Category: 3811-73-2

Zurlinden, Todd J.; Saili, Katerine S.; Rush, Nathaniel; Kothiya, Parth; Judson, Richard S.; Houck, Keith A.; Hunter, E. Sidney; Baker, Nancy C.; Palmer, Jessica A.; Thomas, Russell S.; Knudsen, Thomas B. published the artcile< Profiling the ToxCast library with a pluripotent human (H9) stem cell line-based biomarker assay for developmental toxicity>, SDS of cas: 3811-73-2, the main research area is toxcast library pluripotent human stem cell line development toxicity; developmental toxicity; embryonic stem cells; predictive toxicology.

The Stemina devTOX quickPredict platform is a human pluripotent stem cell-based assay that predicts the developmental toxicity potential based on changes in cellular metabolism following chem. exposure. Using this assay, we screened 1065 ToxCast phase I and II chems. in single-concentration or concentration-response for the targeted biomarker (ratio of ornithine to cystine secreted or consumed from the media). The dataset from the Stemina (STM) assay is annotated in the ToxCast portfolio as STM. Major findings from the anal. of ToxCast_STM dataset include (1) 19% of 1065 chems. yielded a prediction of developmental toxicity, (2) assay performance reached 79%-82% accuracy with high specificity (> 84%) but modest sensitivity (< 67%) when compared with in vivo animal models of human prenatal developmental toxicity, (3) sensitivity improved as more stringent weights of evidence requirements were applied to the animal studies, and (4) statistical anal. of the most potent chem. hits on specific biochem. targets in ToxCast revealed pos. and neg. associations with the STM response, providing insights into the mechanistic underpinnings of the targeted endpoint and its biol. domain. The results of this study will be useful to improving our ability to predict in vivo developmental toxicants based on in vitro data and in silico models. Toxicological Sciences published new progress about Analysis (toxicol.). 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, SDS of cas: 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Campos, Debora L.; Machado, Ignacio; Ribeiro, Camila M.; Gambino, Dinorah; Pavan, Fernando R. published the artcile< Bactericidal effect of pyridine-2-thiol 1-oxide sodium salt and its complex with iron against resistant clinical isolates of Mycobacterium tuberculosis>, Category: pyridine-derivatives, the main research area is Mycobacterium antibacterial pyridine thiol oxide sodium salt.

We determined the activity of pyridine-2-thiol 1-oxide sodium salt (Na mpo) and its complex with iron [Fe(mpo)3] against Mycobacterium tuberculosis. The compounds were tested against a standard strain of M. tuberculosis H37Rv (ATCC 27294), with minimal inhibitory concentrations (MIC90) of 7.20 and 1.07 μM to Na mpo and [Fe(mpo)3], resp., and against 3 clin. isolates with different genotypic profiles, with MIC values ranging 0.74-6.52 and 0.30-2.25 μM to Na mpo and [Fe(mpo)3], resp. [Fe(mpo)3] was more effective against susceptible strains but both compounds were effective in inhibiting MDR and XDR-TB clin. strains. The profile activity was determined through the methodol. of a time-kill curve against standard and clin. strains of M. tuberculosis. Time-kill studies indicated that Na mpo had an early bactericidal activity against H37Rv and clin. isolates, with sterilizing effects observed in 5 and 7 days, resp., at its MIC90. The anti MDR and XDR-M. tuberculosis activity and bactericidal effect of Na mpo and [Fe(mpo)3] demonstrate their potential as new compounds for the treatment of tuberculosis.

Journal of Antibiotics published new progress about Mycobacterium tuberculosis. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Huang, Haw-Tyng; Zhu, Li; Ward, Matthew D.; Wang, Tao; Chen, Bo; Chaloux, Brian L.; Wang, Qianqian; Biswas, Arani; Gray, Jennifer L.; Kuei, Brooke; Cody, George D.; Epshteyn, Albert; Crespi, Vincent H.; Badding, John V.; Strobel, Timothy A. published the artcile< Nanoarchitecture through Strained Molecules: Cubane-Derived Scaffolds and the Smallest Carbon Nanothreads>, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt, the main research area is cubane derived scaffold carbon nanothread.

Relative to the rich library of small-mol. organics, few examples of ordered extended (i.e., nonmol.) hydrocarbon networks are known. In particular, sp3 bonded, diamond-like materials represent appealing targets because of their desirable mech., thermal, and optical properties. While many covalent organic frameworks (COFs)-extended, covalently bonded, and porous structures-have been realized through mol. architecture with exceptional control, the design and synthesis of dense, covalent-extended solids has been a longstanding challenge. We report the preparation of a sp3-bonded, low-dimensional hydrocarbon synthesized via high-pressure, solid-state diradical polymerization of cubane (C8H8), which is a saturated, but immensely strained, cage-like mol. Exptl. measurements show that the obtained product is crystalline with 3-dimensional order that appears to largely preserve the basic structural topol. of the cubane mol. precursor and exhibits high hardness (comparable to fused quartz) and thermal stability ≤300°. Among the plausible theor. candidate structures, 1-dimensional carbon scaffolds comprising 6- and 4-membered rings that pack within a pseudosquare lattice provide the best agreement with exptl. data. These diamond-like mol. rods with extraordinarily small thickness are among the smallest members in the carbon nanothread family, and calculations indicate 1 of the stiffest 1-dimensional systems known. These results present opportunities for the synthesis of purely sp3-bonded extended solids formed through the strain release of saturated mols., as opposed to only unsaturated precursors.

Journal of the American Chemical Society published new progress about Compression. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Siegel, David J.; Howarth, Alexis N.; Traver, Joseph R.; Hillesheim, Patrick C.; Zeller, Matthias; Mirjafari, Arsalan published the artcile< 2,2'-[Methylenebis(sulfanediyl)]bis(pyridine 1-oxide)>, Electric Literature of 3811-73-2, the main research area is pyridine N oxide compound synthesis crystal structure.

The title compound, C11H10N2O2S2, crystallizes with one complete mol. in the asym. unit. In the crystal, weak hydrogen bonding is observed between the N-oxide moieties and several C-H units.

IUCrData published new progress about Crystal structure. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Electric Literature of 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lopez Quezada, Landys; Li, Kelin; McDonald, Stacey L.; Nguyen, Quyen; Perkowski, Andrew J.; Pharr, Cameron W.; Gold, Ben; Roberts, Julia; McAulay, Kathrine; Saito, Kohta; Somersan Karakaya, Selin; Javidnia, Prisca Elis; Porras de Francisco, Esther; Amieva, Manuel Marin; Diaz, Sara Palomo; Mendoza Losana, Alfonso; Zimmerman, Matthew; Liang, Hsin-Pin Ho; Zhang, Jun; Dartois, Veronique; Sans, Stephanie; Lagrange, Sophie; Goullieux, Laurent; Roubert, Christine; Nathan, Carl; Aube, Jeffrey published the artcile< Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis>, Electric Literature of 3811-73-2, the main research area is pyrithione containing cephalosporin Mycobacterium replication; antimycobacterial; cephalosporin; pyrithione; tuberculosis; β-lactamase.

The historical view of β-lactams as ineffective antimycobacterials has given way to growing interest in the activity of this class against Mycobacterium tuberculosis (Mtb) in the presence of a β-lactamase inhibitor. However, most antimycobacterial β-lactams kill Mtb only or best when the bacilli are replicating. Here, a screen of 1904 β-lactams led to the identification of cephalosporins substituted with a pyrithione moiety at C3′ that are active against Mtb under both replicating and nonreplicating conditions, neither activity requiring a β-lactamase inhibitor. Studies showed that activity against nonreplicating Mtb required the in situ release of the pyrithione, independent of the known class A β-lactamase, BlaC. In contrast, replicating Mtb could be killed both by released pyrithione and by the parent β-lactam. Thus, the antimycobacterial activity of pyrithione-containing cephalosporins arises from 2 mechanisms that kill mycobacteria in different metabolic states.

ACS Infectious Diseases published new progress about Blood plasma. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Electric Literature of 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Schubert, Steffen; Bauer, Andrea; Hillen, Uwe; Werfel, Thomas; Geier, Johannes; Brans, Richard; IVDK published the artcile< Occupational contact dermatitis in painters and varnishers: Data from the Information Network of Departments of Dermatology ( IVDK ), 2000 to 2019>, Category: pyridine-derivatives, the main research area is occupational contact dermatitis paints varnish human; allergic contact dermatitis; epoxy resin; face dermatitis; methylchloroisothiazolinone; methylisothiazolinone; occupational dermatitis; painter; patch test; varnisher.

Painters and varnishers (“”painters””) are exposed to various contact allergens and skin irritants, and therefore, are at risk for developing occupational dermatitis (OD). To describe the spectrum of occupational sensitizations in painters and revise the corresponding current patch test recommendations. Retrospective anal. of Information Network of Departments of Dermatol. (IVDK) data from 2000 to 2019 with focus on male painters with OD, ages 20-59 years (n = 557) in comparison to age-matched male painters without OD (n = 422) and male OD patients who have had never worked as painters (n = 13 862). Male painters with OD have a significantly higher rate of allergic contact dermatitis and face dermatitis than male patients with OD who work in other professions. Pos. patch tests to epoxy resin, methylisothiazolinone (MI), and methylchloroisothiazolinone (MCI)/MI were significantly more frequent in painters with OD than in the other groups. Epoxy resin sensitization was significantly associated with face dermatitis. Epoxy resin, MI, and MCI/MI represent the most important occupational sensitizers in painters. In addition to baseline, resins and glues, and industrial biocides series, the patients′ own workplace materials should be tested in painters with suspected OD.

Contact Dermatitis published new progress about Alcohols, C16-18, ethoxylated Role: ADV (Adverse Effect, Including Toxicity), BIOL (Biological Study). 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Soczewka, Piotr; Tribouillard-Tanvier, Deborah; di Rago, Jean-Paul; Zoladek, Teresa; Kaminska, Joanna published the artcile< Targeting copper homeostasis improves functioning of vps13δ yeast mutant cells, a model of VPS13-related diseases>, Name: 2-Mercaptopyridinen-oxide sodiumsalt, the main research area is CCC2 VPS13A CTR1 cox11 Parkinson Menke Wilson disease; CCC2; CTR1; FET3; VPS13; copper homeostasis; disulfiram; elesclomol; pyrithione; yeast model, neurodegeneration.

Ion homeostasis is crucial for organism functioning, and its alterations may cause diseases. For example, copper insufficiency and overload are associated with Menkes andWilsons diseases, respectivley, and iron imbalance is observed in Parkinsons and Alzheimers diseases. To better understand human diseases, Saccharomyces cerevisiae yeast are used as a model organism. In our studies, we used the vps13δ yeast strain as a model of rare neurol. diseases caused by mutations in VPS13A-D genes. In this work, we show that overexpression of genes encoding copper transporters, CTR1, CTR3, and CCC2, or the addition of copper salt to the medium, improved functioning of the vps13δ mutant. We show that their mechanism of action, at least partially, depends on increasing iron content in the cells by the copper-dependent iron uptake system. Finally, we present that treatment with copper ionophores, disulfiram, elesclomol, and sodium pyrithione, also resulted in alleviation of the defects observed in vps13δ cells. Our study points at copper and iron homeostasis as a potential therapeutic target for further investigation in higher eukaryotic models of VPS13-related diseases.

International Journal of Molecular Sciences published new progress about Alzheimer disease. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Name: 2-Mercaptopyridinen-oxide sodiumsalt.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dallaston, Madeleine A.; Brusnahan, Jason S.; Wall, Craig; Williams, Craig M. published the artcile< Thermal and Sensitiveness Determination of Cubanes: Towards Cubane-Based Fuels for Infrared Countermeasures>, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt, the main research area is cubane fuel IR countermeasure thermal sensitivity determination; Yoshida; cubane; energetic materials; infrared; pyrotechnics.

As IR seeking technol. evolves, threats are better able to distinguish defensive IR flares from true targets. Spectrally matched flares, which generally employ carbon-based fuels, are better able to decoy some advanced missiles by more closely mimicking the IR emission of the target. Cubane is a high-energy carbon-based scaffold which may be suitable for use as a fuel in spectrally matched flares. The enthalpy of formation and strain energy of a series of cubanes was predicted in silico, and their thermal and impact stability examined All were found to undergo highly exothermic decomposition in sealed cell differential scanning calorimetry, and two cubanes subsequently underwent quant. sensitiveness testing. Despite their F of I values being in the secondary explosive range, cubane-1,4-dicarboxylic acid (F of I = 70) and 4-carbamoylcubane-1-carboxylic acid (F of I = 90) were identified as potentially useful fuels for pyrotechnic IR countermeasure flare formulations.

Chemistry – A European Journal published new progress about Explosives. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kokhan, Serhii O.; Valter, Yevheniia B.; Tymtsunik, Andriy V.; Komarov, Igor V.; Grygorenko, Oleksandr O. published the artcile< 3-Carboxy-/3-Aminobicyclo[1.1.1]pentane-Derived Sulfonamides and Sulfonyl Fluorides - Advanced Bifunctional Reagents for Organic Synthesis and Drug Discovery>, Computed Properties of 3811-73-2, the main research area is carboxy aminobicyclopentane derived sulfonamide sulfonyl fluoride preparation.

A convenient approach to 1,3-bifunctional sulfonyl fluorides, sulfonamides and sulfinates bearing a bicyclo[1.1.1]pentane unit attached to the sulfur atom and (protected) amino or carboxyl group is described. The method relied on photochem. decomposition of Barton [1-hydroxypyridine-2(1H)-thione] esters of the corresponding carboxylic acids as the key step, followed by oxidation and cleavage of the 2-pyridyl moiety. The title building blocks were obtained on a gram scale, and their utility was demonstrated by preparation of an isosteric analog of classical sulfonamide anitibiotic sulfanilamide, as well as some other common chem. modifications.

European Journal of Organic Chemistry published new progress about Sulfinates Role: SPN (Synthetic Preparation), PREP (Preparation). 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Computed Properties of 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem