Category: 3731-53-1

Wang, Jianjian; Tang, Qingjie; Jin, Shiwei; Wang, Yanxin; Yuan, Ziliang; Chi, Quan; Zhang, Zehui published the artcile< Mild and selective hydrogenation of nitriles into primary amines over a supported Ni catalyst>, Electric Literature of 3731-53-1, the main research area is selective hydrogenation nitrile nickel catalyst alumina support green chem.

The development of new heterogeneous non-noble catalytic systems for the selective hydrogenation of nitriles into primary amines is a challenging task. In this study, a mesoporous Al2O3-supported Ni catalyst (denoted as Ni/Al2O3-600, where 600 represents the reduction temperature) demonstrated a high catalytic activity for the hydrogenation of nitriles under mild conditions (60-80°C and 2.5 bar H2) with ammonia as the additive. This catalytic system has a wide substrate range; and the Ni/Al2O3 catalyst demonstrated a good tolerance to other functional groups, which was possibly due to its high catalytic activity under mild conditions. A plausible reaction pathway was proposed for the hydrogenation of nitriles into primary amines, and it was found that ammonia played a great role in the enhancement of the selectivity of primary amines by the inhibition of the side reaction to generate secondary amines. In addition, the Ni/Al2O3-600 catalyst could be reused five times without activity loss through convenient magnetic recovery.

New Journal of Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Electric Literature of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mikle, Gabor; Bede, Fanni; Kollar, Laszlo published the artcile< Synthesis of N-picolylcarboxamides in aminocarbonylation>, Quality Control of 3731-53-1, the main research area is picolylcarboxamide preparation; iodocamphene steroidal iodoalkene picolylamine aminocarbonylation palladium catalyst.

Palladium-catalyzed aminocarbonylation of iodocamphene and steroidal iodoalkenes was carried out in the presence of 2-, 3- and 4-picolylamine, as well as secondary amines possessing 1-picolyl substituent. In general, primary picolylamines require less than 2 h to achieve practically complete conversion. The secondary amines proved to be less reactive, requiring 6-24 h depending on the substrate structure. The corresponding carboxamides were isolated in moderate to excellent yields. The synthesis of α,β-unsaturated carboxamides is based on the synthesis of iodoalkene substrates from enolizable ketones.

Tetrahedron published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Xiaotong; Ke, Weijun; Traore, Boubacar; Guo, Peijun; Hadar, Ido; Kepenekian, Mikael; Even, Jacky; Katan, Claudine; Stoumpos, Constantinos C.; Schaller, Richard D.; Kanatzidis, Mercouri G. published the artcile< Two-Dimensional Dion-Jacobson Hybrid Lead Iodide Perovskites with Aromatic Diammonium Cations>, Reference of 3731-53-1, the main research area is aminomethylpyridinium methylammonium lead iodide perovskite luminescence crystal structure.

Two-dimensional (2D) halide perovskites have extraordinary optoelectronic properties and structural tunability. Among them, the Dion-Jacobson phases with the inorganic layers stacking exactly on top of each other are less explored. Two-dimensional (2D) Dion-Jacobson halide perovskites are presented, which adopt the general formula of A’An-1PbnI3n+1 (A’ = 4-(aminomethyl)pyridinium (4AMPY), A = methylammonium (MA), n = 1-4). By modifying the position of the CH2NH3+ group from 4AMPY to 3AMPY (3AMPY = 3-(aminomethyl)pyridinium), the stacking of the inorganic layers changes from exactly eclipsed to slightly offset. The perovskite octahedra tilts are also different between the 2 series, with the 3AMPY series exhibiting smaller bandgaps than the 4AMPY series. Compared to the aliphatic cation of the same size (AMP = (aminomethyl)piperidinium), the aromatic spacers increase the rigidity of the cation, reduce the interlayer spacing, and decrease the dielec. mismatch between inorganic layer and the organic spacer, showing the indirect but powerful influence of the organic cations on the structure and consequently on the optical properties of the perovskite materials. All A’An-1PbnI3n+1 compounds exhibit strong luminescence (PL) at room temperature Preliminary solar cell devices based on the n = 4 perovskites as absorbers of both series exhibit promising performances, with a champion power conversion efficiency (PCE) of 9.20% for (3AMPY)(MA)3Pb4I13-based devices, which is higher than the (4AMPY)(MA)3Pb4I13 and the corresponding aliphatic analog (3AMP)(MA)3Pb4I13-based ones.

Journal of the American Chemical Society published new progress about Band gap. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Reference of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dabaghian, Farid; Khanavi, Mahnaz; Zarshenas, Mohammad M. published the artcile< Bioactive compounds with possible inhibitory activity of Angiotensin-Converting Enzyme-II; a gate to manage and prevent COVID-19>, Synthetic Route of 3731-53-1, the main research area is covid19 virus angiotensin converting enzyme II review.

A review. This letter to the editor looks at bioactive compounds with possible inhibitory activity of Angiotensin-Converting Enzyme-II.

Medical Hypotheses published new progress about COVID-19. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Synthetic Route of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sepehri, Nima; Khoshneviszadeh, Mehdi; Farid, Sara Moghadam; Moayedi, Seyedeh Sara; Asgari, Mohammad Sadegh; Moazzam, Ali; Hosseini, Samanesadat; Adibi, Hossein; Larijani, Bagher; Pirhadi, Somayeh; Attarroshan, Mahshid; Sakhteman, AmirHossein; Kabiri, Maryam; Hamedifar, Haleh; Iraji, Aida; Mahdavi, Mohammad published the artcile< Design, synthesis, biological evaluation, and molecular docking study of thioxo-2,3-dihydroquinazolinone derivative as tyrosinase inhibitors>, Related Products of 3731-53-1, the main research area is thioxo dihydroquinazolinone preparation antioxidant docking tyrosinase inhibitor.

In this study, a series of thioxo-dihydroquinazolinone compounds I (R1 = i-Pr, Ph, pyridin-3-ylmethyl, cyclopentyl, etc.) were designed and synthesized as tyrosinase inhibitors. Among the investigated compounds, I (R1 = i-Pr (III)) demonstrated the best inhibitory activity with an IC50 value of 15.48μM compared to kojic acid as a pos. control with IC50 value of 9.30μM. In kinetic evaluation against tyrosinase, (III) depicted a mixed inhibition pattern. Addnl., antioxidant evaluations exhibited moderate to weak potency in 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The detailed interactions and binding mode toward tyrosinase of the most potent derivative were explicated by mol. docking study. Moreover, the computer-aided drug-likeness and pharmacokinetic studies were also carried out.

Journal of Molecular Structure published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dong, Zhen; Liu, Junzi; Wen, Di; Zhai, Maolin; Zhao, Long published the artcile< Aminomethylpyridine isomers functionalized cellulose microspheres for TcO-4/ReO-4 uptake: Structure-properties relationship and their application in different aquatic systems>, Safety of Pyridin-4-ylmethanamine, the main research area is cellulose aminomethylpyridine isomer technetium rhenium oxide adsorption; (99)Tc; Adsorption mechanism; ReO(4)(-); Removal; Structure-properties relationship.

Technetium-99 (99Tc) is a long-lived radioactive nuclide that poses great threat to environment, hence selective removal of 99Tc from aquatic system is always an issue. Aminomethylpyridine (AMP) equipped with pyridine and amino, is a promising receptor for TcO4- and its surrogate ReO4-, thus it is of interest to explore and understand the structure-properties relationship of ReO4- adsorption related to n-AMP structure that differ in amino Me position. In this work, three n-AMP functionalized cellulose microspheres (n-AMPR, n = 2, 3, 4) were synthesized and employed for TcO4-/ReO4- uptake. The effect of aminomethyl position on adsorption properties of n-AMPR for ReO4- were investigated and compared. Adsorption kinetics and adsorption isotherm showed that adsorption speed and adsorption capacity were in order of 3-AMPR > 2-AMPR > 4-AMPR. DFT calculation verified that the adsorption of ReO4- by n-AMPR was attributed to electrostatic interaction and hydrogen bonding interaction, the order of adsorption abilities of n-AMPR was due to that steric effect and hydrogen bond collaborated in stabilizing n-AMPR-ReO4- complexes. The column experiments demonstrated that 3-AMPR can be selectively remove ReO4- from simulated groundwater. More importantly, 99Tc column experiments showed that 3-AMPR had a better ability for actual radioactive TcO4-.

Journal of Hazardous Materials published new progress about Adsorption. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Safety of Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kowalkowska-Zedler, D.; Dolega, A.; Nedelko, N.; Lyszczek, R.; Aleshkevych, P.; Demchenko, I.; Luczak, J.; Slawska-Waniewska, A.; Pladzyk, A. published the artcile< Structural, magnetic and spectral properties of tetrahedral cobalt(II) silanethiolates: a variety of structures and manifestation of field-induced slow magnetic relaxation>, Name: Pyridin-4-ylmethanamine, the main research area is cobalt silanethiolate aminopyridine aminomethylpyridine complex preparation magnetic property; thermal stability cobalt silanethiolate aminopyridine aminomethylpyridine; crystal structure cobalt silanethiolate aminopyridine aminomethylpyridine.

Blue crystals of five heteroleptic cobalt(II) silanethiolates 1-5 have been obtained by the reaction of [Co{SSi(tBuO)3}2(NH3)]2 with aminopyridines and aminomethylpyridines at an appropriate molar ratio and their structural, spectral, thermal and magnetic properties have been established and described. All complexes 1-5 contain Co(II) ions in a tetrahedral CoN2S2 environment formed by (tBuO)3SiS- residues and pyridines and present variable structures. Complexes 1-3 are mononuclear [Co{SSi(tBuO)3}2(L1)2] (L1 = 2-aminopyridine 2AP, 3-aminopyridine 3AP, and 4-aminopyridine 4AP). The application of 3AMP and 4AMP (3-aminomethylpyridine and 4-aminomethylpyridine) allows either dinuclear complex 4 [Co{SSi(tBuO)3}2(μ-3AMP)]2 or 1D coordination polymer 5 with the formula of [Co{SSi(tBuO)3}2(μ-4AMP)]n to be obtained. The mol. structures of 1-5 were determined by single-crystal X-ray and powder diffraction, UV-vis and FTIR spectrocopy for solid samples and their thermal properties were characterized by TG-DSC and TG-FTIR methods. The dc and ac magnetic and EPR studies of polycrystalline samples have been performed. For all complexes, the obtained data show a behavior typical of paramagnetic high-spin Co(II) ions in a tetrahedral geometry, with a considerable contribution of the ZFS effect in a low temperature range. All complexes were also probed for SIM behavior. The modeling of the magnetic and EPR data was done for samples 1, 3, 4 and 5 to estimate ZFS parameters. The obtained results imply a neg. value of the axial parameter D in complex 4 and pos. D values for the rest of the compounds A comparative magneto-structural anal. of complexes 4 and 5 points to the high sensitivity of the single-ion magnetic anisotropy of tetrahedral Co(II) complexes to subtle changes in the first and second coordination spheres of Co(II) ions.

Dalton Transactions published new progress about Aminopyridines Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation) (cobalt complexes). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Name: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reusch, Engelbert; Holzmeier, Fabian; Gerlach, Marius; Fischer, Ingo; Hemberger, Patrick published the artcile< Decomposition of Picolyl Radicals at High Temperature: A Mass Selective Threshold Photoelectron Spectroscopy Study>, HPLC of Formula: 3731-53-1, the main research area is picolyl radical decomposition mechanism potential energy surface; ionization energy; photoelectron spectroscopy; pyrolysis; radicals; synchrotron radiation.

The reaction products of the picolyl radicals at high temperature were characterized by mass-selective threshold photoelectron spectroscopy in the gas phase. Aminomethylpyridines were pyrolyzed to initially produce picolyl radicals (m/z=92). At higher temperatures further thermal reaction products are generated in the pyrolysis reactor. All compounds were identified by mass-selected threshold photoelectron spectroscopy and several hitherto unexplored reactive mols. were characterized. The mechanism for several dissociation pathways was outlined in computations. The spectrum of m/z=91, resulting from hydrogen loss of picolyl, shows four isomers, two ethynyl pyrroles with adiabatic ionization energies (IEad) of 7.99 eV (2-ethynyl-1H-pyrrole) and 8.12 eV (3-ethynyl-1H-pyrrole), and two cyclopentadiene carbonitriles with IE’s of 9.14 eV (cyclopenta-1,3-diene-1-carbonitrile) and 9.25 eV (cyclopenta-1,4-diene-1-carbonitrile). A second consecutive hydrogen loss forms the cyanocyclopentadienyl radical with IE’s of 9.07 eV (T0) and 9.21 eV (S1). This compound dissociates further to acetylene and the cyanopropynyl radical (IE=9.35 eV). Furthermore, the cyclopentadienyl radical, penta-1,3-diyne, cyclopentadiene and propargyl were identified in the spectra. Computations indicate that dissociation of picolyl proceeds initially via a resonance-stabilized seven-membered ring.

Chemistry – A European Journal published new progress about Adiabatic ionization potential. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dong, Wei; Ge, Zemei; Wang, Xin; Li, Ridong; Li, Runtao published the artcile< Cu-mediated one-pot three-component synthesis of 3-N-substituted 1,4,2-benzodithiazine 1,1-dioxide derivatives>, HPLC of Formula: 3731-53-1, the main research area is halobenzenesulfonamide amine carbon disulfide copper catalyst three component reaction; amino benzodithiazine dioxide preparation.

A novel and efficient copper-catalyzed one-pot procedure for the synthesis of 3-N-substituted 1,4,2-benzodithiazine 1,1-dioxide derivatives from 2-halobenzenesulfonamides, amines and CS2 was described. The reaction proceeded through Ullmann-type S-arylation, intramol. addition of NH2 with C=S and dehydrosulfide, which provided a new and useful strategy for construction of cyclic aromatic sulfonamides.

Tetrahedron published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Kai; Kang, Qi-Kai; Li, Yuntong; Wu, Wen-Qiang; Zhu, Hui; Shi, Hang published the artcile< Catalytic Amination of Phenols with Amines>, Product Details of C6H8N2, the main research area is aryl amine preparation; phenol amine amination rhodium catalyst.

Herein, a rhodium-catalyzed amination of phenols, which provided concise access to diverse anilines, with water as the sole byproduct was described. The arenophilic rhodium catalyst facilitated the inherently difficult keto-enol tautomerization of phenols by means of π-coordination, allowing for the subsequent dehydrative condensation with amines. The generality of this redox-neutral catalysis by carrying out reactions of a large array of phenols with various electronic properties and a wide variety of primary and secondary amines was demonstrated. Several examples of late-stage functionalization of structurally complex bioactive mols., including pharmaceuticals, further illustrated the potential broad utility of the method.

Journal of the American Chemical Society published new progress about Amination. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Product Details of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem