered perylene nanoaggregates>, HPLC of Formula: 3731-53-1, the main research area is perylene nanoaggregate heparin fluorescent sensor.

Highly ordered perylene nanoaggregates with ultra-low fluorescence were employed for the selective and sensitive fluorescence sensing of heparin. A supramol. host-guest complex was used as a displacement probe to improve the sensitivity.

Chemical Communications (Cambridge, United Kingdom) published new progress about Fluorescence. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Datong; Pan, Fei; Gao, Li; Tao, Yongxin; Kong, Yong published the artcile< An ionic-based carbon dot for enantioselective discrimination of nonaromatic amino alcohols>, Synthetic Route of 3731-53-1, the main research area is fluorescent sensor amino alc copper binding energy chiral recognition.

Here, ionized chiral carbon dots, (S,S)-C-dots-1 (λex = 430 nm, λem = 480 nm), were synthesized via a facile route with relatively high quantum yield (~24.4%) and used as a fluorescent chiral sensor. One of the advantages of the synthetic process is that it avoids the loss of the chiral center. That is, the chiral bromo compound can directly form an ionic pair with the pyridyl group, which is derived from the amine precursor in the first step. Furthermore, (S,S)-C-dots-1 shows clear discrimination toward different configurations of nonaromatic amino alcs. in the presence of Cu(II). When the (R)-isomer is added to a solution of (S,S)-C-dots-1 + Cu(II), it shows much higher fluorescent intensity than the (S)-isomer. The values of IR/IS are 2.9 and 2.3 for 2-aminobutan-1-ol and 2-aminopropan-1-ol, resp. In summary, we believe that this work can expand the synthetic routes and potential applications of functional carbon dots in the field of enantioselective sensing.

Analyst (Cambridge, United Kingdom) published new progress about Amino alcohols Role: ANT (Analyte), PEP (Physical, Engineering or Chemical Process), PRP (Properties), ANST (Analytical Study), PROC (Process). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Synthetic Route of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gao, Kaige; Liu, Chunlin; Zhang, Wei; Wang, Kangni; Liu, Wenlong published the artcile< Pyroelectricity and fieldinduced spin-flop in 4-(aminomethyl)pyridinium manganese chloride dihydrate>, Quality Control of 3731-53-1, the main research area is aminomethyl pyridinium manganese chloride dihydrate pyroelectricity spinflop; ferroelectric; pyroelectric; single crystal; spin-flop.

Large single crystals of (4-(Aminomethyl)pyridinium)2 MnCl4 • 2H2O (1) were grown by slow evaporation of solution The crystal structure was solved to be Pi, which belongs to the ̅central sym. space group. But small pyroelec. current was detected, as well as a ferroelec. hysteresis loop. The pyroelec. and the ferroelec. properties were attributed to the strain caused by defects. Temperature-dependent magnetic curves and the M-H curve show that 1 is antiferromagnetic ordering below 2.5 K. A field-induced spin-flop is observed in the antiferromagnetic ordering state.

Royal Society Open Science published new progress about Antiferromagnetic films. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tan, Yee Seng; Tiekink, Edward R. T. published the artcile< Crystal structure of catena-poly{(μ2-N1,N2-bis[(pyridin-4-yl)methyl]ethanediamide-κ2N:N′)-bis(O,O′-di-isopropyldithiophosphato-κ1S)zinc(II)} - acetonitrile (1/1), C26H42N4O6P2S4Zn[n.8901]C2H3N>, Related Products of 3731-53-1, the main research area is crystal structure catenapolypyridinmethylethanediamideisopropyldithiophosphatoacetonitrile.

C28H45N5O6P2S4Zn, monoclinic, P21/c (number 14), a = 7.73670(10) Å, b = 21.56370(10) Å, c = 23.1184(2) Å, β = 99.121(1)°, V = 3808.12(6) Å3, Z = 4, Rgt(F) = 0.0210, wRref(F2) = 0.0580, T = 100(2) K. CCDC number: 1959644. The Zn[S2P(O-iPr)2]2precursor was prepared in high yield from the in situ reaction of Zn(NO3)2·6 H2O (Alfa Aesar; 14.87 g, 0.05 mol), iPrOH (Merck; 16.05 mL, 0.21 mol), P2S5(Sigma-Aldrich; 11.11 g, 0.05 mol) and 50% weight/weight NaOH solution (Merck; 8.80 mL, 0.11 mol). N, N-Bis(pyridin-4-ylmethyl) ethanediamide (4LH2) was prepared in high yield from the 2:1 reaction (reflux) of 4-picolylamine (Aldrich; 2.03 mL, 0.02 mol) and di-Et oxalate (Aldrich; 1.36 mL, 0.01 mol) in ethanol solution (Merck; 5 mL). The title compound was obtained by mixing a suspension of Zn[S2P(O-iPr)2]2(0.50 g, 1.02 mmol) and N,N-bis(pyridin-4-ylmethyl)ethanediamide (0.28 g, 1.04 mmol) in DMF (Merck; 5 mL), followed by stirring for 30 min at 373 K. The solution was filtered, the filtrate taken in acetonitrile (Merck; 1 mL) and transferred to a vial for crystallization Yellow crystals formed after one day.

Zeitschrift fuer Kristallographie – New Crystal Structures published new progress about Crystal structure. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem