Reference of 386704-05-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 386704-05-8, name is 2-Chloro-6-(trifluoromethyl)nicotinamide. This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 6 Preparation of 3-amino-2-chloro-6-trifluoromethylpyridine To a mixture of 200 g of 2-chloro-6-trifluoromethylnicotinamide and 1,000 ml of water, 432 ml of a 11.6 wt% aqueous sodium hypochlorite solution and 190 ml of a 10 N aqueous sodium hydroxide solution were dropwise added in order under cooling with ice, followed by stirring at 90C for 30 minutes. The reaction mixture was cooled to 10C, crystals precipitated were collected by filtration, washed three times with 100 ml of cooled water, and then dried at room temperature for 24 hours to obtain 144 g of 3-amino-2-chloro-6-trifluoromethylpyridine (melting point: 96 to 97C). 1H-NMR(CDCl3) delta= 4.47(2H, bs, NH2), 7.09(1H, d, J= 7.8 Hz), 7.42(1H, d, J= 7.8 Hz).
According to the analysis of related databases, 386704-05-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ISHIHARA SANGYO KAISHA, LTD.; EP2251329; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem