Category: 381247-99-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 381247-99-0, name is Methyl 5-bromo-6-hydroxynicotinate. A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 5-bromo-6-hydroxynicotinate

Methyl 3-(5-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-6-methoxypyridin-3-yl)-2,2-dimethylpropanoate [0562] As shown in reaction scheme 7, Compound 31, an intermediate compound, was synthesized, and then Compound 349 (0.28 g, 69.5%) as white solid foam was obtained according to the similar method to the synthesis of compound 285. [0563] 1H NMR (400 MHz, DMSO-d6); atropisomer mixture; delta7.86 (m, 1H), 7.81, 7.83 (2d, 1H, J=1.77, 1.83 Hz), 7.74-7.75 (m, 2H), 7.02, 7.05 (2d, 1H, J=1.77, 1.77 Hz), 5.60, 5.63 (2d, 1H, J=5.94, 6.00 Hz), 3.91-4.03 (m, 2H), 3.85, 3.88 (2d, 3H), 3.64, 3.65 (2s, 3H), 3.46-3.52 (m, 1H), 2.73-2.80 (m, 2H), 1.90-1.95 (m, 2H), 1.43-1.48 (m, 2H), 1.16-1.20 (m, 6H), 1.01-1.09 (m, 6H), 0.28, 0.49 (2d, 3H, J=4.89, 4.89 Hz); MS (ESI) m/z 657.2 (M++H)

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Reference:
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; Lee, SeoHee; Oh, Jung Taek; Lee, JaeKwang; Lee, JaeWon; Bae, Suyeal; Ha, Nina; Lee, Sera; US2014/31335; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 381247-99-0, name is Methyl 5-bromo-6-hydroxynicotinate. A new synthetic method of this compound is introduced below., SDS of cas: 381247-99-0

Methyl 5-bromo-6-oxo- 1 ,6-dthydropyridine-3-carboxylate (3.0 g, 1.0 eq) and potassium carbonate (3.6 g, 2.0 eq) were dissolved in N,N-dimethylformamide, and dropwisely added with iodomethane (1.5 eq) at room temperature. The reaction mixture was stirred at 35C for 3 hours. Upon completion of the reaction, the resultant was diluted with ethyl acetate, washed with water, dried with magnesium sulfate and filtered, and concentrated under reduced pressure. The resulting residue was dissolved in dichloromethane and crystallized with hexane to obtain a title compound (2.5 g, yield 79%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 381247-99-0, Methyl 5-bromo-6-hydroxynicotinate.

Reference:
Patent; DAEWOONG PHARMACEUTICAL CO., LTD.; PARK, Joon Seok; YOON, Youn Jung; PARK, Chang Min; NA, Yun Soo; CHO, Min Jae; LEE, Ho Bin; HAN, Mi Ryeong; PARK, Yeon Jung; KIM, Ji Duck; WO2015/60613; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 381247-99-0, name is Methyl 5-bromo-6-hydroxynicotinate. A new synthetic method of this compound is introduced below., SDS of cas: 381247-99-0

Methyl 5-bromo-6-oxo- 1 ,6-dthydropyridine-3-carboxylate (3.0 g, 1.0 eq) and potassium carbonate (3.6 g, 2.0 eq) were dissolved in N,N-dimethylformamide, and dropwisely added with iodomethane (1.5 eq) at room temperature. The reaction mixture was stirred at 35C for 3 hours. Upon completion of the reaction, the resultant was diluted with ethyl acetate, washed with water, dried with magnesium sulfate and filtered, and concentrated under reduced pressure. The resulting residue was dissolved in dichloromethane and crystallized with hexane to obtain a title compound (2.5 g, yield 79%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 381247-99-0, Methyl 5-bromo-6-hydroxynicotinate.

Reference:
Patent; DAEWOONG PHARMACEUTICAL CO., LTD.; PARK, Joon Seok; YOON, Youn Jung; PARK, Chang Min; NA, Yun Soo; CHO, Min Jae; LEE, Ho Bin; HAN, Mi Ryeong; PARK, Yeon Jung; KIM, Ji Duck; WO2015/60613; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 381247-99-0, name is Methyl 5-bromo-6-hydroxynicotinate. A new synthetic method of this compound is introduced below., SDS of cas: 381247-99-0

Methyl 5-bromo-6-oxo- 1 ,6-dthydropyridine-3-carboxylate (3.0 g, 1.0 eq) and potassium carbonate (3.6 g, 2.0 eq) were dissolved in N,N-dimethylformamide, and dropwisely added with iodomethane (1.5 eq) at room temperature. The reaction mixture was stirred at 35C for 3 hours. Upon completion of the reaction, the resultant was diluted with ethyl acetate, washed with water, dried with magnesium sulfate and filtered, and concentrated under reduced pressure. The resulting residue was dissolved in dichloromethane and crystallized with hexane to obtain a title compound (2.5 g, yield 79%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 381247-99-0, Methyl 5-bromo-6-hydroxynicotinate.

Reference:
Patent; DAEWOONG PHARMACEUTICAL CO., LTD.; PARK, Joon Seok; YOON, Youn Jung; PARK, Chang Min; NA, Yun Soo; CHO, Min Jae; LEE, Ho Bin; HAN, Mi Ryeong; PARK, Yeon Jung; KIM, Ji Duck; WO2015/60613; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 381247-99-0, name is Methyl 5-bromo-6-hydroxynicotinate. A new synthetic method of this compound is introduced below., SDS of cas: 381247-99-0

Step 1: Methyl 5-bromo-l-methyl–oxo-1,6-dihvdropyridine-3-carboxvlate. A mixture of methyl 5-bromo-6-oxo-l,6-dihydropyridine-3-caboxylate (1.5 g, 6.5 mmol)and potassium carbonate (0.99 g, 7.15 mmol) in DMF (25 mL) was stirred at room temperature for 15 min followed by the addition of methyl iodide (0.42 mL, 6.83 mmol). The resulting suspension was stirred at room temperature for 17 h. The mixture was partitioned between ethylacetate and water. The organic phase was separated and the aqueous phase was extracted with ethylacetate. The organic extracts were combined, washed with brine, dried over MgSO4 and concentrated to afford the title compound as a light yellow solid. MS m/z: 246(M+1).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 381247-99-0, Methyl 5-bromo-6-hydroxynicotinate.

Reference:
Patent; AMGEN INC.; WO2007/62007; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 381247-99-0, name is Methyl 5-bromo-6-hydroxynicotinate. A new synthetic method of this compound is introduced below., SDS of cas: 381247-99-0

Step 1: Methyl 5-bromo-l-methyl–oxo-1,6-dihvdropyridine-3-carboxvlate. A mixture of methyl 5-bromo-6-oxo-l,6-dihydropyridine-3-caboxylate (1.5 g, 6.5 mmol)and potassium carbonate (0.99 g, 7.15 mmol) in DMF (25 mL) was stirred at room temperature for 15 min followed by the addition of methyl iodide (0.42 mL, 6.83 mmol). The resulting suspension was stirred at room temperature for 17 h. The mixture was partitioned between ethylacetate and water. The organic phase was separated and the aqueous phase was extracted with ethylacetate. The organic extracts were combined, washed with brine, dried over MgSO4 and concentrated to afford the title compound as a light yellow solid. MS m/z: 246(M+1).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 381247-99-0, Methyl 5-bromo-6-hydroxynicotinate.

Reference:
Patent; AMGEN INC.; WO2007/62007; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem