Category: 3796-23-4

Gu, Yiting; Shen, Yangyang; Zarate, Cayetana; Martin, Ruben published the artcile< A Mild and Direct Site-Selective sp2 C-H Silylation of (Poly)Azines>, Product Details of C6H4F3N, the main research area is silylation pyridine pyrimidine pyrazine quinoline silyl dioxaborolane reagent; base promoted silylation azine borylsilane regioselective orthogonal process.

A base-mediated protocol that allows for the site-selective sp2 C-H silylation of pyridines, pyrazines, pyridazines, pyrimidines and quinolines by Et3SiBpin is described. The substitution typically proceeds in 4- or 2-position of the pyridine ring. This method is distinguished by its mild conditions, simplicity and excellent site-selective modulation for a diverse set of azines, even in the context of late-stage functionalization, while exhibiting orthogonal reactivity with classical silylation reactions.

Journal of the American Chemical Society published new progress about Boronic acids, esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (borylsilanes). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Product Details of C6H4F3N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Xiang; Jin, Jianbo; Chen, Pinhong; Liu, Guosheng published the artcile< Catalytic remote hydrohalogenation of internal alkenes>, Reference of 3796-23-4, the main research area is primary alkyl halide preparation palladium catalyst; terminal internal alkene hydrohalogenation.

Abstract: Primary alkyl halides have broad utility as fine chems. in organic synthesis. The direct halogenation of alkenes is one of the most efficient approaches for the synthesis of these halides. Internal alkenes, in particular mixtures of isomers from refineries, constitute readily available and inexpensive feedstock and are the most attractive starting materials for this synthesis. However, the hydrohalogenation of alkenes generally affords branched alkyl halides; there are no catalytic methods to prepare linear alkyl halides directly from internal alkenes, let alone from a mixture of alkene isomers. Here a report the remote oxidative halogenation of alkenes under palladium catalysis via which both terminal and internal alkenes yield primary alkyl halides efficiently. Engineering pyridine-oxazoline ligands by introducing a hydroxyl group is essential for achieving excellent chemo- and regioselectivity. The catalytic system is also good for the mixture of alkene isomers generated from dehydrogenation of alkanes, providing a window to investigate the high-value utilization of inexpensive alkanes.

Nature Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Reference of 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yu, Hsien-Cheng; Islam, Shahidul M.; Mankad, Neal P. published the artcile< Cooperative Heterobimetallic Substrate Activation Enhances Catalytic Activity and Amplifies Regioselectivity in 1,4-Hydroboration of Pyridines>, Application of C6H4F3N, the main research area is cooperative catalyst NHC copper iron half sandwich regioselective borylation; pyridine regioselective borylation cooperative copper iron imidazolylidene catalyst; dihydropyridine boronate preparation regioselective hydroboration pyridine cooperative bimetallic catalyst.

Regioselective 1,4-hydroboration of pyridine derivatives and quinoline with pinacolborane is catalyzed efficiently by the heterobinuclear catalyst, (IPr)CuFeCp(CO)2, at only 2 mol % loading, providing access to valuable 1,4-dihydropyridine (1,4-DHP) products. A variety of reactive functional groups are tolerated in the pyridine 3-position, and sufficient catalytic activity was obtained for reduction of sterically hindered cases such as 3,5-disubstituted pyridines and even 4-substituted pyridines. Mechanistic experiments indicate that the superior catalytic activity and 1,4-regioselectivity of the Cu/Fe heterobinuclear catalyst, compared to the corresponding mononuclear Cu catalyst, is derived from biphilic cooperativity of two key catalytic intermediates: electrophilic CpFe(CO)2(Bpin) activates the pyridine substrates toward regioselective nucleophilic addition by (IPr)CuH.

ACS Catalysis published new progress about Boronic acids, esters Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Application of C6H4F3N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sen, Subhabrata; Barman, Dhiraj; Khan, Haya; Das, Ranajit; Maiti, Debajit published the artcile< Cu(II)-Catalyzed Multicomponent Reaction of Pyridine Derivatives/Isoquinolines with Iodonium Ylide and 1,4-Quinones Using Mechanochemistry>, Application of C6H4F3N, the main research area is isoindolopyridine preparation green chem regioselective mechanochem DFT photoluminescence anticancer; pyridine iodonium ylide quinone multicomponent reaction copper catalyst; isoindoloisoquinoline preparation green chem regioselective mechanochem DFT photoluminescence anticancer; isoquinoline iodonium ylide quinone multicomponent reaction copper catalyst.

An efficient copper-catalyzed solvent-free multicomponent reaction for pyridine derivatives such as 3-methylpyridine, pyridine-3-carbonitrile, 3-(trifluoromethyl)pyridine, etc. Ph iodonium di-Me malonate, and 1,4-quinones such as benzoquinone, p-methylbenzoquinone, anthraquinone and naphthoquinone is developed via a room-temperature ball milling technique. The reported protocol provides a sustainable synthesis of isoindolo[2,1-a]pyridine/isoquinoline class of mols., e.g., I (R = F, H) and e.g., II in good to excellent yield in a mixer mill (RETSCH MM400) engaging the com. available copper acetate (Cu(OAc)2) as a catalyst without the use of organic solvents. It tolerates a myriad of electron-rich and electron-deficient functionalities on the pyridine moiety. The scalability of the protocol was illustrated by successfully performing the reaction in the gram scale. The photoluminescence and related cellular study revealed that these can be used as a fluorescent chromophore-based cellular probe. A clean reaction profile and a facile exptl. setup that is devoid of anhydrous reaction conditions and toxic organic solvents have established the advantages of this strategy over the reported process.

Journal of Organic Chemistry published new progress about Antitumor agents. 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Application of C6H4F3N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3796-23-4, name is 3-(Trifluoromethyl)pyridine, molecular formula is C6H4F3N, molecular weight is 147.1, as common compound, the synthetic route is as follows.HPLC of Formula: C6H4F3N

General procedure: Add 3-trifluoromethylpyridine (73.6g, 0.5mol) and WCl6 (9.9g, 0.025mol) to a 250mL three-necked flask, purge nitrogen into the flask, heat with stirring to 120 C, and wait for the temperature to stabilize after nitrogen Switch to chlorine gas (100 mL / min), and react for 15 hours at 120 C with chlorine gas bubbling, stop heating, and switch the chlorine gas to nitrogen again to end the reaction.The temperature was then raised to 200 C and the entire product was distilled off. A 10 wt% NaOH solution was added to the steamed product to neutralize it, and extraction and liquid separation were performed to obtain an oily product.The obtained oily product was dried with anhydrous sodium sulfate and weighed 96.0 g.Qualitative analysis was performed by GC-MS, and quantitative analysis was performed by internal standard method of gas chromatography.The results are shown in Table 1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3796-23-4, 3-(Trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; Zhejiang Chemical Institute Co., Ltd.; Zhejiang Lantian Environmental Protection Gao Technology Co., Ltd.; Sinochem Lantian Group Co., Ltd.; Yan Bo; Yu Wanjin; Lin Shengda; Liu Minyang; Liu Wucan; Zhang Jianjun; (10 pag.)CN110627711; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem