Category: 3731-53-1

Hu, Jun-Chao; Sun, Shanshan; Li, Ming-De; Xia, Wu; Wu, Jin; Liu, Hongfang; Wang, Feng published the artcile< A biomimetic self-assembled cobaloxime@CdS/rGO hybrid for boosting photocatalytic H2 production>, Synthetic Route of 3731-53-1, the main research area is biomimetic cobaloxime CdS rGO hybrid photocatalytic hydrogen prduction.

A biomimetic CoPe@CdS/rGO hybrid that self-assembles via the integration of a mol. cobalt catalyst and CdS nano-semiconductor on reduced graphene oxide was constructed for boosting photocatalytic H2 production Photoinduced electron transfer from CdS/rGO to the mol. catalyst occurs and a long-lived charge-separation state forms for high H2 production

Chemical Communications (Cambridge, United Kingdom) published new progress about Attenuated-total-reflectance IR spectroscopy. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Synthetic Route of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ngo, Khang; Collins-Kautz, Chelsey; Gerstenecker, Stefan; Wagner, Bjoern; Heine, Andreas; Klebe, Gerhard published the artcile< Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins?>, Product Details of C6H8N2, the main research area is Protein Induced ligand protonation trypsin thrombin.

Trypsin and thrombin, structurally similar serine proteases, recognize different substrates; thrombin cleaves after Arg, whereas trypsin cleaves after Lys/Arg. Both recognize basic substrate headgroups via Asp189 at the bottom of the S1 pocket. By crystallog. and isothermal titration calorimetry (ITC), we studied a series of D-Phe/D-DiPhe-Pro-(amino)pyridines. Identical ligand pairs show the same binding poses. Surprisingly, one ligand binds to trypsin in protonated state and to thrombin in unprotonated state at P1 along with differences in the residual solvation pattern. While trypsin binding is mediated by an ordered water mol., in thrombin, water is scattered over three hydration sites. Although having highly similar S1 pockets, our results suggest different electrostatic properties of Asp189 possibly contributing to the selectivity determinant. Thrombin binds a specific Na+ ion next to Asp189, which is absent in trypsin. The electrostatic properties across the S1 pocket are further attenuated by charged Glu192 at the rim of S1 in thrombin, which is replaced by uncharged Gln192 in trypsin.

Journal of Medicinal Chemistry published new progress about Enzyme functional sites, active. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Product Details of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kumar, Sonu; Sarmah, Manash P.; Reddy, Yella; Bhatt, Ashish; Kant, Ravi published the artcile< A one-step synthesis of substituted benzo- and pyridine-fused 1H-imidazoles>, Electric Literature of 3731-53-1, the main research area is aryl benzoimidazole preparation; fluoronitrobenzene amine cyclization microwave irradiation; imidazopyridine aryl preparation; amine nitrofluoropyrdine cyclization microwave irradiation.

A one-step microwave accelerated synthesis of substituted benzo- and pyridine-fused 1H-imidazoles were described. Mechanistically, the reaction proceeded by reacting substituted 2-fluoronitrobenzene and substituted arylamine through the formation of N-hydroxy intermediate, which at higher temperature cleaved to afford the desired product. This approach achieved reductions in reaction times, higher yields, cleaner reactions than the previously described synthetic processes.

Synthetic Communications published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Electric Literature of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

El-Marrouki, Dalel; Touchet, Sabrina; Abdelli, Abderrahmen; M’Rabet, Hedi; Efrit, Mohamed Lotfi; Gros, Philippe C. published the artcile< Tuneable access to indole, indolone, and cinnoline derivatives from a common 1,4-diketone Michael acceptor>, SDS of cas: 3731-53-1, the main research area is indole preparation; cinnoline preparation; diketone primary amine Michael; 1,4-diketone; N-heterocycle; cinnoline; indole; indolone.

A straightforward and metal-free strategy for the synthesis of nitrogen-containing heterocyclic moieties, indoles I [R1 = Me, Et; R2 = Bn, CH(Me)Ph, CH2(CH2)2NMe2, etc.], indolones II [R3 = Me, Et, Ph; R4 = Bn, 4-BrC6H4, 4-pyridylmethyl, etc.] and cinnolines III [R5 = Me, Ph, 2-thienyl, etc.; R6 = H, Me] was developed via Michael reaction 1,4-diketones and primary amines. The protocols developed here used mild conditions, were functional-group tolerant, transition-metal-free, proceeded in moderate to good yield.

Beilstein Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, SDS of cas: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Salinas, Yolanda; Brueggemann, Oliver; Monkowius, Uwe; Teasdale, Ian published the artcile< Visible light photocleavable ruthenium-based molecular gates to reversibly control release from mesoporous silica nanoparticles>, Category: pyridine-derivatives, the main research area is ruthenium silicon nanoparticle delivery controlled release visible light irradiation; cargo release on demand; mesoporous silica nanoparticles (MSNs); molecular gates; reversibility; ruthenium complex; visible light photocleavage.

Herein we present hybrid mesoporous silica nanomaterials (MSN) with visible light-sensitive ruthenium complexes acting as gates. Two different [Ru(bpy)2L1L2]2+ complexes were investigated by grafting [Ru(bpy)2(4AMP)2](PF6)2 (RC1) and [Ru(bpy)2(PPh3)Cl]Cl (RC2) via two or one ligands onto the surface of mesoporous silica nanoparticles (MSNs), to give MSN1-RC1 and MSN2-RC2, resp. The pores were previously loaded with a common dye, safranin O, and release studies were conducted. The number and position of the ligands were shown to influence the photocages behavior and thus the release of the cargo. Release studies from MSN1-RC1 in acetonitrile showed that in the dark the amount of dye released was minimal after 300 min, whereas a significant increase was measured upon visible light irradiation (ca. 90%). Release studies from the second nanomaterial MSN2-RC2, where the complex RC2 was bound to the MSN via only one ligand, showed stability under darkness and in aqueous solution up to 180 min and, rapid release of the dye when irradiated with visible light. Furthermore, this system was demonstrated to be reversible, since, upon heating to 80°C, the system could effectively re-close the pores and re-open it again upon visible light irradiation

Nanomaterials published new progress about Ligands Role: THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zeng, Xiaojun; Yan, Wenhao; Zacate, Samson B.; Cai, Aijie; Wang, Yufei; Yang, Dongqi; Yang, Kundi; Liu, Wei published the artcile< Copper-Catalyzed Deaminative Difluoromethylation>, SDS of cas: 3731-53-1, the main research area is copper catalyst deaminative difluoromethylation alkyl amine; copper; deamination; difluoromethylation; homogeneous catalysis; pyridinium salts.

The difluoromethyl group (CF2H) is considered to be a lipophilic and metabolically stable bioisostere of an amino (NH2) group. Therefore, methods that can rapidly convert an NH2 group into a CF2H group would be of great value to medicinal chem. The authors report herein an efficient Cu-catalyzed approach for the conversion of alkyl pyridinium salts, which can be readily synthesized from the corresponding alkyl amines, to their alkyl difluoromethane analogs. This method tolerates a broad range of functional groups and can be applied to the late-stage modification of complex amino-containing pharmaceuticals.

Angewandte Chemie, International Edition published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, SDS of cas: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Attatsi, Isaac Kwaku; Zhu, Weihua; Liang, Xu published the artcile< Noncovalent immobilization of Co(II) porphyrin through axial coordination as an enhanced electrocatalyst on carbon electrodes for oxygen reduction and evolution>, Category: pyridine-derivatives, the main research area is cobalt tetraphenylporphyrin carbon nanotube glassy carbon oxygen reduction evolution.

Catalysis of fuel-producing reactions can be transferred from homogeneous solution to a surface via attachment of the mol. catalyst. A pyrene-pyridine hybrid (Py-Py) was used as an axial ligand to bridge Co(II)tetraphenylporphyrin which was finally immobilized on carbon nanotubes via noncovalent interactions and further deposited on glassy carbon. This noncovalent immobilization of Co(II)porphyrin through axial coordination provides significantly enhanced electrochem. catalyzed oxygen reduction and oxygen evolution, illustrating a new insight into understanding surface catalysis.

New Journal of Chemistry published new progress about Bifunctional catalysts. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bonardd, Sebastian; Angel, Alejandro; Norambuena, Angel; Coll, Deysma; Tundidor-Camba, Alain; Ortiz, Pablo A. published the artcile< Novel polyelectrolytes obtained by direct alkylation and ion replacement of a new aromatic polyamide copolymer bearing pyridinyl pendant groups>, SDS of cas: 3731-53-1, the main research area is aromatic polyamide copolymer pyridinyl pendant bearing polyelectrolyte alkylation; polyamide; polyelectrolyte; pyridinyl groups; quaternisation.

The following work shows, for the first time, the synthesis and characterization of a new family of polyelectrolytes, along with their preliminary assessments in terms of desalin water treatment. These materials fall into the category of aromatic co-polyamides, which are obtained by the direct condensation of monomers 4,4′-oxydianiline (ODA), isophthaloyl chloride, and 3,5-diamino-N-(pyridin-4-ylmethyl)benzamide (PyMDA). Thereby, the charged nature exhibited by these materials was achieved through the quaternization of PyMDA moieties using linear iodoalkanes of different lengths (CnI with n = 1, 2, 4, and 6). After completing the quaternization process, polyelectrolytes were subjected to a one-step anion substitution process, where iodide counterions were replaced by bis(trifluoromethane)sulfonamide entities. For all the obtained materials, solubility tests were carried out, showing that those alkylated with Me and Et chains exhibit high solubility in rutinary aprotic polar solvents, while those containing Bu and n-hexyl units resulted in the formation of insoluble gels. Due to the above, the latest were discarded from this study early on. The structural characterization of the initial neutral co-polyamide was carried out by means of IR spectroscopy (FT-IR), NMR (1H, 13C-NMR), and size-exclusion chromatog. (SEC), while the structure of methylated and ethylated polyelectrolytes was successfully confirmed through FT-IR, 1H, 13C, and 19F-NMR. Addnl., the thermal behavior of these materials was analyzed in terms of thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC), showing thermal degradation temperatures above 300°C and glass transition temperatures (Tg) above 200°C, resulting in polymers with outstanding thermal properties for water treatment applications. On the other hand, through the solvent-casting method, both neutral and charged polymers were found to be easily prepared into films, exhibiting a remarkably flexibility. The mech. properties of the films were analyzed using the traction test, from which tensile strength values ranging between 83.5 and 87.9 Mpa, along with Young’s modulus values between 2.4 and 2.5 Gpa were obtained. Moreover, through contact angle measurements and absorption anal. by immersion, polyelectrolytes showed important changes in terms of affinity against polar and polar substances (water, n-heptane, and benzene), exhibiting a higher rejection regarding the neutral polymer. Finally, as a preliminary test against the seepage of saline waters, thin polymer films (from 11.4 to 17.1μm) were deposited on top of com. filter disks and tested as filters of saline solutions ([NaCl] = 1000 and 2000 ppm). These tests revealed a decrease of the salt concentration in the obtained filtrates, with retention values ranging between 6.2 and 20.3%, depending on the concentration of the former solution and the polymer used.

Polymers (Basel, Switzerland) published new progress about Absorption. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, SDS of cas: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Barraza, Scott J.; Sindac, Janice A.; Dobry, Craig J.; Delekta, Philip C.; Lee, Pil H.; Miller, David J.; Larsen, Scott D. published the artcile< Synthesis and biological activity of conformationally restricted indole-based inhibitors of neurotropic alphavirus replication: Generation of a three-dimensional pharmacophore>, Application In Synthesis of 3731-53-1, the main research area is indole preparation neurotropic alphavirus replication inhibitor; Antiviral; Conformationally restricted; Neurotropic alphavirus; Pharmacophore; Western equine encephalitis virus.

Authors have previously reported the development of indole-based CNS-active antivirals for the treatment of neurotropic alphavirus infection, but further optimization is impeded by a lack of knowledge of the mol. target and binding site. Herein authors describe the design, synthesis and evaluation of a series of conformationally restricted analogs with the dual objectives of improving potency/selectivity and identifying the most bioactive conformation. Although this campaign was only modestly successful at improving potency, the sharply defined SAR of the rigid analogs enabled the definition of a three-dimensional pharmacophore, which authors believe will be of value in further analog design and virtual screening for alternative antiviral leads.

Bioorganic & Medicinal Chemistry Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application In Synthesis of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shokurov, Alexander V.; Meshkov, Ivan N.; Bulach, Veronique; Gorbunova, Yulia G.; Hosseini, Mir Wais; Tsivadze, Aslan Yu.; Arslanov, Vladimir V.; Selektor, Sofia L. published the artcile< Restriction of the rotational relaxation of a butadiyne-bridged porphyrin dimer in ultrathin films>, Application In Synthesis of 3731-53-1, the main research area is porphyrin dimer diazabicyclooctane aminomethylpyridine film preparation dynamic behavior UV.

The dynamic behavior of a porphyrin dimer, based on the covalent linkage of two macrocyclic moieties with a butadiyne connector, was studied in thin films by UV-visible and emission spectroscopies. The degree of π-conjugation through control of intramol. motion was studied without employing extreme conditions such as cryogenic temperatures or high viscosity. By exploiting the propensity of the dimer to bind axial ligands through Zn-N bonds, the coplanar and orthogonal conformations of the dimer may be stabilized in ultrathin films at the air/water interface. Also, using the Langmuir-Blodgett technique, monolayer-thick matrix-free films on solid substrates containing the porphyrin dimer were obtained. In the latter case, the dimer exists in either an exclusively coplanar state or a mixture of conformational states depending on the nature of the axial ligand: 1,4-diazabicyclo[2.2.2]-octane (DABCO) or 4-aminomethylpyridine (AMP).

New Journal of Chemistry published new progress about Lattice dynamics. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application In Synthesis of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem