Category: 38875-53-5

Application of 38875-53-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 38875-53-5 as follows.

To a solution of 2,3-diamino-5-bromopyridine (5 g, 27 mmol) in THF (87 mL) was added CDI (3.02 g, 18.6 mmol), and the reaction mixture was stirred at 80 C for 16 h. Then, water was added, and the mixture was filtered. The solids were collected by filtration, washed with water and Et2O, and dried under vacuum to afford the title compound (5.3 g, 25 mmol, 93%), which was used in the next step without further purification. MS (ESI): mass calcd. for C6H4BrN3O, 212.95; m/z found, 214 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,38875-53-5, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; CHROVIAN, Christa C.; LETAVIC, Michael A.; RECH, Jason C.; RUDOLPH, Dale A.; JOHNSON, Akinola Soyode; STENNE, Brice M.; WALL, Jessica L.; (533 pag.)WO2018/67786; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 38875-53-5, name is 5-Bromo-2,3-diaminopyridine. This compound has unique chemical properties. The synthetic route is as follows. 38875-53-5

General procedure: 136 (360mg, 2.92mmol) and disuccinimido carbonate (749mg, 2.92mmol) were dissolved in chloroform (5mL) and heated at reflux for 48h under N2. The reaction was then concentrated, and the residue dissolved in a 1:3 mixture of CyHex/EtOAc (200mL) and heated to reflux for 10min. The reaction was then cooled and the precipitate filtered and dried to obtain 145 as a solid (210mg, 48%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 38875-53-5, 5-Bromo-2,3-diaminopyridine.

Reference:
Article; Blackmore, Timothy R.; Jacobson, Jonathan; Jarman, Kate E.; Lewin, Sharon R.; Nguyen, William; Purcell, Damian F.; Sabroux, Helene Jousset; Sleebs, Brad E.; European Journal of Medicinal Chemistry; vol. 195; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 38875-53-5, name is 5-Bromo-2,3-diaminopyridine. This compound has unique chemical properties. The synthetic route is as follows. 38875-53-5

To a soln of [BROMOACETALDEHYDE] diethyl acetal (2.37 mL, 15.4 [MMOL)] in [DIOXANE/H20] (2: 1/15 mL) at rt was added conc. [HCI] (0.3 mL) and the mixture was refluxed for 30 min. The mixture was cooled to rt whereupon [NAHCO3] (2.6 g, 30.8 [MMOL)] was carefully added followed by dropwise addition of diamino derivative (1.5 g, 7.7 [MMOL)] in [DIOXANE/H20] (2: [1/15] mL). The resultant mixture was stirred at reflux for 14 h and was cooled to rt. The mixture was diluted with 1 M [NAOH] (30 mL) and was extracted with [CH2CI2] (3 x 35 mL). The organic layers were combined, washed with brine [(1] x 20 mL), dried [(NA2SO4),] filtered and concentrated under reduced pressure to afford 1.5 g (92%) of the desired compound [[M +] H = 214. [0].]

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 38875-53-5, 5-Bromo-2,3-diaminopyridine.

Reference:
Patent; SCHERING CORPORATION; WO2004/26867; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem