Category: 3731-53-1

Kim, Yung-Yoon; Uezu, Kazuya published the artcile< Functional Microfiber Nonwoven Fabric with Copper Ion-Immobilized Polymer Brush for Detection and Adsorption of Acetone Gas>, Quality Control of 3731-53-1, the main research area is copper ion immobilization polymer brush MNWF acetone gas adsorption; 4-picolylamine; VOCs; acetone; coordination bonding; copper ions; microfiber nonwoven fabric; radiation-induced graft polymerization.

The detection and removal of volatile organic compounds (VOCs) are emerging as an important problem in modern society. In this study, we attempted to develop a new material capable of detecting or adsorbing VOCs by introducing a new functional group and immobilizing metal ions into a microfiber nonwoven fabric (MNWF) made through radiation-induced graft polymerization The suitable metal complex was selected according to the data in “”Cambridge Crystallog. Data Center (CCDC)””. The 4-picolylamine (4-AMP), designated as a ligand through the metal complex data of CCDC, was introduced at an average mole conversion rate of 63%, and copper ions were immobilized at 0.51 mmol/g to the maximum It was confirmed that degree of grafting (dg) 170% 4-AMP-Cu MNWF, where copper ions are immobilized, can adsorb up to 50% of acetone gas at about 50 ppm, 0.04 mmol/g- 4-AMP-Cu-MNWF, at room temperature and at a ratio of copper ion to adsorbed acetone of 1:10.

Sensors published new progress about Adsorption. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jiao, Zhi-Feng; Zhao, Ji-Xiao; Guo, Xiao-Ning; Tong, Xi-Li; Zhang, Bin; Jin, Guo-Qiang; Qin, Yong; Guo, Xiang-Yun published the artcile< Turning the product selectivity of nitrile hydrogenation from primary to secondary amines by precise modification of Pd/SiC catalysts using NiO nanodots>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is nickel oxide palladium silicon carbide support preparation; nitrile nickel oxide palladium catalyst selective hydrogenation; amine preparation green chem.

The selectivity of Pd/SiC catalysts for the hydrogenation of nitriles with H2 can be turned from primary to secondary amines by modification of NiO nanodots. In the modified catalysts, the NiO nanodots act as reactive sites to consume hydrogen radicals on the Pd surface, and thus prolong the lifetime of an imine intermediate that determines the product selectivity. Under mild conditions (30 °C, atm. H2), Pd/SiC and NiO-Pd/SiC catalysts exhibit high selectivity to primary (94%) and secondary (99%) amines, resp.

Catalysis Science & Technology published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Wenbin; Sidhik, Siraj; Traore, Boubacar; Asadpour, Reza; Hou, Jin; Zhang, Hao; Fehr, Austin; Essman, Joseph; Wang, Yafei; Hoffman, Justin M.; Spanopoulos, Ioannis; Crochet, Jared J.; Tsai, Esther; Strzalka, Joseph; Katan, Claudine; Alam, Muhammad A.; Kanatzidis, Mercouri G.; Even, Jacky; Blancon, Jean-Christophe; Mohite, Aditya D. published the artcile< Light-activated interlayer contraction in two-dimensional perovskites for high-efficiency solar cells>, Name: Pyridin-4-ylmethanamine, the main research area is light activated interlayer contraction 2D perovskite solar cell.

Abstract: Understanding and tailoring the phys. behavior of halide perovskites under practical environments is critical for designing efficient and durable optoelectronic devices. Here, we report that continuous light illumination leads to >1% contraction in the out-of-plane direction in two-dimensional hybrid perovskites, which is reversible and strongly dependent on the specific superlattice packing. XPS measurements show that constant light illumination results in the accumulation of pos. charges in the terminal iodine atoms, thereby enhancing the bonding character of inter-slab I-I interactions across the organic barrier and activating out-of-plane contraction. Correlated charge transport, structural and photovoltaic measurements confirm that the onset of the light-induced contraction is synchronized to a threefold increase in carrier mobility and conductivity, which is consistent with an increase in the electronic band dispersion predicted by first-principles calculations Flux-dependent space-charge-limited current measurement reveals that light-induced interlayer contraction activates interlayer charge transport. The enhanced charge transport boosts the photovoltaic efficiency of two-dimensional perovskite solar cells up to 18.3% by increasing the device′s fill factor and open-circuit voltage.

Nature Nanotechnology published new progress about Band gap. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Name: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Deping; Liu, Wenwu; Huang, Yaoguan; Liu, Mingyue; Tian, Caizhi; Lu, Hongyuan; Jia, Hui; Xu, Zihua; Ding, Huaiwei; Zhao, Qingchun published the artcile< Facile synthesis of C1-substituted β-carbolines as CDK4 inhibitors for the treatment of cancer>, Quality Control of 3731-53-1, the main research area is beta carboline preparation SAR antitumor human CDK4 inhibitor; CDK4; HCT116; Harmine; β-carboline.

Cyclin-dependent kinase 4 (CDK4), which is involved in dynamic regulation of cell cycle, has gained particularly attention for its role in controlling tumor growth. Increasing evidence showed that β-carboline derivatives have the potential to inhibit CDK4. Herein, on the basis of previous work, authors designed and synthesized a series of novel β-carbolines and evaluated their antitumor activity. Among them, compounds I and II, with the most potent anti-proliferative activity and CDK4 enzymic inhibition activity, were selected for further pharmacol. research in vitro and in vivo. The results in vitro showed that I and II exhibited potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. In vivo, I showed significant tumor growth inhibition in HCT116 tumor xenograft model without causing significant weight loss and toxicity consistent with the acute toxicity test. In addition, silico study showed I and II not only have good biol. actions, but also acceptable predicted ADME and physicochem. properties. Taken together, compounds I and II could be selected for further modification and preclin. evaluation.

Bioorganic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Su, Xuxian; Wang, Wen-Jin; Cao, Qian; Zhang, Hang; Liu, Bin; Ling, Yuyi; Zhou, Xiaotong; Mao, Zong-Wan published the artcile< A Carbonic Anhydrase IX (CAIX)-Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti-Tumor Immunity>, Formula: C6H8N2, the main research area is CAIX ruthenium photosensitizer preparation cancer PDT pyroptosis immunity; anti-tumor immunity; carbonic anhydrase IX targeting; metallodrugs; photodynamic therapy; pyroptosis.

An ideal cancer treatment should not only destroy primary tumors but also improve the immunogenicity of the tumor microenvironment to achieve a satisfactory anti-tumor immune effect. We designed a carbonic anhydrase IX (CAIX)-anchored rhenium(I) photosensitizer, named CA-Re, that not only performs type-I and type-II photodynamic therapy (PDT) with high efficiency under hypoxia (nanomolar-level phototoxicity), but also evokes gasdermin D (GSDMD) mediated pyroptotic cell death to effectively stimulate tumor immunogenicity. CA-Re could disrupt and self-report the loss of membrane integrity simultaneously. This promoted the maturation and antigen-presenting ability of dendritic cells (DCs), and fully activated T cells dependent adaptive immune response in vivo, eventually eliminating distant tumors at the same time as destroying primary tumors. To the best of our knowledge, CA-Re is the first metal complex-based pyroptosis inducer.

Angewandte Chemie, International Edition published new progress about Adaptive immunity. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pramanik, Bapan; Das, Saurav; Das, Debapratim published the artcile< Aggregation-directed High Fidelity Sensing of Picric Acid by a Perylenediimide-based Luminogen>, Related Products of 3731-53-1, the main research area is aggregation directed fluorescent sensor picric acid perylenediimide luminogen; aggregation caused quenching; chemosensor; explosive sensor; perylenediimide; picric acid.

Widespread use of picric acid (PA) in chem. industries and deadly explosives poses dreadful impact on all living creatures as well as the natural environment and has raised global concerns that necessitate the development of fast and efficient sensing platforms. To address this issue, herein, we report a perylenediimide-peptide conjugate, PDI-1 (I), for detection of PA in methanol. The probe displays typical aggregation caused quenching (ACQ) behavior and exhibits a fluorescence “”turn-off”” sensory response towards PA which is unaffected by the presence of other interfering nitroarom. compounds The sensing mechanism involves PA induced aggregation of the probe into higher order tape like structures which leads to quenching of emission. The probe possesses a low detection limit of 5.6 nM or 1.28 ppb and a significantly high Stern-Volmer constant of 6.87×104 M-1. It also exhibits conducting properties in the presence of PA vapors and thus represents a prospective candidate for vapor phase detection of PA. This is, to the best of our knowledge, the first example of a perylenediimide based probe that demonstrates extremely specific, selective and sensitive detection of PA and thus grasps the potential for application in practical scenarios.

Chemistry – An Asian Journal published new progress about Aggregation. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Evjen, Sigvart; Loege, Oda Siebke; Fiksdahl, Anne; Knuutila, Hanna K. published the artcile< Aminoalkyl-Functionalized Pyridines as High Cyclic Capacity CO2 Absorbents>, Computed Properties of 3731-53-1, the main research area is aminoalkyl functionalized pyridines high cyclic capacity carbon dioxide absorbent.

Recent years have witnessed a growing academic interest in the development of new CO2 capture solvents to reduce the capture costs. This study focused on nine picolylamines (three com. and six synthesized) and one imidazole-amine, most of which have not previously been reported as amine absorbents. The solvent performance was evaluated by measuring the absorption capacity, desorption tendency, and pKa. Several of the amines demonstrated CO2 cyclic capacity significantly higher than that of 30 wt % MEA due to very lean CO2 loadings, driven by low amine pKa. The lean loadings can potentially mitigate solvent degradation At the same time, absorption rates comparable to 30 wt % MEA were obtained for 3 M picolylamines. The results demonstrate the promising nature of picolylamines and derivatives for CO2 capture.

Energy & Fuels published new progress about Absorbents. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Computed Properties of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rutgeerts, Laurens A. J.; Soultan, Al Halifa; Subramani, Ramesh; Toprakhisar, Burak; Ramon, Herman; Paderes, Monissa C.; De Borggraeve, Wim M.; Patterson, Jennifer published the artcile< Robust scalable synthesis of a bis-urea derivative forming thixotropic and cytocompatible supramolecular hydrogels>, Reference of 3731-53-1, the main research area is bis urea derivative nanofiber supramol hydrogel gelator cytocompatibility.

Synthetic hydrogels address a need for affordable, industrially scalable scaffolds for tissue engineering. Herein, a novel low mol. weight gelator is reported that forms self-healing supramol. hydrogels. Its robust synthesis can be performed in a solvent-free manner using ball milling. Strikingly, encapsulated cells spread and proliferate without specific cell adhesion ligands in the nanofibrous material.

Chemical Communications (Cambridge, United Kingdom) published new progress about Biocompatibility. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Reference of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Chaojie; Wei, Zhangwen; Pan, Mei; Deng, Haiying; Jiang, Jijun; Su, Chengyong published the artcile< Structural tuning of coordination polymers by 4-connecting metal node and secondary building process>, Synthetic Route of 3731-53-1, the main research area is transition metal pyridylmethylnaphthalenediimide coordination polymer preparation crystal structure.

Five transition metal coordination polymers, {[Cu(4-pmntd)2(NO3)2]•2CHCl3}n (1), {[Cu(4-pmntd)2(NO3)2]·3C7H8}n (2), {[Cu(4-pmntd)2(CF3SO3)(H2O)]·CF3SO3·H2O·MeOH}n (3), [Cd(4-pmntd)2]n·nSiF6·x(MeOH)·y(CHCl3) (4), and [Zn(4-pmntd)2(CF3SO3)2]n·x(solvent) (5), were obtained from a ditopic ligand, N,N’-bis(4-pyridylmethyl)naphthalene diimide (4-pmntd). Either sql- or dia- structures are generated from four connecting coordination nodes of the metal centers. While delicate interpenetration and structural tuning in these complexes is achieved by the different conformations and spatially extending geometries adopted by the ligand and secondary building process induced by pillar-like anions.

Chinese Chemical Letters published new progress about Coordination polymers Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Synthetic Route of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Hong; Li, Ridong; Ning, Xianling; Zhao, Xuyang; Jin, Yan; Yin, Yuxin published the artcile< Synthesis and anti-tumor efficacy of novel 2, 4-diarylaminopyrimidine derivatives bearing N-(3-pyridinylmethyl) urea moiety as anaplastic lymphoma kinase inhibitors>, Safety of Pyridin-4-ylmethanamine, the main research area is chloro amino pyrimidinylamino methoxyphenyl pyridinylmethyl urea preparation; antitumor activity anaplastic lymphoma kinase inhibition SAR docking cytotoxicity; ALK inhibitor; Anti-proliferation activity; NSCLC; Structure modification.

A series of novel 2,4-diarylaminopyrimidine derivatives I [R = 3,5-dimethoxyphenyl, 6-quinolyl, 3-methoxy-4-morpholino-Ph, etc.] possessing a unique N-(3-pyridinylmethyl)urea moiety as ALK inhibitors were synthesized. The most promising analog compound I [R = 3-methoxy-4-morpholino-phenyl] significantly inhibited proliferation of ALK pos. H3122 and Karpas-299 cells with IC50 values about 10 nM, which were comparable with pos. control LDK378. Compound I [R = 3-methoxy-4-morpholino-phenyl] suppressed phosphorylation of ALK and its downstream proteins and showed low cytotoxicity on normal human primary fibroblast cells (BJ cells). The binding mode of compound I [R = 3-methoxy-4-morpholino-phenyl] was proposed by docking simulation, which explains the important role of N-(3-pyridinylmethyl)urea moiety. Furthermore, compound I [R = 3-methoxy-4-morpholino-phenyl] exhibited favorable liver microsomal stability and significant efficacy in H3122 xenograft mice model. Interestingly, compound I [R = 3-methoxy-4-morpholino-phenyl] also showed broader anti-proliferative activity on other human tumor cell lines, which was different from other ALK inhibitors.

European Journal of Medicinal Chemistry published new progress about Amines Role: ADV (Adverse Effect, Including Toxicity), PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Safety of Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem